LOCUS       NM_026054               6094 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Mus musculus retroelement silencing factor 1 (Resf1), transcript
            variant 3, mRNA.
ACCESSION   NM_026054 XM_132966
VERSION     NM_026054.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 6094)
  AUTHORS   Majocha,M.R., Jackson,D.E., Ha,N.H., Amin,R., Pangracova,M.,
            Ross,C.R., Yang,H.H., Lee,M.P. and Hunter,K.W.
  TITLE     Resf1 is a compound G4 quadruplex-associated tumor suppressor for
            triple negative breast cancer
  JOURNAL   PLoS Genet 20 (5), e1011236 (2024)
   PUBMED   38722825
  REMARK    GeneRIF: Resf1 is a compound G4 quadruplex-associated tumor
            suppressor for triple negative breast cancer.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6094)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 6094)
  AUTHORS   Vojtek,M. and Chambers,I.
  TITLE     Loss of Resf1 reduces the efficiency of embryonic stem cell
            self-renewal and germline entry
  JOURNAL   Life Sci Alliance 4 (12), e202101190 (2021)
   PUBMED   34607919
  REMARK    GeneRIF: Loss of Resf1 reduces the efficiency of embryonic stem
            cell self-renewal and germline entry.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 6094)
  AUTHORS   Fukuda,K., Okuda,A., Yusa,K. and Shinkai,Y.
  TITLE     A CRISPR knockout screen identifies SETDB1-target retroelement
            silencing factors in embryonic stem cells
  JOURNAL   Genome Res 28 (6), 846-858 (2018)
   PUBMED   29728365
  REMARK    GeneRIF: We characterized two factors, MORC2A and RESF1, of which
            RESF1 is a novel molecule in retroelement silencing. Although both
            factors are recruited to repress provirus, their roles in
            repression are different. MORC2A appears to function dependent on
            repressive epigenetic modifications, while RESF1 regulates
            repressive epigenetic modifications associated with SETDB1
REFERENCE   5  (bases 1 to 6094)
  AUTHORS   Archambaud,C., Nahori,M.A., Soubigou,G., Becavin,C., Laval,L.,
            Lechat,P., Smokvina,T., Langella,P., Lecuit,M. and Cossart,P.
  TITLE     Impact of lactobacilli on orally acquired listeriosis
  JOURNAL   Proc Natl Acad Sci U S A 109 (41), 16684-16689 (2012)
   PUBMED   23012479
REFERENCE   6  (bases 1 to 6094)
  AUTHORS   Hudson,Q.J., Smith,C.A. and Sinclair,A.H.
  TITLE     Conserved expression of a novel gene during gonadal development
  JOURNAL   Dev Dyn 233 (3), 1083-1090 (2005)
   PUBMED   15861396
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC163647.3, AK017376.1, BC139436.1, AK020121.1 and DV644998.1.
            
            On Jan 29, 2008 this sequence version replaced NM_026054.2.
            
            Transcript Variant: This variant (3) lacks an exon in the 5' UTR,
            compared to variant 1. Variants 1, 2, and 3 encode the same
            protein.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK220403.1, SRR17253013.4252435.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-16                AC163647.3         145993-146008       c
            17-1521             AK017376.1         3-1507
            1522-5347           BC139436.1         1531-5356
            5348-6069           AK020121.1         293-1014
            6070-6094           DV644998.1         396-420
FEATURES             Location/Qualifiers
     source          1..6094
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 78.89 cM"
     gene            1..6094
                     /gene="Resf1"
                     /gene_synonym="2810474O19Rik; 6720435I21Rik; GET"
                     /note="retroelement silencing factor 1"
                     /db_xref="GeneID:67246"
                     /db_xref="MGI:MGI:1914496"
     exon            1..491
                     /gene="Resf1"
                     /gene_synonym="2810474O19Rik; 6720435I21Rik; GET"
                     /inference="alignment:Splign:2.1.0"
     exon            492..547
                     /gene="Resf1"
                     /gene_synonym="2810474O19Rik; 6720435I21Rik; GET"
                     /inference="alignment:Splign:2.1.0"
     exon            548..4927
                     /gene="Resf1"
                     /gene_synonym="2810474O19Rik; 6720435I21Rik; GET"
                     /inference="alignment:Splign:2.1.0"
     exon            4928..5008
                     /gene="Resf1"
                     /gene_synonym="2810474O19Rik; 6720435I21Rik; GET"
                     /inference="alignment:Splign:2.1.0"
     exon            5009..6080
                     /gene="Resf1"
                     /gene_synonym="2810474O19Rik; 6720435I21Rik; GET"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6052..6057
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Resf1"
                     /gene_synonym="2810474O19Rik; 6720435I21Rik; GET"
                     /note="hexamer: AATAAA"
     polyA_site      6075
                     /gene="Resf1"
                     /gene_synonym="2810474O19Rik; 6720435I21Rik; GET"
                     /note="major polyA site"
ORIGIN      
        1 aacgaaggct gccaccaaac ctctgcgcgc tctgcgcttg gcagaggcct cgtcccttgc
       61 tattggcgtg taagcacccg ccgggcggca ggtctgcttc ggatcgggct tttgttcggc
      121 cccctgggct cggggctggg ttttcgccac ctctgtcccg gcggaggggc gccgcccggg
      181 tcctcgctgt accgcggggt cgctgcgcgc cgggcgggcg cggtctgagg ttgttggccc
      241 gagaagcagg cgggcttgtt gcagctaagc gtcccttccg gtttcggaag gagaagcaga
      301 gctttgtttt gtttttcggt ttctttctgt ctcggtcttc cgctccttgg cccccctgcg
      361 acccagcgga attgccttgc gctccgcctt cgagcgccca ggcctgtgtg agcgccgcgg
      421 cccgcagcat cttggaatct gtttgcattt gtggtactta agagtgcctt cctagaaaaa
      481 tggaaaaaca gaattagagg cgtgaatacc ttgtggaaga gattaaaagg taaaattgta
      541 tttacagatt tatgacattc aaaaccacag actttacaat actgctaagt cagatcaact
      601 atgaattgga atacaaaaca agagaatgtt cccaaacccc caccatattc taaaacccag
      661 tcatctatct tgcagcattt tttaatgact tctacaacat ctcaaagttc tttcaactat
      721 tctccccata accaagaagc atctcaaact tctttcaact attctctcca taaccaagaa
      781 gcatgcatgt attctgggaa ttcaaattca gtttcacagc cacttctgag cggcagaaat
      841 tatataactc ctcagactca gatctctgtt tctaatatgc ctaccagaac aattgtggcc
      901 tcacagtctt caatggaaag agttgtatct acaaatggta aaggaccaca acaaccaaac
      961 cacaatttgc aaacagtgtc ttcaggaatt atgcagaatg tctggttgcc ttcccataca
     1021 gaagcaacca tatctcataa tcccgacgga gggactaata tgccttacat gcatccacca
     1081 cagaatcagc ttgtcacatc agatacctat tctatgcaac tacaaatggc tcctttacat
     1141 tctggaaaag tacctatgac acatcaagga agtcagggac ttaatcactt cataccagat
     1201 cagttggttg actggacaca gtatacatcc aacgaacttt cttatcctga atacaggcca
     1261 cctccaaagc aatactccta catactgcca gctactacat cattacaagt taaaaataat
     1321 cagctcccaa cttatacaca gagcttacag tcaaagcatt ctgtaccttt gtcatcacat
     1381 cagtatgctg cagaagccag caaaagactc tctgcccttc cttacagctg tagatatgaa
     1441 aaccaacatg tgcagaatgc tcagcctgtt tctaaacact tgcctatgga agttcctcag
     1501 agttcagaag tgcactcatc tgaaaaaaag aaagatactt acagaggctt taagcagcag
     1561 tggcagaacc ctaatgagaa agtcagcatt ggacaattct ctgaggtgaa aataaatatc
     1621 aagcagcctt acagtgaatc tgttagacct tctggggatg gtgttcaggc acttgttcaa
     1681 aataatcaag aaaaaagaaa atatacctac aatcctaata caaatcaagt aatagataca
     1741 aatgccacaa aagaaaagct ggtgagggat attaaatctc tagtagaaat caaaaagaag
     1801 ttttcagaac ttgcaagaaa aattaaaatt aataaaagtc ttttgatggc agctggttgt
     1861 agtaaaacag ctaatacttc ttatactgaa ccaattcagc attctgaatt ttcagcaaaa
     1921 gaaatgtctg ctaaaaatgg caatgactgt tccatggaat tgctagcaac atgtctttct
     1981 ctttggaaaa accaaccttc aaaaaccaca gaagaaaatg ttccaaaacc tttagaagaa
     2041 aaacagtgta acacatcaag aatcagtaca accgtagtgg gcagtgccaa tcccacaaat
     2101 gaagttcatg ttaagagttt gtgttctggt gttggaaatt ctcagaaaat gatgagctca
     2161 tcacaaacag tattgccagt tctcataccg agctgtgagt cttccggtgt agctgtagga
     2221 aaaggaacag agcttcagat tgctgtggtg tcgcctttag ttctttcaga tactaatacc
     2281 ttacctggaa aagactcagt gcctgaagtt ttacctgaaa cactgtatcc agttgttaag
     2341 gaaggtagtg tttgtagctt acaaacccaa ccaacagaaa ctgttgcttt accttttgat
     2401 gttataggag ctgtagcaag taataacata tcagcagaga ttcctctgcc tgttgataag
     2461 gaaaagcagc acaaaccaat acagggtgat ccagacatag ctgatagcag cttaggaaaa
     2521 cactctcccc tgggcactga agttctgcct aagcctatgg atagcaccat tgtgagtgga
     2581 cctatgttac aaatcgaaag tatctgttct cttgcagaag gggatgtatc ttacaattcc
     2641 cagatagctg agatattcaa ctctgtacaa actgagcccc agaaaccttc acctaatcag
     2701 gtaattgata gtcaacaaga acaagtatat gataccactg aaaataaaga ctttagctta
     2761 cagaaagata agtgtgtaca gtgtacagat gttcctcatg aggtccctga gcagccagag
     2821 cctctgcagc ctgaagagcc agcatctagt gagtatgtgg aagcaaacag agaagccaca
     2881 gaggaaagct gtagggagta cactggtaga aaagaaagta cagctaagga tgtatgttta
     2941 ccagctgcta ttcagcagga tcctcaccct cgggaaactg atatgttcag taaatcagac
     3001 cacagtcttc ctgcaataaa tgagattaat gatgaaagtg aacctatctc atacctacat
     3061 gaccagctgt cagagctttt aaaagagttc ccttatggca ttgaaacttt taacagacat
     3121 gaagtgtctt tggaccaaca aaagacacat aaaatcgtag aaaatcaaac tggtggtaaa
     3181 actagtaatg tgtctgggga tagcacagac caaataaaaa ttacagtatt aaactctgaa
     3241 caaatcaaag aactatttcc tgaagatgat cagccctgtg acaagttggc ggaacctgag
     3301 aataaagaaa ttgttgcgga agtaaagagc ccatgtgact cacagattcc tagagaagaa
     3361 agtcatgacc ttggaatgtt ggatccagag aaagacaaaa tccattgctg tgccttgggt
     3421 tggctctcaa tggtgtatga aggtgtgcca cagtgtcatt gcagttctac agaaaagaag
     3481 gagaaagacc agtgtttgga catcaacagc agcaaacaag gagagcagcc ctgcaatagt
     3541 ggaatcacta tttttgaaat taatcctgtt tctaataact caaaaactcc tctgacccaa
     3601 gcaactgagg aaggccattt ttctgcagtg catggtgaaa agaccaaagc atctaaaaca
     3661 aaagacaaca gggagggaca ggaattagcc tgtcattttt cagctaaatg ttacaaaaaa
     3721 gataaaaaag gtaattttaa aataaggcat gatacctcac tgaaaatgga gcaaaaacta
     3781 aaaaatattt catctaaatg tgacatacca aacccctcaa aatgcaataa gatagcagcc
     3841 cctgaaatac ttcacgtaac aacttctaac tctgctaaaa atatgccatt ttctaaacaa
     3901 gcctctcagg aaagcctaca gaagaaacac acgtcccaag acttgggtcc agtaaaagca
     3961 cctatagaac tttcgtcaaa cacagatccg tgcaggagta atacctcttc agtacagtca
     4021 gtatcaccag aaaagaaaaa actaaaattc aaagcaggtg gctccaggtt gaaatatttt
     4081 gaaaaaagaa agacggatca cgttattatt ccagatgtag aaataaaaaa gaagaaatat
     4141 gaaaagcaag aacagaacaa aaatgctgga gacacactca aattgtgcag tattcttaca
     4201 gagtcaaatg aaagagccag tgttcaagaa aagacagttc caagtcctga gtcctcagac
     4261 ccaaagggta gctcctctaa gagtactaga gttataacag tgcaggaata tttacaacgg
     4321 cagaaagaca aacaaataac tgggaataat gcttccagaa acatctgtgt agaaactgtg
     4381 ctatgtgact cggggcacac gaagaccagt aagcattctg cagcagtaag ctggggaaag
     4441 ttagttgagg ggcagagtat cagtgcagag actgcaaaag aactggaaca taattctagc
     4501 agccatggta aagacttcaa gatccatcac tctgaggcgt ctagaacaca cagtgtgtca
     4561 aataataata aaggaaagtt tgatgggaag cagcctgata aaatgtttaa aaataagacc
     4621 agtatgaata atgagtccaa ccagatgcct ctccaggtaa aagaacaaag gaaacagtac
     4681 ttgaatcgag ttgcgtttaa atgcacagaa cgggaaagca tatgtctcac caaattggat
     4741 agtgcatcca agaagcttag tatagagaaa aagagtgggg aatatacatc taagacaaaa
     4801 gacacagaca aacctagtat gctggagttt aaattatgtc cagatgtgct attgaagaat
     4861 acaagcactg ttgacaagca ggattgtcct ggtcctggtc ctgagaaaga gcaagcacct
     4921 gtgcaagttt caggaataaa aagtacaaaa gaagactggt taaaatgcat ccctacaagg
     4981 acaaagatgc ctgaatcaag tcaaagagat agtgctgact caagactttc taagagaagc
     5041 ctcagtgcag atgaatttga aatactacaa aacccagtaa aagaatcaaa tatcatgttc
     5101 cggacctaca aaaagatgta ccttgagaag agaagcagaa gcctcgggag tagtccagtt
     5161 aaatagtccc aggaagtcat ggtttttgtt tttaccaaga gaacacccct agtcttttct
     5221 tttcaggctc ccttgcagaa aatacctcag gacagtcaca tcgggatttc tcagccaagg
     5281 agttcctgta tagcttttca ctgatactat gtgactgaaa tgttggatta gctgctggtg
     5341 agcaggcaaa aagaaagatt gcatttgtct gggaattaca aagtgtatgc taatgatgca
     5401 gtgatctgca ttgttgaact gtgtttactg ggttttttgt tttgttttct tttttttttt
     5461 ttttttttga gacagggttt ctctgtagcc cttgctgtcc tggaactcac tctgtagtcc
     5521 aagctggcct tgaactcaga gatccacctg cctctgcctc ccgagtgctg ggattaaagg
     5581 cctgcaccac cacgcctggt tcacgtttac tgttttaagt cttgctggca cagtggtgca
     5641 tacctgtgac cctaacattt gactcgtgga cacaagagga tcaagaattc agggtcattc
     5701 tcaacagaat agtgagtctg gtgaagtcag cttaggctac atgggagcct ctctctaaaa
     5761 gcaaaacaac agcaaccaaa aaaggggaat gagggtggct tatacaaacc ttactttgaa
     5821 atgctgtcat cctgaggtaa cttggttgtt tgactggggc tgtaaataga ttcttgtttc
     5881 taagcacatt agcaaaattt atttttcaga aagtgcccat tgtgaatgtc aaagtatatt
     5941 ccaagtattt tgtacctcat tgtaaaggtt ttttcagaag tcttgtttta tacttttgtt
     6001 aaagtgaatg gagtttttgg aagatgtctt aacattactt ttcatacttg aaataaacat
     6061 ttatttttta aagaactaca aaaaaaaaaa aaaa
//
