LOCUS       NM_026328               1021 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus regenerating islet-derived family, member 4 (Reg4),
            mRNA.
ACCESSION   NM_026328
VERSION     NM_026328.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1021)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1021)
  AUTHORS   Wang,W., Wang,Y., Lu,Y., Zhu,J., Tian,X., Wu,B., Du,J., Cai,W. and
            Xiao,Y.
  TITLE     Reg4 protects against Salmonella infection-associated intestinal
            inflammation via adopting a calcium-dependent lectin-like domain
  JOURNAL   Int Immunopharmacol 113 (Pt A), 109310 (2022)
   PUBMED   36274484
  REMARK    GeneRIF: Reg4 protects against Salmonella infection-associated
            intestinal inflammation via adopting a calcium-dependent
            lectin-like domain.
REFERENCE   3  (bases 1 to 1021)
  AUTHORS   Takasawa,S., Itaya-Hironaka,A., Makino,M., Yamauchi,A.,
            Sakuramoto-Tsuchida,S., Uchiyama,T., Shobatake,R., Takeda,Y. and
            Ota,H.
  TITLE     Upregulation of Reg IV and Hgf mRNAs by Intermittent Hypoxia via
            Downregulation of microRNA-499 in Cardiomyocytes
  JOURNAL   Int J Mol Sci 23 (20), 12414 (2022)
   PUBMED   36293268
  REMARK    GeneRIF: Upregulation of Reg IV and Hgf mRNAs by Intermittent
            Hypoxia via Downregulation of microRNA-499 in Cardiomyocytes.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1021)
  AUTHORS   Dai,J., He,Y., Jiang,M., Niu,M., Li,B., Wu,Z., Bao,J., Wen,L.,
            Wang,X. and Hu,G.
  TITLE     Reg4 regulates pancreatic regeneration following pancreatitis via
            modulating the Notch signaling
  JOURNAL   J Cell Physiol 236 (11), 7565-7577 (2021)
   PUBMED   33899235
  REMARK    GeneRIF: Reg4 regulates pancreatic regeneration following
            pancreatitis via modulating the Notch signaling.
REFERENCE   5  (bases 1 to 1021)
  AUTHORS   Lorchner,H., Hou,Y., Adrian-Segarra,J.M., Kulhei,J., Detzer,J.,
            Gunther,S., Gajawada,P., Warnecke,H., Niessen,H.W., Poling,J. and
            Braun,T.
  TITLE     Reg proteins direct accumulation of functionally distinct
            macrophage subsets after myocardial infarction
  JOURNAL   Cardiovasc Res 114 (12), 1667-1679 (2018)
   PUBMED   29850784
  REMARK    GeneRIF: Cardiomyocytes situated in close proximity to the
            infarcted region produce large amounts of Reg3b, Reg3g, and Reg4,
            thereby forming a chemokine gradient that might direct interstitial
            migration of MHCIIhi/Ly6Clo and MHC-IIlo/Ly6Clo macrophage subsets.
REFERENCE   6  (bases 1 to 1021)
  AUTHORS   Tang,T., Li,L., Tang,J., Li,Y., Lin,W.Y., Martin,F., Grant,D.,
            Solloway,M., Parker,L., Ye,W., Forrest,W., Ghilardi,N., Oravecz,T.,
            Platt,K.A., Rice,D.S., Hansen,G.M., Abuin,A., Eberhart,D.E.,
            Godowski,P., Holt,K.H., Peterson,A., Zambrowicz,B.P. and de
            Sauvage,F.J.
  TITLE     A mouse knockout library for secreted and transmembrane proteins
  JOURNAL   Nat Biotechnol 28 (7), 749-755 (2010)
   PUBMED   20562862
REFERENCE   7  (bases 1 to 1021)
  AUTHORS   Bishnupuri,K.S., Luo,Q., Sainathan,S.K., Kikuchi,K., Sureban,S.M.,
            Sabarinathan,M., Gross,J.H., Aden,K., May,R., Houchen,C.W.,
            Anant,S. and Dieckgraefe,B.K.
  TITLE     Reg IV regulates normal intestinal and colorectal cancer cell
            susceptibility to radiation-induced apoptosis
  JOURNAL   Gastroenterology 138 (2), 616-626 (2010)
   PUBMED   19900450
  REMARK    GeneRIF: Reg IV as an important modulator of gastrointestinal cell
            susceptibility to irradiation; hence, it is a potential target for
            adjunctive treatments for human colorectal cancer and other
            gastrointestinal malignancies.
REFERENCE   8  (bases 1 to 1021)
  AUTHORS   Legoffic,A., Calvo,E., Cano,C., Folch-Puy,E., Barthet,M.,
            Delpero,J.R., Ferres-Maso,M., Dagorn,J.C., Closa,D. and Iovanna,J.
  TITLE     The reg4 gene, amplified in the early stages of pancreatic cancer
            development, is a promising therapeutic target
  JOURNAL   PLoS One 4 (10), e7495 (2009)
   PUBMED   19834624
  REMARK    GeneRIF: reg4 is amplified in the early stages of pancreatic cancer
            development
            Publication Status: Online-Only
REFERENCE   9  (bases 1 to 1021)
  AUTHORS   Okubo,T. and Hogan,B.L.
  TITLE     Hyperactive Wnt signaling changes the developmental potential of
            embryonic lung endoderm
  JOURNAL   J Biol 3 (3), 11 (2004)
   PUBMED   15186480
REFERENCE   10 (bases 1 to 1021)
  AUTHORS   Kamarainen,M., Heiskala,K., Knuutila,S., Heiskala,M., Winqvist,O.
            and Andersson,L.C.
  TITLE     RELP, a novel human REG-like protein with up-regulated expression
            in inflammatory and metaplastic gastrointestinal mucosa
  JOURNAL   Am J Pathol 163 (1), 11-20 (2003)
   PUBMED   12819006
  REMARK    GeneRIF: Cloning and characterization of human REG4/RELP, in
            addition to cloning of mouse Reg4.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK162316.1 and AC121771.3.
            
            On Jul 2, 2009 this sequence version replaced NM_026328.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK162316.1, AK008049.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849377, SAMN00849378
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1014              AK162316.1         2-1015
            1015-1021           AC121771.3         136995-137001
FEATURES             Location/Qualifiers
     source          1..1021
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 42.73 cM"
     gene            1..1021
                     /gene="Reg4"
                     /gene_synonym="2010002L15Rik; GISP; RELP"
                     /note="regenerating islet-derived family, member 4"
                     /db_xref="GeneID:67709"
                     /db_xref="MGI:MGI:1914959"
     exon            1..47
                     /gene="Reg4"
                     /gene_synonym="2010002L15Rik; GISP; RELP"
                     /inference="alignment:Splign:2.1.0"
     exon            48..231
                     /gene="Reg4"
                     /gene_synonym="2010002L15Rik; GISP; RELP"
                     /inference="alignment:Splign:2.1.0"
     CDS             165..638
                     /gene="Reg4"
                     /gene_synonym="2010002L15Rik; GISP; RELP"
                     /note="regenerating islet-derived protein 4; REG-4"
                     /codon_start=1
                     /product="regenerating islet-derived protein 4 precursor"
                     /protein_id="NP_080604.2"
                     /db_xref="CCDS:CCDS17661.1"
                     /db_xref="GeneID:67709"
                     /db_xref="MGI:MGI:1914959"
                     /translation="MASKGVRLLLLLSWVAGPEVLSDILRPSCAPGWFYYRSHCYGYF
                     RKLRNWSHAELECQSYGNGSHLASVLNQKEASVISKYITGYQRNLPVWIGLHDPQKKQ
                     LWQWTDGSTNLYRRWNPRTKSEARHCAEMNPKDKFLTWNKNGCANRQHFLCKYKT"
     exon            232..326
                     /gene="Reg4"
                     /gene_synonym="2010002L15Rik; GISP; RELP"
                     /inference="alignment:Splign:2.1.0"
     exon            327..464
                     /gene="Reg4"
                     /gene_synonym="2010002L15Rik; GISP; RELP"
                     /inference="alignment:Splign:2.1.0"
     exon            465..570
                     /gene="Reg4"
                     /gene_synonym="2010002L15Rik; GISP; RELP"
                     /inference="alignment:Splign:2.1.0"
     exon            571..1021
                     /gene="Reg4"
                     /gene_synonym="2010002L15Rik; GISP; RELP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      995..1000
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Reg4"
                     /gene_synonym="2010002L15Rik; GISP; RELP"
                     /note="hexamer: AGTAAA"
     polyA_site      1017
                     /gene="Reg4"
                     /gene_synonym="2010002L15Rik; GISP; RELP"
                     /note="major polyA site"
ORIGIN      
        1 actcaagctg aagaaggcag ggttctcgga gtgttgcttc caatcagatt gcaggtctag
       61 gagaatccag aaaaaagaga agaaaagaaa agaaaaaaac tggaacgggc tctgagggcc
      121 ttgaaatcaa agcattgaag tatcatctcc atcgaaagag gaagatggct tccaaaggcg
      181 tgcggctact cttactgctg agctgggtag ctggccccga agtcctgagc gatatcttga
      241 gacccagctg tgccccagga tggttttact ataggtccca ctgctatggg tacttccgga
      301 agctaagaaa ctggtctcat gctgagctgg agtgtcagtc atatggaaat ggatcccatc
      361 tggcatctgt cttgaatcaa aaggaagcca gtgtcatatc aaagtacata actggctatc
      421 agagaaacct gcctgtgtgg attggcctgc atgacccaca aaagaagcaa ttatggcagt
      481 ggactgatgg gtctacaaac ctgtacagac gctggaatcc caggacaaag agtgaagcca
      541 ggcattgcgc tgagatgaac cccaaggata aattcttaac ttggaacaaa aatggatgtg
      601 ccaaccgcca acacttcctg tgcaagtata agacatagag caaaaatcaa gcgtctacca
      661 gccttgcaca aactcttccc acttccctct cacctggtgg ctgatctaat cattatccca
      721 gagtaaacac tgtagcaaac attgaggagg cctccagggc actggctatc aagccctgct
      781 tagcatggtg ggacagtggc ttccggtctc agagtttagc atggtgggac ggtgacttcc
      841 ggtctcagag attagcatgg tgggacaagg gcttctggtc tccgtgttca ctctacaatc
      901 ctttctggta ctccccttcc ctctcattgt cttaaacagc aatgcttaac aagctagaaa
      961 tgtgctttct tgactactgc gtctctgtca aaccagtaaa gttttggagc caagaaacag
     1021 c
//
