LOCUS       NM_013893                782 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus regenerating islet-derived 3 delta (Reg3d), transcript
            variant 1, mRNA.
ACCESSION   NM_013893
VERSION     NM_013893.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 782)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 782)
  AUTHORS   Ansarullah, Jain,C., Far,F.F., Homberg,S., Wissmiller,K., von
            Hahn,F.G., Raducanu,A., Schirge,S., Sterr,M., Bilekova,S.,
            Siehler,J., Wiener,J., Oppenlander,L., Morshedi,A.,
            Bastidas-Ponce,A., Collden,G., Irmler,M., Beckers,J.,
            Feuchtinger,A., Grzybek,M., Ahlbrecht,C., Feederle,R.,
            Plettenburg,O., Muller,T.D., Meier,M., Tschop,M.H., Coskun,U. and
            Lickert,H.
  TITLE     Inceptor counteracts insulin signalling in beta-cells to control
            glycaemia
  JOURNAL   Nature 590 (7845), 326-331 (2021)
   PUBMED   33505018
  REMARK    Erratum:[Nature. 2021 Apr;592(7852):E1. PMID: 33712809]
REFERENCE   3  (bases 1 to 782)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 782)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. PMID: 29144450]
REFERENCE   5  (bases 1 to 782)
  AUTHORS   Tuck,E., Estabel,J., Oellrich,A., Maguire,A.K., Adissu,H.A.,
            Souter,L., Siragher,E., Lillistone,C., Green,A.L., Wardle-Jones,H.,
            Carragher,D.M., Karp,N.A., Smedley,D., Adams,N.C., Bussell,J.N.,
            Adams,D.J., Ramirez-Solis,R., Steel,K.P., Galli,A. and White,J.K.
  CONSRTM   Sanger Institute Mouse Genetics Project
  TITLE     A gene expression resource generated by genome-wide lacZ profiling
            in the mouse
  JOURNAL   Dis Model Mech 8 (11), 1467-1478 (2015)
   PUBMED   26398943
REFERENCE   6  (bases 1 to 782)
  AUTHORS   Chang,T.J., Weaver,J.R., Bowman,A., Leone,K., Raab,R., Vinik,A.I.,
            Pittenger,G.L. and Taylor-Fishwick,D.A.
  TITLE     Targeted expression of islet neogenesis associated protein to beta
            cells enhances glucose tolerance and confers resistance to
            streptozotocin-induced hyperglycemia
  JOURNAL   Mol Cell Endocrinol 335 (2), 104-109 (2011)
   PUBMED   21187123
REFERENCE   7  (bases 1 to 782)
  AUTHORS   Taylor-Fishwick,D.A., Bowman,A., Korngiebel-Rosique,M. and
            Vinik,A.I.
  TITLE     Pancreatic islet immunoreactivity to the Reg protein INGAP
  JOURNAL   J Histochem Cytochem 56 (2), 183-191 (2008)
   PUBMED   17998566
  REMARK    GeneRIF: Immunoreactivity to INGAP localized to the pancreatic
            endocrine cells in mouse. INGAP and/or related group 3 Reg proteins
            have a conserved expression in the pancreatic islet.
REFERENCE   8  (bases 1 to 782)
  AUTHORS   Hamblet,N.S., Shi,W., Vinik,A.I. and Taylor-Fishwick,D.A.
  TITLE     The Reg family member INGAP is a marker of endocrine patterning in
            the embryonic pancreas
  JOURNAL   Pancreas 36 (1), 1-9 (2008)
   PUBMED   18192873
REFERENCE   9  (bases 1 to 782)
  AUTHORS   Abe,M., Nata,K., Akiyama,T., Shervani,N.J., Kobayashi,S.,
            Tomioka-Kumagai,T., Ito,S., Takasawa,S. and Okamoto,H.
  TITLE     Identification of a novel Reg family gene, Reg IIIdelta, and
            mapping of all three types of Reg family gene in a 75 kilobase
            mouse genomic region
  JOURNAL   Gene 246 (1-2), 111-122 (2000)
   PUBMED   10767532
REFERENCE   10 (bases 1 to 782)
  AUTHORS   Sasahara,K., Yamaoka,T., Moritani,M., Yoshimoto,K., Kuroda,Y. and
            Itakura,M.
  TITLE     Molecular cloning and tissue-specific expression of a new member of
            the regenerating protein family, islet neogenesis-associated
            protein-related protein
  JOURNAL   Biochim Biophys Acta 1500 (1), 142-146 (2000)
   PUBMED   10564727
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AI594831.1 and AB035204.1.
            
            On Jun 13, 2009 this sequence version replaced NM_013893.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB028625.1, AK019033.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849377, SAMN00849378
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-20                AI594831.1         1-20
            21-782              AB035204.1         1-762
FEATURES             Location/Qualifiers
     source          1..782
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 34.76 cM"
     gene            1..782
                     /gene="Reg3d"
                     /gene_synonym="INGAP; Ingaprp"
                     /note="regenerating islet-derived 3 delta"
                     /db_xref="GeneID:30053"
                     /db_xref="MGI:MGI:1353426"
     exon            1..50
                     /gene="Reg3d"
                     /gene_synonym="INGAP; Ingaprp"
                     /inference="alignment:Splign:2.1.0"
     exon            51..133
                     /gene="Reg3d"
                     /gene_synonym="INGAP; Ingaprp"
                     /inference="alignment:Splign:2.1.0"
     CDS             58..585
                     /gene="Reg3d"
                     /gene_synonym="INGAP; Ingaprp"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; islet neogenesis associated protein-related
                     protein; Reg III delta"
                     /codon_start=1
                     /product="regenerating islet-derived 3 delta isoform 1
                     precursor"
                     /protein_id="NP_038921.2"
                     /db_xref="CCDS:CCDS20254.1"
                     /db_xref="GeneID:30053"
                     /db_xref="MGI:MGI:1353426"
                     /translation="MVSHKTLHSMSWMLLCCLMSLSWVQGEQSQKKLSSPRISCPQEA
                     QAYGSYCYLLILEPQTWANAEIHCQKHFSGHLAFLLTYGEIIFVSSLVKNSLTTFPYI
                     WIGLHDLSLGSLPNENGWKWSSSDPLTFYNWEIPPSMSAHHGYCAALSQASGYQKWRD
                     YYCDTIFPYVCKFKG"
     exon            134..252
                     /gene="Reg3d"
                     /gene_synonym="INGAP; Ingaprp"
                     /inference="alignment:Splign:2.1.0"
     exon            253..390
                     /gene="Reg3d"
                     /gene_synonym="INGAP; Ingaprp"
                     /inference="alignment:Splign:2.1.0"
     exon            391..517
                     /gene="Reg3d"
                     /gene_synonym="INGAP; Ingaprp"
                     /inference="alignment:Splign:2.1.0"
     exon            518..782
                     /gene="Reg3d"
                     /gene_synonym="INGAP; Ingaprp"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtgaaatcac ctctgtgctg tcaaagcatt gcagacctct gtatagacag atataccatg
       61 gtgtctcaca agacccttca tagcatgtcc tggatgctac tgtgttgcct gatgtccctt
      121 tcttgggtac aaggtgaaca atcccagaaa aaactgtctt ctccacgcat cagctgtccc
      181 caagaagccc aagcttatgg ctcctattgc tatttactga ttctggaacc acagacctgg
      241 gctaatgcag agatccactg ccagaagcat ttctcaggac acctggcatt tctgctcact
      301 tatggtgaaa ttatctttgt gtcctctctg gtgaaaaaca gtttgaccac attcccatac
      361 atctggattg gactccatga tctgtcactt gggagtttgc ccaatgaaaa tggatggaag
      421 tggagcagct ctgaccctct gaccttctat aactgggaga taccaccctc catgtctgca
      481 caccacggct actgtgcagc tttgtctcag gcctcaggtt atcagaagtg gagagattat
      541 tattgtgaca caatatttcc ctatgtctgc aaattcaagg gttaggccag ttctgatttc
      601 aactgcctga aagtatcctg aagatcacat agacaaagga gcaagcatga tggctcacca
      661 agaaagtcct tctcacaccc cgacaccgaa ttcctcatct catctctgct gttcttccat
      721 aagtgtattc tctggggact ctggcctaag gattcggaga acaataataa aatttagtca
      781 at
//
