LOCUS       NM_001417183            2292 bp    mRNA    linear   ROD 14-FEB-2025
DEFINITION  Mus musculus avian reticuloendotheliosis viral (v-rel) oncogene
            related B (Relb), transcript variant 3, mRNA.
ACCESSION   NM_001417183 XM_030242243
VERSION     NM_001417183.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2292)
  AUTHORS   Lin,Y., Liu,M., Deng,P. and Zhang,J.
  TITLE     TET1 mediated m5C modification of RelB aggravates cerebral
            ischemia/reperfusion-induced neuroinflammation through regulating
            microglia polarization
  JOURNAL   Cell Signal 120, 111210 (2024)
   PUBMED   38705503
  REMARK    GeneRIF: TET1 mediated m5C modification of RelB aggravates cerebral
            ischemia/reperfusion-induced neuroinflammation through regulating
            microglia polarization.
            Erratum:[Cell Signal. 2024 Dec;124:111367. doi:
            10.1016/j.cellsig.2024.111367.. PMID: 39214841]
REFERENCE   2  (bases 1 to 2292)
  AUTHORS   Ushio,A., Matsuda-Lennikov,M., Kalle-Youngoue,F., Shimizu,A.,
            Abdelmaksoud,A., Kelly,M.C., Ishimaru,N. and Takahama,Y.
  TITLE     Functionally diverse thymic medullary epithelial cells interplay to
            direct central tolerance
  JOURNAL   Cell Rep 43 (4), 114072 (2024)
   PUBMED   38581680
REFERENCE   3  (bases 1 to 2292)
  AUTHORS   Zheng,C., Liu,L., Liu,C., Chu,F., Lang,Y., Liu,S., Mi,Y., Zhu,J.
            and Jin,T.
  TITLE     Alleviation of experimental autoimmune encephalomyelitis by
            transferring low RelB expression tolerogenic dendritic cells
  JOURNAL   Biochim Biophys Acta Mol Basis Dis 1870 (2), 166934 (2024)
   PUBMED   37931715
  REMARK    GeneRIF: Alleviation of experimental autoimmune encephalomyelitis
            by transferring low RelB expression tolerogenic dendritic cells.
REFERENCE   4  (bases 1 to 2292)
  AUTHORS   Navarro,H.I., Liu,Y., Fraser,A., Lefaudeux,D., Chia,J.J., Vong,L.,
            Roifman,C.M. and Hoffmann,A.
  TITLE     RelB-deficient autoinflammatory pathology presents as
            interferonopathy, but in mice is interferon-independent
  JOURNAL   J Allergy Clin Immunol 152 (5), 1261-1272 (2023)
   PUBMED   37460023
  REMARK    GeneRIF: RelB-deficient autoinflammatory pathology presents as
            interferonopathy, but in mice is interferon-independent.
REFERENCE   5  (bases 1 to 2292)
  AUTHORS   Lucas,B., White,A.J., Klein,F., Veiga-Villauriz,C., Handel,A.,
            Bacon,A., Cosway,E.J., James,K.D., Parnell,S.M., Ohigashi,I.,
            Takahama,Y., Jenkinson,W.E., Hollander,G.A., Lu,W.Y. and
            Anderson,G.
  TITLE     Embryonic keratin19+ progenitors generate multiple functionally
            distinct progeny to maintain epithelial diversity in the adult
            thymus medulla
  JOURNAL   Nat Commun 14 (1), 2066 (2023)
   PUBMED   37045811
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2292)
  AUTHORS   Burkly,L., Hession,C., Ogata,L., Reilly,C., Marconi,L.A., Olson,D.,
            Tizard,R., Cate,R. and Lo,D.
  TITLE     Expression of relB is required for the development of thymic
            medulla and dendritic cells
  JOURNAL   Nature 373 (6514), 531-536 (1995)
   PUBMED   7845467
REFERENCE   7  (bases 1 to 2292)
  AUTHORS   Weih,F., Carrasco,D., Durham,S.K., Barton,D.S., Rizzo,C.A.,
            Ryseck,R.P., Lira,S.A. and Bravo,R.
  TITLE     Multiorgan inflammation and hematopoietic abnormalities in mice
            with a targeted disruption of RelB, a member of the NF-kappa B/Rel
            family
  JOURNAL   Cell 80 (2), 331-340 (1995)
   PUBMED   7834753
REFERENCE   8  (bases 1 to 2292)
  AUTHORS   Egwuagu,C.E., Sztein,J., Chan,C.C., Mahdi,R., Nussenblatt,R.B. and
            Chepelinsky,A.B.
  TITLE     gamma Interferon expression disrupts lens and retinal
            differentiation in transgenic mice
  JOURNAL   Dev Biol 166 (2), 557-568 (1994)
   PUBMED   7813776
REFERENCE   9  (bases 1 to 2292)
  AUTHORS   Lo,D., Quill,H., Burkly,L., Scott,B., Palmiter,R.D. and
            Brinster,R.L.
  TITLE     A recessive defect in lymphocyte or granulocyte function caused by
            an integrated transgene
  JOURNAL   Am J Pathol 141 (5), 1237-1246 (1992)
   PUBMED   1443055
REFERENCE   10 (bases 1 to 2292)
  AUTHORS   Ryseck,R.P., Bull,P., Takamiya,M., Bours,V., Siebenlist,U.,
            Dobrzanski,P. and Bravo,R.
  TITLE     RelB, a new Rel family transcription activator that can interact
            with p50-NF-kappa B
  JOURNAL   Mol Cell Biol 12 (2), 674-684 (1992)
   PUBMED   1732739
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC149052.3.
            
            On Mar 1, 2023 this sequence version replaced XM_030242243.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR12282455.15930497.1,
                                           SRR13861859.1996490.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-345               AC149052.3         17776-18120
            346-393             AC149052.3         18226-18273
            394-722             AC149052.3         26354-26682
            723-880             AC149052.3         28277-28434
            881-972             AC149052.3         29759-29850
            973-1104            AC149052.3         30506-30637
            1105-1209           AC149052.3         32311-32415
            1210-1425           AC149052.3         33476-33691
            1426-1494           AC149052.3         34311-34379
            1495-1572           AC149052.3         34496-34573
            1573-2292           AC149052.3         39255-39974
FEATURES             Location/Qualifiers
     source          1..2292
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 9.93 cM"
     gene            1..2292
                     /gene="Relb"
                     /gene_synonym="shep"
                     /note="avian reticuloendotheliosis viral (v-rel) oncogene
                     related B"
                     /db_xref="GeneID:19698"
                     /db_xref="MGI:MGI:103289"
     exon            1..345
                     /gene="Relb"
                     /gene_synonym="shep"
                     /inference="alignment:Splign:2.1.0"
     exon            346..393
                     /gene="Relb"
                     /gene_synonym="shep"
                     /inference="alignment:Splign:2.1.0"
     exon            394..722
                     /gene="Relb"
                     /gene_synonym="shep"
                     /inference="alignment:Splign:2.1.0"
     CDS             456..1961
                     /gene="Relb"
                     /gene_synonym="shep"
                     /note="isoform 3 is encoded by transcript variant 3;
                     transcription factor relB"
                     /codon_start=1
                     /product="transcription factor RelB isoform 3"
                     /protein_id="NP_001404112.1"
                     /db_xref="GeneID:19698"
                     /db_xref="MGI:MGI:103289"
                     /translation="MPRLVPRGPASLSSVTLGPAAPPPPATPSWSCTLGRLVSPGPCP
                     RPYLVITEQPKQRGMRFRYECEGRSAGSILGESSTEASKTLPAIELRDCGGLREVEVT
                     ACLVWKDWPHRVHPHSLVGKDCTDGVCRVRLRPHVSPRHSFNNLGIQCVRKKEIEAAI
                     ERKIQLGIDPYNAGSLKNHQEVDMNVVRICFQASYRDQQGHLHRMDPILSEPVYDKKS
                     TNTSELRICRINKESGPCTGGEELYLLCDKVQKEDISVVFSTASWEGRADFSQADVHR
                     QIAIVFKTPPYEDLEISEPVTVNVFLQRLTDGVCSEPLPFTYLPRDHDSYGVDKKRKR
                     GLPDVLGELSSSDPHGIESKRRKKKPVFLDHFLPGHSSGLFLPPSALQPADSDFFPAS
                     ISLPGLEPPGGPDLLDDGFAYDPSAPTLFTMLDLLPPAPPLASAVVGSGGAGATVVES
                     SGPEPLSLDSFAAPGPGDVGTASLVGSNMFPNQYREAAFGGGLLSPGPEAT"
     exon            723..880
                     /gene="Relb"
                     /gene_synonym="shep"
                     /inference="alignment:Splign:2.1.0"
     exon            881..972
                     /gene="Relb"
                     /gene_synonym="shep"
                     /inference="alignment:Splign:2.1.0"
     exon            973..1104
                     /gene="Relb"
                     /gene_synonym="shep"
                     /inference="alignment:Splign:2.1.0"
     exon            1105..1209
                     /gene="Relb"
                     /gene_synonym="shep"
                     /inference="alignment:Splign:2.1.0"
     exon            1210..1425
                     /gene="Relb"
                     /gene_synonym="shep"
                     /inference="alignment:Splign:2.1.0"
     exon            1426..1494
                     /gene="Relb"
                     /gene_synonym="shep"
                     /inference="alignment:Splign:2.1.0"
     exon            1495..1572
                     /gene="Relb"
                     /gene_synonym="shep"
                     /inference="alignment:Splign:2.1.0"
     exon            1573..2292
                     /gene="Relb"
                     /gene_synonym="shep"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2273..2278
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Relb"
                     /gene_synonym="shep"
                     /note="hexamer: AATAAA"
     polyA_site      2292
                     /gene="Relb"
                     /gene_synonym="shep"
                     /note="major polyA site"
ORIGIN      
        1 attggggctc ggatttcgcc ctgagggaag aacggagacg ggggttttcc tgaggcatca
       61 ggagtcctcc aagtcccacc ttaatgggga aagtagcgga tattgagtga tgattggcgg
      121 agtcaaaggc agaaacgaaa agccagaact tttttcaaga gttagagaag agccggttgt
      181 ggtggcgcac ttgggaggca gaggcaggcg gatttctgag ttcgaggcca gcctggtcta
      241 caaagtgagt tccaggacag ctcagggcta tacagaaaaa cactgtctcg aaaaaccaag
      301 aaaaaaaaaa aggagttaga gaaggctggc ctgcacctga gctcggttcc agtgacctct
      361 cttccctgtc actaacggtc tccaggacca cagaaatcat cgacgaatac attaaggaga
      421 acggctttgg cctggacggg acacagctga gtgagatgcc gcgcctggtg ccccgcgggc
      481 ccgcctcact gagcagcgtc acgctgggcc ctgctgcacc accgcctccg gccacgccgt
      541 cctggagctg cacactgggc aggctggtgt cacccggccc gtgcccacgg ccgtacctgg
      601 tcatcacaga gcagccaaag cagcgtggca tgcgcttccg ctacgagtgc gagggccgct
      661 cggccggcag catcctcggg gagagcagca ccgaagccag caagaccctg cccgccatcg
      721 agcttcgaga ctgtggcggg ctgcgggagg tggaggtgac ggcgtgcctg gtgtggaagg
      781 actggccaca ccgggtacac ccacatagcc tcgtggggaa agactgcacg gacggcgtct
      841 gcagggtgcg gctgcggcct cacgtcagcc cccggcacag ctttaacaac ctgggcatcc
      901 agtgtgttag gaagaaggaa attgaagctg ccattgagcg gaagatccag ctgggaattg
      961 acccctacaa tgctggctcc ctgaagaacc atcaggaggt cgacatgaat gtcgtcagga
     1021 tctgcttcca ggcctcctat cgggaccagc agggacatct gcaccgcatg gaccccatcc
     1081 tctctgagcc tgtctacgac aagaagtcca ccaacacatc ggagctgcgg atttgccgaa
     1141 tcaacaagga gagcgggccg tgcacaggtg gtgaggagct gtacttgctc tgtgacaagg
     1201 tgcaaaaaga ggacatatcc gtggtgttca gcacagcttc ctgggaaggc cgtgccgact
     1261 tctctcaagc tgatgtgcac cggcagatcg ccattgtgtt caaaacgcca ccctacgagg
     1321 acctggagat ctcagagccc gtgactgtca atgtgttctt gcagcggctc acggatgggg
     1381 tgtgcagcga gccgctgccc ttcacgtacc tgcctcggga tcatgacagc tacggtgtgg
     1441 acaagaagcg aaagcgggga ctgcctgatg tccttggaga gttgagcagc tctgatccac
     1501 atggaatcga gagcaaacga aggaaaaaga aaccagtgtt cttggaccac ttcctgcctg
     1561 gccacagctc aggcctgttc ctcccaccat cggctctgca gccggcagac tctgatttct
     1621 tccctgcttc catatccctt cctgggctgg agcctcctgg tggacccgat ctcctggacg
     1681 atggctttgc ctatgatcct tctgccccca cgctcttcac tatgttggac ctgctgcccc
     1741 cagcaccacc acttgccagt gctgtggtgg gtagcggggg tgcaggggcc accgttgtgg
     1801 agtcttctgg cccagagccc ctatcactgg actcttttgc agcgccgggc cccggggatg
     1861 ttggtactgc tagccttgtg ggcagcaaca tgtttcccaa ccagtaccga gaggcagctt
     1921 tcgggggtgg cctcctatct ccagggcctg aagccacgta gcctctgagg taacagagga
     1981 ggcactgggt gaggtatgtg gtatagcact ccattccgaa gccaaccttg atcagtcttc
     2041 cagcttcctc atcctgaatc ggacatctgc agcgctggtg ggaagatggg gagcactccg
     2101 gttctctttg agcccatttt acagaatgct gagtccgaag aggaaaaggg gctcctgcag
     2161 atggacccct tctcaggaca gattctcaga gattgtacat aggggaggag ggagcaggtc
     2221 cccagccttc tcccctaatc ctgaagaagg cagtggattg ttcagttttc ccaataaaaa
     2281 ttagtttttt ga
//
