LOCUS       NM_011036                759 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Mus musculus regenerating islet-derived 3 beta (Reg3b), mRNA.
ACCESSION   NM_011036
VERSION     NM_011036.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 759)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 759)
  AUTHORS   McMahan,R.H., Hulsebus,H.J., Najarro,K.M., Giesy,L.E., Frank,D.N.
            and Kovacs,E.J.
  TITLE     Changes in gut microbiome correlate with intestinal barrier
            dysfunction and inflammation following a 3-day ethanol exposure in
            aged mice
  JOURNAL   Alcohol 107, 136-143 (2023)
   PUBMED   36150609
  REMARK    GeneRIF: Changes in gut microbiome correlate with intestinal
            barrier dysfunction and inflammation following a 3-day ethanol
            exposure in aged mice.
REFERENCE   3  (bases 1 to 759)
  AUTHORS   Yu,Y., Zhang,B., Ji,P., Zuo,Z., Huang,Y., Wang,N., Liu,C., Liu,S.J.
            and Zhao,F.
  TITLE     Changes to gut amino acid transporters and microbiome associated
            with increased E/I ratio in Chd8+/- mouse model of ASD-like
            behavior
  JOURNAL   Nat Commun 13 (1), 1151 (2022)
   PUBMED   35241668
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 759)
  AUTHORS   Zhang,H., Corredor,A.L.G., Messina-Pacheco,J., Li,Q.,
            Zogopoulos,G., Kaddour,N., Wang,Y., Shi,B.Y., Gregorieff,A.,
            Liu,J.L. and Gao,Z.H.
  TITLE     REG3A/REG3B promotes acinar to ductal metaplasia through binding to
            EXTL3 and activating the RAS-RAF-MEK-ERK signaling pathway
  JOURNAL   Commun Biol 4 (1), 688 (2021)
   PUBMED   34099862
  REMARK    GeneRIF: REG3A/REG3B promotes acinar to ductal metaplasia through
            binding to EXTL3 and activating the RAS-RAF-MEK-ERK signaling
            pathway.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 759)
  AUTHORS   Ansarullah, Jain,C., Far,F.F., Homberg,S., Wissmiller,K., von
            Hahn,F.G., Raducanu,A., Schirge,S., Sterr,M., Bilekova,S.,
            Siehler,J., Wiener,J., Oppenlander,L., Morshedi,A.,
            Bastidas-Ponce,A., Collden,G., Irmler,M., Beckers,J.,
            Feuchtinger,A., Grzybek,M., Ahlbrecht,C., Feederle,R.,
            Plettenburg,O., Muller,T.D., Meier,M., Tschop,M.H., Coskun,U. and
            Lickert,H.
  TITLE     Inceptor counteracts insulin signalling in beta-cells to control
            glycaemia
  JOURNAL   Nature 590 (7845), 326-331 (2021)
   PUBMED   33505018
  REMARK    Erratum:[Nature. 2021 Apr;592(7852):E1. doi:
            10.1038/s41586-021-03347-z.. PMID: 33712809]
REFERENCE   6  (bases 1 to 759)
  AUTHORS   Lasserre,C., Colnot,C., Brechot,C. and Poirier,F.
  TITLE     HIP/PAP gene, encoding a C-type lectin overexpressed in primary
            liver cancer, is expressed in nervous system as well as in
            intestine and pancreas of the postimplantation mouse embryo
  JOURNAL   Am J Pathol 154 (5), 1601-1610 (1999)
   PUBMED   10329612
REFERENCE   7  (bases 1 to 759)
  AUTHORS   Narushima,Y., Unno,M., Nakagawara,K., Mori,M., Miyashita,H.,
            Suzuki,Y., Noguchi,N., Takasawa,S., Kumagai,T., Yonekura,H. and
            Okamoto,H.
  TITLE     Structure, chromosomal localization and expression of mouse genes
            encoding type III Reg, RegIII alpha, RegIII beta, RegIII gamma
  JOURNAL   Gene 185 (2), 159-168 (1997)
   PUBMED   9055810
REFERENCE   8  (bases 1 to 759)
  AUTHORS   McKie,A.T., Simpson,R.J., Ghosh,S., Peters,T.J. and Farzaneh,F.
  TITLE     Regulation of pancreatitis-associated protein (HIP/PAP) mRNA levels
            in mouse pancreas and small intestine
  JOURNAL   Clin Sci (Lond) 91 (2), 213-218 (1996)
   PUBMED   8795446
REFERENCE   9  (bases 1 to 759)
  AUTHORS   Lasserre,C., Simon,M.T., Ishikawa,H., Diriong,S., Nguyen,V.C.,
            Christa,L., Vernier,P. and Brechot,C.
  TITLE     Structural organization and chromosomal localization of a human
            gene (HIP/PAP) encoding a C-type lectin overexpressed in primary
            liver cancer
  JOURNAL   Eur J Biochem 224 (1), 29-38 (1994)
   PUBMED   8076648
REFERENCE   10 (bases 1 to 759)
  AUTHORS   Itoh,T. and Teraoka,H.
  TITLE     Cloning and tissue-specific expression of cDNAs for the human and
            mouse homologues of rat pancreatitis-associated protein (PAP)
  JOURNAL   Biochim Biophys Acta 1172 (1-2), 184-186 (1993)
   PUBMED   7679928
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            D63359.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC027525.1, BX515246.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849377, SAMN00849378
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..759
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 34.76 cM"
     gene            1..759
                     /gene="Reg3b"
                     /gene_synonym="HIP; Pap; PAP1; REG-III"
                     /note="regenerating islet-derived 3 beta"
                     /db_xref="GeneID:18489"
                     /db_xref="MGI:MGI:97478"
     exon            1..26
                     /gene="Reg3b"
                     /gene_synonym="HIP; Pap; PAP1; REG-III"
                     /inference="alignment:Splign:2.1.0"
     exon            27..107
                     /gene="Reg3b"
                     /gene_synonym="HIP; Pap; PAP1; REG-III"
                     /inference="alignment:Splign:2.1.0"
     CDS             32..559
                     /gene="Reg3b"
                     /gene_synonym="HIP; Pap; PAP1; REG-III"
                     /note="regenerating islet-derived protein 3-beta;
                     REG-3-beta; reg III-beta; pancreatitis-associated protein
                     1; regenerating islet-derived protein III-beta; RegIII
                     (beta)"
                     /codon_start=1
                     /product="regenerating islet-derived protein 3-beta
                     precursor"
                     /protein_id="NP_035166.1"
                     /db_xref="CCDS:CCDS20253.1"
                     /db_xref="GeneID:18489"
                     /db_xref="MGI:MGI:97478"
                     /translation="MLPPTACSVMSWMLLSCLMLLSQVQGEDSLKNIPSARISCPKGS
                     QAYGSYCYALFQIPQTWFDAELACQKRPGGHLVSVLNSAEASFLSSMVKRTGNSYQYT
                     WIGLHDPTLGAEPNGGGWEWSNNDVMNYFNWERNPSTALDRAFCGSLSRASGFLKWRD
                     MTCEVKLPYVCKFTG"
     exon            108..226
                     /gene="Reg3b"
                     /gene_synonym="HIP; Pap; PAP1; REG-III"
                     /inference="alignment:Splign:2.1.0"
     exon            227..364
                     /gene="Reg3b"
                     /gene_synonym="HIP; Pap; PAP1; REG-III"
                     /inference="alignment:Splign:2.1.0"
     exon            365..491
                     /gene="Reg3b"
                     /gene_synonym="HIP; Pap; PAP1; REG-III"
                     /inference="alignment:Splign:2.1.0"
     exon            492..759
                     /gene="Reg3b"
                     /gene_synonym="HIP; Pap; PAP1; REG-III"
                     /inference="alignment:Splign:2.1.0"
     regulatory      736..741
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Reg3b"
                     /gene_synonym="HIP; Pap; PAP1; REG-III"
                     /note="hexamer: AATAAA"
     polyA_site      759
                     /gene="Reg3b"
                     /gene_synonym="HIP; Pap; PAP1; REG-III"
                     /note="major polyA site"
ORIGIN      
        1 acaccatcca gatctctgga agacagacaa gatgctgcct ccaacagcct gctccgtcat
       61 gtcctggatg ctgctctcct gcctgatgct cttatctcag gttcaaggtg aagactccct
      121 gaagaatata ccctccgcac gcattagttg ccccaagggc tcccaggctt atggctccta
      181 ctgctatgcc ttgtttcaga taccacagac ctggtttgat gcagaactgg cctgccaaaa
      241 gaggcctgga ggacacctcg tatctgtgct caatagcgct gaggcttcat tcttgtcctc
      301 catggtgaag agaacaggaa acagctacca atacacttgg attgggctcc atgaccccac
      361 tctgggtgca gaacccaatg gaggtggatg ggaatggagt aacaatgacg tgatgaatta
      421 ctttaactgg gagaggaacc catctactgc cttagaccgt gctttctgtg gcagcttgtc
      481 aagagcttct ggatttctaa aatggagaga tatgacatgt gaggtgaagt tgccctatgt
      541 ctgcaaattt actggttaaa cttatcagac agcaaacatc ccgaatttgt cttgaagagc
      601 atcatggaca agggacaaaa tgtgaagact cacctagaaa aagcattttc tatctacagt
      661 ccacattaga gccttaatct gctctttcca tatctgtctt tagtcctttt ggtataagtt
      721 tgggctcaat tctaaaataa aaataagctt tctgtcaca
//
