LOCUS       NM_023881                718 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Mus musculus resistin like beta (Retnlb), mRNA.
ACCESSION   NM_023881
VERSION     NM_023881.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 718)
  AUTHORS   Mihi,B., Gong,Q., Nolan,L.S., Gale,S.E., Goree,M., Hu,E.,
            Lanik,W.E., Rimer,J.M., Liu,V., Parks,O.B., Lewis,A.N., Agrawal,P.,
            Laury,M.L., Kumar,P., Huang,E., Bidani,S.S., Luke,C.J., Kolls,J.K.
            and Good,M.
  TITLE     Interleukin-22 signaling attenuates necrotizing enterocolitis by
            promoting epithelial cell regeneration
  JOURNAL   Cell Rep Med 2 (6), 100320 (2021)
   PUBMED   34195684
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 718)
  AUTHORS   Propheter,D.C., Chara,A.L., Harris,T.A., Ruhn,K.A. and Hooper,L.V.
  TITLE     Resistin-like molecule beta is a bactericidal protein that promotes
            spatial segregation of the microbiota and the colonic epithelium
  JOURNAL   Proc Natl Acad Sci U S A 114 (42), 11027-11033 (2017)
   PUBMED   28973871
  REMARK    GeneRIF: promotes host-bacterial mutualism by regulating the
            spatial segregation between the microbiota and the intestinal
            epithelium
REFERENCE   3  (bases 1 to 718)
  AUTHORS   Wernstedt Asterholm,I., Kim-Muller,J.Y., Rutkowski,J.M., Crewe,C.,
            Tao,C. and Scherer,P.E.
  TITLE     Pathological Type-2 Immune Response, Enhanced Tumor Growth, and
            Glucose Intolerance in Retnlbeta (RELMbeta) Null Mice: A Model of
            Intestinal Immune System Dysfunction in Disease Susceptibility
  JOURNAL   Am J Pathol 186 (9), 2404-2416 (2016)
   PUBMED   27397737
  REMARK    GeneRIF: lack of RELMbeta leads to increased colonic expression of
            T helper cell type-2 cytokines and IL-17, associated with a reduced
            ability to maintain intestinal homeostasis
REFERENCE   4  (bases 1 to 718)
  AUTHORS   Chellappa,K., Deol,P., Evans,J.R., Vuong,L.M., Chen,G.,
            Briancon,N., Bolotin,E., Lytle,C., Nair,M.G. and Sladek,F.M.
  TITLE     Opposing roles of nuclear receptor HNF4alpha isoforms in colitis
            and colitis-associated colon cancer
  JOURNAL   Elife 5, e10903 (2016)
   PUBMED   27166517
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 718)
  AUTHORS   Chen,G., Wang,S.H., Jang,J.C., Odegaard,J.I. and Nair,M.G.
  TITLE     Comparison of RELMalpha and RELMbeta Single- and
            Double-Gene-Deficient Mice Reveals that RELMalpha Expression
            Dictates Inflammation and Worm Expulsion in Hookworm Infection
  JOURNAL   Infect Immun 84 (4), 1100-1111 (2016)
   PUBMED   26831469
  REMARK    GeneRIF: These data demonstrate that RELMalpha but not RELMbeta
            significantly impacts the immune response to N. brasiliensis
            infection by downregulating the Th2 adaptive immune response in the
            lung.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 718)
  AUTHORS   He,W., Wang,M.L., Jiang,H.Q., Steppan,C.M., Shin,M.E.,
            Thurnheer,M.C., Cebra,J.J., Lazar,M.A. and Wu,G.D.
  TITLE     Bacterial colonization leads to the colonic secretion of
            RELMbeta/FIZZ2, a novel goblet cell-specific protein
  JOURNAL   Gastroenterology 125 (5), 1388-1397 (2003)
   PUBMED   14598255
  REMARK    GeneRIF: Secretion of RELMbeta is dramatically reduced in germ-free
            mice. Furthermore, introduction of germ-free mice into a
            conventional environment results in enhanced expression and robust
            secretion of RELMbeta within 48 hours.
REFERENCE   7  (bases 1 to 718)
  AUTHORS   Gerstmayer,B., Kusters,D., Gebel,S., Muller,T., Van Miert,E.,
            Hofmann,K. and Bosio,A.
  TITLE     Identification of RELMgamma, a novel resistin-like molecule with a
            distinct expression pattern
  JOURNAL   Genomics 81 (6), 588-595 (2003)
   PUBMED   12782128
REFERENCE   8  (bases 1 to 718)
  AUTHORS   Banerjee,R.R. and Lazar,M.A.
  TITLE     Dimerization of resistin and resistin-like molecules is determined
            by a single cysteine
  JOURNAL   J Biol Chem 276 (28), 25970-25973 (2001)
   PUBMED   11358969
REFERENCE   9  (bases 1 to 718)
  AUTHORS   Steppan,C.M., Brown,E.J., Wright,C.M., Bhat,S., Banerjee,R.R.,
            Dai,C.Y., Enders,G.H., Silberg,D.G., Wen,X., Wu,G.D. and Lazar,M.A.
  TITLE     A family of tissue-specific resistin-like molecules
  JOURNAL   Proc Natl Acad Sci U S A 98 (2), 502-506 (2001)
   PUBMED   11209052
REFERENCE   10 (bases 1 to 718)
  AUTHORS   Holcomb,I.N., Kabakoff,R.C., Chan,B., Baker,T.W., Gurney,A.,
            Henzel,W., Nelson,C., Lowman,H.B., Wright,B.D., Skelton,N.J.,
            Frantz,G.D., Tumas,D.B., Peale,F.V. Jr., Shelton,D.L. and
            Hebert,C.C.
  TITLE     FIZZ1, a novel cysteine-rich secreted protein associated with
            pulmonary inflammation, defines a new gene family
  JOURNAL   EMBO J 19 (15), 4046-4055 (2000)
   PUBMED   10921885
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AF290871.1 and AK020240.1.
            
            On Mar 21, 2009 this sequence version replaced NM_023881.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF290871.1, BY720630.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849377, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-116               AF290871.1         2-117
            117-693             AK020240.1         5-581
            694-718             AF290871.1         696-720
FEATURES             Location/Qualifiers
     source          1..718
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="16"
                     /map="16 30.75 cM"
     gene            1..718
                     /gene="Retnlb"
                     /gene_synonym="9030012B21Rik; Fizz2; Relmb; RELMbeta;
                     Xcp3"
                     /note="resistin like beta"
                     /db_xref="GeneID:57263"
                     /db_xref="MGI:MGI:1888505"
     exon            1..216
                     /gene="Retnlb"
                     /gene_synonym="9030012B21Rik; Fizz2; Relmb; RELMbeta;
                     Xcp3"
                     /inference="alignment:Splign:2.1.0"
     exon            217..368
                     /gene="Retnlb"
                     /gene_synonym="9030012B21Rik; Fizz2; Relmb; RELMbeta;
                     Xcp3"
                     /inference="alignment:Splign:2.1.0"
     CDS             242..559
                     /gene="Retnlb"
                     /gene_synonym="9030012B21Rik; Fizz2; Relmb; RELMbeta;
                     Xcp3"
                     /note="resistin-like molecule beta; cysteine-rich secreted
                     protein FIZZ2; cysteine-rich secreted protein A12-beta;
                     found in inflammatory zone 2"
                     /codon_start=1
                     /product="resistin-like beta precursor"
                     /protein_id="NP_076370.3"
                     /db_xref="CCDS:CCDS28210.1"
                     /db_xref="GeneID:57263"
                     /db_xref="MGI:MGI:1888505"
                     /translation="MKPTLCFLFILVSLLPLIVPGNAQCSFESLVDQRIKEALSRQEP
                     KTISCTSVTSSGRLASCPAGMVVTGCACGYGCGSWDIRNGNTCHCQCSVMDWASARCC
                     RMA"
     exon            369..431
                     /gene="Retnlb"
                     /gene_synonym="9030012B21Rik; Fizz2; Relmb; RELMbeta;
                     Xcp3"
                     /inference="alignment:Splign:2.1.0"
     exon            432..696
                     /gene="Retnlb"
                     /gene_synonym="9030012B21Rik; Fizz2; Relmb; RELMbeta;
                     Xcp3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      671..676
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Retnlb"
                     /gene_synonym="9030012B21Rik; Fizz2; Relmb; RELMbeta;
                     Xcp3"
                     /note="hexamer: AATAAA"
     polyA_site      694
                     /gene="Retnlb"
                     /gene_synonym="9030012B21Rik; Fizz2; Relmb; RELMbeta;
                     Xcp3"
                     /note="major polyA site"
ORIGIN      
        1 ggcagctgtt gcttatcaag gacacactca agtttattgt ggtgatgtgt caagacacag
       61 aaaatattta catatgtgtg catatatatt aagagtgtac aggtctacat tctcaaagta
      121 acacatccag aagaccattt cctgagcttt ctggagagtg aatctgctct taggggaaaa
      181 ctcttccctt tccttctcca aaaagctaga actgagctcc aggaggctga ctttctacag
      241 tatgaagcct acactgtgtt tccttttcat cctcgtctcc cttctcccac tgatagtccc
      301 agggaacgcg caatgctcct ttgagtcttt ggtggatcaa aggatcaagg aagctctcag
      361 tcgtcaagag cctaagacga tctcctgcac tagtgtcacg tcttctggca gactggcctc
      421 ctgtcctgct gggatggttg tcactggatg tgcttgtggc tatggctgtg gatcgtggga
      481 tatccggaat ggaaatactt gccactgcca gtgctcagtc atggactggg cctctgcccg
      541 ctgctgccga atggcttaag aatgaggagg ttgagaaacc aatttcaaaa tgatgagcat
      601 aatgaaacca cggtctcgac caggaaacct gactcattgt cttcatatta ctaaataatt
      661 cttcttgaat aataaaggca gacctgtacc tttgcaaaaa aaaaaaaaaa aaaaaaaa
//
