LOCUS       NM_001034851            3139 bp    mRNA    linear   ROD 19-AUG-2024
DEFINITION  Mus musculus reticulophagy regulator 1 (Retreg1), transcript
            variant 1, mRNA.
ACCESSION   NM_001034851
VERSION     NM_001034851.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3139)
  AUTHORS   Iavarone,F., Zaninello,M., Perrone,M., Monaco,M., Barth,E.,
            Gaedke,F., Pizzo,M.T., Di Lorenzo,G., Desiderio,V., Sommella,E.,
            Merciai,F., Salviati,E., Campiglia,P., Luongo,L., De Leonibus,E.,
            Rugarli,E. and Settembre,C.
  TITLE     Fam134c and Fam134b shape axonal endoplasmic reticulum architecture
            in vivo
  JOURNAL   EMBO Rep 25 (8), 3651-3677 (2024)
   PUBMED   39039299
  REMARK    GeneRIF: Fam134c and Fam134b shape axonal endoplasmic reticulum
            architecture in vivo.
REFERENCE   2  (bases 1 to 3139)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 3139)
  AUTHORS   Duan,Y., Yao,R.Q., Zheng,L.Y., Dong,N., Wu,Y., Yao,Y.M. and
            Dai,X.G.
  TITLE     [Influence of family with sequence similarity 134, member
            B-mediated reticulophagy on lipopolysaccharide-induced apoptosis of
            mouse dendritic cells]
  JOURNAL   Zhonghua Shao Shang Yu Chuang Mian Xiu Fu Za Zhi 39 (9), 857-866
            (2023)
   PUBMED   37805802
  REMARK    GeneRIF: [Influence of family with sequence similarity 134, member
            B-mediated reticulophagy on lipopolysaccharide-induced apoptosis of
            mouse dendritic cells].
REFERENCE   4  (bases 1 to 3139)
  AUTHORS   Chen,B., Hu,X., Chen,M., Chen,Y., Yan,L., Zeng,G., Wang,C., Liu,L.,
            Yang,C. and Song,W.
  TITLE     Identification of sensory dysfunction and nervous structure changes
            in Fam134b knockout mice
  JOURNAL   Neurol Res 45 (1), 41-48 (2023)
   PUBMED   36302074
  REMARK    GeneRIF: Identification of sensory dysfunction and nervous
            structure changes in Fam134b knockout mice.
REFERENCE   5  (bases 1 to 3139)
  AUTHORS   Reggio,A., Buonomo,V., Berkane,R., Bhaskara,R.M., Tellechea,M.,
            Peluso,I., Polishchuk,E., Di Lorenzo,G., Cirillo,C., Esposito,M.,
            Hussain,A., Huebner,A.K., Hubner,C.A., Settembre,C., Hummer,G.,
            Grumati,P. and Stolz,A.
  TITLE     Role of FAM134 paralogues in endoplasmic reticulum remodeling,
            ER-phagy, and Collagen quality control
  JOURNAL   EMBO Rep 22 (9), e52289 (2021)
   PUBMED   34338405
REFERENCE   6  (bases 1 to 3139)
  AUTHORS   Chiramel,A.I., Dougherty,J.D., Nair,V., Robertson,S.J. and
            Best,S.M.
  TITLE     FAM134B, the Selective Autophagy Receptor for Endoplasmic Reticulum
            Turnover, Inhibits Replication of Ebola Virus Strains Makona and
            Mayinga
  JOURNAL   J Infect Dis 214 (suppl 3), S319-S325 (2016)
   PUBMED   27511895
  REMARK    GeneRIF: FAM134B-dependent endoplasmic reticulum (ER)-phagy is an
            important limiting event in Ebola virus (EBOV) replication in mouse
            cells
REFERENCE   7  (bases 1 to 3139)
  AUTHORS   Khaminets,A., Heinrich,T., Mari,M., Grumati,P., Huebner,A.K.,
            Akutsu,M., Liebmann,L., Stolz,A., Nietzsche,S., Koch,N., Mauthe,M.,
            Katona,I., Qualmann,B., Weis,J., Reggiori,F., Kurth,I., Hubner,C.A.
            and Dikic,I.
  TITLE     Regulation of endoplasmic reticulum turnover by selective autophagy
  JOURNAL   Nature 522 (7556), 354-358 (2015)
   PUBMED   26040720
  REMARK    GeneRIF: selective endoplasmic reticulum (ER)-phagy via FAM134
            proteins is indispensable for mammalian cell homeostasis and
            controls ER morphology and turnover in mice and humans
REFERENCE   8  (bases 1 to 3139)
  AUTHORS   Scheubert,L., Schmidt,R., Repsilber,D., Lustrek,M. and Fuellen,G.
  TITLE     Learning biomarkers of pluripotent stem cells in mouse
  JOURNAL   DNA Res 18 (4), 233-251 (2011)
   PUBMED   21791477
REFERENCE   9  (bases 1 to 3139)
  AUTHORS   Kurth,I., Pamminger,T., Hennings,J.C., Soehendra,D., Huebner,A.K.,
            Rotthier,A., Baets,J., Senderek,J., Topaloglu,H., Farrell,S.A.,
            Nurnberg,G., Nurnberg,P., De Jonghe,P., Gal,A., Kaether,C.,
            Timmerman,V. and Hubner,C.A.
  TITLE     Mutations in FAM134B, encoding a newly identified Golgi protein,
            cause severe sensory and autonomic neuropathy
  JOURNAL   Nat Genet 41 (11), 1179-1181 (2009)
   PUBMED   19838196
  REMARK    GeneRIF: show that loss-of-function mutations in FAM134B, encoding
            a newly identified cis-Golgi protein, cause hereditary sensory and
            autonomic neuropathy type II.
REFERENCE   10 (bases 1 to 3139)
  AUTHORS   Carninci,P., Waki,K., Shiraki,T., Konno,H., Shibata,K., Itoh,M.,
            Aizawa,K., Arakawa,T., Ishii,Y., Sasaki,D., Bono,H., Kondo,S.,
            Sugahara,Y., Saito,R., Osato,N., Fukuda,S., Sato,K., Watahiki,A.,
            Hirozane-Kishikawa,T., Nakamura,M., Shibata,Y., Yasunishi,A.,
            Kikuchi,N., Yoshiki,A., Kusakabe,M., Gustincich,S., Beisel,K.,
            Pavan,W., Aidinis,V., Nakagawara,A., Held,W.A., Iwata,H., Kono,T.,
            Nakauchi,H., Lyons,P., Wells,C., Hume,D.A., Fagiolini,M.,
            Hensch,T.K., Brinkmeier,M., Camper,S., Hirota,J., Mombaerts,P.,
            Muramatsu,M., Okazaki,Y., Kawai,J. and Hayashizaki,Y.
  TITLE     Targeting a complex transcriptome: the construction of the mouse
            full-length cDNA encyclopedia
  JOURNAL   Genome Res 13 (6B), 1273-1289 (2003)
   PUBMED   12819125
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CB724233.1, BY779369.1, AK015182.1 and AC162303.4.
            
            On Apr 3, 2013 this sequence version replaced NM_001034851.1.
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7345562.1575621.1,
                                           SRR7974084.5126.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-168               CB724233.1         120-287
            169-516             BY779369.1         1-348
            517-1424            AK015182.1         129-1036
            1425-3139           AC162303.4         78986-80700         c
FEATURES             Location/Qualifiers
     source          1..3139
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 9.59 cM"
     gene            1..3139
                     /gene="Retreg1"
                     /gene_synonym="1810015C04Rik; Fam134b; Retreg1d"
                     /note="reticulophagy regulator 1"
                     /db_xref="GeneID:66270"
                     /db_xref="MGI:MGI:1913520"
     exon            1..315
                     /gene="Retreg1"
                     /gene_synonym="1810015C04Rik; Fam134b; Retreg1d"
                     /inference="alignment:Splign:2.1.0"
     CDS             47..1489
                     /gene="Retreg1"
                     /gene_synonym="1810015C04Rik; Fam134b; Retreg1d"
                     /note="isoform 1 is encoded by transcript variant 1;
                     protein FAM134B; reticulophagy receptor Fam134b; family
                     with sequence similarity 134, member B; reticulophagy
                     receptor 1"
                     /codon_start=1
                     /product="reticulophagy regulator 1 isoform 1"
                     /protein_id="NP_001030023.1"
                     /db_xref="CCDS:CCDS37050.1"
                     /db_xref="GeneID:66270"
                     /db_xref="MGI:MGI:1913520"
                     /translation="MASPAPEEHATQGCPATEEQPPRPGVPGEEAGPEGAGPQVEEAA
                     GRVAAALTWLLGEPVLWLGWRADELLSWKRPLRSLLTFLGANLLFWFLALTPWRVYHL
                     ISVMILGRVIMQIIKEMVLSRTRGAQLWRSLTESWEVINSKPDERARLSQCIAESWMN
                     FSMFLQEMSLFKQQSPGKFCLLVCSVCTFFTILGSYIPGVILSYLLLLFAFLCPLFKC
                     NDIGQKIYSKVKSILLKLDFGIGEYINQKKRERSEADKEKSHKDDSELDFSALCPKIS
                     LTVAAKELSVSDTDVSEVSWTDNGTFNLSEGYTPQTDTSDDLDRPSEEVFSRDLSDFP
                     SLENGTGTNDEDELSLGLPTELKRKKQQLDSAHRPSKERQSAAGLSLPLKSDQALHLM
                     SNLAGDVITAAMTAAIKDQLEGARQALTQVAPTAGEDTDTEEGDDFELLDQAELDQIE
                     SELGLTQDQGAEAQQSKKSSGFLSNLLGGH"
     exon            316..422
                     /gene="Retreg1"
                     /gene_synonym="1810015C04Rik; Fam134b; Retreg1d"
                     /inference="alignment:Splign:2.1.0"
     exon            423..453
                     /gene="Retreg1"
                     /gene_synonym="1810015C04Rik; Fam134b; Retreg1d"
                     /inference="alignment:Splign:2.1.0"
     exon            454..580
                     /gene="Retreg1"
                     /gene_synonym="1810015C04Rik; Fam134b; Retreg1d"
                     /inference="alignment:Splign:2.1.0"
     exon            581..665
                     /gene="Retreg1"
                     /gene_synonym="1810015C04Rik; Fam134b; Retreg1d"
                     /inference="alignment:Splign:2.1.0"
     exon            666..803
                     /gene="Retreg1"
                     /gene_synonym="1810015C04Rik; Fam134b; Retreg1d"
                     /inference="alignment:Splign:2.1.0"
     exon            804..868
                     /gene="Retreg1"
                     /gene_synonym="1810015C04Rik; Fam134b; Retreg1d"
                     /inference="alignment:Splign:2.1.0"
     exon            869..995
                     /gene="Retreg1"
                     /gene_synonym="1810015C04Rik; Fam134b; Retreg1d"
                     /inference="alignment:Splign:2.1.0"
     exon            996..3139
                     /gene="Retreg1"
                     /gene_synonym="1810015C04Rik; Fam134b; Retreg1d"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3109..3114
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Retreg1"
                     /gene_synonym="1810015C04Rik; Fam134b; Retreg1d"
                     /note="hexamer: TATAAA"
     polyA_site      3115
                     /gene="Retreg1"
                     /gene_synonym="1810015C04Rik; Fam134b; Retreg1d"
                     /note="major polyA site"
ORIGIN      
        1 tgtccccgtc cccatccccg tccccgccag caaaacaccg ctgaagatgg cgagcccggc
       61 gcccgaggag cacgccacac aaggatgccc ggctaccgag gagcagccgc cgcggcctgg
      121 agttcccgga gaggaagcag ggccagaggg cgcggggccg caggtggagg aggccgccgg
      181 gagggtggcc gccgccctga cctggctgct cggggaaccc gtgctgtggc tgggctggcg
      241 cgcagacgag ctcctgagct ggaagaggcc gctgcgcagc ctgctcacct tcctgggtgc
      301 caacctgctg ttctggttcc ttgccttgac tccttggaga gtgtatcacc tcatttccgt
      361 catgattctt gggcgtgtta tcatgcagat catcaaggaa atggttttgt ccaggacaag
      421 aggtgcccag ctgtggagaa gcctcactga aagctgggaa gtcatcaatt ccaagccaga
      481 tgaaagagcc agactgagcc agtgcattgc agaatcatgg atgaatttca gcatgtttct
      541 tcaagaaatg tctcttttta aacagcagag tcctggcaag ttttgcctcc tggtctgcag
      601 tgtgtgcaca ttttttacaa tcttgggaag ttacattcct ggggtcatac tcagctacct
      661 tctgttactg tttgcttttt tgtgtccact gtttaaatgt aatgatattg gacaaaaaat
      721 atacagcaaa gtcaagtcca ttctattaaa actagatttt ggaattggag aatatattaa
      781 ccagaagaaa cgtgagagat ctgaagcaga taaagaaaaa agtcacaagg atgacagtga
      841 attagacttt tcagctcttt gtcctaagat tagcctcaca gttgctgcca aagagttatc
      901 tgtgtcagac acagatgtgt cagaagtctc ttggactgac aatgggacct tcaacctttc
      961 agaggggtac actccgcaga cagacacttc tgacgatctt gaccggccca gtgaggaagt
     1021 tttctctcga gatctttcag attttccatc tctggaaaat gggacgggaa caaatgatga
     1081 agatgaatta agcctgggct tacccacaga gctcaagaga aagaagcagc agttggatag
     1141 tgctcacaga ccaagcaaag aacggcagtc ggcagctggc ctctcacttc ctctcaagag
     1201 cgaccaagcc cttcacttga tgagcaacct ggctggggat gtcatcacag ccgccatgac
     1261 ggctgccatc aaagaccagc tagaaggagc ccggcaggca ctcactcagg tggcgcccac
     1321 tgcgggagag gacacagaca ctgaggaggg ggatgacttt gaactacttg accaggcaga
     1381 gctagatcaa attgagagtg agctgggact aacacaagac caaggggcag aagcccagca
     1441 aagtaagaaa tcctcaggct tcctctccaa tctgcttgga ggccattaac cgggaatcac
     1501 ctggcagcca gcgaagcaca gataaaccac ccaaaaagtt caaacaagca gggggaaaaa
     1561 atggaaaaaa aatggaattg taagctttaa ttactttagt ttttttttct tttgttttgt
     1621 tttcttttcc cttctatagt gagttggatg tgtatcagtt gataatgata gactgacatt
     1681 tctgatagtt atttttctgt aataagcatg gaaatgaact ttatagttac atatatacat
     1741 actgtggtgt cctaagtgct taggggctgt ttgtaaagtg aagagaaaaa aaaaaaaacc
     1801 aaaaacacca acccccatca aactattaag gtctttctat aagtattctt tttcgttata
     1861 attcccaagc atgcagagat ttatcataac ttgctaaaaa gtgacagctg tgagcacatg
     1921 ctgcagcagc cccttcgtta tcatctcaga agcagtccat caaatcctga cagatgttaa
     1981 tgtcaaaagg agaacgtatc caaacgtttg tagttgaagg gctatggaca tgctgtcaaa
     2041 attaattttc taggaaaacc tttaaaaata agtactacct ataggctgaa atatttccat
     2101 gttacttcta cagttgtaga cataggctta cttgtcgagt ggcatgctcc actgactgcc
     2161 acatctagtc ttgaaaagag gtggtactga cccacaggaa gcaggcagtt atgtatctct
     2221 tagtgatgct cttgcaatgt ttgcaatggt aagtgcacac tattttgcac actcagatgt
     2281 aagcaaaccc cgatgtttct gtattgtgtt atcgtctcct aggattgtaa aactagctac
     2341 tggtatggcc atgagtgatg tggtcattgg tgatgaaaaa ctacttctgt ttttttcagt
     2401 ttacaaatgc agaacagaga agcttgcttg aacttgaaag tgtatactct gccactgcag
     2461 tctcaatatg taatccgttt cttactggga atctagacca tgctttttcc tttaaactgt
     2521 cttttcatca cctttacgta atcaaatttg acttacagtg gaaaccaaga tagttgtttt
     2581 tgcgaaacaa tcttttagta agactgaggg accatgtcag caactatctt aaatcttcag
     2641 ttatagctgg catttccaca cagacatgca agaccctgac aaaggaaggg gtaataatat
     2701 aagactatag aaatctgtgt ttcagtttca tctcttttat ttctaaagaa taattacagg
     2761 taacttgatc ttttaatgta ccatctccta tttatttatt gttttctttc tgaggtatta
     2821 aaatatctag actgaatttt gccaaatgta agagggagaa agttcctgaa gactctgact
     2881 acttgcttat ttttgattga ccttctatgc ttatgtcatt agtgcctcac aacgtgtttg
     2941 atgtccttta ttgatacaaa gtgagcctgt gccttcattt tcttgcccat tttggtacca
     3001 atgtaaattt gtgttagaaa atcttgaaac tctgtgagtc tgggaagaat atatctgaat
     3061 cctattcaat acatttgctg gatgtgaaga aaaatacagc cacatattta taaaacagtt
     3121 gttaccagta ttccttttt
//
