LOCUS       NP_080435                609 aa            linear   ROD 06-AUG-2024
DEFINITION  all-trans-retinol 13,14-reductase precursor [Mus musculus].
ACCESSION   NP_080435
VERSION     NP_080435.3
DBSOURCE    REFSEQ: accession NM_026159.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 609)
  AUTHORS   Kiefer,M.F., Meng,Y., Yang,N., Vahrenbrink,M., Wulff,S., Li,C.,
            Wowro,S.J., Petricek,K.M., Sommerfeld,M., Flores,R.E.,
            Obermayer,B., Piepelow,K., Klaus,S., Hartl,K., Guillot,A.,
            Tacke,F., Sigal,M. and Schupp,M.
  TITLE     Intestinal retinol saturase is implicated in the development of
            obesity and epithelial homeostasis upon injury
  JOURNAL   Am J Physiol Endocrinol Metab 327 (2), E203-E216 (2024)
   PUBMED   38895981
  REMARK    GeneRIF: Intestinal retinol saturase is implicated in the
            development of obesity and epithelial homeostasis upon injury.
REFERENCE   2  (residues 1 to 609)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (residues 1 to 609)
  AUTHORS   Tarban,N., Halasz,H., Gogolak,P., Garabuczi,E., Moise,A.R.,
            Palczewski,K., Sarang,Z. and Szondy,Z.
  TITLE     Regenerating Skeletal Muscle Compensates for the Impaired
            Macrophage Functions Leading to Normal Muscle Repair in Retinol
            Saturase Null Mice
  JOURNAL   Cells 11 (8), 1333 (2022)
   PUBMED   35456012
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 609)
  AUTHORS   Jiang,X., He,Y., Shen,Q., Duan,L., Yuan,Y., Tang,L., Shi,Y.,
            Liu,B., Zhai,H., Shi,P., Yang,C. and Chen,Y.
  TITLE     RETSAT Mutation Selected for Hypoxia Adaptation Inhibits Tumor
            Growth
  JOURNAL   Front Cell Dev Biol 9, 744992 (2021)
   PUBMED   34805153
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 609)
  AUTHORS   Sarang,Z., Saghy,T., Budai,Z., Ujlaky-Nagy,L., Bedekovics,J.,
            Beke,L., Mehes,G., Nagy,G., Ruhl,R., Moise,A.R., Palczewski,K. and
            Szondy,Z.
  TITLE     Retinol Saturase Knock-Out Mice are Characterized by Impaired
            Clearance of Apoptotic Cells and Develop Mild Autoimmunity
  JOURNAL   Biomolecules 9 (11), 737 (2019)
   PUBMED   31766264
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 609)
  AUTHORS   Moise,A.R., Dominguez,M., Alvarez,S., Alvarez,R., Schupp,M.,
            Cristancho,A.G., Kiser,P.D., de Lera,A.R., Lazar,M.A. and
            Palczewski,K.
  TITLE     Stereospecificity of retinol saturase: absolute configuration,
            synthesis, and biological evaluation of dihydroretinoids
  JOURNAL   J Am Chem Soc 130 (4), 1154-1155 (2008)
   PUBMED   18179220
  REMARK    GeneRIF: Mouse RetSat catalyzes the stereospecific saturation of
            the C13-C14 double bond of all-trans-retinol to produce
            (13R)-all-trans-13,14-dihydroretinol.
REFERENCE   7  (residues 1 to 609)
  AUTHORS   Sun,Y., Ng,L., Lam,W., Lo,C.K., Chan,P.T., Yuen,Y.L., Wong,P.F.,
            Tsang,D.S., Cheung,W.T. and Lee,S.S.
  TITLE     Identification and characterization of a novel mouse peroxisome
            proliferator-activated receptor alpha-regulated and
            starvation-induced gene, Ppsig
  JOURNAL   Int J Biochem Cell Biol 40 (9), 1775-1791 (2008)
   PUBMED   18289917
  REMARK    GeneRIF: Here, we report the identification and characterization of
            Ppsig (for PPARalpha-regulated and starvation-induced gene) with
            unknown biological function from mouse liver
REFERENCE   8  (residues 1 to 609)
  AUTHORS   Nagaoka-Yasuda,R., Matsuo,N., Perkins,B., Limbaeck-Stokin,K. and
            Mayford,M.
  TITLE     An RNAi-based genetic screen for oxidative stress resistance
            reveals retinol saturase as a mediator of stress resistance
  JOURNAL   Free Radic Biol Med 43 (5), 781-788 (2007)
   PUBMED   17664141
  REMARK    GeneRIF: suggest a novel role for retinol saturase in regulating
            sensitivity to oxidative stress
REFERENCE   9  (residues 1 to 609)
  AUTHORS   Moise,A.R., Kuksa,V., Imanishi,Y. and Palczewski,K.
  TITLE     Identification of all-trans-retinol:all-trans-13,14-dihydroretinol
            saturase
  JOURNAL   J Biol Chem 279 (48), 50230-50242 (2004)
   PUBMED   15358783
REFERENCE   10 (residues 1 to 609)
  AUTHORS   Wang,Y., Hu,L., Yao,R., Wang,M., Crist,K.A., Grubbs,C.J.,
            Johanning,G.L., Lubet,R.A. and You,M.
  TITLE     Altered gene expression profile in chemically induced rat mammary
            adenocarcinomas and its modulation by an aromatase inhibitor
  JOURNAL   Oncogene 20 (53), 7710-7721 (2001)
   PUBMED   11753649
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC125039.4.
            
            On Sep 24, 2004 this sequence version replaced NP_080435.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: EF620365.1, EF620363.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..609
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 32.27 cM"
     Protein         1..609
                     /product="all-trans-retinol 13,14-reductase precursor"
                     /EC_number="1.3.99.23"
                     /note="all-trans-retinol 13,14-reductase;
                     all-trans-13,14-dihydroretinol saturase;
                     PPAR-alpha-regulated and starvation-induced gene protein"
                     /calculated_mol_wt=64498
     sig_peptide     1..25
                     /note="/evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q64FW2.3)"
                     /calculated_mol_wt=2855
     mat_peptide     26..609
                     /product="All-trans-retinol 13,14-reductase.
                     /id=PRO_0000225667"
                     /note="propagated from UniProtKB/Swiss-Prot (Q64FW2.3)"
                     /calculated_mol_wt=64498
     Region          68..589
                     /region_name="COG1233"
                     /note="Phytoene dehydrogenase-related protein [Secondary
                     metabolites biosynthesis, transport and catabolism]"
                     /db_xref="CDD:440846"
     CDS             1..609
                     /gene="Retsat"
                     /gene_synonym="0610039N19Rik; MMT-7; Ppsig"
                     /coded_by="NM_026159.5:27..1856"
                     /db_xref="CCDS:CCDS20244.1"
                     /db_xref="GeneID:67442"
                     /db_xref="MGI:MGI:1914692"
ORIGIN      
        1 mwitalllav lllvilhrvy vglyaasspn pfaedvkrpp eplvtdkear kkvlkqafsv
       61 srvpekldav vigsgiggla saavlakagk rvlvleqhtk aggcchtfge nglefdtgih
      121 yigrmregni grfildqite gqldwapmas pfdlmilegp ngrkefpmys grkeyiqglk
      181 kkfpkeeavi dkymelvkvv argvshavll kflplpltql lskfglltrf spfcrastqs
      241 laevlqqlga srelqavlsy ifptygvtps htafslhall vdhyiqgayy prggsseiaf
      301 htipliqrag gavltratvq svlldsagra cgvsvkkgqe lvniycpvvi snagmfntyq
      361 hllpetvrhl pdvkkqlamv rpglsmlsif iclkgtkedl klqstnyyvy fdtdmdkame
      421 ryvsmpkeka pehipllfia fpsskdptwe erfpdrstmt alvpmafewf eewqeepkgk
      481 rgvdyetlkn afveasmsvi mklfpqlegk vesvtggspl tnqyylaapr gatygadhdl
      541 arlhphamas iraqtpipnl yltgqdiftc glmgalqgal lcssailkrn lysdlqalgs
      601 kvkaqkkkm
//
