LOCUS       NM_009045               2662 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Mus musculus v-rel reticuloendotheliosis viral oncogene homolog A
            (avian) (Rela), transcript variant 1, mRNA.
ACCESSION   NM_009045
VERSION     NM_009045.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2662)
  AUTHORS   Hossain,M.N., Gao,Y., Li,X., Zhao,L., Liu,X., Marie de Avila,J.,
            Zhu,M.J. and Du,M.
  TITLE     Single-cell RNA transcriptomics in mice reveals embryonic origin of
            fibrosis due to maternal obesity
  JOURNAL   EBioMedicine 109, 105421 (2024)
   PUBMED   39476533
  REMARK    Erratum:[EBioMedicine. 2025 Jan 27;112:105573. doi:
            10.1016/j.ebiom.2025.105573.. PMID: 39874704]
REFERENCE   2  (bases 1 to 2662)
  AUTHORS   Lu,J., Zhang,J., Jiang,H., Hu,Z., Zhang,Y., He,L., Yang,J., Xie,Y.,
            Wu,D., Li,H., Zeng,K., Tan,P., Xiao,Q., Song,Z., Pan,C., Bai,X. and
            Yu,X.
  TITLE     Vangl2 suppresses NF-kappaB signaling and ameliorates sepsis by
            targeting p65 for NDP52-mediated autophagic degradation
  JOURNAL   Elife 12, 87935 (2024)
   PUBMED   39269442
  REMARK    GeneRIF: Vangl2 suppresses NF-kappaB signaling and ameliorates
            sepsis by targeting p65 for NDP52-mediated autophagic degradation.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2662)
  AUTHORS   Xie,Y., Chi,Y., Tao,X., Yu,P., Liu,Q., Zhang,M., Yang,N., Liu,S.
            and Zhu,W.
  TITLE     Rabies Virus Regulates Inflammatory Response in BV-2 Cells through
            Activation of Myd88 and NF-kappaB Signaling Pathways via TLR7
  JOURNAL   Int J Mol Sci 25 (17), 9144 (2024)
   PUBMED   39273091
  REMARK    GeneRIF: Rabies Virus Regulates Inflammatory Response in BV-2 Cells
            through Activation of Myd88 and NF-kappaB Signaling Pathways via
            TLR7.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2662)
  AUTHORS   Jyotsna, Sarkar,B., Yadav,M., Deka,A., Markandey,M., Sanyal,P.,
            Nagarajan,P., Gaikward,N., Ahuja,V., Mohanty,D., Basak,S. and
            Gokhale,R.S.
  TITLE     A hepatocyte-specific transcriptional program driven by Rela and
            Stat3 exacerbates experimental colitis in mice by modulating bile
            synthesis
  JOURNAL   Elife 12, 93273 (2024)
   PUBMED   39137024
  REMARK    GeneRIF: A hepatocyte-specific transcriptional program driven by
            Rela and Stat3 exacerbates experimental colitis in mice by
            modulating bile synthesis.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2662)
  AUTHORS   Feng,W., Niu,N., Lu,P., Chen,Z., Rao,H., Zhang,W., Ma,C., Liu,C.,
            Xu,Y., Gao,W.Q., Xue,J. and Li,L.
  TITLE     Multilevel Regulation of NF-kappaB Signaling by NSD2 Suppresses
            Kras-Driven Pancreatic Tumorigenesis
  JOURNAL   Adv Sci (Weinh) 11 (30), e2309387 (2024)
   PUBMED   38889281
  REMARK    GeneRIF: Multilevel Regulation of NF-kappaB Signaling by NSD2
            Suppresses Kras-Driven Pancreatic Tumorigenesis.
REFERENCE   6  (bases 1 to 2662)
  AUTHORS   Verma,I.M., Stevenson,J.K., Schwarz,E.M., Van Antwerp,D. and
            Miyamoto,S.
  TITLE     Rel/NF-kappa B/I kappa B family: intimate tales of association and
            dissociation
  JOURNAL   Genes Dev 9 (22), 2723-2735 (1995)
   PUBMED   7590248
  REMARK    Review article
REFERENCE   7  (bases 1 to 2662)
  AUTHORS   Guerrini,L., Blasi,F. and Denis-Donini,S.
  TITLE     Synaptic activation of NF-kappa B by glutamate in cerebellar
            granule neurons in vitro
  JOURNAL   Proc Natl Acad Sci U S A 92 (20), 9077-9081 (1995)
   PUBMED   7568076
REFERENCE   8  (bases 1 to 2662)
  AUTHORS   Beg,A.A., Sha,W.C., Bronson,R.T., Ghosh,S. and Baltimore,D.
  TITLE     Embryonic lethality and liver degeneration in mice lacking the RelA
            component of NF-kappa B
  JOURNAL   Nature 376 (6536), 167-170 (1995)
   PUBMED   7603567
REFERENCE   9  (bases 1 to 2662)
  AUTHORS   Dunn,S.M., Coles,L.S., Lang,R.K., Gerondakis,S., Vadas,M.A. and
            Shannon,M.F.
  TITLE     Requirement for nuclear factor (NF)-kappa B p65 and
            NF-interleukin-6 binding elements in the tumor necrosis factor
            response region of the granulocyte colony-stimulating factor
            promoter
  JOURNAL   Blood 83 (9), 2469-2479 (1994)
   PUBMED   7513199
REFERENCE   10 (bases 1 to 2662)
  AUTHORS   Nolan,G.P., Ghosh,S., Liou,H.C., Tempst,P. and Baltimore,D.
  TITLE     DNA binding and I kappa B inhibition of the cloned p65 subunit of
            NF-kappa B, a rel-related polypeptide
  JOURNAL   Cell 64 (5), 961-969 (1991)
   PUBMED   2001591
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC126029.3 and AC134563.5.
            
            On Jul 24, 2018 this sequence version replaced NM_009045.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC094053.1, AK158072.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-301               AC126029.3         6135-6435           c
            302-328             AC126029.3         5518-5544           c
            329-480             AC126029.3         5274-5425           c
            481-629             AC126029.3         4973-5121           c
            630-721             AC126029.3         4026-4117           c
            722-853             AC126029.3         3542-3673           c
            854-958             AC126029.3         2691-2795           c
            959-1171            AC126029.3         2300-2512           c
            1172-1252           AC134563.5         135736-135816       c
            1253-1327           AC134563.5         135554-135628       c
            1328-2662           AC134563.5         133007-134341       c
FEATURES             Location/Qualifiers
     source          1..2662
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 4.34 cM"
     gene            1..2662
                     /gene="Rela"
                     /gene_synonym="p65; p65 NF-kappa B; p65 NFkB"
                     /note="v-rel reticuloendotheliosis viral oncogene homolog
                     A (avian)"
                     /db_xref="GeneID:19697"
                     /db_xref="MGI:MGI:103290"
     exon            1..301
                     /gene="Rela"
                     /gene_synonym="p65; p65 NF-kappa B; p65 NFkB"
                     /inference="alignment:Splign:2.1.0"
     CDS             295..1944
                     /gene="Rela"
                     /gene_synonym="p65; p65 NF-kappa B; p65 NFkB"
                     /note="isoform 1 is encoded by transcript variant 1; avian
                     reticuloendotheliosis viral (v-rel) oncogene homolog A;
                     transcription factor p65; nuclear factor NF-kappa-B p65
                     subunit; nuclear factor of kappa light polypeptide gene
                     enhancer in B-cells 3"
                     /codon_start=1
                     /product="transcription factor p65 isoform 1"
                     /protein_id="NP_033071.1"
                     /db_xref="CCDS:CCDS29473.1"
                     /db_xref="GeneID:19697"
                     /db_xref="MGI:MGI:103290"
                     /translation="MDDLFPLIFPSEPAQASGPYVEIIEQPKQRGMRFRYKCEGRSAG
                     SIPGERSTDTTKTHPTIKINGYTGPGTVRISLVTKDPPHRPHPHELVGKDCRDGYYEA
                     DLCPDRSIHSFQNLGIQCVKKRDLEQAISQRIQTNNNPFHVPIEEQRGDYDLNAVRLC
                     FQVTVRDPAGRPLLLTPVLSHPIFDNRAPNTAELKICRVNRNSGSCLGGDEIFLLCDK
                     VQKEDIEVYFTGPGWEARGSFSQADVHRQVAIVFRTPPYADPSLQAPVRVSMQLRRPS
                     DRELSEPMEFQYLPDTDDRHRIEEKRKRTYETFKSIMKKSPFNGPTEPRPPTRRIAVP
                     TRNSTSVPKPAPQPYTFPASLSTINFDEFSPMLLPSGQISNQALALAPSSAPVLAQTM
                     VPSSAMVPLAQPPAPAPVLTPGPPQSLSAPVPKSTQAGEGTLSEALLHLQFDADEDLG
                     ALLGNSTDPGVFTDLASVDNSEFQQLLNQGVSMSHSTAEPMLMEYPEAITRLVTGSQR
                     PPDPAPTPLGTSGLPNGLSGDEDFSSIADMDFSALLSQISS"
     exon            302..328
                     /gene="Rela"
                     /gene_synonym="p65; p65 NF-kappa B; p65 NFkB"
                     /inference="alignment:Splign:2.1.0"
     exon            329..480
                     /gene="Rela"
                     /gene_synonym="p65; p65 NF-kappa B; p65 NFkB"
                     /inference="alignment:Splign:2.1.0"
     exon            481..629
                     /gene="Rela"
                     /gene_synonym="p65; p65 NF-kappa B; p65 NFkB"
                     /inference="alignment:Splign:2.1.0"
     exon            630..721
                     /gene="Rela"
                     /gene_synonym="p65; p65 NF-kappa B; p65 NFkB"
                     /inference="alignment:Splign:2.1.0"
     exon            722..853
                     /gene="Rela"
                     /gene_synonym="p65; p65 NF-kappa B; p65 NFkB"
                     /inference="alignment:Splign:2.1.0"
     exon            854..958
                     /gene="Rela"
                     /gene_synonym="p65; p65 NF-kappa B; p65 NFkB"
                     /inference="alignment:Splign:2.1.0"
     exon            959..1171
                     /gene="Rela"
                     /gene_synonym="p65; p65 NF-kappa B; p65 NFkB"
                     /inference="alignment:Splign:2.1.0"
     exon            1172..1252
                     /gene="Rela"
                     /gene_synonym="p65; p65 NF-kappa B; p65 NFkB"
                     /inference="alignment:Splign:2.1.0"
     exon            1253..1327
                     /gene="Rela"
                     /gene_synonym="p65; p65 NF-kappa B; p65 NFkB"
                     /inference="alignment:Splign:2.1.0"
     exon            1328..2662
                     /gene="Rela"
                     /gene_synonym="p65; p65 NF-kappa B; p65 NFkB"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2638..2643
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rela"
                     /gene_synonym="p65; p65 NF-kappa B; p65 NFkB"
                     /note="hexamer: AATAAA"
     polyA_site      2658
                     /gene="Rela"
                     /gene_synonym="p65; p65 NF-kappa B; p65 NFkB"
                     /note="major polyA site"
ORIGIN      
        1 gtagtcgggc cggcctcggg acaaacagcc tcggcgtcct cccgccgcgc tgcggtgtcc
       61 ccgcccgcgc gcccgccgca caccttccgc gcccagcgtg agtcgcgcac ctgctctcgg
      121 ccccccacgc gcggcggtgg cggtggcggc ggctcagcgc gcaggcgcgg ccggattccg
      181 ggcagtgacg cgacgacggg cgcgcgccgc gcatttccgc ctctggcgaa tggctttact
      241 ttagcgcgcc gtgggctcag ctgcgacccc ggccccgccc ccgggaccct gaccatggac
      301 gatctgtttc ccctcatctt tccctcagag ccagcccagg cttctgggcc ttatgtggag
      361 atcatcgaac agccgaagca acggggcatg cgattccgct ataaatgcga ggggcgctca
      421 gcgggcagta ttcctggcga gagaagcaca gataccacca agacacaccc caccatcaag
      481 atcaatggct acacaggacc aggaacagtt cgaatctccc tggtcaccaa ggatccacct
      541 caccggcctc atccacatga acttgtgggg aaggactgcc gggatggcta ctatgaggct
      601 gacctctgcc cagaccgcag tatccatagc ttccagaacc tggggatcca gtgtgtgaag
      661 aagcgagacc tggagcaagc cattagccag cgaatccaga ccaacaataa cccctttcac
      721 gttcctatag aggagcagcg cggggactat gacttgaatg cagtgcgcct ctgcttccag
      781 gtgacagtgc gggacccagc aggcaggccc ctcctcctga cccctgtcct ctcacatccg
      841 atttttgata accgggcccc caacactgcc gagctcaaga tctgccgagt aaaccggaac
      901 tctgggagct gcctcggtgg ggatgagatc ttcttgctgt gcgacaaggt gcagaaagaa
      961 gacattgagg tgtatttcac gggaccaggc tgggaggcac gaggctcctt ttctcaagct
     1021 gatgtgcatc ggcaagtggc cattgtgttc cggactcctc cgtacgccga ccccagcctc
     1081 caggctcctg ttcgagtctc catgcagcta cggcggcctt ctgatcgcga gctcagtgag
     1141 cccatggagt tccagtactt gccagacaca gatgatcgcc accggattga agagaagcgc
     1201 aaaaggacct atgagacctt caagagtatc atgaagaaga gtcctttcaa tggaccaact
     1261 gaaccccggc ctccaacccg gcgtattgct gtgcctaccc gaaactcaac ttctgtcccc
     1321 aagccagccc cgcagcccta caccttccca gcatccctca gcaccatcaa ctttgatgag
     1381 ttttccccca tgctgttacc atcagggcag atctcaaacc aggccctggc cttggcaccg
     1441 tcctctgccc cagtccttgc ccagaccatg gtcccttcct cagccatggt acctctggct
     1501 cagcccccag ctcctgcccc agttctaacc ccgggtcctc cccagtccct gtctgcacct
     1561 gttccaaaga gcacccaggc tggggaaggc acgctgtcgg aagccctgct gcacctgcag
     1621 tttgatgctg atgaagactt gggggccttg cttggcaaca gcacagaccc aggagtgttc
     1681 acagacctgg catctgtgga caactcagag tttcagcagc tcctgaacca gggtgtgtcc
     1741 atgtctcact ccacagctga gcccatgctg atggagtacc ctgaagctat aactcgcctg
     1801 gtgacagggt cccagaggcc ccctgaccca gctcccacac ccctggggac ctcggggctt
     1861 cccaatggtc tctcaggaga tgaagacttc tcctccattg cggacatgga cttctctgct
     1921 cttttgagtc agatcagctc ctaaggtgct gacagcgacc ctgctcagag caccaggttt
     1981 cagggcactg aagccttccc gaagtgcgta cacattctgg ggagtgtgct ccagctgccc
     2041 ccgacttgtt tgggtgatct ctctggggcg gcacgtttta ctctttatct cgctttcgga
     2101 ggtgctttcg caggagcatt aacctcctgg agacggagct gggaggactc ggtgcatccc
     2161 tgtgttgata gctcctgctt cggtagggaa ctctgagatc ctgcttccat ctccagcttc
     2221 tagcactctc ctagagaggg acagactgga gccatggcct taggccatat agccttacta
     2281 tcaagtgtct tcctccacgc ggattcctgt acaccttgat ccaaagcagt gctcccaaga
     2341 gcagctccta cgtggtgctg cccgacacca gcacatgagg ggccgctctt ctgtcctgtg
     2401 gagctcctgc cctgccagct ctccatgctg agctgtggcc aaggggaaca ggtgggatgt
     2461 tgctggccgc cttcagaatc ggggggagtt tagtctgaga catccctgct cccccttttt
     2521 tcaagtgcct taatagcagg gcaaactgta gagtcaggag ggcaggctag atgctcagcc
     2581 acaagacagc ctttactgaa aaagctattg gactcttgct ctttctagct ctgaactaat
     2641 aaatgtctta tcacgctggc ca
//
