LOCUS       NM_009042                788 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus regenerating islet-derived 1 (Reg1), mRNA.
ACCESSION   NM_009042
VERSION     NM_009042.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 788)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 788)
  AUTHORS   Morisaka,H., Takaishi,M., Akira,S. and Sano,S.
  TITLE     Keratinocyte Regnase-1, a Downregulator of Skin Inflammation,
            Contributes to Protection against Tumor Promotion by Limiting
            Cyclooxygenase-2 Expression
  JOURNAL   J Invest Dermatol 143 (5), 731-739 (2023)
   PUBMED   36470473
  REMARK    GeneRIF: Keratinocyte Regnase-1, a Downregulator of Skin
            Inflammation, Contributes to Protection against Tumor Promotion by
            Limiting Cyclooxygenase-2 Expression.
REFERENCE   3  (bases 1 to 788)
  AUTHORS   Downing,S., Zhang,F., Chen,Z. and Tzanakakis,E.S.
  TITLE     MicroRNA-7 directly targets Reg1 in pancreatic cells
  JOURNAL   Am J Physiol Cell Physiol 317 (2), C366-C374 (2019)
   PUBMED   31166710
  REMARK    GeneRIF: miR-7 directly targets reg1 expression in murine
            pancreatic cells.
REFERENCE   4  (bases 1 to 788)
  AUTHORS   Stone,S., Abreu,D., Mahadevan,J., Asada,R., Kries,K., Graf,R.,
            Marshall,B.A., Hershey,T. and Urano,F.
  TITLE     Pancreatic stone protein/regenerating protein is a potential
            biomarker for endoplasmic reticulum stress in beta cells
  JOURNAL   Sci Rep 9 (1), 5199 (2019)
   PUBMED   30914711
  REMARK    GeneRIF: Pancreatic stone protein/regenerating protein is a
            potential biomarker for endoplasmic reticulum stress in beta cells.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 788)
  AUTHORS   Aida,K., Kobayashi,T., Takeshita,A., Jimbo,E., Nishida,Y.,
            Yagihashi,S., Hosoi,M., Fukui,T., Sugawara,A. and Takasawa,S.
  TITLE     Crucial role of Reg I from acinar-like cell cluster touching with
            islets (ATLANTIS) on mitogenesis of beta cells in EMC virus-induced
            diabetic mice
  JOURNAL   Biochem Biophys Res Commun 503 (2), 963-969 (2018)
   PUBMED   29935186
  REMARK    GeneRIF: These results suggest that Reg1, which is released from
            acinar-like cell clusters touching Langerhans islets with thin
            interstitial surrounding to islet beta cell clusters, has a crucial
            role in beta cell regeneration in ncephalomyocarditis virus-induced
            diabetes.
REFERENCE   6  (bases 1 to 788)
  AUTHORS   Perfetti,R., Egan,J.M., Zenilman,M.E. and Shuldiner,A.R.
  TITLE     Differential expression of reg-I and reg-II genes during aging in
            the normal mouse
  JOURNAL   J Gerontol A Biol Sci Med Sci 51 (5), B308-B315 (1996)
   PUBMED   8808978
REFERENCE   7  (bases 1 to 788)
  AUTHORS   Baeza,N.J., Moriscot,C.I., Renaud,W.P., Okamoto,H., Figarella,C.G.
            and Vialettes,B.H.
  TITLE     Pancreatic regenerating gene overexpression in the nonobese
            diabetic mouse during active diabetogenesis
  JOURNAL   Diabetes 45 (1), 67-70 (1996)
   PUBMED   8522062
REFERENCE   8  (bases 1 to 788)
  AUTHORS   Spur,N.K., Bashir,R., Bushby,K., Cox,A., Cox,S., Hilde Brandt,F.,
            Hill,N., Kao,F.T., Krols,L., Marzella,R., Miller,N., Nothwang,H.G.,
            Rocchi,M., Sarfarazi,M., Stratakis,C.A., Wallgren-Petterson,C. and
            Naylor,S.
  TITLE     Report and abstracts of the Fourth International Workshop on Human
            Chromosome 2 Mapping 1996
  JOURNAL   Cytogenet Cell Genet 73 (4), 255-273 (1996)
   PUBMED   8751373
REFERENCE   9  (bases 1 to 788)
  AUTHORS   Unno,M., Yonekura,H., Nakagawara,K., Watanabe,T., Miyashita,H.,
            Moriizumi,S., Okamoto,H., Itoh,T. and Teraoka,H.
  TITLE     Structure, chromosomal localization, and expression of mouse reg
            genes, reg I and reg II. A novel type of reg gene, reg II, exists
            in the mouse genome
  JOURNAL   J Biol Chem 268 (21), 15974-15982 (1993)
   PUBMED   8340418
REFERENCE   10 (bases 1 to 788)
  AUTHORS   Terazono,K., Yamamoto,H., Takasawa,S., Shiga,K., Yonemura,Y.,
            Tochino,Y. and Okamoto,H.
  TITLE     A novel gene activated in regenerating islets
  JOURNAL   J Biol Chem 263 (5), 2111-2114 (1988)
   PUBMED   2963000
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK133506.1 and BE848902.1.
            
            On Feb 24, 2018 this sequence version replaced NM_009042.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK133506.1, CJ042702.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849376, SAMN00849377
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-770               AK133506.1         5-774
            771-788             BE848902.1         149-166
FEATURES             Location/Qualifiers
     source          1..788
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 34.77 cM"
     gene            1..788
                     /gene="Reg1"
                     /gene_synonym="PSP; PTP"
                     /note="regenerating islet-derived 1"
                     /db_xref="GeneID:19692"
                     /db_xref="MGI:MGI:97895"
     exon            1..25
                     /gene="Reg1"
                     /gene_synonym="PSP; PTP"
                     /inference="alignment:Splign:2.1.0"
     exon            26..132
                     /gene="Reg1"
                     /gene_synonym="PSP; PTP"
                     /inference="alignment:Splign:2.1.0"
     CDS             72..569
                     /gene="Reg1"
                     /gene_synonym="PSP; PTP"
                     /note="lithostathine-1; REG 1; regenerating protein 1;
                     pancreatic stone protein 1; pancreatic thread protein 1;
                     islet of Langerhans regenerating protein 1"
                     /codon_start=1
                     /product="lithostathine-1 precursor"
                     /protein_id="NP_033068.1"
                     /db_xref="CCDS:CCDS20257.1"
                     /db_xref="GeneID:19692"
                     /db_xref="MGI:MGI:97895"
                     /translation="MARNAYFILLSCLIVLSPSQGQEAEEDLPSARISCPEGSNAYSS
                     YCYYFTEDRLTWADADLFCQNMNSGYLVSVLSQAEGNFVASLIKESGTTDANVWTGLH
                     DPKRNRRWHWSSGSLFLYKSWATGSPNSSNRGYCVSLTSNTGYKKWKDDNCDAQYSFV
                     CKFKG"
     exon            133..251
                     /gene="Reg1"
                     /gene_synonym="PSP; PTP"
                     /inference="alignment:Splign:2.1.0"
     exon            252..389
                     /gene="Reg1"
                     /gene_synonym="PSP; PTP"
                     /inference="alignment:Splign:2.1.0"
     exon            390..501
                     /gene="Reg1"
                     /gene_synonym="PSP; PTP"
                     /inference="alignment:Splign:2.1.0"
     exon            502..771
                     /gene="Reg1"
                     /gene_synonym="PSP; PTP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      746..751
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Reg1"
                     /gene_synonym="PSP; PTP"
                     /note="hexamer: AATAAA"
     polyA_site      753
                     /gene="Reg1"
                     /gene_synonym="PSP; PTP"
                     /note="major polyA site"
     polyA_site      771
                     /gene="Reg1"
                     /gene_synonym="PSP; PTP"
ORIGIN      
        1 aagacacctt ggtctcagcc tgcagagatc gttgagttgc atcctaagca aaagactgtc
       61 tgctgctcag catggctagg aacgcctact tcatcctgct ctcatgcctg atcgtcctgt
      121 ctccaagcca aggccaggaa gctgaagaag acctgccatc tgccaggatc agttgcccag
      181 aaggttccaa tgcctacagc tcctattgtt actacttcac tgaagaccgt ttaacttggg
      241 ctgatgcaga tcttttttgc cagaacatga attcaggcta cctggtgtca gttctcagtc
      301 aggctgaggg caactttgtg gcctctctga ttaaggagag tggcactaca gacgccaatg
      361 tctggactgg actccatgat cccaaaagga atcgtcgctg gcactggagc agtgggtctc
      421 tgtttctcta caaatcctgg gcaactgggt ctcctaacag ttccaatcgt ggctactgtg
      481 tatctctgac ttcaaacaca ggatacaaga aatggaagga tgacaactgt gatgcccaat
      541 actcatttgt ctgcaagttc aaaggctgaa gtcacctgaa aaaaaatagt catataaagc
      601 aaaattgaaa ttactatagt gtcagaaatt aaattggacc atctatcaaa agcaaattag
      661 atcctgtctt cctggagaga cattcttgct tcactgtcct atggtacctg tatctccatt
      721 attttctgga aatttgcaca actgaaataa aaacaccttt acaatgttgc aaaaaaaaaa
      781 aaaaaaaa
//
