LOCUS       NM_009046               2193 bp    mRNA    linear   ROD 14-FEB-2025
DEFINITION  Mus musculus avian reticuloendotheliosis viral (v-rel) oncogene
            related B (Relb), transcript variant 1, mRNA.
ACCESSION   NM_009046
VERSION     NM_009046.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2193)
  AUTHORS   Lin,Y., Liu,M., Deng,P. and Zhang,J.
  TITLE     TET1 mediated m5C modification of RelB aggravates cerebral
            ischemia/reperfusion-induced neuroinflammation through regulating
            microglia polarization
  JOURNAL   Cell Signal 120, 111210 (2024)
   PUBMED   38705503
  REMARK    GeneRIF: TET1 mediated m5C modification of RelB aggravates cerebral
            ischemia/reperfusion-induced neuroinflammation through regulating
            microglia polarization.
            Erratum:[Cell Signal. 2024 Dec;124:111367. doi:
            10.1016/j.cellsig.2024.111367.. PMID: 39214841]
REFERENCE   2  (bases 1 to 2193)
  AUTHORS   Ushio,A., Matsuda-Lennikov,M., Kalle-Youngoue,F., Shimizu,A.,
            Abdelmaksoud,A., Kelly,M.C., Ishimaru,N. and Takahama,Y.
  TITLE     Functionally diverse thymic medullary epithelial cells interplay to
            direct central tolerance
  JOURNAL   Cell Rep 43 (4), 114072 (2024)
   PUBMED   38581680
REFERENCE   3  (bases 1 to 2193)
  AUTHORS   Zheng,C., Liu,L., Liu,C., Chu,F., Lang,Y., Liu,S., Mi,Y., Zhu,J.
            and Jin,T.
  TITLE     Alleviation of experimental autoimmune encephalomyelitis by
            transferring low RelB expression tolerogenic dendritic cells
  JOURNAL   Biochim Biophys Acta Mol Basis Dis 1870 (2), 166934 (2024)
   PUBMED   37931715
  REMARK    GeneRIF: Alleviation of experimental autoimmune encephalomyelitis
            by transferring low RelB expression tolerogenic dendritic cells.
REFERENCE   4  (bases 1 to 2193)
  AUTHORS   Navarro,H.I., Liu,Y., Fraser,A., Lefaudeux,D., Chia,J.J., Vong,L.,
            Roifman,C.M. and Hoffmann,A.
  TITLE     RelB-deficient autoinflammatory pathology presents as
            interferonopathy, but in mice is interferon-independent
  JOURNAL   J Allergy Clin Immunol 152 (5), 1261-1272 (2023)
   PUBMED   37460023
  REMARK    GeneRIF: RelB-deficient autoinflammatory pathology presents as
            interferonopathy, but in mice is interferon-independent.
REFERENCE   5  (bases 1 to 2193)
  AUTHORS   Lucas,B., White,A.J., Klein,F., Veiga-Villauriz,C., Handel,A.,
            Bacon,A., Cosway,E.J., James,K.D., Parnell,S.M., Ohigashi,I.,
            Takahama,Y., Jenkinson,W.E., Hollander,G.A., Lu,W.Y. and
            Anderson,G.
  TITLE     Embryonic keratin19+ progenitors generate multiple functionally
            distinct progeny to maintain epithelial diversity in the adult
            thymus medulla
  JOURNAL   Nat Commun 14 (1), 2066 (2023)
   PUBMED   37045811
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2193)
  AUTHORS   Burkly,L., Hession,C., Ogata,L., Reilly,C., Marconi,L.A., Olson,D.,
            Tizard,R., Cate,R. and Lo,D.
  TITLE     Expression of relB is required for the development of thymic
            medulla and dendritic cells
  JOURNAL   Nature 373 (6514), 531-536 (1995)
   PUBMED   7845467
REFERENCE   7  (bases 1 to 2193)
  AUTHORS   Weih,F., Carrasco,D., Durham,S.K., Barton,D.S., Rizzo,C.A.,
            Ryseck,R.P., Lira,S.A. and Bravo,R.
  TITLE     Multiorgan inflammation and hematopoietic abnormalities in mice
            with a targeted disruption of RelB, a member of the NF-kappa B/Rel
            family
  JOURNAL   Cell 80 (2), 331-340 (1995)
   PUBMED   7834753
REFERENCE   8  (bases 1 to 2193)
  AUTHORS   Egwuagu,C.E., Sztein,J., Chan,C.C., Mahdi,R., Nussenblatt,R.B. and
            Chepelinsky,A.B.
  TITLE     gamma Interferon expression disrupts lens and retinal
            differentiation in transgenic mice
  JOURNAL   Dev Biol 166 (2), 557-568 (1994)
   PUBMED   7813776
REFERENCE   9  (bases 1 to 2193)
  AUTHORS   Lo,D., Quill,H., Burkly,L., Scott,B., Palmiter,R.D. and
            Brinster,R.L.
  TITLE     A recessive defect in lymphocyte or granulocyte function caused by
            an integrated transgene
  JOURNAL   Am J Pathol 141 (5), 1237-1246 (1992)
   PUBMED   1443055
REFERENCE   10 (bases 1 to 2193)
  AUTHORS   Ryseck,R.P., Bull,P., Takamiya,M., Bours,V., Siebenlist,U.,
            Dobrzanski,P. and Bravo,R.
  TITLE     RelB, a new Rel family transcription activator that can interact
            with p50-NF-kappa B
  JOURNAL   Mol Cell Biol 12 (2), 674-684 (1992)
   PUBMED   1732739
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC149052.3.
            
            On Feb 28, 2023 this sequence version replaced NM_009046.2.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC019765.1, M83380.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-237               AC149052.3         16769-17005
            238-285             AC149052.3         18226-18273
            286-294             AC149052.3         23262-23270
            295-623             AC149052.3         26354-26682
            624-781             AC149052.3         28277-28434
            782-873             AC149052.3         29759-29850
            874-1005            AC149052.3         30506-30637
            1006-1110           AC149052.3         32311-32415
            1111-1326           AC149052.3         33476-33691
            1327-1395           AC149052.3         34311-34379
            1396-1473           AC149052.3         34496-34573
            1474-2193           AC149052.3         39255-39974
FEATURES             Location/Qualifiers
     source          1..2193
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 9.93 cM"
     gene            1..2193
                     /gene="Relb"
                     /gene_synonym="shep"
                     /note="avian reticuloendotheliosis viral (v-rel) oncogene
                     related B"
                     /db_xref="GeneID:19698"
                     /db_xref="MGI:MGI:103289"
     exon            1..237
                     /gene="Relb"
                     /gene_synonym="shep"
                     /inference="alignment:Splign:2.1.0"
     CDS             186..1862
                     /gene="Relb"
                     /gene_synonym="shep"
                     /note="isoform 1 is encoded by transcript variant 1;
                     transcription factor relB"
                     /codon_start=1
                     /product="transcription factor RelB isoform 1"
                     /protein_id="NP_033072.2"
                     /db_xref="CCDS:CCDS39799.1"
                     /db_xref="GeneID:19698"
                     /db_xref="MGI:MGI:103289"
                     /translation="MPSRRAARESAPELGALGSSDLSSLSLTVSRTTDELEIIDEYIK
                     ENGFGLDGTQLSEMPRLVPRGPASLSSVTLGPAAPPPPATPSWSCTLGRLVSPGPCPR
                     PYLVITEQPKQRGMRFRYECEGRSAGSILGESSTEASKTLPAIELRDCGGLREVEVTA
                     CLVWKDWPHRVHPHSLVGKDCTDGVCRVRLRPHVSPRHSFNNLGIQCVRKKEIEAAIE
                     RKIQLGIDPYNAGSLKNHQEVDMNVVRICFQASYRDQQGHLHRMDPILSEPVYDKKST
                     NTSELRICRINKESGPCTGGEELYLLCDKVQKEDISVVFSTASWEGRADFSQADVHRQ
                     IAIVFKTPPYEDLEISEPVTVNVFLQRLTDGVCSEPLPFTYLPRDHDSYGVDKKRKRG
                     LPDVLGELSSSDPHGIESKRRKKKPVFLDHFLPGHSSGLFLPPSALQPADSDFFPASI
                     SLPGLEPPGGPDLLDDGFAYDPSAPTLFTMLDLLPPAPPLASAVVGSGGAGATVVESS
                     GPEPLSLDSFAAPGPGDVGTASLVGSNMFPNQYREAAFGGGLLSPGPEAT"
     exon            238..285
                     /gene="Relb"
                     /gene_synonym="shep"
                     /inference="alignment:Splign:2.1.0"
     exon            286..294
                     /gene="Relb"
                     /gene_synonym="shep"
                     /inference="alignment:Splign:2.1.0"
     exon            295..623
                     /gene="Relb"
                     /gene_synonym="shep"
                     /inference="alignment:Splign:2.1.0"
     exon            624..781
                     /gene="Relb"
                     /gene_synonym="shep"
                     /inference="alignment:Splign:2.1.0"
     exon            782..873
                     /gene="Relb"
                     /gene_synonym="shep"
                     /inference="alignment:Splign:2.1.0"
     exon            874..1005
                     /gene="Relb"
                     /gene_synonym="shep"
                     /inference="alignment:Splign:2.1.0"
     exon            1006..1110
                     /gene="Relb"
                     /gene_synonym="shep"
                     /inference="alignment:Splign:2.1.0"
     exon            1111..1326
                     /gene="Relb"
                     /gene_synonym="shep"
                     /inference="alignment:Splign:2.1.0"
     exon            1327..1395
                     /gene="Relb"
                     /gene_synonym="shep"
                     /inference="alignment:Splign:2.1.0"
     exon            1396..1473
                     /gene="Relb"
                     /gene_synonym="shep"
                     /inference="alignment:Splign:2.1.0"
     exon            1474..2193
                     /gene="Relb"
                     /gene_synonym="shep"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2174..2179
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Relb"
                     /gene_synonym="shep"
                     /note="hexamer: AATAAA"
     polyA_site      2193
                     /gene="Relb"
                     /gene_synonym="shep"
                     /note="major polyA site"
ORIGIN      
        1 gctcggcccg gcgccccccg cagccccggg cgccgtgcgt ccagcccggc cttcggccct
       61 agccttgcac cgcttgcccg gccggtgatc gtcccagccg accgggctgt ccgactgccc
      121 ggcttgccct cgtgtgcgct cgccctgagc tggccttcgg gctgtcggtc cctacgggcc
      181 gggccatgcc gagtcgccgc gctgccagag agtccgcgcc cgagctaggg gccttgggtt
      241 ccagtgacct ctcttccctg tcactaacgg tctccaggac cacagatgaa ttggaaatca
      301 tcgacgaata cattaaggag aacggctttg gcctggacgg gacacagctg agtgagatgc
      361 cgcgcctggt gccccgcggg cccgcctcac tgagcagcgt cacgctgggc cctgctgcac
      421 caccgcctcc ggccacgccg tcctggagct gcacactggg caggctggtg tcacccggcc
      481 cgtgcccacg gccgtacctg gtcatcacag agcagccaaa gcagcgtggc atgcgcttcc
      541 gctacgagtg cgagggccgc tcggccggca gcatcctcgg ggagagcagc accgaagcca
      601 gcaagaccct gcccgccatc gagcttcgag actgtggcgg gctgcgggag gtggaggtga
      661 cggcgtgcct ggtgtggaag gactggccac accgggtaca cccacatagc ctcgtgggga
      721 aagactgcac ggacggcgtc tgcagggtgc ggctgcggcc tcacgtcagc ccccggcaca
      781 gctttaacaa cctgggcatc cagtgtgtta ggaagaagga aattgaagct gccattgagc
      841 ggaagatcca gctgggaatt gacccctaca atgctggctc cctgaagaac catcaggagg
      901 tcgacatgaa tgtcgtcagg atctgcttcc aggcctccta tcgggaccag cagggacatc
      961 tgcaccgcat ggaccccatc ctctctgagc ctgtctacga caagaagtcc accaacacat
     1021 cggagctgcg gatttgccga atcaacaagg agagcgggcc gtgcacaggt ggtgaggagc
     1081 tgtacttgct ctgtgacaag gtgcaaaaag aggacatatc cgtggtgttc agcacagctt
     1141 cctgggaagg ccgtgccgac ttctctcaag ctgatgtgca ccggcagatc gccattgtgt
     1201 tcaaaacgcc accctacgag gacctggaga tctcagagcc cgtgactgtc aatgtgttct
     1261 tgcagcggct cacggatggg gtgtgcagcg agccgctgcc cttcacgtac ctgcctcggg
     1321 atcatgacag ctacggtgtg gacaagaagc gaaagcgggg actgcctgat gtccttggag
     1381 agttgagcag ctctgatcca catggaatcg agagcaaacg aaggaaaaag aaaccagtgt
     1441 tcttggacca cttcctgcct ggccacagct caggcctgtt cctcccacca tcggctctgc
     1501 agccggcaga ctctgatttc ttccctgctt ccatatccct tcctgggctg gagcctcctg
     1561 gtggacccga tctcctggac gatggctttg cctatgatcc ttctgccccc acgctcttca
     1621 ctatgttgga cctgctgccc ccagcaccac cacttgccag tgctgtggtg ggtagcgggg
     1681 gtgcaggggc caccgttgtg gagtcttctg gcccagagcc cctatcactg gactcttttg
     1741 cagcgccggg ccccggggat gttggtactg ctagccttgt gggcagcaac atgtttccca
     1801 accagtaccg agaggcagct ttcgggggtg gcctcctatc tccagggcct gaagccacgt
     1861 agcctctgag gtaacagagg aggcactggg tgaggtatgt ggtatagcac tccattccga
     1921 agccaacctt gatcagtctt ccagcttcct catcctgaat cggacatctg cagcgctggt
     1981 gggaagatgg ggagcactcc ggttctcttt gagcccattt tacagaatgc tgagtccgaa
     2041 gaggaaaagg ggctcctgca gatggacccc ttctcaggac agattctcag agattgtaca
     2101 taggggagga gggagcaggt ccccagcctt ctcccctaat cctgaagaag gcagtggatt
     2161 gttcagtttt cccaataaaa attagttttt tga
//
