LOCUS       NM_011259                837 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Mus musculus regenerating islet-derived 3 alpha (Reg3a), mRNA.
ACCESSION   NM_011259
VERSION     NM_011259.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 837)
  AUTHORS   Yu,Y., Zhang,B., Ji,P., Zuo,Z., Huang,Y., Wang,N., Liu,C., Liu,S.J.
            and Zhao,F.
  TITLE     Changes to gut amino acid transporters and microbiome associated
            with increased E/I ratio in Chd8+/- mouse model of ASD-like
            behavior
  JOURNAL   Nat Commun 13 (1), 1151 (2022)
   PUBMED   35241668
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 837)
  AUTHORS   Ansarullah, Jain,C., Far,F.F., Homberg,S., Wissmiller,K., von
            Hahn,F.G., Raducanu,A., Schirge,S., Sterr,M., Bilekova,S.,
            Siehler,J., Wiener,J., Oppenlander,L., Morshedi,A.,
            Bastidas-Ponce,A., Collden,G., Irmler,M., Beckers,J.,
            Feuchtinger,A., Grzybek,M., Ahlbrecht,C., Feederle,R.,
            Plettenburg,O., Muller,T.D., Meier,M., Tschop,M.H., Coskun,U. and
            Lickert,H.
  TITLE     Inceptor counteracts insulin signalling in beta-cells to control
            glycaemia
  JOURNAL   Nature 590 (7845), 326-331 (2021)
   PUBMED   33505018
  REMARK    Erratum:[Nature. 2021 Apr;592(7852):E1. doi:
            10.1038/s41586-021-03347-z.. PMID: 33712809]
REFERENCE   3  (bases 1 to 837)
  AUTHORS   Jiang,Z., Liu,Y., Li,C., Chang,L., Wang,W., Wang,Z., Gao,X.,
            Ryffel,B., Wu,Y. and Lai,Y.
  TITLE     IL-36gamma Induced by the TLR3-SLUG-VDR Axis Promotes Wound Healing
            via REG3A
  JOURNAL   J Invest Dermatol 137 (12), 2620-2629 (2017)
   PUBMED   28774595
  REMARK    GeneRIF: skin injury increases IL-36gamma via the activation of
            TLR3-SLUG-VDR axis and IL-36gamma induces REG3A to promote wound
            healing
REFERENCE   4  (bases 1 to 837)
  AUTHORS   Yu,L.T., Yang,M.Q., Liu,J.L., Alfred,M.O., Li,X., Zhang,X.Q.,
            Zhang,J., Wu,M.Y., Wang,M. and Luo,C.
  TITLE     Recombinant Reg3alpha protein protects against experimental acute
            pancreatitis in mice
  JOURNAL   Mol Cell Endocrinol 422, 150-159 (2016)
   PUBMED   26683606
REFERENCE   5  (bases 1 to 837)
  AUTHORS   Moniaux,N., Darnaud,M., Garbin,K., Dos Santos,A., Guettier,C.,
            Samuel,D., Amouyal,G., Amouyal,P., Brechot,C. and Faivre,J.
  TITLE     The Reg3alpha (HIP/PAP) Lectin Suppresses Extracellular Oxidative
            Stress in a Murine Model of Acute Liver Failure
  JOURNAL   PLoS One 10 (5), e0125584 (2015)
   PUBMED   25938566
  REMARK    GeneRIF: Reg3alpha is an extracellular matrix-targeted reactive
            oxygen species scavenger that binds the fibrin scaffold resulting
            from hepatocyte death during acute liver failure.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 837)
  AUTHORS   Wang,Y., Jacovetti,C., Li,B., Siddique,T., Xiong,X., Yin,H.,
            Wang,M., Zhao,H. and Liu,J.L.
  TITLE     Coordinated age-dependent and pancreatic-specific expression of
            mouse Reg2Reg3alpha, and Reg3beta genes
  JOURNAL   Growth Factors 29 (2-3), 72-81 (2011)
   PUBMED   21410322
  REMARK    GeneRIF: Reg2, Reg3alpha, and Reg3beta were abundantly expressed in
            most acinar cells of the pancreas with clear age-dependent and
            isoform-specific patterns.
REFERENCE   7  (bases 1 to 837)
  AUTHORS   Cui,W., De Jesus,K., Zhao,H., Takasawa,S., Shi,B., Srikant,C.B. and
            Liu,J.L.
  TITLE     Overexpression of Reg3alpha increases cell growth and the levels of
            cyclin D1 and CDK4 in insulinoma cells
  JOURNAL   Growth Factors 27 (3), 195-202 (2009)
   PUBMED   19343564
  REMARK    GeneRIF: Reg3alpha stimulates beta-cell replication, by activating
            Akt kinase and increasing the levels of cyclin D1/CDK4.
REFERENCE   8  (bases 1 to 837)
  AUTHORS   Joglekar,M.V., Parekh,V.S., Mehta,S., Bhonde,R.R. and Hardikar,A.A.
  TITLE     MicroRNA profiling of developing and regenerating pancreas reveal
            post-transcriptional regulation of neurogenin3
  JOURNAL   Dev Biol 311 (2), 603-612 (2007)
   PUBMED   17936263
REFERENCE   9  (bases 1 to 837)
  AUTHORS   Abe,M., Nata,K., Akiyama,T., Shervani,N.J., Kobayashi,S.,
            Tomioka-Kumagai,T., Ito,S., Takasawa,S. and Okamoto,H.
  TITLE     Identification of a novel Reg family gene, Reg IIIdelta, and
            mapping of all three types of Reg family gene in a 75 kilobase
            mouse genomic region
  JOURNAL   Gene 246 (1-2), 111-122 (2000)
   PUBMED   10767532
REFERENCE   10 (bases 1 to 837)
  AUTHORS   Narushima,Y., Unno,M., Nakagawara,K., Mori,M., Miyashita,H.,
            Suzuki,Y., Noguchi,N., Takasawa,S., Kumagai,T., Yonekura,H. and
            Okamoto,H.
  TITLE     Structure, chromosomal localization and expression of mouse genes
            encoding type III Reg, RegIII alpha, RegIII beta, RegIII gamma
  JOURNAL   Gene 185 (2), 159-168 (1997)
   PUBMED   9055810
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from D63358.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC119153.1, SRR5189685.170360.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849377, SAMN00849378
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..837
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 34.76 cM"
     gene            1..837
                     /gene="Reg3a"
                     /note="regenerating islet-derived 3 alpha"
                     /db_xref="GeneID:19694"
                     /db_xref="MGI:MGI:109408"
     exon            1..73
                     /gene="Reg3a"
                     /inference="alignment:Splign:2.1.0"
     exon            74..154
                     /gene="Reg3a"
                     /inference="alignment:Splign:2.1.0"
     CDS             79..606
                     /gene="Reg3a"
                     /note="generating islet-derived, mouse homolog 3 alpha;
                     regenerating islet-derived protein 3-alpha; REG-3-alpha;
                     reg III-alpha; lithostathine 3; pancreatitis-associated
                     protein 2; islet of Langerhans regenerating protein 3;
                     regenerating islet-derived protein III-alpha; RegIII
                     (alpha)"
                     /codon_start=1
                     /product="regenerating islet-derived protein 3-alpha
                     precursor"
                     /protein_id="NP_035389.1"
                     /db_xref="CCDS:CCDS20255.1"
                     /db_xref="GeneID:19694"
                     /db_xref="MGI:MGI:109408"
                     /translation="MLPHLVLNSISWMLLSCLLFVFQVQGEDFQKEVPSPRTSCPMGY
                     KAYRSHCYALVMTPKSWFQADLVCQKRPSGHLVSILSGGEASFVSSLVNGRVDNYQDI
                     WIGLHDPTMGQQPNGGGWEWSNSDVLNYLNWDGDPSSTVNRGHCGSLTASSGFLKWGD
                     YYCDGTLPFVCKFKQ"
     exon            155..273
                     /gene="Reg3a"
                     /inference="alignment:Splign:2.1.0"
     exon            274..411
                     /gene="Reg3a"
                     /inference="alignment:Splign:2.1.0"
     exon            412..538
                     /gene="Reg3a"
                     /inference="alignment:Splign:2.1.0"
     exon            539..837
                     /gene="Reg3a"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcccttcctt caaatcctat cataaagcag tcacctttgt cctgacaaac catctcagat
       61 ctctacaaga gagacaagat gctgcctcac ctggtcctca acagtatttc ctggatgctg
      121 ctctcctgcc tgttgtttgt atttcaggta caaggtgaag acttccagaa ggaagtgccc
      181 tctccacgta ccagctgccc catgggttac aaggcttatc gctcccactg ctatgcctta
      241 gttatgacac ctaaatcctg gtttcaagca gatctggtct gccagaagag accctcagga
      301 catctcgtgt ctattcttag tggaggtgag gcttcctttg tgtcctcctt ggtgaacggc
      361 agagtggaca actaccaaga catctggatt gggctccatg atccaacaat gggtcaacaa
      421 cccaatggag gtggatggga gtggagtaac tccgatgtgc tgaattatct taactgggat
      481 ggggatcctt cctctactgt caaccgtggt cactgtggga gtctgacagc aagttcaggg
      541 tttctgaagt ggggagacta ttactgcgat gggacattac catttgtctg caagttcaag
      601 cagtagacaa gcagcatcca gcatttatca tgaagctccc catgacaagg gatgaaatac
      661 aagaattcac ccggcaaggc tgtacttgct ttacagttgt gcatcagact tattctggtt
      721 ttctgtcctc tttcatccat ctccttcccc ttacttcagg cttttcaata tagttcctgc
      781 tttgcaatct tgcagataaa taataaatac aacattttgg ttttactttt gtgtttt
//
