LOCUS       NM_011263               4266 bp    mRNA    linear   ROD 04-MAR-2025
DEFINITION  Mus musculus RE1-silencing transcription factor (Rest), mRNA.
ACCESSION   NM_011263
VERSION     NM_011263.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4266)
  AUTHORS   He,Z., Yan,R.G., Shang,Q.B. and Yang,Q.E.
  TITLE     Transcriptomic dynamics and cell-to-cell communication during the
            transition of prospermatogonia to spermatogonia revealed at
            single-cell resolution
  JOURNAL   BMC Genomics 26 (1), 58 (2025)
   PUBMED   39838296
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4266)
  AUTHORS   Vitale,C., Natali,G., Cerullo,M.S., Floss,T., Michetti,C.,
            Grasselli,G. and Benfenati,F.
  TITLE     The homeostatic effects of the RE-1 silencing transcription factor
            on cortical networks are altered under ictogenic conditions in the
            mouse
  JOURNAL   Acta Physiol (Oxf) 240 (6), e14146 (2024)
   PUBMED   38606882
  REMARK    GeneRIF: The homeostatic effects of the RE-1 silencing
            transcription factor on cortical networks are altered under
            ictogenic conditions in the mouse.
REFERENCE   3  (bases 1 to 4266)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   4  (bases 1 to 4266)
  AUTHORS   Islam,M., Samal,A., Davis,D.J. and Behura,S.K.
  TITLE     Ablation of placental REST deregulates fetal brain metabolism and
            impacts gene expression of the offspring brain at the postnatal and
            adult stages
  JOURNAL   FASEB J 38 (1), e23349 (2024)
   PUBMED   38069914
  REMARK    GeneRIF: Ablation of placental REST deregulates fetal brain
            metabolism and impacts gene expression of the offspring brain at
            the postnatal and adult stages.
REFERENCE   5  (bases 1 to 4266)
  AUTHORS   Natali,G., Michetti,C., Krawczun-Rygmaczewska,A., Floss,T.,
            Cesca,F. and Benfenati,F.
  TITLE     Conditional knockout of REST/NRSF in excitatory neurons reduces
            seizure susceptibility to chemical kindling
  JOURNAL   Front Cell Neurosci 17, 1267609 (2023)
   PUBMED   38034589
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4266)
  AUTHORS   Edlund,T. and Jessell,T.M.
  TITLE     Progression from extrinsic to intrinsic signaling in cell fate
            specification: a view from the nervous system
  JOURNAL   Cell 96 (2), 211-224 (1999)
   PUBMED   9988216
  REMARK    Review article
REFERENCE   7  (bases 1 to 4266)
  AUTHORS   Ko,M.S., Threat,T.A., Wang,X., Horton,J.H., Cui,Y., Wang,X.,
            Pryor,E., Paris,J., Wells-Smith,J., Kitchen,J.R., Rowe,L.B.,
            Eppig,J., Satoh,T., Brant,L., Fujiwara,H., Yotsumoto,S. and
            Nakashima,H.
  TITLE     Genome-wide mapping of unselected transcripts from extraembryonic
            tissue of 7.5-day mouse embryos reveals enrichment in the t-complex
            and under-representation on the X chromosome
  JOURNAL   Hum Mol Genet 7 (12), 1967-1978 (1998)
   PUBMED   9811942
REFERENCE   8  (bases 1 to 4266)
  AUTHORS   Chen,Z.F., Paquette,A.J. and Anderson,D.J.
  TITLE     NRSF/REST is required in vivo for repression of multiple neuronal
            target genes during embryogenesis
  JOURNAL   Nat Genet 20 (2), 136-142 (1998)
   PUBMED   9771705
REFERENCE   9  (bases 1 to 4266)
  AUTHORS   Chong,J.A., Tapia-Ramirez,J., Kim,S., Toledo-Aral,J.J., Zheng,Y.,
            Boutros,M.C., Altshuller,Y.M., Frohman,M.A., Kraner,S.D. and
            Mandel,G.
  TITLE     REST: a mammalian silencer protein that restricts sodium channel
            gene expression to neurons
  JOURNAL   Cell 80 (6), 949-957 (1995)
   PUBMED   7697725
REFERENCE   10 (bases 1 to 4266)
  AUTHORS   Schoenherr,C.J. and Anderson,D.J.
  TITLE     The neuron-restrictive silencer factor (NRSF): a coordinate
            repressor of multiple neuron-specific genes
  JOURNAL   Science 267 (5202), 1360-1363 (1995)
   PUBMED   7871435
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK004945.2, BC127065.1, BE132774.1 and AI121875.1.
            
            On Jul 24, 2009 this sequence version replaced NM_011263.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK004945.2, AK156514.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2862              AK004945.2         4-2865
            2863-3553           BC127065.1         2559-3249
            3554-3966           BE132774.1         1-413               c
            3967-4266           AI121875.1         37-336
FEATURES             Location/Qualifiers
     source          1..4266
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 41.61 cM"
     gene            1..4266
                     /gene="Rest"
                     /gene_synonym="2610008J04Rik; NRSF; REST4"
                     /note="RE1-silencing transcription factor"
                     /db_xref="GeneID:19712"
                     /db_xref="MGI:MGI:104897"
     exon            1..295
                     /gene="Rest"
                     /gene_synonym="2610008J04Rik; NRSF; REST4"
                     /inference="alignment:Splign:2.1.0"
     exon            296..1187
                     /gene="Rest"
                     /gene_synonym="2610008J04Rik; NRSF; REST4"
                     /inference="alignment:Splign:2.1.0"
     CDS             305..3553
                     /gene="Rest"
                     /gene_synonym="2610008J04Rik; NRSF; REST4"
                     /note="neural-restrictive silencer factor"
                     /codon_start=1
                     /product="RE1-silencing transcription factor"
                     /protein_id="NP_035393.2"
                     /db_xref="CCDS:CCDS19372.1"
                     /db_xref="GeneID:19712"
                     /db_xref="MGI:MGI:104897"
                     /translation="MATQVMGQSSGGGSLFNNSANMGMALTNDMYDLHELSKAELAAP
                     QLIMLANVALTGEASGSCCDYLVGEERQMAELMPVGDNHFSESEGEGLEESADLKGLE
                     NMELGSLELSAVEPQPVFEASAAPEIYSANKDPAPETPVAEDKCRSSKAKPFRCKPCQ
                     YEAESEEQFVHHIRIHSAKKFFVEESAEKQAKAWESGSSPAEEGEFSKGPIRCDRCGY
                     NTNRYDHYMAHLKHHLRAGENERIYKCIICTYTTVSEYHWRKHLRNHFPRKVYTCSKC
                     NYFSDRKNNYVQHVRTHTGERPYKCELCPYSSSQKTHLTRHMRTHSGEKPFKCDQCNY
                     VASNQHEVTRHARQVHNGPKPLNCPHCDYKTADRSNFKKHVELHVNPRQFNCPVCDYA
                     ASKKCNLQYHFKSKHPTCPSKTMDVSKVKLKKTKKREADLLNNAVSNEKMENEQTKTK
                     GDVSGKKNEKPVKAVGKDASKEKKPGSSVSVVQVTTRTRKSAVAAETKAAEVKHTDGQ
                     TGNNPEKPCKAKKNKRKKDAEAHPSEEPVNEGPVTKKKKKSECKSKIGTNVPKGGGRA
                     EERPGVKKQSASLKKGTKKTPPKTKTSKKGGKLAPKGMGQTEPSSGALAQVGVSPDPA
                     LIQAEVTGSGSSQTELPSPMDIAKSEPAQMEVSLTGPPPVEPAQMEPSPAKPPQVEAP
                     TYPQPPQRGPAPPTGPAPPTGPAPPTEPAPPTGLAEMEPSPTEPSQKEPPPSMEPPCP
                     EELPQAEPPPMEDCQKELPSPVEPAQIEVAQTAPTQVQEEPPPVSEPPRVKPTKRSSL
                     RKDRAEKELSLLSEMARQEQVLMGVGLVPVRDSKLLKGNKSAQDPPAPPSPSPKGNSR
                     EETPKDQEMVSDGEGTIVFPLKKGGPEEAGESPAELAALKESARVSSSEQNSAMPEGG
                     ASHSKCQTGSSGLCDVDTEQKTDTVPMKDSAAEPVSPPTPTVDRDAGSPAVVASPPIT
                     LAENESQEIDEDEGIHSHDGSDLSDNMSEGSDDSGLHGARPTPPEATSKNGKAGLAGK
                     VTEGEFVCIFCDRSFRKEKDYSKHLNRHLVNVYFLEEAAEEQEEQEEREEQE"
     exon            1188..1271
                     /gene="Rest"
                     /gene_synonym="2610008J04Rik; NRSF; REST4"
                     /inference="alignment:Splign:2.1.0"
     exon            1272..4266
                     /gene="Rest"
                     /gene_synonym="2610008J04Rik; NRSF; REST4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3880..3885
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rest"
                     /gene_synonym="2610008J04Rik; NRSF; REST4"
                     /note="hexamer: GATAAA"
     polyA_site      3903
                     /gene="Rest"
                     /gene_synonym="2610008J04Rik; NRSF; REST4"
     regulatory      4075..4080
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rest"
                     /gene_synonym="2610008J04Rik; NRSF; REST4"
                     /note="hexamer: TATAAA"
     polyA_site      4103
                     /gene="Rest"
                     /gene_synonym="2610008J04Rik; NRSF; REST4"
                     /note="major polyA site"
ORIGIN      
        1 gtcctgtgct ggaatgtgcg gctcccgcga gctcgcggcg cagcagcaga agaccgagga
       61 gcgccgccga ggccgcgggc cccagacccg ggcggccggg accgcagcga cggcagaacc
      121 agggccggcg gtctgatccc gctccgcgat cgcaccccgg gatctcgagg gcctcgacgc
      181 ccaacttttc cccgctctcc ctcccctccc ctcccccgaa agtccagcaa caaagaaaag
      241 gagttggagc ggcggcgacg cgggggtggc ggaccgtggg cgcacagttc agaggagtac
      301 agttatggcc acccaggtga tggggcagtc ttctggagga ggcagtctct tcaacaacag
      361 tgccaacatg ggcatggcct taaccaacga catgtacgac ctgcacgagc tctcgaaagc
      421 tgaactggca gcccctcagc tcatcatgtt agccaacgtg gccctgacgg gggaggcaag
      481 cggcagctgc tgcgattacc tggtcggtga agagaggcag atggccgaat tgatgcccgt
      541 gggagacaac cacttctcag aaagtgaagg agaaggcctg gaagagtcgg ctgacctcaa
      601 agggctggaa aacatggaac tgggaagttt ggagctaagt gctgtagaac cccagcccgt
      661 atttgaagcc tcagctgccc cagaaatata cagcgccaat aaagatcccg ctccagaaac
      721 acccgtggcg gaagacaaat gcaggagttc taaggccaag cccttccggt gtaagccttg
      781 ccagtacgaa gccgaatctg aagagcagtt tgtgcatcac atccggattc acagcgctaa
      841 gaagttcttt gtggaggaaa gtgcagagaa acaggccaaa gcctgggagt cggggtcgtc
      901 tccggccgaa gagggcgagt tctccaaagg ccccatccgc tgtgaccgct gtggctacaa
      961 taccaaccgg tatgaccact acatggcaca cctgaagcac cacctgcgag ctggcgagaa
     1021 cgagcgcatc tacaagtgca tcatctgcac gtacacgacg gtcagcgagt accactggag
     1081 gaaacacctg agaaaccatt tccccaggaa agtctacacc tgcagcaagt gcaactactt
     1141 ctcagacaga aaaaataact acgttcagca cgtgcgaact cacacaggag aacgcccgta
     1201 taaatgtgaa ctttgtcctt actcaagctc tcagaagact catctaacgc gacacatgcg
     1261 gactcattca ggtgagaagc catttaaatg tgatcagtgc aattatgtgg cctctaatca
     1321 gcatgaagtg acccgacatg caagacaggt tcacaacggg cctaaacctc ttaattgccc
     1381 gcactgtgac tacaaaacag cagatagaag caacttcaaa aagcacgtgg agctgcatgt
     1441 taacccacgg cagttcaact gccccgtgtg tgactacgcg gcttctaaga agtgtaatct
     1501 acaataccat ttcaaatcta agcatcccac ctgtcccagc aaaacaatgg atgtctccaa
     1561 agtgaagcta aagaaaacca aaaagagaga ggctgacctg cttaataacg ccgtcagcaa
     1621 cgagaagatg gagaatgagc aaacaaaaac aaagggggat gtgtctggga agaagaacga
     1681 gaaacctgta aaagctgtgg gaaaagatgc ttcaaaagag aagaagcctg gtagcagtgt
     1741 ctcagtggtc caggtaacta ccaggactcg gaagtcagcg gtggcggcgg agactaaagc
     1801 agcagaggtg aaacacacag acggacaaac aggaaacaat ccagaaaagc cctgtaaagc
     1861 caagaaaaac aaaagaaaga aggatgctga ggcccatccc tccgaagagc ctgtgaacga
     1921 gggaccagtg acaaaaaaga aaaagaagtc tgagtgcaaa tcaaaaatcg gtaccaacgt
     1981 gccaaagggc ggcggccgag cggaggagag gccgggggtc aagaagcaaa gcgcttccct
     2041 taagaaaggc acaaagaaga cgccgcccaa gacaaagaca agtaaaaaag gtggcaaact
     2101 tgctccaaag gggatggggc agacagaacc ttcttctggg gcattggctc aagtgggggt
     2161 gtctccagac cctgccctca ttcaggcaga ggtcaccggg tcaggatctt ctcagacaga
     2221 gcttccttca cccatggata ttgctaagtc agagcccgcc cagatggagg tttccctaac
     2281 agggccacct ccggtggagc ctgctcaaat ggagccatcg cctgcgaaac ctccccaggt
     2341 agaagcaccc acttaccccc agcctcccca aagggggcct gcccctccca cggggcctgc
     2401 ccctcccacg gggcctgccc ctcccacgga gcctgcccct cccacggggc ttgccgagat
     2461 ggaaccttct cccacggagc cttcccagaa ggaaccacct cccagtatgg agcctccctg
     2521 ccccgaggag ctgcctcagg ccgagccacc tcctatggag gattgtcaga aggagctgcc
     2581 ttctcccgtg gagcccgctc agattgaggt tgctcagacg gcccctacgc aggttcagga
     2641 ggagccccct cctgtctcgg agccacctcg ggtgaagcca accaaaagat catctctccg
     2701 gaaagacaga gcagagaagg agctgagcct gctgagtgag atggcgcggc aggagcaggt
     2761 cctcatgggg gttggcttgg tgcctgttag agacagcaag cttctgaagg gaaacaagag
     2821 cgcccaggac cccccagccc caccgtcacc atcgccaaag ggaaactcga gggaagagac
     2881 acccaaggac caagaaatgg tctctgatgg ggaaggaact atagtattcc ctctcaagaa
     2941 aggaggacca gaggaagctg gagagagtcc agctgagttg gctgctctca aggagtctgc
     3001 ccgtgtttca tcctctgaac aaaactcagc catgccagag ggtggagcat cacacagcaa
     3061 gtgtcagact ggctcctctg ggctttgtga cgtggacact gagcagaaga cagatactgt
     3121 ccccatgaaa gactccgcag cagagccagt gtcccctcct accccaacag tggaccgtga
     3181 cgcagggtca ccagctgtag tggcctcccc tcctatcacg ttggctgaaa acgagtctca
     3241 ggaaattgat gaagatgaag gcatccatag ccatgatgga agtgacctga gtgacaacat
     3301 gtctgagggg agtgacgact caggactgca cggggctcgg ccgacaccac cagaagctac
     3361 gtcaaaaaat gggaaggcag ggttggctgg taaagtgact gagggagagt ttgtgtgtat
     3421 tttctgtgat cgttctttta gaaaggaaaa agattatagc aaacacctca atcgccactt
     3481 ggtgaatgtg tacttcctag aagaagcagc tgaggagcag gaggagcagg aggagcggga
     3541 ggagcaggag tagctgagcc tcggcagaag caccgtgcag actttgtgag catgcaattt
     3601 taatttgtag acaaacgcaa gcttgcttta attagtctcc aaggctgagt tttcagtaac
     3661 attctttttc ttaggactgt acatctattt agtgtttgtt gcataaatct tagcaaatcc
     3721 tcgggagtta atgtaagagg acagatatgt aactagctcg tgcaggcagg tgcaaggaga
     3781 agggtaagat ggtggaacac accacttgcc ttgtctgcct acaacctgtt gggttttctt
     3841 ttcacggtag ttcctaattt ttagttactt gtttagatcg ataaaaattg gcttagtaaa
     3901 ttacttgaag aatttgcctg ctttatataa attaagttag cactttacag tttctttaga
     3961 gatgaaaaaa aagagatttt aattggagag aaattctcaa cattggacat tgtatctgtc
     4021 caggtaattg cttcctaact tgctatcaat attttgtgtt tatatgttaa tcgttataaa
     4081 aagtgatttt tgttttttgg gtatttttta ttttggtgct tttctggctt aagatgttgc
     4141 acatggttct tgtttttgtt tctttaacct atgcagttaa tctcccttcc cctgaaacag
     4201 cgttgtgtta aatagtaaca ctatacagat atatgcatgg tttttttttt tgtttgtttg
     4261 tttgtt
//
