LOCUS       NM_009047               1603 bp    mRNA    linear   ROD 31-MAY-2024
DEFINITION  Mus musculus rad and gem related GTP binding protein 1 (Rem1),
            mRNA.
ACCESSION   NM_009047
VERSION     NM_009047.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1603)
  AUTHORS   Puckerin,A.A., Chang,D.D., Subramanyam,P. and Colecraft,H.M.
  TITLE     Similar molecular determinants on Rem mediate two distinct modes of
            inhibition of CaV1.2 channels
  JOURNAL   Channels (Austin) 10 (5), 379-394 (2016)
   PUBMED   27115600
  REMARK    GeneRIF: These results reveal that similar molecular determinants
            on Rem are repurposed to initiate 2 independent mechanisms of
            CaV1.2 inhibition.
REFERENCE   2  (bases 1 to 1603)
  AUTHORS   Beqollari,D., Romberg,C.F., Filipova,D., Meza,U., Papadopoulos,S.
            and Bannister,R.A.
  TITLE     Rem uncouples excitation-contraction coupling in adult skeletal
            muscle fibers
  JOURNAL   J Gen Physiol 146 (1), 97-108 (2015)
   PUBMED   26078055
REFERENCE   3  (bases 1 to 1603)
  AUTHORS   Beqollari,D., Romberg,C.F., Meza,U., Papadopoulos,S. and
            Bannister,R.A.
  TITLE     Differential effects of RGK proteins on L-type channel function in
            adult mouse skeletal muscle
  JOURNAL   Biophys J 106 (9), 1950-1957 (2014)
   PUBMED   24806927
  REMARK    GeneRIF: amino-termini of Rad and Rem as the structural elements
            dictating the specific modes of inhibition of CaV1.1
REFERENCE   4  (bases 1 to 1603)
  AUTHORS   Romberg,C.F., Beqollari,D., Meza,U. and Bannister,R.A.
  TITLE     RGK protein-mediated impairment of slow depolarization- dependent
            Ca2+ entry into developing myotubes
  JOURNAL   Channels (Austin) 8 (3), 243-248 (2014)
   PUBMED   24476902
  REMARK    GeneRIF: Rad, Gem and Rem all reduce depolarization-dependent Ca2+
            entry in developing myotubes.
REFERENCE   5  (bases 1 to 1603)
  AUTHORS   Magyar,J., Kiper,C.E., Sievert,G., Cai,W., Shi,G.X., Crump,S.M.,
            Li,L., Niederer,S., Smith,N., Andres,D.A. and Satin,J.
  TITLE     Rem-GTPase regulates cardiac myocyte L-type calcium current
  JOURNAL   Channels (Austin) 6 (3), 166-173 (2012)
   PUBMED   22854599
  REMARK    GeneRIF: Loss of an REM1 protein increased L-type calcium current
            density in vivo in cardiac myocytes.
REFERENCE   6  (bases 1 to 1603)
  AUTHORS   Crump,S.M., Correll,R.N., Schroder,E.A., Lester,W.C., Finlin,B.S.,
            Andres,D.A. and Satin,J.
  TITLE     L-type calcium channel alpha-subunit and protein kinase inhibitors
            modulate Rem-mediated regulation of current
  JOURNAL   Am J Physiol Heart Circ Physiol 291 (4), H1959-H1971 (2006)
   PUBMED   16648185
  REMARK    GeneRIF: We conclude that Rem is capable of regulating L-type
            current, that release of Rem block is modulated by cellular kinase
            pathways, and that the Ca(V)1.2 COOH terminus contributes to
            Rem-dependent channel inhibition.
REFERENCE   7  (bases 1 to 1603)
  AUTHORS   Jerez-Timaure,N.C., Eisen,E.J. and Pomp,D.
  TITLE     Fine mapping of a QTL region with large effects on growth and
            fatness on mouse chromosome 2
  JOURNAL   Physiol Genomics 21 (3), 411-422 (2005)
   PUBMED   15769905
REFERENCE   8  (bases 1 to 1603)
  AUTHORS   Finlin,B.S., Crump,S.M., Satin,J. and Andres,D.A.
  TITLE     Regulation of voltage-gated calcium channel activity by the Rem and
            Rad GTPases
  JOURNAL   Proc Natl Acad Sci U S A 100 (24), 14469-14474 (2003)
   PUBMED   14623965
  REMARK    GeneRIF: both Rem and Rad bind directly to Ca2+ channel
            beta-subunits (CaV beta) in vivo
REFERENCE   9  (bases 1 to 1603)
  AUTHORS   Finlin,B.S. and Andres,D.A.
  TITLE     Phosphorylation-dependent association of the Ras-related
            GTP-binding protein Rem with 14-3-3 proteins
  JOURNAL   Arch Biochem Biophys 368 (2), 401-412 (1999)
   PUBMED   10441394
REFERENCE   10 (bases 1 to 1603)
  AUTHORS   Finlin,B.S. and Andres,D.A.
  TITLE     Rem is a new member of the Rad- and Gem/Kir Ras-related GTP-binding
            protein family repressed by lipopolysaccharide stimulation
  JOURNAL   J Biol Chem 272 (35), 21982-21988 (1997)
   PUBMED   9268335
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AK053133.1.
            
            [WARNING] On Oct 26, 2024 this sequence was replaced by
            NM_009047.6.
            
            On Apr 6, 2007 this sequence version replaced NM_009047.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK053133.1, AK084460.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1603              AK053133.1         2-1604
FEATURES             Location/Qualifiers
     source          1..1603
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 75.41 cM"
     gene            1..1603
                     /gene="Rem1"
                     /gene_synonym="E030011C07Rik; Ras; Rem"
                     /note="rad and gem related GTP binding protein 1"
                     /db_xref="GeneID:19700"
                     /db_xref="MGI:MGI:1097696"
     exon            1..39
                     /gene="Rem1"
                     /gene_synonym="E030011C07Rik; Ras; Rem"
                     /inference="alignment:Splign:2.1.0"
     exon            40..575
                     /gene="Rem1"
                     /gene_synonym="E030011C07Rik; Ras; Rem"
                     /inference="alignment:Splign:2.1.0"
     CDS             236..1129
                     /gene="Rem1"
                     /gene_synonym="E030011C07Rik; Ras; Rem"
                     /EC_number="3.6.5.2"
                     /note="RAS-like GTP binding protein Rem; rad and Gem-like
                     GTP-binding protein 1"
                     /codon_start=1
                     /product="GTP-binding protein REM 1"
                     /protein_id="NP_033073.1"
                     /db_xref="CCDS:CCDS16895.1"
                     /db_xref="GeneID:19700"
                     /db_xref="MGI:MGI:1097696"
                     /translation="MTLNTQQEAKTTLRRRASTPLPLSSRGHQPGRLCTAPSAPSQHP
                     RLGQSVSLNPPVRKPSPAQDGWSSESSDSEGSWEALYRVVLLGDPGVGKTSLASLFAE
                     KQDRDPHEQLGGVYERTLSVDGEDTTLVVMDTWEAEKLDESWCQESCLQAGSAYVIVY
                     SIADRSSFESASELRIQLRRTHQANHVPIILVGNKADLARCREVSVEEGRACAVVFDC
                     KFIETSATLQHNVTELFEGVVRQLRLRRQDNAAPETPSPRRRASLGQRARRFLARLTA
                     RSARRRALKARSKSCHNLAVL"
     exon            576..655
                     /gene="Rem1"
                     /gene_synonym="E030011C07Rik; Ras; Rem"
                     /inference="alignment:Splign:2.1.0"
     exon            656..857
                     /gene="Rem1"
                     /gene_synonym="E030011C07Rik; Ras; Rem"
                     /inference="alignment:Splign:2.1.0"
     exon            858..1603
                     /gene="Rem1"
                     /gene_synonym="E030011C07Rik; Ras; Rem"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      1586
                     /gene="Rem1"
                     /gene_synonym="E030011C07Rik; Ras; Rem"
ORIGIN      
        1 atttggggcg gcgaggactc ggagcctcca cgcgtcaagg cctgaaacca gcagccccgg
       61 aacccaagga gccgaagagt ttcttcccag ttgaacctga gagggctctg gaggaaatta
      121 tttccaccgt ctatcgggcc ctaagaaggg actccgggct acaggctaca gacttactgt
      181 ccttcttttg gaaggaagga agaagccagg gaagctaaag atttcctcac agaggatgac
      241 tcttaacacc cagcaggaag caaagaccac tctgcgacgt cgagcaagca caccactacc
      301 cctgtcgtcc aggggccacc agcctggccg cctgtgcaca gcaccctctg ctccatccca
      361 gcatccccga ctgggtcagt cagtctctct caaccctccc gtccggaaac cctcccctgc
      421 ccaggatggg tggtcctctg aatccagcga ctccgaaggc tcttgggagg cactctaccg
      481 ggtggtgctt cttggagacc ctggtgttgg gaagactagc ctggctagcc tcttcgcaga
      541 gaaacaagac cgagaccctc acgagcagct gggaggtgtg tacgagagaa cgctgtcagt
      601 ggacggagag gacaccactc tggtggtcat ggacacctgg gaggctgaga aactggatga
      661 aagctggtgc caggagtcat gcctgcaggc aggcagcgcc tacgtcatcg tgtactccat
      721 agcggatcgc agcagctttg agagcgcctc ggagctccga atccagctga ggcgcacgca
      781 tcaggccaac cacgtgccca tcatcctggt gggcaacaag gccgacctgg cccgctgccg
      841 ggaagtctcg gtagaagagg gtcgcgcctg cgccgtggtg ttcgactgca agttcatcga
      901 gacttcggcc actctgcagc acaatgtgac agagctcttc gagggcgtgg tgcgccaact
      961 gcgcctgcgc cgccaggaca atgcagcccc ggagacacct tcacctcgac gacgggccag
     1021 cttgggccag cgcgcccgcc gattcctggc acgtctgaca gcacgcagcg cacgacgccg
     1081 ggcacttaaa gcccgctcca agtcctgcca caacctggct gtgctctgag gccagcgcct
     1141 ctctctgggg tgatgggaca ctatggtgcc actgaggaga aaaggtacgt tgttggagtc
     1201 ctcgtggtcg accttgcgta ttgccaggat ggcaatagca tcgccaggaa ccagagcttt
     1261 gggaaccctt cctgccgggc gaaaggatga ataggcagac tatggggcta taaacccaag
     1321 ctaggcacaa ggttttttct ttttcttttt cttttttaca gggtgggtgt ctttttgtaa
     1381 aaaaaaaaaa caaaacaaaa caaatctttc ttgtccctgg gatatgacca actctcagaa
     1441 tgtaccacaa taagcaggtc caggatgtcc tgtctgatgt gtggaggtct ctccgtgggc
     1501 tcttccaggc atctccactc tctccccaaa catctaactt gactgtagac tggcttggcc
     1561 tgctggccca gatgtctcag acaatccata aagtcagtga att
//
