LOCUS       NM_026395               1594 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus retention in endoplasmic reticulum sorting receptor 1
            (Rer1), transcript variant 1, mRNA.
ACCESSION   NM_026395
VERSION     NM_026395.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1594)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1594)
  AUTHORS   Hara,T., Maejima,I., Akuzawa,T., Hirai,R., Kobayashi,H.,
            Tsukamoto,S., Tsunoda,M., Ono,A., Yamakoshi,S., Oikawa,S. and
            Sato,K.
  TITLE     Rer1-mediated quality control system is required for neural stem
            cell maintenance during cerebral cortex development
  JOURNAL   PLoS Genet 14 (9), e1007647 (2018)
   PUBMED   30260951
  REMARK    GeneRIF: Study in knockout mice and genetically modified human HAP1
            cell line suggests that Rer1 maintains Notch signaling by
            maintaining sufficient expression of the gamma-secretase complex on
            the cell surface and regulating neural stem cell maintenance during
            cerebral cortex development.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1594)
  AUTHORS   Valkova,C., Liebmann,L., Kramer,A., Hubner,C.A. and Kaether,C.
  TITLE     The sorting receptor Rer1 controls Purkinje cell function via
            voltage gated sodium channels
  JOURNAL   Sci Rep 7, 41248 (2017)
   PUBMED   28117367
  REMARK    GeneRIF: Rer1 controls the assembly and transport of Nav1.1 and
            1.6, the principal sodium channels responsible for recurrent
            firing, in Purkinje cells.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1594)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   5  (bases 1 to 1594)
  AUTHORS   Jurisch-Yaksi,N., Rose,A.J., Lu,H., Raemaekers,T., Munck,S.,
            Baatsen,P., Baert,V., Vermeire,W., Scales,S.J., Verleyen,D.,
            Vandepoel,R., Tylzanowski,P., Yaksi,E., de Ravel,T., Yost,H.J.,
            Froyen,G., Arrington,C.B. and Annaert,W.
  TITLE     Rer1p maintains ciliary length and signaling by regulating
            gamma-secretase activity and Foxj1a levels
  JOURNAL   J Cell Biol 200 (6), 709-720 (2013)
   PUBMED   23479743
REFERENCE   6  (bases 1 to 1594)
  AUTHORS   Ulyanova,T., Jiang,Y., Padilla,S., Nakamoto,B. and
            Papayannopoulou,T.
  TITLE     Combinatorial and distinct roles of alpha and alpha integrins in
            stress erythropoiesis in mice
  JOURNAL   Blood 117 (3), 975-985 (2011)
   PUBMED   20956802
REFERENCE   7  (bases 1 to 1594)
  AUTHORS   Valkova,C., Albrizio,M., Roder,I.V., Schwake,M., Betto,R.,
            Rudolf,R. and Kaether,C.
  TITLE     Sorting receptor Rer1 controls surface expression of muscle
            acetylcholine receptors by ER retention of unassembled
            alpha-subunits
  JOURNAL   Proc Natl Acad Sci U S A 108 (2), 621-625 (2011)
   PUBMED   21187406
  REMARK    GeneRIF: Rer1 is a functionally important unique factor that
            controls surface expression of muscle acetylcholine receptors by
            localizing unassembled alpha-subunits to the early secretory
            pathway
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY164316.1, AK002550.1 and BM898853.1.
            
            On May 4, 2018 this sequence version replaced NM_026395.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK002550.1, AK078396.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164135, SAMN01164137
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-56                BY164316.1         1-56
            57-1574             AK002550.1         1-1518
            1575-1594           BM898853.1         1-20                c
FEATURES             Location/Qualifiers
     source          1..1594
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 86.17 cM"
     gene            1..1594
                     /gene="Rer1"
                     /gene_synonym="1110060F11Rik; 5830454N22Rik"
                     /note="retention in endoplasmic reticulum sorting receptor
                     1"
                     /db_xref="GeneID:67830"
                     /db_xref="MGI:MGI:1915080"
     exon            1..149
                     /gene="Rer1"
                     /gene_synonym="1110060F11Rik; 5830454N22Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            150..237
                     /gene="Rer1"
                     /gene_synonym="1110060F11Rik; 5830454N22Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             157..747
                     /gene="Rer1"
                     /gene_synonym="1110060F11Rik; 5830454N22Rik"
                     /note="RER1 retention in endoplasmic reticulum 1 homolog"
                     /codon_start=1
                     /product="protein RER1"
                     /protein_id="NP_080671.1"
                     /db_xref="CCDS:CCDS19022.1"
                     /db_xref="GeneID:67830"
                     /db_xref="MGI:MGI:1915080"
                     /translation="MSEGDSVGDSVHGKPSVVYRFFSRLGQIYQSWLDKSTPYTAVRW
                     VVTLGLSFVYMIRVYLLQGWYIVTYALGIYHLNLFIAFLSPKVDPSLMEDSDDGPSLP
                     TKQNEEFRPFIRRLPEFKFWHAATKGILVAMICTFFEAFNVPVFWPILVMYFIMLFCI
                     TMKRQIKHMIKYRYIPFTHGKRRYKGKEDVGKTFAS"
     exon            238..342
                     /gene="Rer1"
                     /gene_synonym="1110060F11Rik; 5830454N22Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            343..442
                     /gene="Rer1"
                     /gene_synonym="1110060F11Rik; 5830454N22Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            443..521
                     /gene="Rer1"
                     /gene_synonym="1110060F11Rik; 5830454N22Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            522..657
                     /gene="Rer1"
                     /gene_synonym="1110060F11Rik; 5830454N22Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            658..1577
                     /gene="Rer1"
                     /gene_synonym="1110060F11Rik; 5830454N22Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      899..904
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rer1"
                     /gene_synonym="1110060F11Rik; 5830454N22Rik"
                     /note="hexamer: AAGAAA"
     polyA_site      921
                     /gene="Rer1"
                     /gene_synonym="1110060F11Rik; 5830454N22Rik"
                     /note="major polyA site"
     regulatory      1285..1290
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rer1"
                     /gene_synonym="1110060F11Rik; 5830454N22Rik"
                     /note="hexamer: AATATA"
     polyA_site      1303
                     /gene="Rer1"
                     /gene_synonym="1110060F11Rik; 5830454N22Rik"
     regulatory      1501..1506
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rer1"
                     /gene_synonym="1110060F11Rik; 5830454N22Rik"
                     /note="hexamer: AATAAT"
     polyA_site      1523
                     /gene="Rer1"
                     /gene_synonym="1110060F11Rik; 5830454N22Rik"
                     /note="major polyA site"
     regulatory      1550..1555
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rer1"
                     /gene_synonym="1110060F11Rik; 5830454N22Rik"
                     /note="hexamer: ATTAAA"
     polyA_site      1577
                     /gene="Rer1"
                     /gene_synonym="1110060F11Rik; 5830454N22Rik"
ORIGIN      
        1 atcttggcgg ctggaggcgc cgcgggacgg aacggaagtg cctgtgcagc ttcccggatc
       61 cggagccgag ctctggcggc cgccctgccc gccatcctcc ttccgcagcc gtgagggaga
      121 ccgcggctcg gctgcaccgg agctgcgagt tacagaatgt ctgaagggga cagtgttgga
      181 gactctgtcc atgggaagcc ctcggtggtg tacagatttt tctcacggct tggacagatt
      241 tatcagtcct ggctggacaa gtctaccccc tacacagccg tccggtgggt tgtgacactg
      301 ggcctgagtt ttgtctacat gattagagtt tacctgttac aaggttggta cattgtgacc
      361 tacgccttgg gaatttacca cctaaacctt ttcattgcgt tcctttctcc caaagtggat
      421 ccttccttga tggaagactc agatgacggc ccttcattac caaccaaaca gaatgaggaa
      481 tttcgtccct tcattcgaag gcttccagaa ttcaaatttt ggcacgcagc tacaaaaggc
      541 attcttgtgg ctatgatctg taccttcttc gaggctttta acgtcccagt gttctggccg
      601 atcctggtga tgtacttcat catgcttttc tgtatcacaa tgaagaggca aatcaagcac
      661 atgattaaat accggtacat accattcaca cacgggaaga ggagatacaa agggaaggag
      721 gacgtgggca agacatttgc tagttagaag ctggactgat tctcacacgg actcaagaac
      781 ggttttgagc cattgtaaca atgccttttt cttcacataa agtagttgat tatgaggaag
      841 ttgaattttc tttttaagag gagcctcaat gatttgtatc tgaaatatca ggttcttgaa
      901 gaaactggca tttaaaccaa attgcattga tttctttttc agtgatgttc atgtgtttga
      961 aatggacaga ttgtagtgaa ccgtaggctt gggaggcgag gtgggtggca accaccgaga
     1021 gggaggacgg gagtgcggcc ctggagagct gccttcctga ccccgctgag gccactcctc
     1081 tgtgccagag ggacaagcca gcctgcttcc tgctgtgaaa aagactgtac cgctttgagg
     1141 gtgatttcac agagctctgt ggggttctca tgccagtgtc tgaatctcat ctcactagag
     1201 atgtttctcg aattggcctc gatcataatg actcaaaact atgttcttaa ctaccatgat
     1261 tgcttttgag ggcctggaat tataaatata tattatattt taattgtttg agactatttt
     1321 gacactttcc tttgatatat aacatttgct tttgattaat ttaaacttgt tctcatgcaa
     1381 caagctcttt aaggaaagag aatgggccag agcacaccaa gtctggggct tatcgcatgg
     1441 ccttttactt tctatgggga aaacagacct accacgtgtc aaacttttta atgtgataaa
     1501 aataatactc tttaaacatt ttactaagtg acttttaaat cccagtttta ttaaagacag
     1561 tgtcccttgc ttgtgcaaaa aaaaaaaaaa aaaa
//
