LOCUS       NM_001164212            2254 bp    mRNA    linear   ROD 24-SEP-2024
DEFINITION  Mus musculus RAS-like, estrogen-regulated, growth-inhibitor (Rerg),
            transcript variant 1, mRNA.
ACCESSION   NM_001164212
VERSION     NM_001164212.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2254)
  AUTHORS   Nevorankova,P., Sulcova,M., Kavkova,M., Zimcik,D., Balkova,S.M.,
            Peleskova,K., Kristekova,D., Jakesova,V., Zikmund,T., Kaiser,J.,
            Hola,L.I., Kolar,M. and Buchtova,M.
  TITLE     Region-specific gene expression profiling of early mouse mandible
            uncovered SATB2 as a key molecule for teeth patterning
  JOURNAL   Sci Rep 14 (1), 18212 (2024)
   PUBMED   39107332
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2254)
  AUTHORS   Li,H., Jones,K.L., Hooper,J.E. and Williams,T.
  TITLE     The molecular anatomy of mammalian upper lip and primary palate
            fusion at single cell resolution
  JOURNAL   Development 146 (12) (2019)
   PUBMED   31118233
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2254)
  AUTHORS   Bouma,G.J., Hudson,Q.J., Washburn,L.L. and Eicher,E.M.
  TITLE     New candidate genes identified for controlling mouse gonadal sex
            determination and the early stages of granulosa and Sertoli cell
            differentiation
  JOURNAL   Biol Reprod 82 (2), 380-389 (2010)
   PUBMED   19864314
REFERENCE   4  (bases 1 to 2254)
  AUTHORS   Nef,S., Schaad,O., Stallings,N.R., Cederroth,C.R., Pitetti,J.L.,
            Schaer,G., Malki,S., Dubois-Dauphin,M., Boizet-Bonhoure,B.,
            Descombes,P., Parker,K.L. and Vassalli,J.D.
  TITLE     Gene expression during sex determination reveals a robust female
            genetic program at the onset of ovarian development
  JOURNAL   Dev Biol 287 (2), 361-377 (2005)
   PUBMED   16214126
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC144767.4, AK133734.1 and AC122303.2.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longer isoform (a). Variants 1 and 2
            each encode isoform a.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK133734.1, SRR7652917.960180.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164133, SAMN01164134
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-19                AC144767.4         165164-165182
            20-2248             AK133734.1         2-2230
            2249-2254           AC122303.2         75192-75197         c
FEATURES             Location/Qualifiers
     source          1..2254
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 66.73 cM"
     gene            1..2254
                     /gene="Rerg"
                     /note="RAS-like, estrogen-regulated, growth-inhibitor"
                     /db_xref="GeneID:232441"
                     /db_xref="MGI:MGI:2665139"
     exon            1..239
                     /gene="Rerg"
                     /inference="alignment:Splign:2.1.0"
     exon            240..407
                     /gene="Rerg"
                     /inference="alignment:Splign:2.1.0"
     CDS             347..946
                     /gene="Rerg"
                     /EC_number="3.6.5.2"
                     /note="isoform a is encoded by transcript variant 1;
                     ras-related and estrogen-regulated growth inhibitor"
                     /codon_start=1
                     /product="ras-related and estrogen-regulated growth
                     inhibitor isoform a"
                     /protein_id="NP_001157684.1"
                     /db_xref="CCDS:CCDS20663.1"
                     /db_xref="GeneID:232441"
                     /db_xref="MGI:MGI:2665139"
                     /translation="MAKSAEVKLAIFGRAGVGKSAIVVRFLTKRFIWEYDPTLESTYR
                     HQATIDDEVVSMEILDTAGQEDTIQREGHMRWGEGFVLVYDITDRGSFEEVLPLKNIL
                     DEVKKPKNVTLILVGNKADLDHSRQVSTEEGEKLATELACAFYECSACTGEGNITEVF
                     YELCREVRRRRMVQGKTRRRSSTTHVKQAINKMLTKISS"
     exon            408..464
                     /gene="Rerg"
                     /inference="alignment:Splign:2.1.0"
     exon            465..538
                     /gene="Rerg"
                     /inference="alignment:Splign:2.1.0"
     exon            539..2254
                     /gene="Rerg"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2230..2235
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rerg"
                     /note="hexamer: AATAAA"
     polyA_site      2251
                     /gene="Rerg"
                     /note="major polyA site"
ORIGIN      
        1 ggagctcgcg tcctgccgca gtctctgcgc tgctagtctg agcgagcgcg agggaagaga
       61 ccccgtccgg gcaccgcact tgcagcccca gcgactccca accgcaatcg cggcccccca
      121 actctcaaac gcctcctgta gcccgcgtgg gtcagggtgg gagagcttcc tagtctccgc
      181 gggcggattg cgaacttgga gaggaccgcg gctgtctccc cggcctggac agtgaacagg
      241 attgtgaact cttctgactg gcgatgacac agtgaaacta aaggccacca tcaaaaccat
      301 ctgctcacat ctggaatctg aacattaaac tctgtcacta ccagccatgg ctaagagcgc
      361 agaggtcaag ctggccatat ttggaagagc gggcgtgggc aagtcagcga ttgtagtgag
      421 atttctgacc aaacggttca tctgggagta cgatccaacc ctcgaatcaa cctaccgaca
      481 ccaggcaacc atagacgatg aagttgtttc tatggagatc ctggacaccg ctggccagga
      541 agacaccatc cagagggaag ggcacatgcg ctggggagaa ggcttcgtgt tggtttacga
      601 catcaccgat cgagggagct tcgaagaagt gctgccgctg aagaacatct tagatgaagt
      661 caaaaaaccc aaaaacgtga ctctcatctt ggtcggaaac aaagccgact tggaccactc
      721 cagacaagtg agcacagaag aaggggagaa gctggcgacg gaactggcgt gtgcgtttta
      781 cgaatgttcc gcctgcacgg gagaagggaa catcacggag gtgttctatg agctctgtcg
      841 agaggtgcgt cgcagaagga tggtgcaggg caagacaagg cgccgcagct ccaccacaca
      901 cgtcaagcaa gcgattaaca agatgctcac caaaatcagt agttagaggt cttgccgaaa
      961 tgtgctggaa cgtgggaagg ccttcctggc tctcctgctg cccctctagc cacagccaag
     1021 atgtccttct ccttattctg agtttggggg atgtcagggt ttctcgtggg tccctctcca
     1081 ctatatgctg ggaaattctc tgagtatctt ctgcagcccc atgctgtgac agtctctccc
     1141 ttccctgctt gccgtaggat ccgtgcaaat gtagtttgaa gatgcaacca ccaaagatgc
     1201 tgaagtggct gggttcgtgg aggctaattg taggcatctc tgccttgatt taacaagttg
     1261 aagtcttttc aaaggcattt taagattctg aatcttgtgg aagactacaa aggtcaccat
     1321 aaggttttgt gatgtctggt gtgaacttga ggaaggtagc tgagcgatta gagccgggga
     1381 acagaattct agttcccatt tgaagtgagg atttttttaa ttgttattat tattacctta
     1441 cttaaattat gccatttttc tttaacattt tattttattt ttagattgaa atgttattac
     1501 tgactttgtg atggaattgc ccatttcaat taaaattgat tctctcaata atctacagcg
     1561 gtccttacat accctattct attatttcct taataacaaa agaaacaaga cccgcaattc
     1621 acaccgtgct gtggctttgc ttccccaagc cttggtgata agaaaaacaa acccactagg
     1681 aatctttgtg cccactcctg acctcactgc atgttagtag aggattgcaa ttagagacac
     1741 ctggtttgta tattactcta ttagcaccgt agtgggaagc taaccctctt gagaaaatta
     1801 tggcgcttag ttatttctct ttggaagcaa aggcagaatc ctatgcattc agaaagagcc
     1861 agccgctgat tcagtaagtt ggccacatgc cttgttaacc ttctaacctt tgggtaagat
     1921 taattcacat gggagaattc agaaaaataa tgggtgagta aaattcactc tacgtgaacg
     1981 agcgtgcaca aagtagatgc ttggctggca aaaggattat gtaactgcca agagtttatg
     2041 atccttctct tcatttcctg ccccatatcc tgagatttgg ccactttatt ttagaataaa
     2101 atatatatct tttatgatgt atttatatgt atacatataa gtatgtataa aatttgtaag
     2161 cagcgaagat tttaattcac caatgtattt gaacaatctg gtgtaactga cttcgtttta
     2221 tgtgattata ataaaaaata taattttcaa attc
//
