LOCUS       NM_023132               1434 bp    mRNA    linear   ROD 17-DEC-2022
DEFINITION  Mus musculus renin binding protein (Renbp), transcript variant 1,
            mRNA.
ACCESSION   NM_023132
VERSION     NM_023132.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1434)
  AUTHORS   Tian E, Wang S, Zhang L, Zhang Y, Malicdan MC, Mao Y,
            Christoffersen C, Tabak LA, Schjoldager KT and Ten Hagen KG.
  TITLE     Galnt11 regulates kidney function by glycosylating the endocytosis
            receptor megalin to modulate ligand binding
  JOURNAL   Proc Natl Acad Sci U S A 116 (50), 25196-25202 (2019)
   PUBMED   31740596
REFERENCE   2  (bases 1 to 1434)
  AUTHORS   Bergfeld AK, Pearce OM, Diaz SL, Pham T and Varki A.
  TITLE     Metabolism of vertebrate amino sugars with N-glycolyl groups:
            elucidating the intracellular fate of the non-human sialic acid
            N-glycolylneuraminic acid
  JOURNAL   J Biol Chem 287 (34), 28865-28881 (2012)
   PUBMED   22692205
REFERENCE   3  (bases 1 to 1434)
  AUTHORS   Schmitz C, Gotthardt M, Hinderlich S, Leheste JR, Gross V, Vorum H,
            Christensen EI, Luft FC, Takahashi S and Willnow TE.
  TITLE     Normal blood pressure and plasma renin activity in mice lacking the
            renin-binding protein, a cellular renin inhibitor
  JOURNAL   J Biol Chem 275 (20), 15357-15362 (2000)
   PUBMED   10809771
REFERENCE   4  (bases 1 to 1434)
  AUTHORS   Frattini A, Chatterjee A, Faranda S, Sacco MG, Villa A, Herman GE
            and Vezzoni P.
  TITLE     The chromosome localization and the HCF repeats of the human host
            cell factor gene (HCFC1) are conserved in the mouse homologue
  JOURNAL   Genomics 32 (2), 277-280 (1996)
   PUBMED   8833156
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY082557.1, AK146652.1 and BF456232.1.
            
            [WARNING] On Nov 30, 2023 this sequence was replaced by
            NM_023132.4.
            
            On Sep 11, 2009 this sequence version replaced NM_023132.2.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            CCDS Note: The coding region has been updated to extend the
            N-terminus to one that is more supported by the available
            transcript data. The updated start codon, which adds 1 aa to the
            protein, is only conserved in mouse and rat, and it has a weak
            Kozak signal. It is possible that ribosomal leaky scanning may
            allow the better conserved downstream start codon to be used some
            of the time. There is no experimental evidence indicating which
            start codon is preferentially used in vivo.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY183138.1, AK146652.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849382, SAMN01164134
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-40                BY082557.1         2-41
            41-1415             AK146652.1         6-1380
            1416-1434           BF456232.1         1-19                c
FEATURES             Location/Qualifiers
     source          1..1434
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 37.49 cM"
     gene            1..1434
                     /gene="Renbp"
                     /gene_synonym="Age; Rnbp"
                     /note="renin binding protein"
                     /db_xref="GeneID:19703"
                     /db_xref="MGI:MGI:105940"
     exon            1..137
                     /gene="Renbp"
                     /gene_synonym="Age; Rnbp"
                     /inference="alignment:Splign:2.1.0"
     CDS             108..1400
                     /gene="Renbp"
                     /gene_synonym="Age; Rnbp"
                     /EC_number="5.1.3.8"
                     /note="isoform 1 is encoded by transcript variant 1;
                     N-acylglucosamine 2-epimerase; N-acetyl-D-glucosamine
                     2-epimerase; GlcNAc 2-epimerase"
                     /codon_start=1
                     /product="N-acylglucosamine 2-epimerase isoform 1"
                     /protein_id="NP_075621.3"
                     /db_xref="CCDS:CCDS41015.2"
                     /db_xref="GeneID:19703"
                     /db_xref="MGI:MGI:105940"
                     /translation="MMDLGLLMLQDMEKERETLQVWKKRVEQELDRVIAFWMEHSHDQ
                     EHGGFFTCLGRDGKVYDHLKYVWLQGRQVWMYCRLYRSFERFRRVELLDAARAGGEFL
                     LRYARVAPPGKKCAFVLTRDGRPVKVQRTIFSECFYTMAMNELWKVTGEVRYQSEAIE
                     MMDQIIHWVREDPAGLGRPQLSGALATEPMAVPMMLLSLVEQLGEEDEELTNMYAELG
                     DWCVHRILQHVQRDGQVVLENVSEDGKELPGCLGRHQNPGHTLEAGWFLLQYALRKGD
                     PKLRMHIIDKFLLLPFHSGWDPEHGGLFYFQDADGLCPTQLEWNMKLWWPHSEAMIAF
                     LMGYSDSGDPALLHLFYKVAEYTFRQFRDPEYGEWFGYLNQEGKVALTIKGGPFKGCF
                     HVPRCLAMCEQILGALLQRLEPAPLDSSPAVSTHEGSK"
     exon            138..247
                     /gene="Renbp"
                     /gene_synonym="Age; Rnbp"
                     /inference="alignment:Splign:2.1.0"
     exon            248..323
                     /gene="Renbp"
                     /gene_synonym="Age; Rnbp"
                     /inference="alignment:Splign:2.1.0"
     exon            324..399
                     /gene="Renbp"
                     /gene_synonym="Age; Rnbp"
                     /inference="alignment:Splign:2.1.0"
     exon            400..572
                     /gene="Renbp"
                     /gene_synonym="Age; Rnbp"
                     /inference="alignment:Splign:2.1.0"
     exon            573..797
                     /gene="Renbp"
                     /gene_synonym="Age; Rnbp"
                     /inference="alignment:Splign:2.1.0"
     exon            798..879
                     /gene="Renbp"
                     /gene_synonym="Age; Rnbp"
                     /inference="alignment:Splign:2.1.0"
     exon            880..1055
                     /gene="Renbp"
                     /gene_synonym="Age; Rnbp"
                     /inference="alignment:Splign:2.1.0"
     exon            1056..1187
                     /gene="Renbp"
                     /gene_synonym="Age; Rnbp"
                     /inference="alignment:Splign:2.1.0"
     exon            1188..1275
                     /gene="Renbp"
                     /gene_synonym="Age; Rnbp"
                     /inference="alignment:Splign:2.1.0"
     exon            1276..1418
                     /gene="Renbp"
                     /gene_synonym="Age; Rnbp"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggggcccttc ggaactctga agaggatcag gtgggtggga cactgctcgg tcagctgagt
       61 gatagtcacg ggatcgcgac caagtctgaa ttcctggagg aaagcagatg atggacctag
      121 gactcctaat gttacaggac atggagaagg aacgggagac actgcaggtc tggaagaagc
      181 gtgtggaaca agagcttgat cgtgtgatcg ctttctggat ggagcattcc catgaccagg
      241 aacacggggg cttcttcaca tgtcttggcc gtgatgggaa ggtatatgat cacctcaaat
      301 atgtttggct gcaggggagg caggtatgga tgtattgtcg cttataccgc agttttgagc
      361 gcttccgccg tgttgagctt ctggatgcag caagagcagg tggtgaattt ttgctgcgtt
      421 atgcccgggt ggcaccacct ggcaagaaat gtgcttttgt gctgactcgg gatggccggc
      481 cagtgaaggt gcagcggacc attttcagcg agtgcttcta caccatggcc atgaatgaac
      541 tgtggaaagt aacgggggaa gtgcgttatc agagtgaagc catagagatg atggatcaga
      601 tcatccactg ggtacgggag gacccggctg ggttgggccg gcctcagctc tcaggggcac
      661 tggccacaga gcccatggca gtgcccatga tgctgctcag cctggtggag cagcttggag
      721 aagaagatga ggagctgacc aacatgtatg cagaactagg ggactggtgt gtccacagga
      781 ttcttcagca tgtccagagg gatggacaag ttgtactgga gaatgtatca gaggatggaa
      841 aagagcttcc tggttgcctt ggaagacatc agaacccagg ccacacactg gaagctggct
      901 ggtttctgct ccagtatgcc ctcaggaaag gtgaccccaa acttcgaatg cacatcattg
      961 acaagtttct cttattgcct ttccactctg gatgggaccc tgaacatgga ggcctcttct
     1021 acttccagga tgcggatggt ctctgcccta cccagctgga atggaacatg aagctgtggt
     1081 ggccacacag tgaagccatg attgccttcc tcatgggtta tagtgacagt ggggaccctg
     1141 ccttgctgca tctcttctac aaggtggctg agtacacctt ccgccagttt cgtgatcctg
     1201 agtatgggga atggtttggc tacctgaacc aagagggaaa ggtggccctc accatcaagg
     1261 gaggtccttt taaaggctgc ttccatgtgc cgcggtgcct ggccatgtgc gagcagattc
     1321 taggagccct actccaacgc cttgagcccg cccccctcga ctcctcgccc gctgtctcta
     1381 cccatgaagg ctcgaaataa agatgaccct gttccacaaa aaaaaaaaaa aaaa
//
