LOCUS       NP_062516               1249 aa            linear   ROD 11-FEB-2025
DEFINITION  DNA repair protein REV1 isoform 1 [Mus musculus].
ACCESSION   NP_062516
VERSION     NP_062516.2
DBSOURCE    REFSEQ: accession NM_019570.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 1249)
  AUTHORS   Shah,P., Hill,R., Dion,C., Clark,S.J., Abakir,A., Willems,J.,
            Arends,M.J., Garaycoechea,J.I., Leitch,H.G., Reik,W. and
            Crossan,G.P.
  TITLE     Primordial germ cell DNA demethylation and development require DNA
            translesion synthesis
  JOURNAL   Nat Commun 15 (1), 3734 (2024)
   PUBMED   38702312
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 1249)
  AUTHORS   In Het Panhuis,W., Tsaalbi-Shtylik,A., Schonke,M., van Harmelen,V.,
            Pronk,A.C.M., Streefland,T.C.M., Sips,H.C.M., Afkir,S., Willems van
            Dijk,K., Rensen,P.C.N., de Wind,N. and Kooijman,S.
  TITLE     Rev1 deficiency induces replication stress to cause metabolic
            dysfunction differently in males and females
  JOURNAL   Am J Physiol Endocrinol Metab 322 (3), E319-E329 (2022)
   PUBMED   35156394
  REMARK    GeneRIF: Rev1 deficiency induces replication stress to cause
            metabolic dysfunction differently in males and females.
REFERENCE   3  (residues 1 to 1249)
  AUTHORS   Fakouri,N.B., Durhuus,J.A., Regnell,C.E., Angleys,M., Desler,C.,
            Hasan-Olive,M.M., Martin-Pardillos,A., Tsaalbi-Shtylik,A.,
            Thomsen,K., Lauritzen,M., Bohr,V.A., de Wind,N., Bergersen,L.H. and
            Rasmussen,L.J.
  TITLE     Rev1 contributes to proper mitochondrial function via the
            PARP-NAD+-SIRT1-PGC1alpha axis
  JOURNAL   Sci Rep 7 (1), 12480 (2017)
   PUBMED   28970491
  REMARK    GeneRIF: Rev1 contributes to proper mitochondrial function via the
            PARP-NAD-SIRT1-PGC1A axis.
            Erratum:[Sci Rep. 2018 Mar 6;8(1):4245. doi:
            10.1038/s41598-018-20586-9.. PMID: 29511198]
            Publication Status: Online-Only
REFERENCE   4  (residues 1 to 1249)
  AUTHORS   Martin-Pardillos,A., Tsaalbi-Shtylik,A., Chen,S., Lazare,S., van
            Os,R.P., Dethmers-Ausema,A., Fakouri,N.B., Bosshard,M.,
            Aprigliano,R., van Loon,B., Salvatori,D.C.F., Hashimoto,K.,
            Dingemanse-van der Spek,C., Moriya,M., Rasmussen,L.J., de Haan,G.,
            Raaijmakers,M.H.G.P. and de Wind,N.
  TITLE     Genomic and functional integrity of the hematopoietic system
            requires tolerance of oxidative DNA lesions
  JOURNAL   Blood 130 (13), 1523-1534 (2017)
   PUBMED   28827409
  REMARK    Erratum:[Blood. 2018 Feb 8;131(6):710. doi:
            10.1182/blood-2017-12-823302.. PMID: 29438974]
REFERENCE   5  (residues 1 to 1249)
  AUTHORS   Sasatani,M., Xi,Y., Kajimura,J., Kawamura,T., Piao,J., Masuda,Y.,
            Honda,H., Kubo,K., Mikamoto,T., Watanabe,H., Xu,Y., Kawai,H.,
            Shimura,T., Noda,A., Hamasaki,K., Kusunoki,Y., Zaharieva,E.K. and
            Kamiya,K.
  TITLE     Overexpression of Rev1 promotes the development of
            carcinogen-induced intestinal adenomas via accumulation of point
            mutation and suppression of apoptosis proportionally to the Rev1
            expression level
  JOURNAL   Carcinogenesis 38 (5), 570-578 (2017)
   PUBMED   28498946
  REMARK    GeneRIF: These data indicate that dysregulation of cellular Rev1
            levels leads to the accumulation of mutations and suppression of
            cell death, which accelerates the tumorigenic activities of
            DNA-damaging agents.
REFERENCE   6  (residues 1 to 1249)
  AUTHORS   Jansen,J.G., Tsaalbi-Shtylik,A., Langerak,P., Calleja,F.,
            Meijers,C.M., Jacobs,H. and de Wind,N.
  TITLE     The BRCT domain of mammalian Rev1 is involved in regulating DNA
            translesion synthesis
  JOURNAL   Nucleic Acids Res 33 (1), 356-365 (2005)
   PUBMED   15653636
  REMARK    GeneRIF: The BRCT domain of Rev1 is involved in regulating DNA
            replication during the mutagenic bypass of spontaneous and induced
            DNA lesions.
            Publication Status: Online-Only
REFERENCE   7  (residues 1 to 1249)
  AUTHORS   Guo,C., Fischhaber,P.L., Luk-Paszyc,M.J., Masuda,Y., Zhou,J.,
            Kamiya,K., Kisker,C. and Friedberg,E.C.
  TITLE     Mouse Rev1 protein interacts with multiple DNA polymerases involved
            in translesion DNA synthesis
  JOURNAL   EMBO J 22 (24), 6621-6630 (2003)
   PUBMED   14657033
REFERENCE   8  (residues 1 to 1249)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   9  (residues 1 to 1249)
  AUTHORS   Masuda,Y., Takahashi,M., Fukuda,S., Sumii,M. and Kamiya,K.
  TITLE     Mechanisms of dCMP transferase reactions catalyzed by mouse Rev1
            protein
  JOURNAL   J Biol Chem 277 (4), 3040-3046 (2002)
   PUBMED   11711549
REFERENCE   10 (residues 1 to 1249)
  AUTHORS   Araki,K., Imaizumi,T., Sekimoto,T., Yoshinobu,K., Yoshimuta,J.,
            Akizuki,M., Miura,K., Araki,M. and Yamamura,K.
  TITLE     Exchangeable gene trap using the Cre/mutated lox system
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 45 (5), 737-750 (1999)
   PUBMED   10512203
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK048838.1 and BC058093.1.
            
            On Dec 20, 2003 this sequence version replaced NP_062516.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC058093.1, SRR13861889.54283.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1249
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 16.46 cM"
     Protein         1..1249
                     /product="DNA repair protein REV1 isoform 1"
                     /note="DNA repair protein REV1; rev1-like terminal
                     deoxycytidyl transferase; REV1 homolog"
                     /calculated_mol_wt=137210
     Region          48..131
                     /region_name="BRCT_Rev1"
                     /note="BRCT domain of DNA repair protein Rev1 and similar
                     proteins; cd17719"
                     /db_xref="CDD:349351"
     Region          253..323
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q920Q2.1)"
     Region          346..822
                     /region_name="PolY_Rev1"
                     /note="DNA polymerase Rev1; cd01701"
                     /db_xref="CDD:176455"
     Site            order(349..351,353..357,359..360,367,421..426,446,
                     507..508,511,514,520..521,523,565..566,568..569,623,
                     647..654,657,683..684,708..716,750,771..773,777..781,783)
                     /site_type="DNA binding"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:176455"
     Region          350..360
                     /region_name="Interaction with target DNA.
                     /evidence=ECO:0000250"
                     /note="propagated from UniProtKB/Swiss-Prot (Q920Q2.1)"
     Site            order(355,421..426,507..508,511,514,520,568..569,623)
                     /site_type="active"
                     /db_xref="CDD:176455"
     Region          651..654
                     /region_name="Interaction with target DNA.
                     /evidence=ECO:0000250"
                     /note="propagated from UniProtKB/Swiss-Prot (Q920Q2.1)"
     Region          707..715
                     /region_name="Interaction with target DNA.
                     /evidence=ECO:0000250"
                     /note="propagated from UniProtKB/Swiss-Prot (Q920Q2.1)"
     Site            768
                     /site_type="other"
                     /note="Interaction with target DNA. /evidence=ECO:0000250;
                     propagated from UniProtKB/Swiss-Prot (Q920Q2.1)"
     Site            781
                     /site_type="other"
                     /note="Interaction with target DNA. /evidence=ECO:0000250;
                     propagated from UniProtKB/Swiss-Prot (Q920Q2.1)"
     Region          929..962
                     /region_name="Rev1_UBM2"
                     /note="Ubiquitin-Binding Motif 2 (UBM2) of Y-family
                     polymerase Rev1; cd19318"
                     /db_xref="CDD:412037"
     Site            order(931..933,937..939,941..942,945..947,949..950,953,
                     957)
                     /site_type="other"
                     /note="ubiquitin binding interface [polypeptide binding]"
                     /db_xref="CDD:412037"
     Region          1005..1040
                     /region_name="Rev1_UBM2"
                     /note="Ubiquitin-Binding Motif 2 (UBM2) of Y-family
                     polymerase Rev1; cd19318"
                     /db_xref="CDD:412037"
     Site            order(1009..1011,1015..1017,1019..1020,1023..1025,
                     1027..1028,1031,1035)
                     /site_type="other"
                     /note="ubiquitin binding interface [polypeptide binding]"
                     /db_xref="CDD:412037"
     Region          1035..1109
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q920Q2.1)"
     Region          1072..1078
                     /region_name="Nuclear localization signal.
                     /evidence=ECO:0000255"
                     /note="propagated from UniProtKB/Swiss-Prot (Q920Q2.1)"
     Region          1150..1249
                     /region_name="Protein interaction domain, mediates
                     interaction with DNA polymerase zeta"
                     /note="propagated from UniProtKB/Swiss-Prot (Q920Q2.1)"
     Region          1155..1248
                     /region_name="Rev1_C"
                     /note="C-terminal domain of the Y-family polymerase Rev1;
                     cd12145"
                     /db_xref="CDD:213388"
     Site            order(1156..1161,1169..1170,1173,1177,1179..1181,
                     1183..1184,1187..1188)
                     /site_type="other"
                     /note="Polymerase eta interaction site [polypeptide
                     binding]"
                     /db_xref="CDD:213388"
     CDS             1..1249
                     /gene="Rev1"
                     /gene_synonym="1110027I23Rik; Rev1l"
                     /coded_by="NM_019570.4:216..3965"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS14899.1"
                     /db_xref="GeneID:56210"
                     /db_xref="MGI:MGI:1929074"
ORIGIN      
        1 mrrggwrkrt endgwekwgg ymaakvqkle eqfrtdaanq kdgtasaifs gvaiyvngyt
       61 dpsaeelrnl mmlhggqyhv yysrsktthi iatnlpnaki kelkgekvir pewivesika
      121 grllssapyq lytkpsaaqk slnfnpvckp edpgpgpsnr akqlnnrvnh iikkietese
      181 vkanglsswn edgvnddfsf edlehtfpgr kqngvmhprd tavifnghth ssngalktqd
      241 clvpvgnsva srlsldstqe ekraeksnad frdctvqhlq hstrsadalr sphrtnslsp
      301 slhsntking ahhstvqgps stkstsvltl skvapsvpsk psdcnfisdf ysrsrlhhis
      361 twkceltefv ntlqrqssgi fpgreklkkv ktgrsslvvt dtgtmsvlss prhqscvmhv
      421 dmdcffvsvg irnrpdlkgk pvavtsnrgt gtaplrpgan pqlewqyyqn ralrgkaadi
      481 pdssvwenqd stqtngidsv lskaeiascs yearqvgikn gmffgyakql cpnlqavpyd
      541 fhacrevaqa myetlasyth sieavscdea lidvtdilae tklspeefaa alrieikdkt
      601 kcaasvgigs nillarmatk kakpdgqyhl qpdevddfir gqlvtnlpgv grsmesklas
      661 lgiktcgdlq cltmaklqke fgpktgqmly rfcrglddrp vrtekerksv saeinygirf
      721 tqpkeaeafl lslseeiqrr leaagmkgkr ltlkimvrkp gapietakfg ghgicdniar
      781 tvtldqatds akiigkatln mfhtmklnis dmrgvgiqvn qlvpansnls tcssrpsaqs
      841 slfsgrphsv rdlfqlqkak kpteeehkev flaavdlevs stsracglls plsahlaasv
      901 spdtnsgecs rkwnglhspv sgqsrlnlsi evpspsqidq svlealpldl reqieqvcaa
      961 qqgeprgkkk epvngcssgv lphpvgtvll qipepqepcn sdskisvial pafsqvdpdv
     1021 faalpaelqk elkaaydqrq rqgedtthqq ptstsvpknp llqlkppamk dkrnkrknli
     1081 gsprksplkn kllsspaktl pgaygspqkl mdgflqhegm aserpleevs astpgaqdls
     1141 sllpgqsscf rpaapnlaga vefsdvktll kewittisdp meedilqvvr yctdlieekd
     1201 lekldlviky mkrlmqqsve svwnmafdfi ldnvqvvlqq tygstlkvt
//
