LOCUS       NM_181596                610 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus resistin like gamma (Retnlg), mRNA.
ACCESSION   NM_181596
VERSION     NM_181596.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 610)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 610)
  AUTHORS   Rauch,F., Geng,Y., Lamplugh,L., Hekmatnejad,B., Gaumond,M.H.,
            Penney,J., Yamanaka,Y. and Moffatt,P.
  TITLE     Crispr-Cas9 engineered osteogenesis imperfecta type V leads to
            severe skeletal deformities and perinatal lethality in mice
  JOURNAL   Bone 107, 131-142 (2018)
   PUBMED   29174564
REFERENCE   3  (bases 1 to 610)
  AUTHORS   Liu,X., Jiao,Y., Cao,Y., Deng,N., Ma,Y., Hasty,K.A., Kang,A.,
            Chen,H., Stuart,J.M. and Gu,W.
  TITLE     Decreased expression levels of Ifi genes is associated to the
            increased resistance to spontaneous arthritis disease in mice
            deficiency of IL-1RA
  JOURNAL   BMC Immunol 17 (1), 25 (2016)
   PUBMED   27480124
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 610)
  AUTHORS   Park,S.H., Chen,W.C., Durmus,N., Bleck,B., Reibman,J.,
            Riemekasten,G. and Grunig,G.
  TITLE     The Effects of Antigen-Specific IgG1 Antibody for the
            Pulmonary-Hypertension-Phenotype and B Cells for Inflammation in
            Mice Exposed to Antigen and Fine Particles from Air Pollution
  JOURNAL   PLoS One 10 (6), e0129910 (2015)
   PUBMED   26079807
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 610)
  AUTHORS   Choi,K.C., Lee,S.Y., Yoo,H.J., Ryu,O.H., Lee,K.W., Kim,S.M.,
            Baik,S.H. and Choi,K.M.
  TITLE     Effect of PPAR-delta agonist on the expression of visfatin,
            adiponectin, and resistin in rat adipose tissue and 3T3-L1
            adipocytes
  JOURNAL   Biochem Biophys Res Commun 357 (1), 62-67 (2007)
   PUBMED   17418807
  REMARK    GeneRIF: The present study provides a novel evidence to suggest
            that the PPAR-delta agonist has regulatory effects on a variety of
            adipokines, and these effects might explain some of their metabolic
            function.
REFERENCE   6  (bases 1 to 610)
  AUTHORS   Bowman,T.V., McCooey,A.J., Merchant,A.A., Ramos,C.A., Fonseca,P.,
            Poindexter,A., Bradfute,S.B., Oliveira,D.M., Green,R., Zheng,Y.,
            Jackson,K.A., Chambers,S.M., McKinney-Freeman,S.L., Norwood,K.G.,
            Darlington,G., Gunaratne,P.H., Steffen,D. and Goodell,M.A.
  TITLE     Differential mRNA processing in hematopoietic stem cells
  JOURNAL   Stem Cells 24 (3), 662-670 (2006)
   PUBMED   16373690
REFERENCE   7  (bases 1 to 610)
  AUTHORS   Shojima,N., Ogihara,T., Inukai,K., Fujishiro,M., Sakoda,H.,
            Kushiyama,A., Katagiri,H., Anai,M., Ono,H., Fukushima,Y.,
            Horike,N., Viana,A.Y., Uchijima,Y., Kurihara,H. and Asano,T.
  TITLE     Serum concentrations of resistin-like molecules beta and gamma are
            elevated in high-fat-fed and obese db/db mice, with increased
            production in the intestinal tract and bone marrow
  JOURNAL   Diabetologia 48 (5), 984-992 (2005)
   PUBMED   15834545
  REMARK    GeneRIF: Serum concentrations of RELMbeta and RELMgamma may be a
            novel intestinal-tract-mediating regulator of insulin sensitivity,
            possibly involved in insulin resistance induced by obesity and a
            high-fat diet.
REFERENCE   8  (bases 1 to 610)
  AUTHORS   Chumakov,A.M., Kubota,T., Walter,S. and Koeffler,H.P.
  TITLE     Identification of murine and human XCP1 genes as
            C/EBP-epsilon-dependent members of FIZZ/Resistin gene family
  JOURNAL   Oncogene 23 (19), 3414-3425 (2004)
   PUBMED   15064728
REFERENCE   9  (bases 1 to 610)
  AUTHORS   Schinke,T., Haberland,M., Jamshidi,A., Nollau,P., Rueger,J.M. and
            Amling,M.
  TITLE     Cloning and functional characterization of resistin-like molecule
            gamma
  JOURNAL   Biochem Biophys Res Commun 314 (2), 356-362 (2004)
   PUBMED   14733912
  REMARK    GeneRIF: RELMgamma is a secreted molecule with a restricted
            expression pattern that may play a role in promyelocytic
            differentiation
REFERENCE   10 (bases 1 to 610)
  AUTHORS   Gerstmayer,B., Kusters,D., Gebel,S., Muller,T., Van Miert,E.,
            Hofmann,K. and Bosio,A.
  TITLE     Identification of RELMgamma, a novel resistin-like molecule with a
            distinct expression pattern
  JOURNAL   Genomics 81 (6), 588-595 (2003)
   PUBMED   12782128
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DY246276.1, BY236131.1, AJ536019.1 and BX631439.1.
            
            On Mar 17, 2009 this sequence version replaced NM_181596.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: DY242945.1, DY246276.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-13                DY246276.1         33-45
            14-37               BY236131.1         2-25
            38-606              AJ536019.1         1-569
            607-610             BX631439.1         1-4                 c
FEATURES             Location/Qualifiers
     source          1..610
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="16"
                     /map="16 30.75 cM"
     gene            1..610
                     /gene="Retnlg"
                     /gene_synonym="Fizz3; Relmg; Xcp1"
                     /note="resistin like gamma"
                     /db_xref="GeneID:245195"
                     /db_xref="MGI:MGI:2667763"
     exon            1..93
                     /gene="Retnlg"
                     /gene_synonym="Fizz3; Relmg; Xcp1"
                     /inference="alignment:Splign:2.1.0"
     exon            94..245
                     /gene="Retnlg"
                     /gene_synonym="Fizz3; Relmg; Xcp1"
                     /inference="alignment:Splign:2.1.0"
     CDS             101..454
                     /gene="Retnlg"
                     /gene_synonym="Fizz3; Relmg; Xcp1"
                     /note="RELMgamma; resistin-like molecule gamma;
                     ten-cysteine protein 1"
                     /codon_start=1
                     /product="resistin-like gamma precursor"
                     /protein_id="NP_853627.2"
                     /db_xref="CCDS:CCDS49865.1"
                     /db_xref="GeneID:245195"
                     /db_xref="MGI:MGI:2667763"
                     /translation="MLTFNKMKTTTCSLLICISLLQLMVPVNTEGTLESIVEKKVKEL
                     LANRDDCPSTVTKTFSCTSITASGRLASCPSGMTVTGCACGYGCGSWDIRDGNTCHCQ
                     CSTMDWATARCCQLA"
     exon            246..326
                     /gene="Retnlg"
                     /gene_synonym="Fizz3; Relmg; Xcp1"
                     /inference="alignment:Splign:2.1.0"
     exon            327..608
                     /gene="Retnlg"
                     /gene_synonym="Fizz3; Relmg; Xcp1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      581..586
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Retnlg"
                     /gene_synonym="Fizz3; Relmg; Xcp1"
                     /note="hexamer: AATAAA"
     polyA_site      608
                     /gene="Retnlg"
                     /gene_synonym="Fizz3; Relmg; Xcp1"
                     /note="major polyA site"
ORIGIN      
        1 gcttgtatat agtaagggta cacaggtcag taatcccacg gtgtattaaa gcatctcatc
       61 tggccaggtc ctggaacctt tcctgagatt ctgccctagg atgctgactt tcaacaagat
      121 gaagactaca acttgttccc ttctcatctg catctccctt ctccagctga tggtcccagt
      181 gaatactgag gggaccttag aatctattgt ggagaaaaag gtcaaggaac ttcttgccaa
      241 tcgagatgac tgtccctcca ctgtaacaaa gactttctcc tgtactagta tcacggcttc
      301 aggcagactg gcctcctgtc cttctggaat gactgtcact ggttgtgctt gtggctatgg
      361 ctgtggatct tgggatatcc gggatggaaa tacttgccac tgtcagtgct caacaatgga
      421 ctgggccacc gcccgttgct gccaactggc ctaagaatga ggaagctgag aacctagctt
      481 tgaaatgaag actataacaa aagcacaatc ccaacttgga aacctggctc atatcccatt
      541 gatgaattca tattgtccat tagccctgct tcttgaaaaa aataaagaca aatttgcacg
      601 tgtctgtaaa
//
