LOCUS       NM_080726               1887 bp    mRNA    linear   ROD 04-AUG-2023
DEFINITION  Mus musculus rad and gem related GTP binding protein 2 (Rem2),
            mRNA.
ACCESSION   NM_080726
VERSION     NM_080726.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1887)
  AUTHORS   Richards SEV, Moore AR, Nam AY, Saxena S, Paradis S and Van Hooser
            SD.
  TITLE     Experience-Dependent Development of Dendritic Arbors in Mouse
            Visual Cortex
  JOURNAL   J Neurosci 40 (34), 6536-6556 (2020)
   PUBMED   32669356
REFERENCE   2  (bases 1 to 1887)
  AUTHORS   Royer L, Herzog JJ, Kenny K, Tzvetkova B, Cochrane JC, Marr MT 2nd
            and Paradis S.
  TITLE     The Ras-like GTPase Rem2 is a potent inhibitor of
            calcium/calmodulin-dependent kinase II activity
  JOURNAL   J Biol Chem 293 (38), 14798-14811 (2018)
   PUBMED   30072381
  REMARK    GeneRIF: report that substitution of two key amino acid residues in
            the Rem2 N terminus (Arg-79 and Arg-80) completely abolishes its
            ability to inhibit CaMKII
REFERENCE   3  (bases 1 to 1887)
  AUTHORS   Moore AR, Richards SE, Kenny K, Royer L, Chan U, Flavahan K, Van
            Hooser SD and Paradis S.
  TITLE     Rem2 stabilizes intrinsic excitability and spontaneous firing in
            visual circuits
  JOURNAL   Elife 7, e33092 (2018)
   PUBMED   29809135
  REMARK    GeneRIF: Rem2 stabilizes intrinsic excitability and spontaneous
            firing in visual circuits.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1887)
  AUTHORS   Kenny K, Royer L, Moore AR, Chen X, Marr MT 2nd and Paradis S.
  TITLE     Rem2 signaling affects neuronal structure and function in part by
            regulation of gene expression
  JOURNAL   Mol Cell Neurosci 85, 190-201 (2017)
   PUBMED   29066292
  REMARK    GeneRIF: Our results highlight Rem2 as a unique molecule that
            transduces changes in neuronal activity detected at the cell
            membrane to morphologically relevant changes in gene expression in
            the nucleus
REFERENCE   5  (bases 1 to 1887)
  AUTHORS   Liput DJ, Lu VB, Davis MI, Puhl HL and Ikeda SR.
  TITLE     Rem2, a member of the RGK family of small GTPases, is enriched in
            nuclei of the basal ganglia
  JOURNAL   Sci Rep 6, 25137 (2016)
   PUBMED   27118437
  REMARK    GeneRIF: Study have shown that Rem2 is expressed in a variety of
            nervous system tissues, but is enriched in the basal ganglia. The
            function of Rem2 in the basal ganglia is unknown, but may be
            important for neuronal maturation during development, and/or
            neuroplasticity in adulthood.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1887)
  AUTHORS   Yokoyama S, Ito Y, Ueno-Kudoh H, Shimizu H, Uchibe K, Albini S,
            Mitsuoka K, Miyaki S, Kiso M, Nagai A, Hikata T, Osada T, Fukuda N,
            Yamashita S, Harada D, Mezzano V, Kasai M, Puri PL, Hayashizaki Y,
            Okado H, Hashimoto M and Asahara H.
  TITLE     A systems approach reveals that the myogenesis genome network is
            regulated by the transcriptional repressor RP58
  JOURNAL   Dev Cell 17 (6), 836-848 (2009)
   PUBMED   20059953
REFERENCE   7  (bases 1 to 1887)
  AUTHORS   Bierings R, Beato M and Edel MJ.
  TITLE     An endothelial cell genetic screen identifies the GTPase Rem2 as a
            suppressor of p19ARF expression that promotes endothelial cell
            proliferation and angiogenesis
  JOURNAL   J Biol Chem 283 (7), 4408-4416 (2008)
   PUBMED   18056257
REFERENCE   8  (bases 1 to 1887)
  AUTHORS   Correll RN, Botzet GJ, Satin J, Andres DA and Finlin BS.
  TITLE     Analysis of the Rem2 - voltage dependant calcium channel beta
            subunit interaction and Rem2 interaction with phosphorylated
            phosphatidylinositide lipids
  JOURNAL   Cell Signal 20 (2), 400-408 (2008)
   PUBMED   18068949
  REMARK    GeneRIF: Voltage dependant calcium channels blockade by Rem2 is
            likely to be controlled by both the localized concentration of
            membrane phosphorylated phosphatidylinositide lipids and direct
            14-3-3 binding to the Rem2 C-terminus.
REFERENCE   9  (bases 1 to 1887)
  AUTHORS   Mahalakshmi RN, Ng MY, Guo K, Qi Z, Hunziker W and Beguin P.
  TITLE     Nuclear localization of endogenous RGK proteins and modulation of
            cell shape remodeling by regulated nuclear transport
  JOURNAL   Traffic 8 (9), 1164-1178 (2007)
   PUBMED   17605760
  REMARK    GeneRIF: Nuclear localization of RGK proteins (Rad, Rem, and Rem2)
            contributes to the suppression of RGK-mediated cell shape
            remodeling.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK090165.1.
            
            [WARNING] On Oct 7, 2023 this sequence was replaced by NM_080726.4.
            
            On Apr 6, 2007 this sequence version replaced NM_080726.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK090165.1, BC018219.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1887              AK090165.1         2-1888
FEATURES             Location/Qualifiers
     source          1..1887
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 27.8 cM"
     gene            1..1887
                     /gene="Rem2"
                     /note="rad and gem related GTP binding protein 2"
                     /db_xref="GeneID:140743"
                     /db_xref="MGI:MGI:2155260"
     exon            1..275
                     /gene="Rem2"
                     /inference="alignment:Splign:2.1.0"
     CDS             173..1198
                     /gene="Rem2"
                     /EC_number="3.6.5.2"
                     /note="rad and Gem-like GTP-binding protein 2"
                     /codon_start=1
                     /product="GTP-binding protein REM 2"
                     /protein_id="NP_542764.2"
                     /db_xref="CCDS:CCDS27090.2"
                     /db_xref="GeneID:140743"
                     /db_xref="MGI:MGI:2155260"
                     /translation="MHTDLDTDMDMDTETVALCSSSSRQASPLGTPTPEADTTLLKQK
                     PEKLLAELDLSGPPPAPGVPRRRGSMPVPYKHQLRRAQAVDELDWPPQASPSGSSDSL
                     GSGEAALTQKDGVFKVMLVGESGVGKSTLAGTFGGLQGDHAHEMENSEDTYERRIMVD
                     KEEVTLIVYDIWEQGDAGGWLQDHCLQTGDAFLIVFSVTDRRSFSKVPETLLRLRAGR
                     PHHDLPVILVGNKSDLARSREVSLEEGRHLAGTLSCKHIETSAALHHNTRELFEGAVR
                     QIRLRRGRGHAGGQRPEPSSPDGPAPPTRRESLTKKAKRFLANLVPRNAKFFKQRSRS
                     CHDLSVL"
     exon            276..620
                     /gene="Rem2"
                     /inference="alignment:Splign:2.1.0"
     exon            621..694
                     /gene="Rem2"
                     /inference="alignment:Splign:2.1.0"
     exon            695..902
                     /gene="Rem2"
                     /inference="alignment:Splign:2.1.0"
     exon            903..1887
                     /gene="Rem2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1863..1868
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rem2"
                     /note="putative"
     polyA_site      1887
                     /gene="Rem2"
                     /note="putative"
ORIGIN      
        1 attagcatat gtgacctcat caggaggcgg gacaatttcc ccaggtgtct ggagcgggga
       61 ggggtgggga atatgatggg ggggggcagt atttaaaggg aaaagctgac agtgctgctg
      121 agtgaggaac cggtgctctg agccgctggg ctgcactcgc acatgcacgc cgatgcacac
      181 ggaccttgac accgacatgg acatggacac agaaaccgta gcactttgtt cttccagcag
      241 ccgccaggcc tccccactgg ggacacccac accagaagca gatactacac ttctgaaaca
      301 gaagccagag aaactgttag cagagttgga cctgagcggg cctcctcctg ctcctggggt
      361 ccccagacga agaggaagca tgcccgtgcc ctacaaacac cagctgcggc gggcccaagc
      421 tgtagatgaa cttgactggc caccccaggc ctccccctct ggctcctctg actccttggg
      481 ctcaggggag gcagccctta cccaaaaaga tggcgtcttt aaggtcatgc tcgtggggga
      541 gagtggcgtg ggcaagagca ctctagcggg cacttttgga ggtctccagg gagaccatgc
      601 tcacgagatg gagaactcag aggacaccta tgagagacgg atcatggtgg acaaagaaga
      661 agtgacttta attgtttatg acatctggga acagggagat gcaggaggat ggctgcagga
      721 tcactgcctt cagacggggg atgcctttct catcgtcttc tcagtgacag atcgacgaag
      781 cttctctaaa gttccagaaa cccttcttcg gctccgggct gggaggcccc accatgacct
      841 acctgtcatc cttgttggaa ataagagtga cctggcccgc tcccgggagg tatcactgga
      901 ggagggtcgc catctggctg ggacgctgag ctgcaagcac atcgagacgt cggccgctct
      961 ccaccacaac actcgtgagc tcttcgaggg tgctgtgcgt cagatcaggc tgcggcgggg
     1021 ccggggtcat gccgggggcc agcgacccga acctagcagc ccggacggcc ccgcgccgcc
     1081 tacgcgccgt gagagcctca ccaagaaagc taagcgcttc ctcgccaacc tggtgccgcg
     1141 caacgctaag ttcttcaagc aacgctccag gtcatgtcac gacctctctg tgctctgagc
     1201 cacggtcgcc atggtcactg cagtcgccat ggtcaccgtg ccctccgctc gccccctcac
     1261 cccactcctg tccgtctagg aaaccaaaaa tacccaggat gccctggtgt gagcgggagg
     1321 cggggacggg tagctggtag gtccaccacc accacctctc ctggtcttaa cagccgacca
     1381 ttcacagagc ctcaagacct gcaagtcagg gaagaaaacc gtgctgcaag gtatttttta
     1441 ttgttattat taacttgcaa gaagccacct ctcccggaaa gacactccaa aaactagaac
     1501 cgaaaaagtg ctttgtagcc tcctggatgg agctgacctc cttggtactc ggaacatgcc
     1561 ttacctttaa gtaagtttta aaggtaaaaa cccagagatg acttttccag agataactga
     1621 aaattatcct ctgtcctggt ccactttgcc cttaagaagt tcttcagaga aagggctgga
     1681 agttattctt gaaattggac tctgacttac cattctagta tggcacgttt cctttaaggt
     1741 tattgatgtg acgatgtggg cagactctct gcatttagat gccctaaggt agatctgagg
     1801 gctggcagcc cctttgccta gggactagga ggcaccagca agggccaccc tttccccttt
     1861 ccaataaatt tttttttcta ttgcact
//
