LOCUS       NM_001404065            7441 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus RALBP1 associated Eps domain containing protein 2
            (Reps2), transcript variant 8, mRNA.
ACCESSION   NM_001404065 XM_017318436
VERSION     NM_001404065.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 7441)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 7441)
  AUTHORS   Somma,G., Alger,H.M., McGuire,R.M., Kretlow,J.D., Ruiz,F.R.,
            Yatsenko,S.A., Stankiewicz,P., Harrison,W., Funk,E.,
            Bergamaschi,A., Oghalai,J.S., Mikos,A.G., Overbeek,P.A. and
            Pereira,F.A.
  TITLE     Head bobber: an insertional mutation causes inner ear defects,
            hyperactive circling, and deafness
  JOURNAL   J Assoc Res Otolaryngol 13 (3), 335-349 (2012)
   PUBMED   22383091
REFERENCE   3  (bases 1 to 7441)
  AUTHORS   Badway,J.A. and Baleja,J.D.
  TITLE     Reps2: a cellular signaling and molecular trafficking nexus
  JOURNAL   Int J Biochem Cell Biol 43 (12), 1660-1663 (2011)
   PUBMED   21907823
  REMARK    Review article
REFERENCE   4  (bases 1 to 7441)
  AUTHORS   Tomassi,L., Costantini,A., Corallino,S., Santonico,E., Carducci,M.,
            Cesareni,G. and Castagnoli,L.
  TITLE     The central proline rich region of POB1/REPS2 plays a regulatory
            role in epidermal growth factor receptor endocytosis by binding to
            14-3-3 and SH3 domain-containing proteins
  JOURNAL   BMC Biochem 9, 21 (2008)
   PUBMED   18647389
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 7441)
  AUTHORS   Huang,K.M., Geunes-Boyer,S., Wu,S., Dutra,A., Favor,J. and
            Stambolian,D.
  TITLE     Organization and annotation of the Xcat critical region:
            elimination of seven positional candidate genes
  JOURNAL   Genomics 83 (5), 893-901 (2004)
   PUBMED   15081118
REFERENCE   6  (bases 1 to 7441)
  AUTHORS   Oshiro,T., Koyama,S., Sugiyama,S., Kondo,A., Onodera,Y.,
            Asahara,T., Sabe,H. and Kikuchi,A.
  TITLE     Interaction of POB1, a downstream molecule of small G protein Ral,
            with PAG2, a paxillin-binding protein, is involved in cell
            migration
  JOURNAL   J Biol Chem 277 (41), 38618-38626 (2002)
   PUBMED   12149250
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL672123.16, AL672039.9 and AL672125.9.
            
            On Apr 7, 2022 this sequence version replaced XM_017318436.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR9219381.337728.1,
                                           SRR7345562.97659.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-378               AL672123.16        27476-27853         c
            379-502             AL672039.9         150377-150500       c
            503-651             AL672039.9         139946-140094       c
            652-775             AL672039.9         137692-137815       c
            776-870             AL672039.9         131904-131998       c
            871-1009            AL672039.9         111407-111545       c
            1010-1073           AL672039.9         108071-108134       c
            1074-1216           AL672039.9         105270-105412       c
            1217-1311           AL672039.9         103478-103572       c
            1312-1384           AL672039.9         99428-99500         c
            1385-1446           AL672039.9         56944-57005         c
            1447-1530           AL672039.9         26186-26269         c
            1531-1676           AL672039.9         23797-23942         c
            1677-1782           AL672039.9         12802-12907         c
            1783-2542           AL672039.9         2001-2760           c
            2543-7441           AL672125.9         105928-110826       c
FEATURES             Location/Qualifiers
     source          1..7441
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 74.67 cM"
     gene            1..7441
                     /gene="Reps2"
                     /gene_synonym="POB1"
                     /note="RALBP1 associated Eps domain containing protein 2"
                     /db_xref="GeneID:194590"
                     /db_xref="MGI:MGI:2663511"
     exon            1..378
                     /gene="Reps2"
                     /gene_synonym="POB1"
                     /inference="alignment:Splign:2.1.0"
     CDS             145..1851
                     /gene="Reps2"
                     /gene_synonym="POB1"
                     /note="isoform 8 is encoded by transcript variant 8;
                     ralBP1-associated Eps domain-containing protein 2; partner
                     of RalBP1; ralBP1-interacting protein 2"
                     /codon_start=1
                     /product="ralBP1-associated Eps domain-containing protein
                     2 isoform 8"
                     /protein_id="NP_001390994.1"
                     /db_xref="GeneID:194590"
                     /db_xref="MGI:MGI:2663511"
                     /translation="MEVAAGGGCGAGPPLLLSDSEQQCYSELFARCAGAASGGPGPGP
                     PEATRVAPGTATAAAGPVADLFRASQLPPETLHQITELCGAKRVGYFGPTQFYVALKL
                     IAAAQAGLPVRTESIKCELPLPRFVMSKNDGEIRFGNPAELHGPKVQIPYLTTEKNSF
                     KRMDNEDKQETQSPTMSPLASPPSSPPHYQRVSLSHGYSKLRSGTEQMHPAPYERQPI
                     GQPEGPSSEGPGAKPFRRQASLIRSFSVEREPQENNSNYPDEPWRITEEQREYYVNQF
                     RSLQPDPSSFISGSVAKNFFTKSKLSIPELSYIWELSDADCDGALTLSEFCAAFHLIV
                     ARKNGYPLPEGLPPTLQPEYLQAAFPKSKWECAIFDSYSESMPANQQSCDLNRMEKTS
                     VKDVADFPVPTQDVTTADDKQAANSGLLPPPPALPPRPCPTQSEPVSEADLHSQLNRA
                     PSQAAESSPTKMDAPHAQPPSKPIRRKFRPENQTTESQEPAAAVGGAVSAAMVKPHPT
                     VQKQSSKQKKAIQTAIRKNKEANAVLARLNSELQQQLKEVHQERIALENQLEQLRPVT
                     VL"
     exon            379..502
                     /gene="Reps2"
                     /gene_synonym="POB1"
                     /inference="alignment:Splign:2.1.0"
     exon            503..651
                     /gene="Reps2"
                     /gene_synonym="POB1"
                     /inference="alignment:Splign:2.1.0"
     exon            652..775
                     /gene="Reps2"
                     /gene_synonym="POB1"
                     /inference="alignment:Splign:2.1.0"
     exon            776..870
                     /gene="Reps2"
                     /gene_synonym="POB1"
                     /inference="alignment:Splign:2.1.0"
     exon            871..1009
                     /gene="Reps2"
                     /gene_synonym="POB1"
                     /inference="alignment:Splign:2.1.0"
     exon            1010..1073
                     /gene="Reps2"
                     /gene_synonym="POB1"
                     /inference="alignment:Splign:2.1.0"
     exon            1074..1216
                     /gene="Reps2"
                     /gene_synonym="POB1"
                     /inference="alignment:Splign:2.1.0"
     exon            1217..1311
                     /gene="Reps2"
                     /gene_synonym="POB1"
                     /inference="alignment:Splign:2.1.0"
     exon            1312..1384
                     /gene="Reps2"
                     /gene_synonym="POB1"
                     /inference="alignment:Splign:2.1.0"
     exon            1385..1446
                     /gene="Reps2"
                     /gene_synonym="POB1"
                     /inference="alignment:Splign:2.1.0"
     exon            1447..1530
                     /gene="Reps2"
                     /gene_synonym="POB1"
                     /inference="alignment:Splign:2.1.0"
     exon            1531..1676
                     /gene="Reps2"
                     /gene_synonym="POB1"
                     /inference="alignment:Splign:2.1.0"
     exon            1677..1782
                     /gene="Reps2"
                     /gene_synonym="POB1"
                     /inference="alignment:Splign:2.1.0"
     exon            1783..7441
                     /gene="Reps2"
                     /gene_synonym="POB1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      7418..7423
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Reps2"
                     /gene_synonym="POB1"
                     /note="hexamer: AATAAA"
     polyA_site      7441
                     /gene="Reps2"
                     /gene_synonym="POB1"
                     /note="major polyA site"
ORIGIN      
        1 gctctcttgg aggaagcggc ggcgctgcag ctgcggggcg tgggggcggc ggcttcggag
       61 gccgaggcgg cggtggtggc cctggcggca gcaccagcac ctcggccagg gaaggcggtc
      121 ggttcggacg ctacagaagg ccctatggaa gtggcagcgg gcggaggctg cggcgccggg
      181 ccgcctttgc tgctgagcga tagcgagcag cagtgctact ctgagctctt cgcgcgctgt
      241 gcgggcgctg caagcggggg ccccggacct ggtccccccg aggctaccag ggtcgccccc
      301 ggcactgcca ctgcggccgc tggtccagta gctgatctgt ttcgagcgtc gcagctgcca
      361 ccagagacat tgcaccagat cacagaactg tgtggtgcaa agcgggttgg ttattttggc
      421 ccaacacagt tttatgttgc cctgaaattg attgctgcag cacaggctgg cctccctgtg
      481 agaacagaga gtattaaatg tgaactgcct ctgcctcgct ttgtgatgtc gaagaatgat
      541 ggtgagatac ggtttgggaa cccagctgag ctgcatggac cgaaggttca gattccatac
      601 ttaaccacag agaaaaattc cttcaaaaga atggacaatg aggataagca ggaaacacag
      661 tctcccacga tgtcacccct cgcctcccct ccttcttccc cgcctcatta ccagagggtg
      721 tccttgagcc atggctacag caaactgcgg agcggcacag aacagatgca tccagctcca
      781 tatgaaaggc agcccattgg ccagcctgaa ggaccctcat cagagggtcc aggagccaaa
      841 ccctttcgtc ggcaggcatc tcttattcgg tccttttcag tggagagaga accgcaggag
      901 aacaacagta attacccaga tgagccctgg aggataactg aagaacagcg ggagtactac
      961 gtcaatcagt ttcggtccct ccagccagac ccgagttcct tcatttcagg gtctgtggcc
     1021 aagaacttct tcaccaaatc aaagctctcc attccagaac tctcttatat ctgggaactc
     1081 agtgatgctg actgtgatgg agccctgacc ttgtccgagt tttgtgctgc attccatctc
     1141 atcgtagccc ggaagaacgg ctacccactg ccagagggcc tgcctccaac tctgcagcca
     1201 gagtacttgc aagcagcttt ccctaaatcc aagtgggagt gtgcaatttt tgattcttat
     1261 tctgagtcaa tgccagcaaa ccaacagtcc tgtgacttga atcggatgga gaagacatct
     1321 gttaaagacg tggctgactt ccctgtccct acccaagatg tgactactgc tgatgacaaa
     1381 caagctgcta actcaggatt gttaccccca ccaccggcac ttcctccgag accgtgtcca
     1441 acacagtctg aaccagtgtc tgaagctgat ttacactctc agctgaacag agctccttcc
     1501 caagctgcag aaagcagtcc aacaaagatg gatgcaccac atgctcagcc tccatcaaag
     1561 cctattcgca ggaaattccg acctgaaaat caaacaacag aaagccaaga gcctgctgct
     1621 gcagttggag gggcagtttc tgcagcaatg gtgaagcccc atccaacagt acaaaagcag
     1681 tcttccaagc agaagaaggc tattcagact gccattcgca aaaataagga ggccaatgca
     1741 gtgctggccc gattgaacag tgagctgcag cagcagctga aggaagttca tcaagaacgg
     1801 atcgcattgg aaaaccaatt ggaacaactt cgcccagtca cagtgttgtg acatcctaga
     1861 ggcttgagtg acagcaggtg accttgtctg ccaagatctt ccttttgagt gtttaagccc
     1921 aactacttgt catatatgtc tgaatgtcaa aagctgtcag cagcacaaca caatctatat
     1981 gactttctct tttgcacttc acttgtgtat tttacagtgg tagtaaaata tgtcttcaac
     2041 tgatcattgc acttaaaata ttaatacttc ggaggataaa gcagaagggt cataagctca
     2101 aggccatttt tagaagcttg ttgggacact gtctccaata gaaagtgaaa agagaagtgt
     2161 gtgtatagct cagtggtaga gtgcttgcct gatatacagg aagcctcagt ttaatcctaa
     2221 atcccatttc aaaaatatac ttatcattgg aatttatctc ccattttaac cacttttaga
     2281 tactgctcct tatttaagtt acccttttag cagataattc ggagcattat ttatttaaag
     2341 aatttataat tctacagtac ctattaatgc tgtacttcca ggatgctcat gcccatttta
     2401 ttcttatatg tatgctacat acagtatgtt ggtttcccga atagtgtgca ttccagctgg
     2461 atagtcttag gcatgatgat aataaaatca aaagctggaa tacaattaaa gcatcagatt
     2521 tacactggca ctgtgccctc taccactata tgccaaaaac tgcttctgta gtaccatttt
     2581 gatattatgt cagttataca taatatctga ctattgtttt ctattaaata tcagaacctt
     2641 actgggtctt tacacctctg tgaagtagag aattttggca atgaactgtt taacttggcc
     2701 aatctaggcc atcaacctag ataacttagt ccttttcatg taaatttttg tgcaagcaca
     2761 atctacttta actgccttgc ctgaccaaat taaataaata gttgccagat ctctgctttt
     2821 atcctgcatg ggataacatc tttgtaaatg tataagcttg gaaaccaccc aacaaatatt
     2881 agtagctgga tagctaccta tttgttgttg aatccgggta tccaggctga gaagggaaga
     2941 aaaatagcca ctaactctgc aacaatcctt ggctgttgtc attgttgtct ttattttagg
     3001 ctggatttca gatgtgttgc ttctgaagac acaatgaaag aatgcaatct tcccaccagc
     3061 tacatgacta cttgttctct gtgaagtgta ctcttgggaa gtattaactt tatatacagt
     3121 tcaggggatc tcagctaact ctagtggaag tgatacaaag caagcttaaa ttacagaagc
     3181 aactatcctg tcgaaatgtc gtaatacagt ccagctgaaa gtaggaaatg actgacctgt
     3241 agggttatag ggtccctgaa tcactgatct tcaacagggc attttaatat tagcattagt
     3301 gtgcacaggg tacttttgaa atggttttgg atagatttac aatatgtaag attaagctgt
     3361 tgatttcaat agagctgaga gcttttagta aaaataggca tttatttaat atttccctgt
     3421 tcctttggca agctttatca gtagcttaac aacagaagag aagagttcaa acagatgatg
     3481 ttttttccaa agaaaaacaa attgttgact ctcttccatg catattttaa ggatttgaat
     3541 ctgatttgat ttggaaagtc atgaaacttg aacagtttct gcatttcttt tttcctttgg
     3601 ctgccttttg tttgtttgtt tgtttgttgt tcttgtgggg agggctcagg aatgatttaa
     3661 ccccccctaa gattatggtt gggtcagtac agattccagg tgacttcctt tttccatgtg
     3721 ccgggatggg agggctgtgt tatgattaca gcatgtttgg cattttgtac attcaataga
     3781 ggaaagacta acatatgcac tttatctcaa gatcttccag tgcatataca ctcacgtggg
     3841 agagcacttc atatccacca agcagacata acctaaggaa tgttagtcca ctgagcagtt
     3901 aaaaaacact gacatattgc ttccctcatg aagtaaacga tacagggaac tggttgaaga
     3961 gattggaatt ttatttagtt ggctttgttt tccttaaagg ataaaacttg cattggacaa
     4021 tcaaggacaa tgaagcctca ccaatatatt tcttgtggtg ctgggatcaa acccaggaca
     4081 gcattcatcc taggcaaatg ctggaccata ccctcagccc atcaccaata ttttaactga
     4141 ggcattgcat taaaccacac accacacaca cacacacaca cacacacaca cacacacaca
     4201 cacacacaca cacacagtat ttttagctgg acttttgatc agttgagtag ttgcttatac
     4261 atagattctt aaaagaaaat acttgtgttt ctattaaata tacactacta aatacatgtt
     4321 atgtgactag tatttatcct ttacttctgt gttttcttag gatgtacact tttagagtta
     4381 tagtgcctga taatattttt tgagagcctt taatatgata taggaaggca gatacattga
     4441 tatcacttgt agaactactt tggaatttat ctccattttc cacaaaaaga agcttctttg
     4501 atgaaggagg agagatgaag agttgcttgt tttgcagaat tctatagcat gaaggttaac
     4561 cttgtctcca ttcatggggg tttaattgcc ctattgctca atggtgttct tgcatgggga
     4621 ttctccagtc ctacagatga aagcaaagta ggaaatgatc atgggcttat tggggctttt
     4681 agcatctcta gtaagtagca tacagctttg gctggctttc tatccacaaa cctaaagcag
     4741 agcttgaatg ataaatagca agaatggatg tgtaatgtga caatcaaggc agatatttgt
     4801 tctagttgga aagacgaagc actttataag catcagacaa gtgtttggga ctaattgaga
     4861 aacaagccag cttagatgga agctgtgctg tgtgactatt agaactaggc aggaccagtg
     4921 ctcctctttt atagctagca tgggaaaatc ccatccctaa taattgtgga ctcttggccc
     4981 aggaatccac aataatagct agtggtagaa ttgggatgta gcctgattat atagattcca
     5041 aggtagtcct ctgtctatcc taaaagtaga ttagaaagcc ttttttattt atcatgttga
     5101 attttattga cttaattggt ctgtagatat gaaagcatct tctaaggagt tttagattta
     5161 gatatttctc tccgctttaa aaaaaaataa aatttgagtg gaaataatgt tattaaacca
     5221 ttcttctaat gcttcacttt tgatgatgca gtatgttcct ttaaatcttg gcagaacttt
     5281 ctaaagctac tgctttcaat agattccagc cgcatattcc catgggcata ttcccatgct
     5341 ttctcaaata gactactgtg ataaaaatga actcaatatg tagtagctta tacttttctc
     5401 cagtatattg ttggtcactc acaaatgatt catttgaaca cattttaggg ataagtaatc
     5461 aaaaccatga acttttattt gacttcccac caatgtctaa actattgtaa aatagtatga
     5521 ttctttagcc gtgttttgac tgtctagtat ttctaaatat ttctctgtat cctggatggt
     5581 ctcataacgt tggccataat aggtacataa tcagaagatc acttagacaa catctgatat
     5641 taatgtgatt cttgcattca agacacttgc aaatgtcttt ttctaagcag tagttagaaa
     5701 gagctcaatt atagtattaa caccttaaag ccaaaacatt tgttcaacac aaactaccat
     5761 cacacctctg acttgatatt atcatgagaa tgtggatgta caagtgtaaa aacaggaatg
     5821 tactatctct cctgagcaga ttgcctgatg ggattgacaa ggaggctcat tgggttgtgg
     5881 tttgaacatc gagggtgtga agaaaatgaa gcagtggcta aagaaatctt ctcctctcac
     5941 aaaatacaac actagtgtct ttcttttctc tttctagctg aatagttcta tttcaaatgt
     6001 tcccttaaaa ctcagacttc aacacatcag ttaaatttgt actttagttg tgggtgttag
     6061 agtttttgtg tcatgactca gtgtggttca cattcctagt gagaagcaga gatctggagg
     6121 tgtgcagtcc tcagcctcac agcttccttc ccttttcagc aggctgatgg agacatgcca
     6181 ccaacataga caggttggtc accgatggcc attttcataa atatttctgt gggccatttt
     6241 gctttgcttg tttgtgaaaa gaattgtctc taattatttg aacctctgaa gaattgtaca
     6301 caaggaggat cagactttaa aactatccat gtggattctg agagctgctg cccagcagaa
     6361 gtcttagaaa tatgccttga agcagccgtt gtgtaattat gagctgggca gcccaggtat
     6421 agttagtttt aggcttgtag gtttacttcc tagtttcttt aaacacacct gatggtaaag
     6481 aacacattga aagtactgca ggttgcagtt gacagtaccc acatggtctg caaaagcctg
     6541 gctttgctgg caactattgg agaatgcttg gtttgcatgt cttgtgattt ctcctgtatt
     6601 gttcctagct aatttcatgg ctgtgggaag ttagcaacac taggtttatg actctgaaga
     6661 ccagaggaca gcaggcttta agagggctta aattgggagt caaggactat agtcaggaga
     6721 cccccaggta cctggttcag agcagtccgg gatgatagga cgagatccta aagttctttc
     6781 agggagctct gccatgagag caaacagagc atatctatca tatgccactt tgacgaacta
     6841 agttggagtt tttgtttcaa gtcaacttgt gtgataagtt ctactgcacc tatcttggga
     6901 agcagggata ccctcttctt taggactaga gctgccattc ttttcatctt tagcacaagg
     6961 aaggtattta agtgagccag agacaaacag agccatttta gtcttcatag ttatctgcta
     7021 agagagataa tgagctgact gtctatttta aactcgaagg taaaaaaatg tatattatat
     7081 tttttcacta taggtacatg taacagtaaa acgtgtaaca gcaaagtata tatttgatgt
     7141 tttctgtctt tcatgatatt gtgctaacaa gttgtgctaa tatttaactc agccagagtt
     7201 tcactcattt gctaagcatt gggaacattc tgtgtattta ccttaaacat aaataaattc
     7261 ctgagagtgt cctatatttg gattgtgatt tgtagactca tgctaacttt actgcctctt
     7321 tttcacactt gttgaaaaat ctgtgaagaa catagtaagt taaggttttc caacttggaa
     7381 aaatgtacat gatgtgaaac tggggtgcta tgttaaaaat aaatgtatga taactcatgg
     7441 a
//
