LOCUS       NM_170755               2559 bp    mRNA    linear   ROD 08-MAY-2023
DEFINITION  Mus musculus reticulophagy regulator family member 2 (Retreg2),
            transcript variant 1, mRNA.
ACCESSION   NM_170755
VERSION     NM_170755.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2559)
  AUTHORS   Reggio A, Buonomo V, Berkane R, Bhaskara RM, Tellechea M, Peluso I,
            Polishchuk E, Di Lorenzo G, Cirillo C, Esposito M, Hussain A,
            Huebner AK, Hubner CA, Settembre C, Hummer G, Grumati P and Stolz
            A.
  TITLE     Role of FAM134 paralogues in endoplasmic reticulum remodeling,
            ER-phagy, and Collagen quality control
  JOURNAL   EMBO Rep 22 (9), e52289 (2021)
   PUBMED   34338405
REFERENCE   2  (bases 1 to 2559)
  AUTHORS   Will AJ, Cova G, Osterwalder M, Chan WL, Wittler L, Brieske N,
            Heinrich V, de Villartay JP, Vingron M, Klopocki E, Visel A,
            Lupianez DG and Mundlos S.
  TITLE     Composition and dosage of a multipartite enhancer cluster control
            developmental expression of Ihh (Indian hedgehog)
  JOURNAL   Nat Genet 49 (10), 1539-1545 (2017)
   PUBMED   28846100
REFERENCE   3  (bases 1 to 2559)
  AUTHORS   Kurth I, Pamminger T, Hennings JC, Soehendra D, Huebner AK,
            Rotthier A, Baets J, Senderek J, Topaloglu H, Farrell SA, Nurnberg
            G, Nurnberg P, De Jonghe P, Gal A, Kaether C, Timmerman V and
            Hubner CA.
  TITLE     Mutations in FAM134B, encoding a newly identified Golgi protein,
            cause severe sensory and autonomic neuropathy
  JOURNAL   Nat Genet 41 (11), 1179-1181 (2009)
   PUBMED   19838196
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK034667.1, AK160400.1 and AA166220.1.
            
            [WARNING] On May 18, 2023 this sequence was replaced by
            NM_170755.3.
            
            On Jan 27, 2007 this sequence version replaced NM_170755.1.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK034667.1, AK172093.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-481               AK034667.1         2-482
            482-2553            AK160400.1         436-2507
            2554-2559           AA166220.1         1-6                 c
FEATURES             Location/Qualifiers
     source          1..2559
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1"
     gene            1..2559
                     /gene="Retreg2"
                     /gene_synonym="Fam134a"
                     /note="reticulophagy regulator family member 2"
                     /db_xref="GeneID:227298"
                     /db_xref="MGI:MGI:2388278"
     exon            1..343
                     /gene="Retreg2"
                     /gene_synonym="Fam134a"
                     /inference="alignment:Splign:2.1.0"
     CDS             78..1703
                     /gene="Retreg2"
                     /gene_synonym="Fam134a"
                     /note="isoform 1 is encoded by transcript variant 1;
                     protein FAM134A; family with sequence similarity 134,
                     member A; reticulophagy regulator 2"
                     /codon_start=1
                     /product="reticulophagy regulator 2 isoform 1"
                     /protein_id="NP_739561.2"
                     /db_xref="CCDS:CCDS35621.1"
                     /db_xref="GeneID:227298"
                     /db_xref="MGI:MGI:2388278"
                     /translation="MASSGGGNTGAGGTSGLGLGLGLSLGMGEATGDAEEEAAAAEAV
                     GRLATSLWLRLRGWEAVLAAAQRLLVWEKPLHSLVTAATLNGLFWLLSSSSLRPFFLL
                     SISLLTYFLLDLWHPRFLPDVSAPPPEEPHSDSEGAGSGAQPHLLSVPELCRYLAESW
                     LTFQIHLQELLQYKRQNPAQFCARGCAACAVLAVLGHYVPGVMISYIVLLSILLWPLV
                     VYHELIQRMYTRLEPLLMQLDYSMKAEADALHHKHDKRKRQGKSAPPAGDEPLAETES
                     ESEAELAGFSPVVDVKKTALALAITDSELSDEEASILESGGFSVSRATTPQLTDVSED
                     LDQQSLPSEPEEALNRELGEGEETELASPEDLLSAPPALSKQALDTEEEGAADKEALL
                     QLSSPLHFVNTHFNGAGSPQDGVKCPPGAPVKTLSPEAVSGDLMAPSSTLSPQLCLAE
                     SGPVTPLSPSVLPSLPQDSPQPLAAPEEEEALTTEDFELLDQGELEQLNAELGLGPEM
                     PPKPPDVLPPPPLGADSHSLVQSDQEAHAEVEP"
     exon            344..450
                     /gene="Retreg2"
                     /gene_synonym="Fam134a"
                     /inference="alignment:Splign:2.1.0"
     exon            451..481
                     /gene="Retreg2"
                     /gene_synonym="Fam134a"
                     /inference="alignment:Splign:2.1.0"
     exon            482..617
                     /gene="Retreg2"
                     /gene_synonym="Fam134a"
                     /inference="alignment:Splign:2.1.0"
     exon            618..702
                     /gene="Retreg2"
                     /gene_synonym="Fam134a"
                     /inference="alignment:Splign:2.1.0"
     exon            703..846
                     /gene="Retreg2"
                     /gene_synonym="Fam134a"
                     /inference="alignment:Splign:2.1.0"
     exon            847..941
                     /gene="Retreg2"
                     /gene_synonym="Fam134a"
                     /inference="alignment:Splign:2.1.0"
     exon            942..1077
                     /gene="Retreg2"
                     /gene_synonym="Fam134a"
                     /inference="alignment:Splign:2.1.0"
     exon            1078..2557
                     /gene="Retreg2"
                     /gene_synonym="Fam134a"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2535..2540
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Retreg2"
                     /gene_synonym="Fam134a"
                     /note="putative"
     polyA_site      2553
                     /gene="Retreg2"
                     /gene_synonym="Fam134a"
                     /note="putative"
ORIGIN      
        1 ttccgtctga cgcgcccccg gcggcggccg cgcagccctg gctcctcgcg ggctcgggca
       61 gcggctgcgg cgcggtgatg gcgagcagcg gtggcggtaa caccggcgcg ggtggcacct
      121 cggggctggg cctgggcctg gggctgagcc tcggcatggg tgaggccact ggcgacgcgg
      181 aggaggaggc ggccgcagcc gaggcagtgg gacgtttagc tacgtccctg tggctgcggc
      241 tccgcggctg ggaggcggtg ctggcggccg cacagcgact gctggtttgg gagaagccgc
      301 tgcacagcct ggtcacggcg gccacactca acggcctctt ctggttgttg tcttcgtcgt
      361 ccctccggcc cttcttcctg ctcagcatct cacttttgac ctattttcta ctggatctct
      421 ggcatcctcg ctttctccct gacgtttcag caccaccccc tgaagaacca cactctgaca
      481 gtgagggtgc ggggtcaggc gcccagccgc acctgctgag tgtgcccgag ttgtgcagat
      541 acctggctga gagctggctc accttccaga ttcacctgca agagctgttg cagtacaaga
      601 ggcagaatcc agctcagttc tgcgctcggg gctgcgctgc ctgtgctgtg ctggctgtgt
      661 tgggacacta tgttccggga gttatgattt cctacattgt cttgctgagt atcctgctgt
      721 ggcccctggt ggtctatcac gagttgatcc agaggatgta tactcgcctg gagcccttgc
      781 tcatgcagct ggactacagc atgaaagctg aagctgatgc cctgcaccac aaacatgaca
      841 agagaaagcg ccaagggaag agtgcacccc cagcaggaga tgagccactg gcggaaacag
      901 agagtgaaag cgaggcagag ttggctggct tctctccagt ggtggatgtg aagaaaacag
      961 ccctggcctt ggctattaca gactctgagc tgtcagatga ggaggcctct atcttagaga
     1021 gcggcggttt ctctgtatct cgggccacca ctccacaact gacagatgtt tctgaagatt
     1081 tggaccagca gagcctgcca agtgagccag aagaggctct gaaccgagag ctgggggagg
     1141 gggaagagac agagctggcc tctcctgaag acctgctaag tgcgcctcca gccctctcaa
     1201 agcaagcttt ggacaccgaa gaggaggggg ctgcagacaa ggaagccttg cttcagctct
     1261 catcccctct tcactttgtg aatacgcact tcaatggggc agggtccccc caagatggag
     1321 tgaaatgccc tcctggtgca ccagtgaaga ccctgagccc agaggcagtg agtggtgacc
     1381 taatggctcc atccagcacc ctctcacccc aactttgcct tgctgaaagt ggtccagtta
     1441 cccccctctc tccctctgtg ctcccatccc ttccccagga ctcacctcaa cccctggctg
     1501 ctcctgagga ggaagaggca ctcacaactg aggactttga gttgctggat cagggggagc
     1561 tggagcaact gaatgcagag ctgggcttgg gaccagagat gcctccaaag ccccctgatg
     1621 ttctgcctcc tcctcccctg ggggcagaca gccattccct ggtacagtca gaccaagagg
     1681 ctcatgcaga ggttgagcca tgagccatgg cagaatgagc tgcaggcata ctagggcttc
     1741 ctaactaggc atgtcacatt ttctcctctc cctgtcactc tggggagagg cactatgtgg
     1801 aaaagctggc tgtcagatgg aagccagccc actctgcctg cctgcctgcc tgcctgcctg
     1861 ctgtcctggg acctggtata gtacctgtgc ctaggattgg ttttatgtct gtaaatactt
     1921 ttccatctga gttagtggat gtgatgaagg ctaggggcat ccttccgtag cctgcagttg
     1981 cttccctgcc tcatcccttg tcattctact gtgtcctaag ccctggtggt cgaccttttc
     2041 tttttcttcc tatcctcagg gacctgtgct gctccaccct cgtgtcccac ttggttgttt
     2101 agttgaggca ctttataatt ttctctactg tcccacactc ccgttggctt tatttccctg
     2161 ctgtctcctg tcctttgcag cgtgaccccc actctttgcc aactcctcct tcccacaggc
     2221 actggccaag ctttagggca ggttctcttc tgagggaact gggtggtgtc aggccagcag
     2281 tgctgtgctt gggtcactgt cgccttgaac ctacactgta cccttgtcca gctcagcact
     2341 catgatgcag gacagcaggg tcccctagca ctttgccagc actgaggatg gcatgttctc
     2401 ttctcttttg gaggcgaggg acttcccttc tgtattaggg gagaagaaca gaacctactc
     2461 gtctggacca cagttgagac tccctgctag ggtgtaaagt ggatagtaag atctgtgtag
     2521 gtgttaactg gaaaaataaa ctgttgattg gctagaaaa
//
