LOCUS       NM_139292               2036 bp    mRNA    linear   ROD 31-MAY-2024
DEFINITION  Mus musculus receptor accessory protein 6 (Reep6), transcript
            variant 1, mRNA.
ACCESSION   NM_139292
VERSION     NM_139292.2
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2036)
  AUTHORS   Son,Y., Choi,C., Saha,A., Park,J.H., Im,H., Cho,Y.K., Seong,J.K.,
            Burl,R.B., Rondini,E.A., Granneman,J.G. and Lee,Y.H.
  TITLE     REEP6 knockout leads to defective beta-adrenergic signaling in
            adipocytes and promotes obesity-related metabolic dysfunction
  JOURNAL   Metabolism 130, 155159 (2022)
   PUBMED   35150731
  REMARK    GeneRIF: REEP6 knockout leads to defective beta-adrenergic
            signaling in adipocytes and promotes obesity-related metabolic
            dysfunction.
REFERENCE   2  (bases 1 to 2036)
  AUTHORS   Liang,Q., Wu,N., Zaneveld,S., Liu,H., Fu,S., Wang,K., Bertrand,R.,
            Wang,J., Li,Y. and Chen,R.
  TITLE     Transcript isoforms of Reep6 have distinct functions in the retina
  JOURNAL   Hum Mol Genet 30 (21), 1907-1918 (2021)
   PUBMED   34104971
REFERENCE   3  (bases 1 to 2036)
  AUTHORS   Devlin,D.J., Agrawal Zaneveld,S., Nozawa,K., Han,X., Moye,A.R.,
            Liang,Q., Harnish,J.M., Matzuk,M.M. and Chen,R.
  TITLE     Knockout of mouse receptor accessory protein 6 leads to sperm
            function and morphology defectsdagger
  JOURNAL   Biol Reprod 102 (6), 1234-1247 (2020)
   PUBMED   32101290
  REMARK    GeneRIF: Knockout of mouse receptor accessory protein 6 leads to
            sperm function and morphology defectsdagger.
REFERENCE   4  (bases 1 to 2036)
  AUTHORS   Collin,G.B., Gogna,N., Chang,B., Damkham,N., Pinkney,J., Hyde,L.F.,
            Stone,L., Naggert,J.K., Nishina,P.M. and Krebs,M.P.
  TITLE     Mouse Models of Inherited Retinal Degeneration with Photoreceptor
            Cell Loss
  JOURNAL   Cells 9 (4), 931 (2020)
   PUBMED   32290105
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2036)
  AUTHORS   Agrawal,S.A., Burgoyne,T., Eblimit,A., Bellingham,J., Parfitt,D.A.,
            Lane,A., Nichols,R., Asomugha,C., Hayes,M.J., Munro,P.M., Xu,M.,
            Wang,K., Futter,C.E., Li,Y., Chen,R. and Cheetham,M.E.
  TITLE     REEP6 deficiency leads to retinal degeneration through disruption
            of ER homeostasis and protein trafficking
  JOURNAL   Hum Mol Genet 26 (14), 2667-2677 (2017)
   PUBMED   28475715
  REMARK    GeneRIF: Data suggest that REEP6 plays an essential role in
            maintaining cGMP homeostasis though facilitating the stability
            and/or trafficking of guanylate cyclases and maintaining ER and
            mitochondrial homeostasis.
REFERENCE   6  (bases 1 to 2036)
  AUTHORS   Layman,W.S., McEwen,D.P., Beyer,L.A., Lalani,S.R., Fernbach,S.D.,
            Oh,E., Swaroop,A., Hegg,C.C., Raphael,Y., Martens,J.R. and
            Martin,D.M.
  TITLE     Defects in neural stem cell proliferation and olfaction in Chd7
            deficient mice indicate a mechanism for hyposmia in human CHARGE
            syndrome
  JOURNAL   Hum Mol Genet 18 (11), 1909-1923 (2009)
   PUBMED   19279158
REFERENCE   7  (bases 1 to 2036)
  AUTHORS   Moore-Scott,B.A., Opoka,R., Lin,S.C., Kordich,J.J. and Wells,J.M.
  TITLE     Identification of molecular markers that are expressed in discrete
            anterior-posterior domains of the endoderm from the gastrula stage
            to mid-gestation
  JOURNAL   Dev Dyn 236 (7), 1997-2003 (2007)
   PUBMED   17576135
REFERENCE   8  (bases 1 to 2036)
  AUTHORS   Sato,H., Tomita,H., Nakazawa,T., Wakana,S. and Tamai,M.
  TITLE     Deleted in polyposis 1-like 1 gene (Dp1l1): a novel gene richly
            expressed in retinal ganglion cells
  JOURNAL   Invest Ophthalmol Vis Sci 46 (3), 791-796 (2005)
   PUBMED   15728532
  REMARK    GeneRIF: TB2-like 1 is a membrane protein that belongs to the
            YOP1/TB2/DP1/HVA22 family, and it probably plays an important role
            in intracellular membrane trafficking in RGCs
REFERENCE   9  (bases 1 to 2036)
  AUTHORS   Saito,H., Kubota,M., Roberts,R.W., Chi,Q. and Matsunami,H.
  TITLE     RTP family members induce functional expression of mammalian
            odorant receptors
  JOURNAL   Cell 119 (5), 679-691 (2004)
   PUBMED   15550249
REFERENCE   10 (bases 1 to 2036)
  AUTHORS   Yoshida,S., Mears,A.J., Friedman,J.S., Carter,T., He,S., Oh,E.,
            Jing,Y., Farjo,R., Fleury,G., Barlow,C., Hero,A.O. and Swaroop,A.
  TITLE     Expression profiling of the developing and mature Nrl-/- mouse
            retina: identification of retinal disease candidates and
            transcriptional regulatory targets of Nrl
  JOURNAL   Hum Mol Genet 13 (14), 1487-1503 (2004)
   PUBMED   15163632
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK002562.1 and AB039933.1.
            
            On Mar 17, 2011 this sequence version replaced NM_139292.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB039933.1, BI330565.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-25                AK002562.1         1-25
            26-2036             AB039933.1         1-2011
FEATURES             Location/Qualifiers
     source          1..2036
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 39.72 cM"
     gene            1..2036
                     /gene="Reep6"
                     /gene_synonym="0610011M24Rik; Dp1l1"
                     /note="receptor accessory protein 6"
                     /db_xref="GeneID:70335"
                     /db_xref="MGI:MGI:1917585"
     exon            1..201
                     /gene="Reep6"
                     /gene_synonym="0610011M24Rik; Dp1l1"
                     /inference="alignment:Splign:2.1.0"
     CDS             87..692
                     /gene="Reep6"
                     /gene_synonym="0610011M24Rik; Dp1l1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     deleted in polyposis 1-like 1; receptor
                     expression-enhancing protein 6; TB2 protein-like 1;
                     polyposis locus protein 1-like 1"
                     /codon_start=1
                     /product="receptor expression-enhancing protein 6 isoform
                     1"
                     /protein_id="NP_647453.1"
                     /db_xref="CCDS:CCDS35979.1"
                     /db_xref="GeneID:70335"
                     /db_xref="MGI:MGI:1917585"
                     /translation="MDGLRQRFERFLEQKNVATEALGALEARTGVEKRYLAAGALALL
                     GLYLLFGYGASLLCNVIGFVYPAYASVKAIESPSKEDDTVWLTYWVVYALFGLVEFFS
                     DLLLFWFPFYYAGKCAFLLFCMTPGPWNGALLLYHRVIRPLFLKHHMALDSAASQLSG
                     RALDLAAGITRDVLQALARGRALVTPASTSEPPAALELDPK"
     exon            202..295
                     /gene="Reep6"
                     /gene_synonym="0610011M24Rik; Dp1l1"
                     /inference="alignment:Splign:2.1.0"
     exon            296..434
                     /gene="Reep6"
                     /gene_synonym="0610011M24Rik; Dp1l1"
                     /inference="alignment:Splign:2.1.0"
     exon            435..603
                     /gene="Reep6"
                     /gene_synonym="0610011M24Rik; Dp1l1"
                     /inference="alignment:Splign:2.1.0"
     exon            604..684
                     /gene="Reep6"
                     /gene_synonym="0610011M24Rik; Dp1l1"
                     /inference="alignment:Splign:2.1.0"
     exon            685..2016
                     /gene="Reep6"
                     /gene_synonym="0610011M24Rik; Dp1l1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1993..1998
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Reep6"
                     /gene_synonym="0610011M24Rik; Dp1l1"
                     /note="hexamer: AATAAA"
     polyA_site      2016
                     /gene="Reep6"
                     /gene_synonym="0610011M24Rik; Dp1l1"
                     /note="major polyA site"
ORIGIN      
        1 gcgggtggtg aaagtgcgct ctcggcggcg ccggtgcgcg aggttgcggg cgtgcttcag
       61 tggcctgccc cgcgcccgcc gctgccatgg acggtctgcg ccagcgcttc gaacgttttc
      121 tggaacagaa gaacgtggcc accgaagcgc tcggggcgct cgaagcaagg accggtgtag
      181 agaagcggta tctcgccgcg ggagccctcg cccttctagg cctgtatctt ctgttcggtt
      241 acggggcctc tctactgtgc aatgtcatcg gatttgtata ccccgcatat gcttcagtca
      301 aagctatcga gagcccaagc aaggaagacg acactgtgtg gctaacctac tgggtggtgt
      361 acgccctgtt cggtctggtc gaattcttca gcgatctact cctgttctgg ttccctttct
      421 actacgcggg caagtgcgcc ttcctgttat tttgcatgac gcccggaccc tggaacgggg
      481 cattactact ataccatcgc gtcataagac cactctttct aaagcaccac atggctctag
      541 acagcgccgc gagccagcta agcggaagag cattggacct agcagctggg ataacccggg
      601 acgtacttca ggccttggct cggggccggg ctctcgtcac cccagcatca acatcggaac
      661 ccccagccgc tctggaactg gaccccaagt aaagtcagac cccactcctg aaccacaagt
      721 gaggaggtct gctggcagtc tgtgtgcgga ttccccagcc aatgacaagg aacgcacagc
      781 tgataatgtc caggcctctg acagttcttc agactcccag acaaagacac cactgcaacc
      841 acagcctcag ccacaaccgc aaccgcaacc acaaccacaa ccacaaccac aaccacaacc
      901 acaacgccga acctcaagcc caagtaagac agtaggaagc ccctcacggg ccacgaatgg
      961 gcagtccccg tccccagtca gcccaggccc tgcatctgta tcccggggtc agctggccac
     1021 tgtttctgcc agcggctccc agattcccag caagtcccgg ccccatcgca gccggggcag
     1081 tttgactccc agggctgcac agcgtgcccg actgcccagt gggactctgg gctccgctca
     1141 gctgcccatg cgctcgggag gtgcctccca gccagcaggc cggaccttgg gacacaatcg
     1201 cacaacaggc cgccacacgg gaacaaacca ccagacccct caggtctccg ccacaggccg
     1261 atcggcagcc gcagcaacag cctccgcagc agccccagca gccccagcag ccccagcagc
     1321 agcagcgcca gcagccacaa ctgcacccac ttccacacag cgtgtcagtg tctccgccca
     1381 ggactcacct agggcccagt ctcccagcac atcccctgac cccaaccagg ctggcagcaa
     1441 ggctcctgtg gagccagggg acgcaggttc caagaacaag cagggccaga agacacaggt
     1501 ggccggcacc tcagcaccct ccgaggcact ggtcccctgt cactctgatt cctctctgga
     1561 ttatttgtcc gagtctacca cggagatcac ctgtaaatgg ccacagtata gtcaccagct
     1621 gcgttgcccc agacactgct ggcttttgcc acatctggca tactagcacc acccttgcac
     1681 acatgtgggc cacaagaccg agagacccct gcccaaggag ccacatgaaa cactagacca
     1741 cctgagcacc gtacaagagc ctcaccgaat aactgcccgt catcaaaaca agtcaaacat
     1801 ctgccgcagt gccacatgaa acacccacca ggcaggcctc cacacgtcag acctgcccgt
     1861 ggactcccaa gtgagacacc ttttacacag ccccacatga aacaccctca cagcagcaca
     1921 aaacacccat gaaggtgcac gtgaaacacc atcccgtggt cccccgtgta acatctctcc
     1981 tccaaggtgt gcaataaaac cacccgctca ggctcaaaaa aaaaaaaaaa aaaaaa
//
