LOCUS       NM_001359104            7149 bp    mRNA    linear   ROD 01-MAY-2024
DEFINITION  Mus musculus RALBP1 associated Eps domain containing protein 2
            (Reps2), transcript variant 5, mRNA.
ACCESSION   NM_001359104
VERSION     NM_001359104.2
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 7149)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 7149)
  AUTHORS   Somma,G., Alger,H.M., McGuire,R.M., Kretlow,J.D., Ruiz,F.R.,
            Yatsenko,S.A., Stankiewicz,P., Harrison,W., Funk,E.,
            Bergamaschi,A., Oghalai,J.S., Mikos,A.G., Overbeek,P.A. and
            Pereira,F.A.
  TITLE     Head bobber: an insertional mutation causes inner ear defects,
            hyperactive circling, and deafness
  JOURNAL   J Assoc Res Otolaryngol 13 (3), 335-349 (2012)
   PUBMED   22383091
REFERENCE   3  (bases 1 to 7149)
  AUTHORS   Badway,J.A. and Baleja,J.D.
  TITLE     Reps2: a cellular signaling and molecular trafficking nexus
  JOURNAL   Int J Biochem Cell Biol 43 (12), 1660-1663 (2011)
   PUBMED   21907823
  REMARK    Review article
REFERENCE   4  (bases 1 to 7149)
  AUTHORS   Tomassi,L., Costantini,A., Corallino,S., Santonico,E., Carducci,M.,
            Cesareni,G. and Castagnoli,L.
  TITLE     The central proline rich region of POB1/REPS2 plays a regulatory
            role in epidermal growth factor receptor endocytosis by binding to
            14-3-3 and SH3 domain-containing proteins
  JOURNAL   BMC Biochem 9, 21 (2008)
   PUBMED   18647389
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 7149)
  AUTHORS   Huang,K.M., Geunes-Boyer,S., Wu,S., Dutra,A., Favor,J. and
            Stambolian,D.
  TITLE     Organization and annotation of the Xcat critical region:
            elimination of seven positional candidate genes
  JOURNAL   Genomics 83 (5), 893-901 (2004)
   PUBMED   15081118
REFERENCE   6  (bases 1 to 7149)
  AUTHORS   Oshiro,T., Koyama,S., Sugiyama,S., Kondo,A., Onodera,Y.,
            Asahara,T., Sabe,H. and Kikuchi,A.
  TITLE     Interaction of POB1, a downstream molecule of small G protein Ral,
            with PAG2, a paxillin-binding protein, is involved in cell
            migration
  JOURNAL   J Biol Chem 277 (41), 38618-38626 (2002)
   PUBMED   12149250
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL672039.9 and AL672125.9.
            
            On Apr 7, 2022 this sequence version replaced NM_001359104.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK147418.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-35                AL672039.9         150631-150665       c
            36-159              AL672039.9         150377-150500       c
            160-308             AL672039.9         139946-140094       c
            309-432             AL672039.9         137692-137815       c
            433-527             AL672039.9         131904-131998       c
            528-666             AL672039.9         111407-111545       c
            667-730             AL672039.9         108071-108134       c
            731-873             AL672039.9         105270-105412       c
            874-968             AL672039.9         103478-103572       c
            969-1038            AL672039.9         99428-99497         c
            1039-1092           AL672039.9         97828-97881         c
            1093-1154           AL672039.9         56944-57005         c
            1155-1238           AL672039.9         26186-26269         c
            1239-1384           AL672039.9         23797-23942         c
            1385-1490           AL672039.9         12802-12907         c
            1491-2250           AL672039.9         2001-2760           c
            2251-7149           AL672125.9         105928-110826       c
FEATURES             Location/Qualifiers
     source          1..7149
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 74.67 cM"
     gene            1..7149
                     /gene="Reps2"
                     /gene_synonym="POB1"
                     /note="RALBP1 associated Eps domain containing protein 2"
                     /db_xref="GeneID:194590"
                     /db_xref="MGI:MGI:2663511"
     exon            1..35
                     /gene="Reps2"
                     /gene_synonym="POB1"
                     /inference="alignment:Splign:2.1.0"
     exon            36..159
                     /gene="Reps2"
                     /gene_synonym="POB1"
                     /inference="alignment:Splign:2.1.0"
     exon            160..308
                     /gene="Reps2"
                     /gene_synonym="POB1"
                     /inference="alignment:Splign:2.1.0"
     CDS             183..1559
                     /gene="Reps2"
                     /gene_synonym="POB1"
                     /note="isoform 5 is encoded by transcript variant 5;
                     ralBP1-associated Eps domain-containing protein 2; partner
                     of RalBP1; ralBP1-interacting protein 2"
                     /codon_start=1
                     /product="ralBP1-associated Eps domain-containing protein
                     2 isoform 5"
                     /protein_id="NP_001346033.1"
                     /db_xref="GeneID:194590"
                     /db_xref="MGI:MGI:2663511"
                     /translation="MSKNDGEIRFGNPAELHGPKVQIPYLTTEKNSFKRMDNEDKQET
                     QSPTMSPLASPPSSPPHYQRVSLSHGYSKLRSGTEQMHPAPYERQPIGQPEGPSSEGP
                     GAKPFRRQASLIRSFSVEREPQENNSNYPDEPWRITEEQREYYVNQFRSLQPDPSSFI
                     SGSVAKNFFTKSKLSIPELSYIWELSDADCDGALTLSEFCAAFHLIVARKNGYPLPEG
                     LPPTLQPEYLQAAFPKSKWECAIFDSYSESMPANQQSCDLNRMETSVKDVADFPVPTQ
                     DVTTADDKQALKSTVNESLPKDVSEDTAANSGLLPPPPALPPRPCPTQSEPVSEADLH
                     SQLNRAPSQAAESSPTKMDAPHAQPPSKPIRRKFRPENQTTESQEPAAAVGGAVSAAM
                     VKPHPTVQKQSSKQKKAIQTAIRKNKEANAVLARLNSELQQQLKEVHQERIALENQLE
                     QLRPVTVL"
     exon            309..432
                     /gene="Reps2"
                     /gene_synonym="POB1"
                     /inference="alignment:Splign:2.1.0"
     exon            433..527
                     /gene="Reps2"
                     /gene_synonym="POB1"
                     /inference="alignment:Splign:2.1.0"
     exon            528..666
                     /gene="Reps2"
                     /gene_synonym="POB1"
                     /inference="alignment:Splign:2.1.0"
     exon            667..730
                     /gene="Reps2"
                     /gene_synonym="POB1"
                     /inference="alignment:Splign:2.1.0"
     exon            731..873
                     /gene="Reps2"
                     /gene_synonym="POB1"
                     /inference="alignment:Splign:2.1.0"
     exon            874..968
                     /gene="Reps2"
                     /gene_synonym="POB1"
                     /inference="alignment:Splign:2.1.0"
     exon            969..1038
                     /gene="Reps2"
                     /gene_synonym="POB1"
                     /inference="alignment:Splign:2.1.0"
     exon            1039..1092
                     /gene="Reps2"
                     /gene_synonym="POB1"
                     /inference="alignment:Splign:2.1.0"
     exon            1093..1154
                     /gene="Reps2"
                     /gene_synonym="POB1"
                     /inference="alignment:Splign:2.1.0"
     exon            1155..1238
                     /gene="Reps2"
                     /gene_synonym="POB1"
                     /inference="alignment:Splign:2.1.0"
     exon            1239..1384
                     /gene="Reps2"
                     /gene_synonym="POB1"
                     /inference="alignment:Splign:2.1.0"
     exon            1385..1490
                     /gene="Reps2"
                     /gene_synonym="POB1"
                     /inference="alignment:Splign:2.1.0"
     exon            1491..7149
                     /gene="Reps2"
                     /gene_synonym="POB1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      7126..7131
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Reps2"
                     /gene_synonym="POB1"
                     /note="hexamer: AATAAA"
     polyA_site      7149
                     /gene="Reps2"
                     /gene_synonym="POB1"
                     /note="major polyA site"
ORIGIN      
        1 actggaggga aagaccactc aaccactgca tacatatcac agaactgtgt ggtgcaaagc
       61 gggttggtta ttttggccca acacagtttt atgttgccct gaaattgatt gctgcagcac
      121 aggctggcct ccctgtgaga acagagagta ttaaatgtga actgcctctg cctcgctttg
      181 tgatgtcgaa gaatgatggt gagatacggt ttgggaaccc agctgagctg catggaccga
      241 aggttcagat tccatactta accacagaga aaaattcctt caaaagaatg gacaatgagg
      301 ataagcagga aacacagtct cccacgatgt cacccctcgc ctcccctcct tcttccccgc
      361 ctcattacca gagggtgtcc ttgagccatg gctacagcaa actgcggagc ggcacagaac
      421 agatgcatcc agctccatat gaaaggcagc ccattggcca gcctgaagga ccctcatcag
      481 agggtccagg agccaaaccc tttcgtcggc aggcatctct tattcggtcc ttttcagtgg
      541 agagagaacc gcaggagaac aacagtaatt acccagatga gccctggagg ataactgaag
      601 aacagcggga gtactacgtc aatcagtttc ggtccctcca gccagacccg agttccttca
      661 tttcagggtc tgtggccaag aacttcttca ccaaatcaaa gctctccatt ccagaactct
      721 cttatatctg ggaactcagt gatgctgact gtgatggagc cctgaccttg tccgagtttt
      781 gtgctgcatt ccatctcatc gtagcccgga agaacggcta cccactgcca gagggcctgc
      841 ctccaactct gcagccagag tacttgcaag cagctttccc taaatccaag tgggagtgtg
      901 caatttttga ttcttattct gagtcaatgc cagcaaacca acagtcctgt gacttgaatc
      961 ggatggagac atctgttaaa gacgtggctg acttccctgt ccctacccaa gatgtgacta
     1021 ctgctgatga caaacaagct ttgaaaagta ctgttaacga atccttacca aaggacgtat
     1081 ctgaggatac agctgctaac tcaggattgt tacccccacc accggcactt cctccgagac
     1141 cgtgtccaac acagtctgaa ccagtgtctg aagctgattt acactctcag ctgaacagag
     1201 ctccttccca agctgcagaa agcagtccaa caaagatgga tgcaccacat gctcagcctc
     1261 catcaaagcc tattcgcagg aaattccgac ctgaaaatca aacaacagaa agccaagagc
     1321 ctgctgctgc agttggaggg gcagtttctg cagcaatggt gaagccccat ccaacagtac
     1381 aaaagcagtc ttccaagcag aagaaggcta ttcagactgc cattcgcaaa aataaggagg
     1441 ccaatgcagt gctggcccga ttgaacagtg agctgcagca gcagctgaag gaagttcatc
     1501 aagaacggat cgcattggaa aaccaattgg aacaacttcg cccagtcaca gtgttgtgac
     1561 atcctagagg cttgagtgac agcaggtgac cttgtctgcc aagatcttcc ttttgagtgt
     1621 ttaagcccaa ctacttgtca tatatgtctg aatgtcaaaa gctgtcagca gcacaacaca
     1681 atctatatga ctttctcttt tgcacttcac ttgtgtattt tacagtggta gtaaaatatg
     1741 tcttcaactg atcattgcac ttaaaatatt aatacttcgg aggataaagc agaagggtca
     1801 taagctcaag gccattttta gaagcttgtt gggacactgt ctccaataga aagtgaaaag
     1861 agaagtgtgt gtatagctca gtggtagagt gcttgcctga tatacaggaa gcctcagttt
     1921 aatcctaaat cccatttcaa aaatatactt atcattggaa tttatctccc attttaacca
     1981 cttttagata ctgctcctta tttaagttac ccttttagca gataattcgg agcattattt
     2041 atttaaagaa tttataattc tacagtacct attaatgctg tacttccagg atgctcatgc
     2101 ccattttatt cttatatgta tgctacatac agtatgttgg tttcccgaat agtgtgcatt
     2161 ccagctggat agtcttaggc atgatgataa taaaatcaaa agctggaata caattaaagc
     2221 atcagattta cactggcact gtgccctcta ccactatatg ccaaaaactg cttctgtagt
     2281 accattttga tattatgtca gttatacata atatctgact attgttttct attaaatatc
     2341 agaaccttac tgggtcttta cacctctgtg aagtagagaa ttttggcaat gaactgttta
     2401 acttggccaa tctaggccat caacctagat aacttagtcc ttttcatgta aatttttgtg
     2461 caagcacaat ctactttaac tgccttgcct gaccaaatta aataaatagt tgccagatct
     2521 ctgcttttat cctgcatggg ataacatctt tgtaaatgta taagcttgga aaccacccaa
     2581 caaatattag tagctggata gctacctatt tgttgttgaa tccgggtatc caggctgaga
     2641 agggaagaaa aatagccact aactctgcaa caatccttgg ctgttgtcat tgttgtcttt
     2701 attttaggct ggatttcaga tgtgttgctt ctgaagacac aatgaaagaa tgcaatcttc
     2761 ccaccagcta catgactact tgttctctgt gaagtgtact cttgggaagt attaacttta
     2821 tatacagttc aggggatctc agctaactct agtggaagtg atacaaagca agcttaaatt
     2881 acagaagcaa ctatcctgtc gaaatgtcgt aatacagtcc agctgaaagt aggaaatgac
     2941 tgacctgtag ggttataggg tccctgaatc actgatcttc aacagggcat tttaatatta
     3001 gcattagtgt gcacagggta cttttgaaat ggttttggat agatttacaa tatgtaagat
     3061 taagctgttg atttcaatag agctgagagc ttttagtaaa aataggcatt tatttaatat
     3121 ttccctgttc ctttggcaag ctttatcagt agcttaacaa cagaagagaa gagttcaaac
     3181 agatgatgtt ttttccaaag aaaaacaaat tgttgactct cttccatgca tattttaagg
     3241 atttgaatct gatttgattt ggaaagtcat gaaacttgaa cagtttctgc atttcttttt
     3301 tcctttggct gccttttgtt tgtttgtttg tttgttgttc ttgtggggag ggctcaggaa
     3361 tgatttaacc ccccctaaga ttatggttgg gtcagtacag attccaggtg acttcctttt
     3421 tccatgtgcc gggatgggag ggctgtgtta tgattacagc atgtttggca ttttgtacat
     3481 tcaatagagg aaagactaac atatgcactt tatctcaaga tcttccagtg catatacact
     3541 cacgtgggag agcacttcat atccaccaag cagacataac ctaaggaatg ttagtccact
     3601 gagcagttaa aaaacactga catattgctt ccctcatgaa gtaaacgata cagggaactg
     3661 gttgaagaga ttggaatttt atttagttgg ctttgttttc cttaaaggat aaaacttgca
     3721 ttggacaatc aaggacaatg aagcctcacc aatatatttc ttgtggtgct gggatcaaac
     3781 ccaggacagc attcatccta ggcaaatgct ggaccatacc ctcagcccat caccaatatt
     3841 ttaactgagg cattgcatta aaccacacac cacacacaca cacacacaca cacacacaca
     3901 cacacacaca cacacacaca cacagtattt ttagctggac ttttgatcag ttgagtagtt
     3961 gcttatacat agattcttaa aagaaaatac ttgtgtttct attaaatata cactactaaa
     4021 tacatgttat gtgactagta tttatccttt acttctgtgt tttcttagga tgtacacttt
     4081 tagagttata gtgcctgata atattttttg agagccttta atatgatata ggaaggcaga
     4141 tacattgata tcacttgtag aactactttg gaatttatct ccattttcca caaaaagaag
     4201 cttctttgat gaaggaggag agatgaagag ttgcttgttt tgcagaattc tatagcatga
     4261 aggttaacct tgtctccatt catgggggtt taattgccct attgctcaat ggtgttcttg
     4321 catggggatt ctccagtcct acagatgaaa gcaaagtagg aaatgatcat gggcttattg
     4381 gggcttttag catctctagt aagtagcata cagctttggc tggctttcta tccacaaacc
     4441 taaagcagag cttgaatgat aaatagcaag aatggatgtg taatgtgaca atcaaggcag
     4501 atatttgttc tagttggaaa gacgaagcac tttataagca tcagacaagt gtttgggact
     4561 aattgagaaa caagccagct tagatggaag ctgtgctgtg tgactattag aactaggcag
     4621 gaccagtgct cctcttttat agctagcatg ggaaaatccc atccctaata attgtggact
     4681 cttggcccag gaatccacaa taatagctag tggtagaatt gggatgtagc ctgattatat
     4741 agattccaag gtagtcctct gtctatccta aaagtagatt agaaagcctt ttttatttat
     4801 catgttgaat tttattgact taattggtct gtagatatga aagcatcttc taaggagttt
     4861 tagatttaga tatttctctc cgctttaaaa aaaaataaaa tttgagtgga aataatgtta
     4921 ttaaaccatt cttctaatgc ttcacttttg atgatgcagt atgttccttt aaatcttggc
     4981 agaactttct aaagctactg ctttcaatag attccagccg catattccca tgggcatatt
     5041 cccatgcttt ctcaaataga ctactgtgat aaaaatgaac tcaatatgta gtagcttata
     5101 cttttctcca gtatattgtt ggtcactcac aaatgattca tttgaacaca ttttagggat
     5161 aagtaatcaa aaccatgaac ttttatttga cttcccacca atgtctaaac tattgtaaaa
     5221 tagtatgatt ctttagccgt gttttgactg tctagtattt ctaaatattt ctctgtatcc
     5281 tggatggtct cataacgttg gccataatag gtacataatc agaagatcac ttagacaaca
     5341 tctgatatta atgtgattct tgcattcaag acacttgcaa atgtcttttt ctaagcagta
     5401 gttagaaaga gctcaattat agtattaaca ccttaaagcc aaaacatttg ttcaacacaa
     5461 actaccatca cacctctgac ttgatattat catgagaatg tggatgtaca agtgtaaaaa
     5521 caggaatgta ctatctctcc tgagcagatt gcctgatggg attgacaagg aggctcattg
     5581 ggttgtggtt tgaacatcga gggtgtgaag aaaatgaagc agtggctaaa gaaatcttct
     5641 cctctcacaa aatacaacac tagtgtcttt cttttctctt tctagctgaa tagttctatt
     5701 tcaaatgttc ccttaaaact cagacttcaa cacatcagtt aaatttgtac tttagttgtg
     5761 ggtgttagag tttttgtgtc atgactcagt gtggttcaca ttcctagtga gaagcagaga
     5821 tctggaggtg tgcagtcctc agcctcacag cttccttccc ttttcagcag gctgatggag
     5881 acatgccacc aacatagaca ggttggtcac cgatggccat tttcataaat atttctgtgg
     5941 gccattttgc tttgcttgtt tgtgaaaaga attgtctcta attatttgaa cctctgaaga
     6001 attgtacaca aggaggatca gactttaaaa ctatccatgt ggattctgag agctgctgcc
     6061 cagcagaagt cttagaaata tgccttgaag cagccgttgt gtaattatga gctgggcagc
     6121 ccaggtatag ttagttttag gcttgtaggt ttacttccta gtttctttaa acacacctga
     6181 tggtaaagaa cacattgaaa gtactgcagg ttgcagttga cagtacccac atggtctgca
     6241 aaagcctggc tttgctggca actattggag aatgcttggt ttgcatgtct tgtgatttct
     6301 cctgtattgt tcctagctaa tttcatggct gtgggaagtt agcaacacta ggtttatgac
     6361 tctgaagacc agaggacagc aggctttaag agggcttaaa ttgggagtca aggactatag
     6421 tcaggagacc cccaggtacc tggttcagag cagtccggga tgataggacg agatcctaaa
     6481 gttctttcag ggagctctgc catgagagca aacagagcat atctatcata tgccactttg
     6541 acgaactaag ttggagtttt tgtttcaagt caacttgtgt gataagttct actgcaccta
     6601 tcttgggaag cagggatacc ctcttcttta ggactagagc tgccattctt ttcatcttta
     6661 gcacaaggaa ggtatttaag tgagccagag acaaacagag ccattttagt cttcatagtt
     6721 atctgctaag agagataatg agctgactgt ctattttaaa ctcgaaggta aaaaaatgta
     6781 tattatattt tttcactata ggtacatgta acagtaaaac gtgtaacagc aaagtatata
     6841 tttgatgttt tctgtctttc atgatattgt gctaacaagt tgtgctaata tttaactcag
     6901 ccagagtttc actcatttgc taagcattgg gaacattctg tgtatttacc ttaaacataa
     6961 ataaattcct gagagtgtcc tatatttgga ttgtgatttg tagactcatg ctaactttac
     7021 tgcctctttt tcacacttgt tgaaaaatct gtgaagaaca tagtaagtta aggttttcca
     7081 acttggaaaa atgtacatga tgtgaaactg gggtgctatg ttaaaaataa atgtatgata
     7141 actcatgga
//
