LOCUS       NM_026501               3304 bp    mRNA    linear   ROD 19-AUG-2024
DEFINITION  Mus musculus reticulophagy regulator family member 3 (Retreg3),
            transcript variant 1, mRNA.
ACCESSION   NM_026501
VERSION     NM_026501.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3304)
  AUTHORS   Iavarone,F., Zaninello,M., Perrone,M., Monaco,M., Barth,E.,
            Gaedke,F., Pizzo,M.T., Di Lorenzo,G., Desiderio,V., Sommella,E.,
            Merciai,F., Salviati,E., Campiglia,P., Luongo,L., De Leonibus,E.,
            Rugarli,E. and Settembre,C.
  TITLE     Fam134c and Fam134b shape axonal endoplasmic reticulum architecture
            in vivo
  JOURNAL   EMBO Rep 25 (8), 3651-3677 (2024)
   PUBMED   39039299
  REMARK    GeneRIF: Fam134c and Fam134b shape axonal endoplasmic reticulum
            architecture in vivo.
REFERENCE   2  (bases 1 to 3304)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 3304)
  AUTHORS   Di Lorenzo,G., Iavarone,F., Maddaluno,M., Plata-Gomez,A.B.,
            Aureli,S., Quezada Meza,C.P., Cinque,L., Palma,A., Reggio,A.,
            Cirillo,C., Sacco,F., Stolz,A., Napolitano,G., Marin,O.,
            Pinna,L.A., Ruzzene,M., Limongelli,V., Efeyan,A., Grumati,P. and
            Settembre,C.
  TITLE     Phosphorylation of FAM134C by CK2 controls starvation-induced
            ER-phagy
  JOURNAL   Sci Adv 8 (35), eabo1215 (2022)
   PUBMED   36044577
REFERENCE   4  (bases 1 to 3304)
  AUTHORS   Reggio,A., Buonomo,V., Berkane,R., Bhaskara,R.M., Tellechea,M.,
            Peluso,I., Polishchuk,E., Di Lorenzo,G., Cirillo,C., Esposito,M.,
            Hussain,A., Huebner,A.K., Hubner,C.A., Settembre,C., Hummer,G.,
            Grumati,P. and Stolz,A.
  TITLE     Role of FAM134 paralogues in endoplasmic reticulum remodeling,
            ER-phagy, and Collagen quality control
  JOURNAL   EMBO Rep 22 (9), e52289 (2021)
   PUBMED   34338405
REFERENCE   5  (bases 1 to 3304)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3304)
  AUTHORS   Fu,B., Wang,L., Li,S. and Dorf,M.E.
  TITLE     ZMPSTE24 defends against influenza and other pathogenic viruses
  JOURNAL   J Exp Med 214 (4), 919-929 (2017)
   PUBMED   28246125
REFERENCE   7  (bases 1 to 3304)
  AUTHORS   Kurth,I., Pamminger,T., Hennings,J.C., Soehendra,D., Huebner,A.K.,
            Rotthier,A., Baets,J., Senderek,J., Topaloglu,H., Farrell,S.A.,
            Nurnberg,G., Nurnberg,P., De Jonghe,P., Gal,A., Kaether,C.,
            Timmerman,V. and Hubner,C.A.
  TITLE     Mutations in FAM134B, encoding a newly identified Golgi protein,
            cause severe sensory and autonomic neuropathy
  JOURNAL   Nat Genet 41 (11), 1179-1181 (2009)
   PUBMED   19838196
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK051025.1, AK004979.1 and BX255926.10.
            
            On Mar 29, 2018 this sequence version replaced NM_026501.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC016089.1, AK004960.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-216               AK051025.1         4-219
            217-3099            AK004979.1         203-3085
            3100-3188           BX255926.10        29110-29198         c
            3189-3304           AK051025.1         3065-3180
FEATURES             Location/Qualifiers
     source          1..3304
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 64.2 cM"
     gene            1..3304
                     /gene="Retreg3"
                     /gene_synonym="1300010M03Rik; 4933404C01Rik; Fam134c"
                     /note="reticulophagy regulator family member 3"
                     /db_xref="GeneID:67998"
                     /db_xref="MGI:MGI:1915248"
     exon            1..301
                     /gene="Retreg3"
                     /gene_synonym="1300010M03Rik; 4933404C01Rik; Fam134c"
                     /inference="alignment:Splign:2.1.0"
     CDS             63..1463
                     /gene="Retreg3"
                     /gene_synonym="1300010M03Rik; 4933404C01Rik; Fam134c"
                     /note="isoform 1 is encoded by transcript variant 1;
                     protein FAM134C; family with sequence similarity 134,
                     member C; reticulophagy regulator 3"
                     /codon_start=1
                     /product="reticulophagy regulator 3 isoform 1"
                     /protein_id="NP_080777.1"
                     /db_xref="CCDS:CCDS25449.1"
                     /db_xref="GeneID:67998"
                     /db_xref="MGI:MGI:1915248"
                     /translation="MEEAEGVAAAPGPASGLAFRGRRAMSGSWERDQQVEAAQRTLVE
                     VLGPYEPLLSRVQAALVWERPARSALWCLGLNAAFWFFALTSLRFVFLLAFSLMIIVC
                     IDQWKNKIWPEINVPRPDALDNESWGFVHPRLLSVPELCHHVAEVWVSGTIFIRNLLL
                     FKKQNPGKFCLLSCGVLTFLAMLGRYIPGLLLSYLMLVIIMMWPLAVYHRLWDRAYVR
                     LKPVLQRLDFSVRGYMMSKQRERQLRRRALHSERATDSHSDSEEELAAFCPQLDDSTV
                     ARELAITDSEHSDAEVSCTENGTFNLSRGQTPLTEGSEDLDGHSDPEESFARDLPDFP
                     SINVDPAGLDDEDDTSIGMPSLMYRSPPGAGDTQVLPASRNEAALPELLLSSLPGGSN
                     LTSNLASLVSQGMIQLALSEASQTDPSGPPPRRATRGFLRAPSSDLDTDAEGDDFELL
                     DQSELNQLDPASSRSH"
     exon            302..408
                     /gene="Retreg3"
                     /gene_synonym="1300010M03Rik; 4933404C01Rik; Fam134c"
                     /inference="alignment:Splign:2.1.0"
     exon            409..439
                     /gene="Retreg3"
                     /gene_synonym="1300010M03Rik; 4933404C01Rik; Fam134c"
                     /inference="alignment:Splign:2.1.0"
     exon            440..566
                     /gene="Retreg3"
                     /gene_synonym="1300010M03Rik; 4933404C01Rik; Fam134c"
                     /inference="alignment:Splign:2.1.0"
     exon            567..651
                     /gene="Retreg3"
                     /gene_synonym="1300010M03Rik; 4933404C01Rik; Fam134c"
                     /inference="alignment:Splign:2.1.0"
     exon            652..789
                     /gene="Retreg3"
                     /gene_synonym="1300010M03Rik; 4933404C01Rik; Fam134c"
                     /inference="alignment:Splign:2.1.0"
     exon            790..872
                     /gene="Retreg3"
                     /gene_synonym="1300010M03Rik; 4933404C01Rik; Fam134c"
                     /inference="alignment:Splign:2.1.0"
     exon            873..1005
                     /gene="Retreg3"
                     /gene_synonym="1300010M03Rik; 4933404C01Rik; Fam134c"
                     /inference="alignment:Splign:2.1.0"
     exon            1006..3304
                     /gene="Retreg3"
                     /gene_synonym="1300010M03Rik; 4933404C01Rik; Fam134c"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3080..3085
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Retreg3"
                     /gene_synonym="1300010M03Rik; 4933404C01Rik; Fam134c"
                     /note="hexamer: AATAAA"
     polyA_site      3101
                     /gene="Retreg3"
                     /gene_synonym="1300010M03Rik; 4933404C01Rik; Fam134c"
                     /note="major polyA site"
ORIGIN      
        1 gcagtcggtg ttattgtgac tcccgggccg tggccccgga tgttgtggct gctgaagggg
       61 agatggagga ggctgaaggg gtggccgcgg ccccgggtcc agcttcgggg ttggctttca
      121 ggggccgccg agctatgtcc ggctcctggg agcgcgacca gcaggttgag gcggcgcagc
      181 ggaccctggt ggaggtgctg ggcccttacg agcctctgct gagccgggtg caggcagccc
      241 tggtgtggga gcggccggcc aggagcgccc tgtggtgcct ggggctgaac gcggcgttct
      301 ggttttttgc attgacatca cttcgttttg tgtttttgct tgcattcagc ttgatgatca
      361 ttgtctgtat tgaccaatgg aagaacaaaa tttggcctga gataaacgtg ccgagacctg
      421 acgccttgga caacgagagc tggggctttg tgcaccctcg gttgctcagc gtgcccgagc
      481 tctgccacca tgtagctgaa gtctgggtta gtgggaccat tttcataagg aatcttttgc
      541 ttttcaaaaa gcaaaaccca ggcaagttct gcctgctgag ctgtggggta ctgacctttt
      601 tggccatgtt gggccgctac atccctgggc tcctgctgtc ctacttgatg cttgtcatca
      661 ttatgatgtg gcctcttgct gtctatcacc gtctgtggga tcgagcctat gtgcgactga
      721 agccagttct gcagcggctg gacttcagtg tccgtggcta catgatgtcc aagcagagag
      781 aaagacaatt gcgccgcaga gctctgcact cagaacgtgc cacggacagc cacagtgaca
      841 gtgaagagga acttgctgcc ttctgtcctc agctggatga ttctactgtt gccagggaat
      901 tggctatcac agattcggag cactctgatg ctgaggtctc ctgtacagaa aatggcacat
      961 ttaacctgtc aagaggccaa acacctctaa cagaaggctc tgaagaccta gatggccaca
     1021 gtgatccaga ggagtcattt gccagagacc tgccagactt cccttccatt aacgtggatc
     1081 ctgctggcct ggacgacgag gacgacacca gcattgggat gcccagcttg atgtaccgct
     1141 ccccaccagg ggctggggat acccaggtcc tgcctgctag tcggaatgag gctgcactgc
     1201 cagagctcct gcttagttcc cttcctggag gatctaacct taccagcaac cttgccagcc
     1261 tggtctccca gggtatgatc caactggcct tgtcagaggc ctcccagaca gacccttctg
     1321 gcccacctcc ccgaagagca acaagaggct tcctccgggc ccctagttca gacctggaca
     1381 ctgatgctga aggagatgat tttgaacttc tggaccaatc agagctgaat cagctagacc
     1441 ctgccagttc taggagccac tgagagactc ctttgagggg ggtcactgtg ctgtaggtta
     1501 ttttcctcca ccccacttac tgtgatgggg caagggaaga acccagtctt gtcccctgaa
     1561 ttttatctgt gtgctgggtg gcctggctga tgcagaggcc tgctaagaga acgtactctt
     1621 acctgctgcc agtgagacat cgtatctgtg cttagtcact gaagtgagaa catactcccg
     1681 ccccaaggga ggcttctctc catcagggtg gtacacgggc aacaaagtag ggatttgatt
     1741 cccctttgag gaggtagtgc tgtttgcttt taggtctggg tgctcagggg ccctcactga
     1801 tacaagagcc catctcttct cctcacctca ctggagccac agaagccagg cagcagctac
     1861 aggagttatc atctgtgtct tttaccatga tttgatttgt gttctcaaag caagtgtgcc
     1921 ctttggttct gcagagcagg cccacttcct gtccctgagc ccatcttcat ttctagaggg
     1981 ctgaccctga gcactccaga gtgcttgcag agtttgagaa atgtgaacat gctgtggggc
     2041 tgagcctctg ctatatcacc gtgagctgta ggatcagctg gctggctggg ttggtgagtg
     2101 cctaccttga ggtctcatga aagctcctgg agctgtgtgg ttgtctttgg tgctgttaac
     2161 ccttggctcc atttgaccat caatctgagc aatgagcaaa gcaatatcat atccatgttt
     2221 atgtccctcc tccttccctt gctcctcctc tggagaagca ctaattacac aggggatagc
     2281 aaagtagcac tttacaaatg gccatggcgt tcatcccaag agccaccagc tcttcttacc
     2341 ataccacttc ctaactcctg taaggatgag cccagttagt aaggatgttg gtaatcagca
     2401 gagaccattc tcaagggtag gtgttctgca gccccgaatc aaatcatgtg aaaacccctt
     2461 aaatgatcat tggttctcaa cctgtgccag catactgcct ctctgtctcc caaatcagag
     2521 ctcaagccaa attcttctat cctctttccc tcttgcatta acctttgctg atcctcaggg
     2581 accactcccc cagcactttt gtgtttgggt gagggatgtt ggacagagcc catttttatg
     2641 tgctgcaggt tgggggttgt gctaacactt ttgctcttgg ttgatggaca agatagaggc
     2701 cagggagtga ataacagtga gaagaggaat ggcaggtgcc tgtttcatag tcagtgagtg
     2761 tgaaagttag gcataataat ggcatctccc cactttaggg ttctcaaata ctttggacat
     2821 ctctttcctt agagccaggt agatgtctta caggtgaact cgatgatgtg gaaaagaaca
     2881 aaaaaaggga ggtgagggaa aggcttgggg ttttgcgtgt ttgcatgagt gtgtgtagct
     2941 tcatgctttg ggagttggca agaggaagag ggagggaagg ggagcaagca aatccaggtc
     3001 ttttcttgta ccagtggaac ctgctctgaa tctcccaagt cctccactgt gaattgggct
     3061 gggtgggggg gtgcagggga ataaatcttg tatgagaaca atcttttaag agactgctgt
     3121 ttcgttgtgt acttccttga taagtcttct cattaatctg ataatagcta atctggtgtg
     3181 gtgatcctca gaagaggaag cccaggtgga tgtcagggac cctcctgccc tttctgtttt
     3241 tccctcttga ggccacgtct cccccctaca accaagacat aaatataact aataccttgc
     3301 gggc
//
