LOCUS       NM_020509                541 bp    mRNA    linear   ROD 03-AUG-2024
DEFINITION  Mus musculus resistin like alpha (Retnla), mRNA.
ACCESSION   NM_020509
VERSION     NM_020509.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 541)
  AUTHORS   Ghorbani,P., Kim,S.Y., Smith,T.K.T., Minarrieta,L.,
            Robert-Gostlin,V., Kilgour,M.K., Ilijevska,M., Alecu,I.,
            Snider,S.A., Margison,K.D., Nunes,J.R.C., Woo,D., Pember,C.,
            O'Dwyer,C., Ouellette,J., Kotchetkov,P., St-Pierre,J.,
            Bennett,S.A.L., Lacoste,B., Blais,A., Nair,M.G. and Fullerton,M.D.
  TITLE     Choline metabolism underpins macrophage IL-4 polarization and
            RELMalpha up-regulation in helminth infection
  JOURNAL   PLoS Pathog 19 (9), e1011658 (2023)
   PUBMED   37747879
  REMARK    GeneRIF: Choline metabolism underpins macrophage IL-4 polarization
            and RELMalpha up-regulation in helminth infection.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 541)
  AUTHORS   Li,J., Kim,S.Y., Lainez,N.M., Coss,D. and Nair,M.G.
  TITLE     Macrophage-Regulatory T Cell Interactions Promote Type 2 Immune
            Homeostasis Through Resistin-Like Molecule alpha
  JOURNAL   Front Immunol 12, 710406 (2021)
   PUBMED   34349768
  REMARK    GeneRIF: Macrophage-Regulatory T Cell Interactions Promote Type 2
            Immune Homeostasis Through Resistin-Like Molecule alpha.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 541)
  AUTHORS   Li,Y., Dong,M., Wang,Q., Kumar,S., Zhang,R., Cheng,W., Xiang,J.,
            Wang,G., Ouyang,K., Zhou,R., Xie,Y., Lu,Y., Yi,J., Duan,H. and
            Liu,J.
  TITLE     HIMF deletion ameliorates acute myocardial ischemic injury by
            promoting macrophage transformation to reparative subtype
  JOURNAL   Basic Res Cardiol 116 (1), 30 (2021)
   PUBMED   33893593
  REMARK    GeneRIF: HIMF deletion ameliorates acute myocardial ischemic injury
            by promoting macrophage transformation to reparative subtype.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 541)
  AUTHORS   Angueira,A.R., Sakers,A.P., Holman,C.D., Cheng,L., Arbocco,M.N.,
            Shamsi,F., Lynes,M.D., Shrestha,R., Okada,C., Batmanov,K.,
            Susztak,K., Tseng,Y.H., Liaw,L. and Seale,P.
  TITLE     Defining the lineage of thermogenic perivascular adipose tissue
  JOURNAL   Nat Metab 3 (4), 469-484 (2021)
   PUBMED   33846639
REFERENCE   5  (bases 1 to 541)
  AUTHORS   Kim,Y.S., Cho,H.H., Cho,D.I., Jeong,H.Y., Lim,S.Y., Jun,J.H.,
            Kim,M.R., Kang,B.G., Cho,M., Kang,H.J., Kang,W.S., Oh,G.T. and
            Ahn,Y.
  TITLE     The adipokine Retnla deficiency increases responsiveness to cardiac
            repair through adiponectin-rich bone marrow cells
  JOURNAL   Cell Death Dis 12 (4), 307 (2021)
   PUBMED   33753732
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 541)
  AUTHORS   Bing,C., Gomez-Ambrosi,J., Zabalegui,N., Williams,G. and
            Trayhurn,P.
  TITLE     Resistin and RELM-alpha gene expression in white adipose tissue of
            lactating mice
  JOURNAL   Biochem Biophys Res Commun 296 (2), 458-462 (2002)
   PUBMED   12163041
  REMARK    GeneRIF: RELM-alpha mRNA in white adipose tissue fell by
            approximately 40% in early lactation; might indicate a role for
            RELM-alpha in the metabolic adaptations of lactation.
REFERENCE   7  (bases 1 to 541)
  AUTHORS   Rajala,M.W., Lin,Y., Ranalletta,M., Yang,X.M., Qian,H.,
            Gingerich,R., Barzilai,N. and Scherer,P.E.
  TITLE     Cell type-specific expression and coregulation of murine resistin
            and resistin-like molecule-alpha in adipose tissue
  JOURNAL   Mol Endocrinol 16 (8), 1920-1930 (2002)
   PUBMED   12145345
  REMARK    GeneRIF: the expression of resistin and RELMalpha are similarly
            regulated in adipose tissue despite the fact that RELMalpha is
            exclusively expressed in the stromal vascular fraction of adipose
            tissue and not in adipocytes
REFERENCE   8  (bases 1 to 541)
  AUTHORS   Banerjee,R.R. and Lazar,M.A.
  TITLE     Dimerization of resistin and resistin-like molecules is determined
            by a single cysteine
  JOURNAL   J Biol Chem 276 (28), 25970-25973 (2001)
   PUBMED   11358969
REFERENCE   9  (bases 1 to 541)
  AUTHORS   Steppan,C.M., Brown,E.J., Wright,C.M., Bhat,S., Banerjee,R.R.,
            Dai,C.Y., Enders,G.H., Silberg,D.G., Wen,X., Wu,G.D. and Lazar,M.A.
  TITLE     A family of tissue-specific resistin-like molecules
  JOURNAL   Proc Natl Acad Sci U S A 98 (2), 502-506 (2001)
   PUBMED   11209052
REFERENCE   10 (bases 1 to 541)
  AUTHORS   Holcomb,I.N., Kabakoff,R.C., Chan,B., Baker,T.W., Gurney,A.,
            Henzel,W., Nelson,C., Lowman,H.B., Wright,B.D., Skelton,N.J.,
            Frantz,G.D., Tumas,D.B., Peale,F.V. Jr., Shelton,D.L. and
            Hebert,C.C.
  TITLE     FIZZ1, a novel cysteine-rich secreted protein associated with
            pulmonary inflammation, defines a new gene family
  JOURNAL   EMBO J 19 (15), 4046-4055 (2000)
   PUBMED   10921885
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC154529.2.
            
            On Mar 21, 2019 this sequence version replaced NM_020509.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK007553.1, AF316397.2 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            RefSeq Select criteria           :: based on single protein-coding
                                                transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-20                AC154529.2         80493-80512         c
            21-172              AC154529.2         80178-80329         c
            173-253             AC154529.2         79488-79568         c
            254-541             AC154529.2         78660-78947         c
FEATURES             Location/Qualifiers
     source          1..541
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="16"
                     /map="16 30.75 cM"
     gene            1..541
                     /gene="Retnla"
                     /gene_synonym="1810019L16Rik; Fizz-1; Fizz1; HIMF;
                     RELM-alpha; RELMa; RELMalpha; Xcp2"
                     /note="resistin like alpha"
                     /db_xref="GeneID:57262"
                     /db_xref="MGI:MGI:1888504"
     exon            1..20
                     /gene="Retnla"
                     /gene_synonym="1810019L16Rik; Fizz-1; Fizz1; HIMF;
                     RELM-alpha; RELMa; RELMalpha; Xcp2"
                     /inference="alignment:Splign:2.1.0"
     exon            21..172
                     /gene="Retnla"
                     /gene_synonym="1810019L16Rik; Fizz-1; Fizz1; HIMF;
                     RELM-alpha; RELMa; RELMalpha; Xcp2"
                     /inference="alignment:Splign:2.1.0"
     CDS             46..381
                     /gene="Retnla"
                     /gene_synonym="1810019L16Rik; Fizz-1; Fizz1; HIMF;
                     RELM-alpha; RELMa; RELMalpha; Xcp2"
                     /note="hypoxia-induced mitogenic factor; cysteine-rich
                     secreted protein FIZZ1; cysteine-rich secreted protein
                     A12-gamma; parasite-induced macrophage novel gene 1
                     protein; found in inflammatory zone 1"
                     /codon_start=1
                     /product="resistin-like alpha precursor"
                     /protein_id="NP_065255.3"
                     /db_xref="CCDS:CCDS49864.2"
                     /db_xref="GeneID:57262"
                     /db_xref="MGI:MGI:1888504"
                     /translation="MKTTTCSLLICISLLQLMVPVNTDETIEIIVENKVKELLANPAN
                     YPSTVTKTLSCTSVKTMNRWASCPAGMTATGCACGFACGSWEIQSGDTCNCLCLLVDW
                     TTARCCQLS"
     exon            173..253
                     /gene="Retnla"
                     /gene_synonym="1810019L16Rik; Fizz-1; Fizz1; HIMF;
                     RELM-alpha; RELMa; RELMalpha; Xcp2"
                     /inference="alignment:Splign:2.1.0"
     exon            254..541
                     /gene="Retnla"
                     /gene_synonym="1810019L16Rik; Fizz-1; Fizz1; HIMF;
                     RELM-alpha; RELMa; RELMalpha; Xcp2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      520..525
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Retnla"
                     /gene_synonym="1810019L16Rik; Fizz-1; Fizz1; HIMF;
                     RELM-alpha; RELMa; RELMalpha; Xcp2"
                     /note="hexamer: AATAAA"
     polyA_site      541
                     /gene="Retnla"
                     /gene_synonym="1810019L16Rik; Fizz-1; Fizz1; HIMF;
                     RELM-alpha; RELMa; RELMalpha; Xcp2"
                     /note="major polyA site"
ORIGIN      
        1 gaacctttcc tgagattctg ccccaggatg ccaactttga ataggatgaa gactacaact
       61 tgttcccttc tcatctgcat ctccctgctc cagctgatgg tcccagtgaa tactgatgag
      121 accatagaga ttatcgtgga gaataaggtc aaggaacttc ttgccaatcc agctaactat
      181 ccctccactg taacgaagac tctctcttgc actagtgtca agactatgaa cagatgggcc
      241 tcctgccctg ctgggatgac tgctactggg tgtgcttgtg gctttgcctg tggatcttgg
      301 gagatccaga gtggagatac ttgcaactgc ctgtgcttac tcgttgactg gaccactgcc
      361 cgctgctgcc aactgtccta agaatgaaga ggtggagaac ccagctttga tatgatgaat
      421 ctaacaaaaa ctgcagtctc aatttggaaa tctgactcat gtgcctttaa atgtgttcat
      481 attgcccatt taccctgctt cttgaaatgc ttcttgaaaa ataaagacaa atttgcatgt
      541 g
//
