LOCUS       NM_177073               2817 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Mus musculus RELT tumor necrosis factor receptor (Relt), transcript
            variant 1, mRNA.
ACCESSION   NM_177073
VERSION     NM_177073.6
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2817)
  AUTHORS   Kim,J.W., Zhang,H., Seymen,F., Koruyucu,M., Hu,Y., Kang,J.,
            Kim,Y.J., Ikeda,A., Kasimoglu,Y., Bayram,M., Zhang,C., Kawasaki,K.,
            Bartlett,J.D., Saunders,T.L., Simmer,J.P. and Hu,J.C.
  TITLE     Mutations in RELT cause autosomal recessive amelogenesis imperfecta
  JOURNAL   Clin Genet 95 (3), 375-383 (2019)
   PUBMED   30506946
REFERENCE   2  (bases 1 to 2817)
  AUTHORS   Choi,B.K., Kim,S.H., Kim,Y.H., Lee,D.G., Oh,H.S., Han,C., Kim,Y.I.,
            Jeon,Y., Lee,H. and Kwon,B.S.
  TITLE     RELT negatively regulates the early phase of the T-cell response in
            mice
  JOURNAL   Eur J Immunol 48 (10), 1739-1749 (2018)
   PUBMED   30138536
  REMARK    GeneRIF: Findings suggest that RELT acts as a negative regulator
            that controls the early phase of T-cell activation probably by
            promoting T-cell apoptosis.
REFERENCE   3  (bases 1 to 2817)
  AUTHORS   Reed,J.C., Doctor,K., Rojas,A., Zapata,J.M., Stehlik,C.,
            Fiorentino,L., Damiano,J., Roth,W., Matsuzawa,S., Newman,R.,
            Takayama,S., Marusawa,H., Xu,F., Salvesen,G. and Godzik,A.
  CONSRTM   RIKEN GER Group; GSL Members
  TITLE     Comparative analysis of apoptosis and inflammation genes of mice
            and humans
  JOURNAL   Genome Res 13 (6B), 1376-1388 (2003)
   PUBMED   12819136
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC150744.2.
            
            On Oct 25, 2007 this sequence version replaced NM_177073.5.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK088621.1, AK049073.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164138, SAMN01164139
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-120               AC150744.2         149639-149758       c
            121-190             AC150744.2         139391-139460       c
            191-265             AC150744.2         137985-138059       c
            266-432             AC150744.2         137699-137865       c
            433-512             AC150744.2         137438-137517       c
            513-770             AC150744.2         136410-136667       c
            771-851             AC150744.2         135144-135224       c
            852-933             AC150744.2         134767-134848       c
            934-1188            AC150744.2         134364-134618       c
            1189-1387           AC150744.2         133741-133939       c
            1388-2817           AC150744.2         132193-133622       c
FEATURES             Location/Qualifiers
     source          1..2817
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 54.44 cM"
     gene            1..2817
                     /gene="Relt"
                     /gene_synonym="E430021K24Rik; Tnfrsf19l"
                     /note="RELT tumor necrosis factor receptor"
                     /db_xref="GeneID:320100"
                     /db_xref="MGI:MGI:2443373"
     exon            1..120
                     /gene="Relt"
                     /gene_synonym="E430021K24Rik; Tnfrsf19l"
                     /inference="alignment:Splign:2.1.0"
     exon            121..190
                     /gene="Relt"
                     /gene_synonym="E430021K24Rik; Tnfrsf19l"
                     /inference="alignment:Splign:2.1.0"
     CDS             125..1435
                     /gene="Relt"
                     /gene_synonym="E430021K24Rik; Tnfrsf19l"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; tumor necrosis factor receptor superfamily
                     member 19L"
                     /codon_start=1
                     /product="tumor necrosis factor receptor superfamily
                     member 19L isoform 1 precursor"
                     /protein_id="NP_796047.2"
                     /db_xref="CCDS:CCDS21506.1"
                     /db_xref="GeneID:320100"
                     /db_xref="MGI:MGI:2443373"
                     /translation="MSLQGLMMKRTLLCWPLSCLFVLLPWPLATPTPITPWLCPPGKE
                     PDPDPGQGTLCRTCPPGTFSASWNSYPCQPHYRCSLQKRLEAQAGTATHDTMCGDCQH
                     GWFGPQGVPHVPCQPCSKAPPSTGGCDESGRRGRRGVEVAAGTSSNGEPRQPGNGTRA
                     GGPEETAAQYAVIAIVPVFCLMGLLGILVCNLLKRKGYHCTAQKEVGPSPGGGGSGIN
                     PAYRTEDANEDTIGVLVRLITEKKENAAALEELLKEYHSKQLVQTSHRPVPRLLPASP
                     SIPHICPHHHHLHTVQGLASLSGPCCSRCSQKWPEVLLSPEAAAATTPAPTLLPTASR
                     APKASAKPGRQGEITILSVGRFRVARIPEQRTSSLLSEVKTITEAGPSEGDLPDSPQP
                     GLPPEQRALLGSGGSHTKWLKPPAENKAEENRYVVRLSESNLVI"
     exon            191..265
                     /gene="Relt"
                     /gene_synonym="E430021K24Rik; Tnfrsf19l"
                     /inference="alignment:Splign:2.1.0"
     exon            266..432
                     /gene="Relt"
                     /gene_synonym="E430021K24Rik; Tnfrsf19l"
                     /inference="alignment:Splign:2.1.0"
     exon            433..512
                     /gene="Relt"
                     /gene_synonym="E430021K24Rik; Tnfrsf19l"
                     /inference="alignment:Splign:2.1.0"
     exon            513..770
                     /gene="Relt"
                     /gene_synonym="E430021K24Rik; Tnfrsf19l"
                     /inference="alignment:Splign:2.1.0"
     exon            771..851
                     /gene="Relt"
                     /gene_synonym="E430021K24Rik; Tnfrsf19l"
                     /inference="alignment:Splign:2.1.0"
     exon            852..933
                     /gene="Relt"
                     /gene_synonym="E430021K24Rik; Tnfrsf19l"
                     /inference="alignment:Splign:2.1.0"
     exon            934..1188
                     /gene="Relt"
                     /gene_synonym="E430021K24Rik; Tnfrsf19l"
                     /inference="alignment:Splign:2.1.0"
     exon            1189..1387
                     /gene="Relt"
                     /gene_synonym="E430021K24Rik; Tnfrsf19l"
                     /inference="alignment:Splign:2.1.0"
     exon            1388..2817
                     /gene="Relt"
                     /gene_synonym="E430021K24Rik; Tnfrsf19l"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2476..2481
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Relt"
                     /gene_synonym="E430021K24Rik; Tnfrsf19l"
                     /note="hexamer: AATAAA"
     polyA_site      2495
                     /gene="Relt"
                     /gene_synonym="E430021K24Rik; Tnfrsf19l"
                     /note="major polyA site"
ORIGIN      
        1 cccggccagg ccggcgattc attcaaaagg cgcgcaggct gcgcggccgg ccccgagcgc
       61 tcgcctagcg gggccccggc gccgcgtcgg acgctgagcg aagctggtgc tgcgggccag
      121 gtcaatgtca ctccagggcc tgatgatgaa gcggaccttg ctgtgctggc ccctgtcttg
      181 cctctttgtg ctgctgccct ggcctctggc cactccaaca ccaataactc cttggctgtg
      241 tccacctggc aaagagcctg acccagatcc aggacagggc acattatgca gaacttgccc
      301 cccaggaacc ttttcagcct catggaactc ctatccatgc cagcctcatt accgatgcag
      361 ccttcaaaag aggctggagg cccaggctgg cacagcaact catgatacaa tgtgtggaga
      421 ctgccagcat gggtggtttg ggccacaggg agttcctcat gttccgtgtc agccatgttc
      481 caaggcacct ccaagtactg gtggctgtga tgagtcaggg cggcggggcc ggcgtggcgt
      541 cgaagtggca gcaggtacca gtagcaacgg tgaacctcgg cagcccggga atggcactcg
      601 ggcaggcggt cctgaggaga cggctgccca gtatgcagtg attgccatcg ttcctgtctt
      661 ttgtctcatg gggcttctgg gcatcctggt gtgcaacctg ctcaagcgga agggctacca
      721 ttgcacagcc caaaaggaag ttgggcccag ccctggtgga ggaggcagcg ggattaatcc
      781 tgcctatagg actgaagatg ccaacgagga caccattgga gtcctggtgc gcctgatcac
      841 agagaagaaa gagaatgcag cggccctgga ggagctgttg aaagaatatc acagcaaaca
      901 gctggtacag acaagtcaca ggcctgtacc caggctgctg ccggcctcac ccagcatacc
      961 ccacatctgc ccgcatcacc accacctgca cactgtgcag ggcctggcct cactctctgg
     1021 cccctgttgc tcccgttgta gccagaagtg gccagaggtg ctgctgtctc ctgaggcagc
     1081 agctgccacc actcctgctc ccacccttct gcctactgca tccagggctc ccaaggctag
     1141 tgccaagcca ggacgtcagg gcgagattac catcttgtct gtgggcaggt tccgtgtggc
     1201 tcgtattcct gagcagcgga ccagttcatt gttatctgag gtgaagacca tcacggaggc
     1261 tgggccttca gagggtgatc tccctgactc cccacagcct ggtcttcccc ccgagcagcg
     1321 ggcactgctg ggaagtggtg ggagccatac taagtggttg aagcccccag cagagaacaa
     1381 agctgaggag aaccgctatg tggtccggct aagtgaaagc aacctggtca tctgatgggc
     1441 tgtctagaat tagacactct gccctgtcct gggaggttct gaaggcttcc tgcaggaggg
     1501 agagctgcag ctgggactga ggaccaagat gcaaaggcca agtcctggag gtgggaccgt
     1561 ccgccccact gaggaggcag cctgcggcac agcacgtgag caggagatca agagcccacc
     1621 ctatccctgc agtcccggtt acttccatgc agggtgctgt aaccctgtgc ctgccctgaa
     1681 cacatcatag gagccctctg tcccttagag gtctggtttg gtggaggagt ggtatctgta
     1741 cctggcccca agcttgtgcc ttgggaacta gccactcttg cccatgtcct ggaccctgga
     1801 tgtgactccc tctcttctgg caggccctat agagggaagg ggtagcaaag agccctgtac
     1861 tggtggcaga gtacctgggt tccaatcctg ggcttatccc taggtacgta ggggaggaga
     1921 actcagttcc caggacctct ccagctcttt gcagattctg ggctgagtcc tgttgggggg
     1981 agcttgactt tgctaccctc ccattagtag ctttatctgg cctgtttttg ctgcttcctg
     2041 ggccttggcc ttcatggctc ccatgggact gtctattatg gtgatgcctt cagaaggggt
     2101 ttaatgcatg tgcctgcccc taccctgcta tttttaatga aactgaaaaa tgacttgact
     2161 tggacagggc tctctggtgc agagcctcag tccaccctgc tgccctcaag ctctggagct
     2221 gtgggaagag gagacaggca ggctagggag tgcctgtggc ctgtggtttt caatgcccct
     2281 gtggtacagt atctgcctga gttttgggta gcaggggtga ctgccaatcc agcctgtctt
     2341 agtctctgct ctggctcagt gcctcgttat ttatgtgggg ccgtgcaggc gcggggccca
     2401 ctgcccatcc catttcttat ttattgaaac ctgctgttgc cctgccccta catctccagc
     2461 cccacacact tgagtaataa aaggtggaaa atgtcgtcat gaggtgcttc ctttccccgt
     2521 atcctctctg aaaactgctc acctccaggg ccctgccagg tgtgcacaca tcgtcctccc
     2581 cctcatcagc accttcctct gaaaccaggg aaataggcag aggtggctcc tcgtctcatc
     2641 ctcaccgagg tccccagagg ccaggttccc caatagaaat acaggctgag ccatatgtgt
     2701 gattgaatgt gttcccatag tcattccaaa aagttgtcta aaaaagggta aacttagtat
     2761 ttttaaccaa gtatatccag aatattttca ttgcaatata aaatcattat gaaaatt
//
