LOCUS       NM_001204959             607 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Mus musculus resistin (Retn), transcript variant 2, mRNA.
ACCESSION   NM_001204959
VERSION     NM_001204959.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 607)
  AUTHORS   Yang,H.M., Kim,J., Shin,D., Kim,J.Y., You,J., Lee,H.C., Jang,H.D.
            and Kim,H.S.
  TITLE     Resistin impairs mitochondrial homeostasis via cyclase-associated
            protein 1-mediated fission, leading to obesity-induced metabolic
            diseases
  JOURNAL   Metabolism 138, 155343 (2023)
   PUBMED   36356648
  REMARK    GeneRIF: Resistin impairs mitochondrial homeostasis via
            cyclase-associated protein 1-mediated fission, leading to
            obesity-induced metabolic diseases.
REFERENCE   2  (bases 1 to 607)
  AUTHORS   Zhao,B., Bouchareb,R. and Lebeche,D.
  TITLE     Resistin deletion protects against heart failure injury by
            targeting DNA damage response
  JOURNAL   Cardiovasc Res 118 (8), 1947-1963 (2022)
   PUBMED   34324657
  REMARK    GeneRIF: Resistin deletion protects against heart failure injury by
            targeting DNA damage response.
REFERENCE   3  (bases 1 to 607)
  AUTHORS   Bonavia,A.S., Chroneos,Z.C., Ruiz-Velasco,V. and Lang,C.H.
  TITLE     Resistin production does not affect outcomes in a mouse model of
            acute surgical sepsis
  JOURNAL   PLoS One 17 (3), e0265241 (2022)
   PUBMED   35286340
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 607)
  AUTHORS   Taouis,M. and Benomar,Y.
  TITLE     Is resistin the master link between inflammation and
            inflammation-related chronic diseases?
  JOURNAL   Mol Cell Endocrinol 533, 111341 (2021)
   PUBMED   34082045
  REMARK    GeneRIF: Is resistin the master link between inflammation and
            inflammation-related chronic diseases?
            Review article
REFERENCE   5  (bases 1 to 607)
  AUTHORS   Ito,K., Schneeberger,M., Gerber,A., Jishage,M., Marchildon,F.,
            Maganti,A.V., Cohen,P., Friedman,J.M. and Roeder,R.G.
  TITLE     Critical roles of transcriptional coactivator MED1 in the formation
            and function of mouse adipose tissues
  JOURNAL   Genes Dev 35 (9-10), 729-748 (2021)
   PUBMED   33888560
REFERENCE   6  (bases 1 to 607)
  AUTHORS   Banerjee,R.R. and Lazar,M.A.
  TITLE     Dimerization of resistin and resistin-like molecules is determined
            by a single cysteine
  JOURNAL   J Biol Chem 276 (28), 25970-25973 (2001)
   PUBMED   11358969
REFERENCE   7  (bases 1 to 607)
  AUTHORS   Kim,K.H., Lee,K., Moon,Y.S. and Sul,H.S.
  TITLE     A cysteine-rich adipose tissue-specific secretory factor inhibits
            adipocyte differentiation
  JOURNAL   J Biol Chem 276 (14), 11252-11256 (2001)
   PUBMED   11278254
REFERENCE   8  (bases 1 to 607)
  AUTHORS   Steppan,C.M., Bailey,S.T., Bhat,S., Brown,E.J., Banerjee,R.R.,
            Wright,C.M., Patel,H.R., Ahima,R.S. and Lazar,M.A.
  TITLE     The hormone resistin links obesity to diabetes
  JOURNAL   Nature 409 (6818), 307-312 (2001)
   PUBMED   11201732
REFERENCE   9  (bases 1 to 607)
  AUTHORS   Steppan,C.M., Brown,E.J., Wright,C.M., Bhat,S., Banerjee,R.R.,
            Dai,C.Y., Enders,G.H., Silberg,D.G., Wen,X., Wu,G.D. and Lazar,M.A.
  TITLE     A family of tissue-specific resistin-like molecules
  JOURNAL   Proc Natl Acad Sci U S A 98 (2), 502-506 (2001)
   PUBMED   11209052
REFERENCE   10 (bases 1 to 607)
  AUTHORS   Holcomb,I.N., Kabakoff,R.C., Chan,B., Baker,T.W., Gurney,A.,
            Henzel,W., Nelson,C., Lowman,H.B., Wright,B.D., Skelton,N.J.,
            Frantz,G.D., Tumas,D.B., Peale,F.V. Jr., Shelton,D.L. and
            Hebert,C.C.
  TITLE     FIZZ1, a novel cysteine-rich secreted protein associated with
            pulmonary inflammation, defines a new gene family
  JOURNAL   EMBO J 19 (15), 4046-4055 (2000)
   PUBMED   10921885
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK131613.1 and BC051196.1.
            
            Transcript Variant: This variant (2) differs in the 3' UTR,
            compared to variant 1. Both variants 1 and 2 encode the same
            protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF290870.1, AK131613.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-23                AK131613.1         2-24
            24-607              BC051196.1         10-593
FEATURES             Location/Qualifiers
     source          1..607
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 1.92 cM"
     gene            1..607
                     /gene="Retn"
                     /gene_synonym="ADSF; Fizz3; Rstn; Xcp4"
                     /note="resistin"
                     /db_xref="GeneID:57264"
                     /db_xref="MGI:MGI:1888506"
     exon            1..74
                     /gene="Retn"
                     /gene_synonym="ADSF; Fizz3; Rstn; Xcp4"
                     /inference="alignment:Splign:2.1.0"
     exon            75..214
                     /gene="Retn"
                     /gene_synonym="ADSF; Fizz3; Rstn; Xcp4"
                     /inference="alignment:Splign:2.1.0"
     exon            215..292
                     /gene="Retn"
                     /gene_synonym="ADSF; Fizz3; Rstn; Xcp4"
                     /inference="alignment:Splign:2.1.0"
     exon            293..434
                     /gene="Retn"
                     /gene_synonym="ADSF; Fizz3; Rstn; Xcp4"
                     /inference="alignment:Splign:2.1.0"
     exon            435..582
                     /gene="Retn"
                     /gene_synonym="ADSF; Fizz3; Rstn; Xcp4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      562..567
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Retn"
                     /gene_synonym="ADSF; Fizz3; Rstn; Xcp4"
                     /note="hexamer: AATAAA"
     polyA_site      582
                     /gene="Retn"
                     /gene_synonym="ADSF; Fizz3; Rstn; Xcp4"
                     /note="major polyA site"
ORIGIN      
        1 gtcaacaaga aggagctgtg ggacaggagc taatacccag aactgagttg tgtcctgcta
       61 agtcctctgc cacgtaccca cgggatgaag aacctttcat ttcccctcct tttccttttc
      121 ttccttgtcc ctgaactgct gggctccagc atgccactgt gtcccatcga tgaagccatc
      181 gacaagaaga tcaaacaaga cttcaactcc ctgtttccaa atgcaataaa gaacattggc
      241 ttaaattgct ggacagtctc ctccagaggg aagttggcct cctgcccaga aggcacagca
      301 gtcttgagct gctcctgtgg ctctgcctgt ggctcgtggg acattcgtga agaaaaagtg
      361 tgtcactgcc agtgtgcaag gatagactgg acagcagccc gctgctgtaa gctgcaggtc
      421 gcttcctgat gtcggggaag tgagcgtggt ttccagcaca gccacccgtt cctgtagctc
      481 cagagatgtc tgatgtcctc cggtctctac aggcacctgc actcacgtgc gcgaatccac
      541 acacaagcac acatacttaa aaataaaaca aaacaggctg gaaaaaaaaa aaaaaaaaaa
      601 aaaaaaa
//
