LOCUS       NM_031192               1423 bp    mRNA    linear   ROD 24-DEC-2024
DEFINITION  Mus musculus renin 1 structural (Ren1), mRNA.
ACCESSION   NM_031192 XM_001471774 XM_622872
VERSION     NM_031192.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1423)
  AUTHORS   Martini,A.G., Smith,J.P., Medrano,S., Finer,G., Sheffield,N.C.,
            Sequeira-Lopez,M.L.S. and Gomez,R.A.
  TITLE     Renin Cell Development: Insights From Chromatin Accessibility and
            Single-Cell Transcriptomics
  JOURNAL   Circ Res 133 (4), 369-371 (2023)
   PUBMED   37395102
REFERENCE   2  (bases 1 to 1423)
  AUTHORS   Gu,X., Heinrich,A., Li,S.Y. and DeFalco,T.
  TITLE     Testicular macrophages are recruited during a narrow fetal time
            window and promote organ-specific developmental functions
  JOURNAL   Nat Commun 14 (1), 1439 (2023)
   PUBMED   36922518
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1423)
  AUTHORS   Gunawardhana,K.L., Hong,L., Rugira,T., Uebbing,S., Kucharczak,J.,
            Mehta,S., Karunamuni,D.R., Cabera-Mendoza,B., Gandotra,N.,
            Scharfe,C., Polimanti,R., Noonan,J.P. and Mani,A.
  TITLE     A systems biology approach identifies the role of dysregulated
            PRDM6 in the development of hypertension
  JOURNAL   J Clin Invest 133 (4), e160036 (2023)
   PUBMED   36602864
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1423)
  AUTHORS   Belyea,B.C., Xu,F., Wiltsie,M., Fountain,H., Charlton,J.,
            Fogo,A.B., Sequeira-Lopez,M.L.S. and Gomez,R.A.
  TITLE     Overexpression of notch signaling in renin cells leads to a
            polycystic kidney phenotype
  JOURNAL   Clin Sci (Lond) 137 (1), 35-45 (2023)
   PUBMED   36503993
REFERENCE   5  (bases 1 to 1423)
  AUTHORS   Madhavan,S.M., Konieczkowski,M., Bruggeman,L.A., DeWalt,M.,
            Nguyen,J.K., O'Toole,J.F. and Sedor,J.R.
  TITLE     Essential role of Wtip in mouse development and maintenance of the
            glomerular filtration barrier
  JOURNAL   Am J Physiol Renal Physiol 323 (3), F272-F287 (2022)
   PUBMED   35862649
REFERENCE   6  (bases 1 to 1423)
  AUTHORS   Kon,Y., Endoh,D., Fukamizu,A., Murakami,K., Hashimoto,Y. and
            Sugimura,M.
  TITLE     Comparative study of renin expression in the coagulating glands of
            C57BL/6 and Balb/c mice
  JOURNAL   J Anat 181 (Pt 2) (Pt 2), 335-343 (1992)
   PUBMED   1295871
REFERENCE   7  (bases 1 to 1423)
  AUTHORS   Paul,M., Burt,D.W., Krieger,J.E., Nakamura,N. and Dzau,V.J.
  TITLE     Tissue specificity of renin promoter activity and regulation in
            mice
  JOURNAL   Am J Physiol 262 (5 Pt 1), E644-E650 (1992)
   PUBMED   1317108
REFERENCE   8  (bases 1 to 1423)
  AUTHORS   Morris,B.J.
  TITLE     Molecular biology of renin. I: Gene and protein structure,
            synthesis and processing
  JOURNAL   J Hypertens 10 (3), 209-214 (1992)
   PUBMED   1315816
  REMARK    Review article
REFERENCE   9  (bases 1 to 1423)
  AUTHORS   Abel,K.J., Howles,P.N. and Gross,K.W.
  TITLE     DNA insertions distinguish the duplicated renin genes of DBA/2 and
            M. hortulanus mice
  JOURNAL   Mamm Genome 2 (1), 32-40 (1992)
   PUBMED   1311969
REFERENCE   10 (bases 1 to 1423)
  AUTHORS   Wilson,C.M., Erdos,E.G., Dunn,J.F. and Wilson,J.D.
  TITLE     Genetic control of renin activity in the submaxillary gland of the
            mouse
  JOURNAL   Proc Natl Acad Sci U S A 74 (3), 1185-1189 (1977)
   PUBMED   15253
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK085309.1 and AC068906.14.
            
            On Mar 17, 2011 this sequence version replaced NM_031192.2.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK085309.1, AK052685.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1420              AK085309.1         1-1420
            1421-1423           AC068906.14        98650-98652
FEATURES             Location/Qualifiers
     source          1..1423
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 57.91 cM"
     gene            1..1423
                     /gene="Ren1"
                     /gene_synonym="Ren; Ren-1; Ren-A; Ren1c; Ren1d; Rn-1; Rnr"
                     /note="renin 1 structural"
                     /db_xref="GeneID:19701"
                     /db_xref="MGI:MGI:97898"
     exon            1..124
                     /gene="Ren1"
                     /gene_synonym="Ren; Ren-1; Ren-A; Ren1c; Ren1d; Rn-1; Rnr"
                     /inference="alignment:Splign:2.1.0"
     exon            125..275
                     /gene="Ren1"
                     /gene_synonym="Ren; Ren-1; Ren-A; Ren1c; Ren1d; Rn-1; Rnr"
                     /inference="alignment:Splign:2.1.0"
     exon            276..399
                     /gene="Ren1"
                     /gene_synonym="Ren; Ren-1; Ren-A; Ren1c; Ren1d; Rn-1; Rnr"
                     /inference="alignment:Splign:2.1.0"
     exon            400..518
                     /gene="Ren1"
                     /gene_synonym="Ren; Ren-1; Ren-A; Ren1c; Ren1d; Rn-1; Rnr"
                     /inference="alignment:Splign:2.1.0"
     exon            519..715
                     /gene="Ren1"
                     /gene_synonym="Ren; Ren-1; Ren-A; Ren1c; Ren1d; Rn-1; Rnr"
                     /inference="alignment:Splign:2.1.0"
     exon            716..835
                     /gene="Ren1"
                     /gene_synonym="Ren; Ren-1; Ren-A; Ren1c; Ren1d; Rn-1; Rnr"
                     /inference="alignment:Splign:2.1.0"
     exon            836..980
                     /gene="Ren1"
                     /gene_synonym="Ren; Ren-1; Ren-A; Ren1c; Ren1d; Rn-1; Rnr"
                     /inference="alignment:Splign:2.1.0"
     exon            981..1079
                     /gene="Ren1"
                     /gene_synonym="Ren; Ren-1; Ren-A; Ren1c; Ren1d; Rn-1; Rnr"
                     /inference="alignment:Splign:2.1.0"
     exon            1080..1423
                     /gene="Ren1"
                     /gene_synonym="Ren; Ren-1; Ren-A; Ren1c; Ren1d; Rn-1; Rnr"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 acacagctct tagaaagcct tggctgaacc agatggacag aaggaggatg cctctctggg
       61 cactcttgtt gctctggagt ccttgcacct tcagtctccc aacacgcacc gctacctttg
      121 aacgaatccc gctcaagaaa atgccttctg tccgggaaat cctggaggag cggggagtgg
      181 acatgaccag gctcagtgct gaatggggcg tattcacaaa gaggccttcc ttgaccaatc
      241 ttacctcccc cgtggtcctc accaactacc tgaataccca gtactacggc gagattggca
      301 tcggtacccc accccagacc ttcaaagtca tctttgacac gggttcagcc aacctctggg
      361 tgccctccac caagtgcagc cgcctctacc ttgcttgtgg gattcacagc ctctatgagt
      421 cctctgactc ctccagctac atggagaacg ggtccgactt caccatccac tacggatcag
      481 ggagagtcaa aggtttcctc agccaggact cggtgactgt gggtggaatc actgtgacac
      541 agacctttgg agaggtcacc gagctgcccc tgatcccttt catgctggcc aagtttgacg
      601 gtgttctagg catgggcttt cccgctcagg ccgttggcgg ggttacccct gtctttgacc
      661 acattctctc ccagggggtg ctaaaggagg aagtgttctc tgtctactac aacaggggtt
      721 cccacctgct ggggggcgag gtggtgctag gaggtagcga cccgcagcat tatcaaggca
      781 attttcacta tgtgagcatc agcaagactg actcctggca gatcacgatg aagggggtgt
      841 ctgtggggtc ttccaccctg ctatgtgaag aaggctgtgc ggtagtggtg gacactggtt
      901 catcctttat ctcggctcct acgagctccc tgaagttgat catgcaagcc ctgggagcca
      961 aggagaagag aatagaagaa tatgttgtga actgtagcca ggtgcccacc ctccccgaca
     1021 tttcctttga cctgggaggc agggcctaca cactcagcag tacggactac gtgctacagt
     1081 atcccaacag gagagacaag ctgtgcacac tggctctcca tgccatggac atcccaccac
     1141 ccactgggcc tgtctgggtc ctgggtgcca ccttcatccg caagttctat acagagtttg
     1201 atcggcataa caatcgcatt ggattcgcct tggcccgcta aggccctctg ccacccagta
     1261 accctaggcc aagccaagct ggcagtcctg ggggccattt tgtctggctt tgtccccaac
     1321 atagggacac tggacacaga gaccctaacg agtgtttgcc ccttcacctg cactcaccct
     1381 tccctgcttt aaggaaaaat cgaataaaga tttcatgttt aaa
//
