LOCUS       NM_011260                790 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus regenerating islet-derived 3 gamma (Reg3g), mRNA.
ACCESSION   NM_011260
VERSION     NM_011260.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 790)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 790)
  AUTHORS   Chakraborty,D., Coslo,D.M., Murray,I.A., Vijay,A., Patterson,A.D.
            and Perdew,G.H.
  TITLE     Immune cell-intrinsic Ah receptor facilitates the expression of
            antimicrobial REG3G in the small intestine
  JOURNAL   FASEB J 38 (4), e23471 (2024)
   PUBMED   38358358
  REMARK    GeneRIF: Immune cell-intrinsic Ah receptor facilitates the
            expression of antimicrobial REG3G in the small intestine.
REFERENCE   3  (bases 1 to 790)
  AUTHORS   Yan,W., Chen,S., Wang,Y., You,Y., Lu,Y., Wang,W., Wu,B., Du,J.,
            Peng,S., Cai,W. and Xiao,Y.
  TITLE     Loss of Mptx2 alters bacteria composition and intestinal
            homeostasis potentially by impairing autophagy
  JOURNAL   Commun Biol 7 (1), 94 (2024)
   PUBMED   38218976
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 790)
  AUTHORS   Shin,J.H., Bozadjieva-Kramer,N. and Seeley,R.J.
  TITLE     Reg3gamma: current understanding and future therapeutic
            opportunities in metabolic disease
  JOURNAL   Exp Mol Med 55 (8), 1672-1677 (2023)
   PUBMED   37524871
  REMARK    GeneRIF: Reg3gamma: current understanding and future therapeutic
            opportunities in metabolic disease.
            Review article
REFERENCE   5  (bases 1 to 790)
  AUTHORS   Mukherjee,S., Partch,C.L., Lehotzky,R.E., Whitham,C.V., Chu,H.,
            Bevins,C.L., Gardner,K.H. and Hooper,L.V.
  TITLE     Regulation of C-type lectin antimicrobial activity by a flexible
            N-terminal prosegment
  JOURNAL   J Biol Chem 284 (8), 4881-4888 (2009)
   PUBMED   19095652
  REMARK    GeneRIF: antibacterial activities of mouse RegIIIgamma and its
            human ortholog, HIP/PAP, are tightly controlled by an inhibitory
            N-terminal prosegment that is removed by trypsin in vivo.
REFERENCE   6  (bases 1 to 790)
  AUTHORS   Yang,X.Y., Yang,T.T., Schubert,W., Factor,S.M. and Chow,C.W.
  TITLE     Dosage-dependent transcriptional regulation by the calcineurin/NFAT
            signaling in developing myocardium transition
  JOURNAL   Dev Biol 303 (2), 825-837 (2007)
   PUBMED   17198697
REFERENCE   7  (bases 1 to 790)
  AUTHORS   Cash,H.L., Whitham,C.V., Behrendt,C.L. and Hooper,L.V.
  TITLE     Symbiotic bacteria direct expression of an intestinal bactericidal
            lectin
  JOURNAL   Science 313 (5790), 1126-1130 (2006)
   PUBMED   16931762
  REMARK    GeneRIF: findings show that RegIIIgamma and its human counterpart,
            HIP/PAP, are directly antimicrobial proteins that bind their
            bacterial targets via interactions with peptidoglycan carbohydrate
REFERENCE   8  (bases 1 to 790)
  AUTHORS   Jensen,P., Magdaleno,S., Lehman,K.M., Rice,D.S., Lavallie,E.R.,
            Collins-Racie,L., McCoy,J.M. and Curran,T.
  TITLE     A neurogenomics approach to gene expression analysis in the
            developing brain
  JOURNAL   Brain Res Mol Brain Res 132 (2), 116-127 (2004)
   PUBMED   15582152
REFERENCE   9  (bases 1 to 790)
  AUTHORS   Abe,M., Nata,K., Akiyama,T., Shervani,N.J., Kobayashi,S.,
            Tomioka-Kumagai,T., Ito,S., Takasawa,S. and Okamoto,H.
  TITLE     Identification of a novel Reg family gene, Reg IIIdelta, and
            mapping of all three types of Reg family gene in a 75 kilobase
            mouse genomic region
  JOURNAL   Gene 246 (1-2), 111-122 (2000)
   PUBMED   10767532
REFERENCE   10 (bases 1 to 790)
  AUTHORS   Narushima,Y., Unno,M., Nakagawara,K., Mori,M., Miyashita,H.,
            Suzuki,Y., Noguchi,N., Takasawa,S., Kumagai,T., Yonekura,H. and
            Okamoto,H.
  TITLE     Structure, chromosomal localization and expression of mouse genes
            encoding type III Reg, RegIII alpha, RegIII beta, RegIII gamma
  JOURNAL   Gene 185 (2), 159-168 (1997)
   PUBMED   9055810
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from D63361.1 and BF020649.1.
            
            On Jul 2, 2016 this sequence version replaced NM_011260.1.
            
            Summary: This gene encodes a C-type lectin that demonstrates
            bactericidal activity. This gene is predominantly expressed in the
            distal small intestine where the encoded protein undergoes
            proteolytic processing by trypsin. Mice lacking the encoded protein
            exhibit altered mucus distribution, increased bacterial contact
            with the epithelium, and elevated inflammatory markers in the
            ileum, and low-grade inflammation. [provided by RefSeq, Jun 2016].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC061139.1, AK008446.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-772               D63361.1           1-772
            773-790             BF020649.1         1-18                c
FEATURES             Location/Qualifiers
     source          1..790
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 34.78 cM"
     gene            1..790
                     /gene="Reg3g"
                     /gene_synonym="reg III-gamma; REG-3-gamma"
                     /note="regenerating islet-derived 3 gamma"
                     /db_xref="GeneID:19695"
                     /db_xref="MGI:MGI:109406"
     exon            1..27
                     /gene="Reg3g"
                     /gene_synonym="reg III-gamma; REG-3-gamma"
                     /inference="alignment:Splign:2.1.0"
     exon            28..108
                     /gene="Reg3g"
                     /gene_synonym="reg III-gamma; REG-3-gamma"
                     /inference="alignment:Splign:2.1.0"
     exon            109..227
                     /gene="Reg3g"
                     /gene_synonym="reg III-gamma; REG-3-gamma"
                     /inference="alignment:Splign:2.1.0"
     exon            228..365
                     /gene="Reg3g"
                     /gene_synonym="reg III-gamma; REG-3-gamma"
                     /inference="alignment:Splign:2.1.0"
     exon            366..489
                     /gene="Reg3g"
                     /gene_synonym="reg III-gamma; REG-3-gamma"
                     /inference="alignment:Splign:2.1.0"
     exon            490..773
                     /gene="Reg3g"
                     /gene_synonym="reg III-gamma; REG-3-gamma"
                     /inference="alignment:Splign:2.1.0"
     regulatory      750..755
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Reg3g"
                     /gene_synonym="reg III-gamma; REG-3-gamma"
                     /note="hexamer: ATTAAA"
     polyA_site      773
                     /gene="Reg3g"
                     /gene_synonym="reg III-gamma; REG-3-gamma"
                     /note="major polyA site"
ORIGIN      
        1 acaccatcct agggatctgc aagacagaca agatgcttcc ccgtataacc atcaccatca
       61 tgtcctggat gctgctctcc tgcctgatgc tcctttctca ggtgcaaggt gaagttgcca
      121 agaaagatgc cccatcttca cgtagcagct gccccaaggg ctcccgtgcc tatggctcct
      181 attgctatgc cttgtttagt gtatctaaaa actggtatga tgcagatatg gcctgccaaa
      241 agaggccctc aggacatctt gtgtctgtgc tcagtggcgc tgaagcttcc ttcctgtcct
      301 ccatgatcaa aagcagtggt aacagtggcc aatatgtatg gattgggctc catgacccga
      361 cactgggcta tgaacccaac agaggtggat gggagtggag caatgctgat gtgatgaatt
      421 acatcaactg ggagacgaat ccttcctctt cctcaggcaa tcactgtggt accctgtcaa
      481 gagcctcagg atttctgaag tggagagaga attattgtaa cttagagtta ccctatgtct
      541 gcaaattcaa ggcctagagt acagaattga catcatgggt tgatatatac ctagccacaa
      601 gcaagatccc aaatgtgaag acagatgaaa aagggaacat tctccccaca atcgaaatct
      661 gacctcctga ttttctcctt ctctggccct tccctcctct catttgagga actctgtgtg
      721 cactatggcc ttaattctca aagcataata ttaaagtata taactcatgc tcaaaaaaaa
      781 aaaaaaaaaa
//
