LOCUS       NM_007874               2910 bp    mRNA    linear   ROD 30-JUL-2024
DEFINITION  Mus musculus receptor accessory protein 5 (Reep5), mRNA.
ACCESSION   NM_007874 XM_289685
VERSION     NM_007874.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2910)
  AUTHORS   Reggio,A., Buonomo,V., Berkane,R., Bhaskara,R.M., Tellechea,M.,
            Peluso,I., Polishchuk,E., Di Lorenzo,G., Cirillo,C., Esposito,M.,
            Hussain,A., Huebner,A.K., Hubner,C.A., Settembre,C., Hummer,G.,
            Grumati,P. and Stolz,A.
  TITLE     Role of FAM134 paralogues in endoplasmic reticulum remodeling,
            ER-phagy, and Collagen quality control
  JOURNAL   EMBO Rep 22 (9), e52289 (2021)
   PUBMED   34338405
REFERENCE   2  (bases 1 to 2910)
  AUTHORS   Lee,S.H., Hadipour-Lakmehsari,S., Murthy,H.R., Gibb,N., Miyake,T.,
            Teng,A.C.T., Cosme,J., Yu,J.C., Moon,M., Lim,S., Wong,V., Liu,P.,
            Billia,F., Fernandez-Gonzalez,R., Stagljar,I., Sharma,P.,
            Kislinger,T., Scott,I.C. and Gramolini,A.O.
  TITLE     REEP5 depletion causes sarco-endoplasmic reticulum vacuolization
            and cardiac functional defects
  JOURNAL   Nat Commun 11 (1), 965 (2020)
   PUBMED   32075961
  REMARK    GeneRIF: Depletion of receptor accessory protein 5 (REEP5) in mouse
            cardiac myocytes results in sarco-endoplasmic reticulum (SR/ER)
            membrane destabilization and luminal vacuolization along with
            decreased myocyte contractility and disrupted Ca(2+) cycling.
            Adeno-associated viral (AAV9)-induced REEP5 depletion in the mouse
            demonstrates cardiac dysfunction.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2910)
  AUTHORS   Zhao,H., Sonada,S., Yoshikawa,A., Ohinata,K. and Yoshikawa,M.
  TITLE     Rubimetide, humanin, and MMK1 exert anxiolytic-like activities via
            the formyl peptide receptor 2 in mice followed by the successive
            activation of DP1, A2A, and GABAA receptors
  JOURNAL   Peptides 83, 16-20 (2016)
   PUBMED   27475912
  REMARK    GeneRIF: it is concluded that the anxiolytic-like activities of
            rubimetide and typical agonist peptides of the FPR2 were mediated
            successively by the PGD2-DP1 receptor, adenosine-A2A receptor, and
            GABA-GABAA receptor systems downstream of the FPR2.
REFERENCE   4  (bases 1 to 2910)
  AUTHORS   Hashimoto,Y., Shirane,M., Matsuzaki,F., Saita,S., Ohnishi,T. and
            Nakayama,K.I.
  TITLE     Protrudin regulates endoplasmic reticulum morphology and function
            associated with the pathogenesis of hereditary spastic paraplegia
  JOURNAL   J Biol Chem 289 (19), 12946-12961 (2014)
   PUBMED   24668814
REFERENCE   5  (bases 1 to 2910)
  AUTHORS   Basta,J.M., Robbins,L., Kiefer,S.M., Dorsett,D. and Rauchman,M.
  TITLE     Sall1 balances self-renewal and differentiation of renal progenitor
            cells
  JOURNAL   Development 141 (5), 1047-1058 (2014)
   PUBMED   24550112
REFERENCE   6  (bases 1 to 2910)
  AUTHORS   Gu,G., Wells,J.M., Dombkowski,D., Preffer,F., Aronow,B. and
            Melton,D.A.
  TITLE     Global expression analysis of gene regulatory pathways during
            endocrine pancreatic development
  JOURNAL   Development 131 (1), 165-179 (2004)
   PUBMED   14660441
REFERENCE   7  (bases 1 to 2910)
  AUTHORS   Kohn,M.J., Bronson,R.T., Harlow,E., Dyson,N.J. and Yamasaki,L.
  TITLE     Dp1 is required for extra-embryonic development
  JOURNAL   Development 130 (7), 1295-1305 (2003)
   PUBMED   12588846
REFERENCE   8  (bases 1 to 2910)
  AUTHORS   Suzuki,H., Fukunishi,Y., Kagawa,I., Saito,R., Oda,H., Endo,T.,
            Kondo,S., Bono,H., Okazaki,Y. and Hayashizaki,Y.
  TITLE     Protein-protein interaction panel using mouse full-length cDNAs
  JOURNAL   Genome Res 11 (10), 1758-1765 (2001)
   PUBMED   11591653
REFERENCE   9  (bases 1 to 2910)
  AUTHORS   Prieschl,E.E., Pendl,G.G., Harrer,N.E. and Baumruker,T.
  TITLE     The murine homolog of TB2/DP1, a gene of the familial adenomatous
            polyposis (FAP) locus
  JOURNAL   Gene 169 (2), 215-218 (1996)
   PUBMED   8647449
REFERENCE   10 (bases 1 to 2910)
  AUTHORS   Kawai,J., Suzuki,H., Taga,C., Hara,A. and Watanabe,S.
  TITLE     Correspondence of RLGS-M spot behavior with tissue expression on
            mouse homologue of DP1/TB2 gene
  JOURNAL   Biochem Biophys Res Commun 213 (3), 967-974 (1995)
   PUBMED   7654261
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BU053115.1, AK013146.1 and AI842075.1.
            
            On Nov 24, 2007 this sequence version replaced NM_007874.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC013052.1, SRR1660815.189417.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-70                BU053115.1         1-70
            71-2892             AK013146.1         2-2823
            2893-2910           AI842075.1         1-18                c
FEATURES             Location/Qualifiers
     source          1..2910
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="18"
                     /map="18 18.57 cM"
     gene            1..2910
                     /gene="Reep5"
                     /gene_synonym="Dp1; DP1/TB2; TB2/DP1"
                     /note="receptor accessory protein 5"
                     /db_xref="GeneID:13476"
                     /db_xref="MGI:MGI:1270152"
     exon            1..212
                     /gene="Reep5"
                     /gene_synonym="Dp1; DP1/TB2; TB2/DP1"
                     /inference="alignment:Splign:2.1.0"
     exon            213..306
                     /gene="Reep5"
                     /gene_synonym="Dp1; DP1/TB2; TB2/DP1"
                     /inference="alignment:Splign:2.1.0"
     exon            307..445
                     /gene="Reep5"
                     /gene_synonym="Dp1; DP1/TB2; TB2/DP1"
                     /inference="alignment:Splign:2.1.0"
     exon            446..614
                     /gene="Reep5"
                     /gene_synonym="Dp1; DP1/TB2; TB2/DP1"
                     /inference="alignment:Splign:2.1.0"
     exon            615..2898
                     /gene="Reep5"
                     /gene_synonym="Dp1; DP1/TB2; TB2/DP1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      769..774
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Reep5"
                     /gene_synonym="Dp1; DP1/TB2; TB2/DP1"
                     /note="hexamer: ATTAAA"
     polyA_site      791
                     /gene="Reep5"
                     /gene_synonym="Dp1; DP1/TB2; TB2/DP1"
                     /note="major polyA site"
     regulatory      2867..2872
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Reep5"
                     /gene_synonym="Dp1; DP1/TB2; TB2/DP1"
                     /note="hexamer: AATAAA"
     polyA_site      2898
                     /gene="Reep5"
                     /gene_synonym="Dp1; DP1/TB2; TB2/DP1"
ORIGIN      
        1 gccgcggcac cgcccgcccc cgccccgccc cggtcagctg ggttccgcgt ccagccggct
       61 gcggagcatc ccgggcggcg cgaacggccc agccatgtcc gcagccatga gggagaggtt
      121 cgaccggttc ctgcacgaga agaactgcat gactgatctc ctcgccaagc tcgaggccaa
      181 gaccggagtg aaccggagct tcatcgcgct cggtgtcatc ggactggtgg ctttgtatct
      241 ggtgttcggt tatggagcct ctctcctctg caacctgata ggtttcggat acccagccta
      301 catctcaatg aaagccatcg agagtcccaa caaagatgat gacacccagt ggctgacgta
      361 ctgggtggta tatggtgtgt tcagcattgc cgaattcttc tccgatctct tcctgtcctg
      421 gttccccttc tactacatgc tgaagtgtgg cttcctgctg tggtgcatgg cccccagccc
      481 ggctaatggg gctgagatgc tctacaggcg aatcatccgt cctatcttcc tcaagcacga
      541 gtcccaggta gacagtgtgg tgaaggacgt gaaggacaaa gccaaagaga ctgcagatgc
      601 catcagcaaa gaagtcaaga aagctacagt gaacttgctg ggcgatgaga agaagagcac
      661 ctgaggcctg gccgggcgcc cctccccccc caccccctgg agctctgtgt catgctaggg
      721 acagtggcac agtcgttgga taatgttgcc ttggaaactt cccgctgtat taaaaatgga
      781 atgtgttgta agctgctttg cctttgttgt cgtatatgta gaaagcattt tcatttaaac
      841 ctaacagagt gggcagtacc tcaagtgttt aaaatatttt gctgtgtagg aagacatgtc
      901 actatactcc aggaaataca aaagagggtt gggaatctct gtctgtaggc cccgtgctct
      961 gcggggctca ctctgcatgc gtctccttgt gcttacagtt aggaaacctt tgtggttgtg
     1021 cttcacgcag tgtatgatta tatatatata tagttctgtg ttttaatgta tctgggcata
     1081 tacatatata tggaaaatgt tattgtttgg ctagaacatg cacagtgctt gtgaggaaga
     1141 ggccaggaga ggcttgtaga cgccacctgt gacctgagaa gggagaccac ctgccgaggc
     1201 tggaggtctg agcttccaat aacgtttcag aaatcaatgc aagcgagtaa gactcgaacc
     1261 cgtgatcagc tccagtttcc caggaaacag tggcaccatc tcccctgctc ctcctctgag
     1321 atgctgaaat gccagccatt tatggtttac ctgaaagctg gctaacaagg tccttagtct
     1381 ctcctcccaa actctttaaa aactagttca tggcacctcc caagacagac atcccacctc
     1441 ccatttttta aaaacacgat cccacgtagc ccaggataac ctccaaatcc cagctgctgc
     1501 tcattgtagc ttgtgcccca cggctggcat acgtgtgtgt tcttgttcct gtcagcagca
     1561 cattgcgctg atgacgtcca gctctaagag ccattctggg caagtgaagg gcagtggcta
     1621 acagctgttg tcggtccagc agtggctggg ttaaactttc tactcttttt tggttttatg
     1681 gccaacctca agaggtctcc ttactttaca attcataatt attagcattc ccttaaaaat
     1741 ctcgttcagt tttaggtttt gttttgacag atagaataaa gtttaagtga ctgcccatgg
     1801 cctgattggt cagaggtttg ggtctaaaaa tctgcagttt gcaccatatg ccagcgtccc
     1861 agcctttgag ttagtctgaa gtggactaaa ggagttgtct accaaagtta acaacaggag
     1921 ttactttcaa gacaaataga tagtaattct cctccagatg actaagatca taataatatg
     1981 atattaaata ttaacaatac aaaataagag gcactgtggc cctagcgtaa tatgggtcac
     2041 tgtgtcagtt ttcctgggga tagcagtcat taggcttcat atgacttagg ggagatcttt
     2101 ttagaaaata agaactattg tttggataaa gtcaattgtt aggctttaaa catcaaaaat
     2161 atttaggtcc ttataagtaa aagcacgttt ttcttgttgg cagaatgaaa attacagtgt
     2221 agcatatagg agcagagtgt taatatacaa aatactttct gtggggaatg ggcaggcagg
     2281 gaatgatgct tacggttaga gattgtattg gtggaaacgc tgcagtgaaa taaactccaa
     2341 aagtaatttt gctgcatcaa ccccacaact ttgcgggaga ctccctgcta ctttctgcag
     2401 ctgtcaatgg gagaaatcat gaatcgactt ctgcctactg gtccttccca aataaagtgt
     2461 catggcttaa gtgttgaaaa tgagctgagt ttgtgtctgg ctggaaacaa agcatttatt
     2521 tgtatctgag tggtatttcc taggcatata aagttctaga attcttgcta aacattaaat
     2581 gtcccaaaga gttcgtgcag caattatttc ctgacattgt gggaaggtcc tccatccaca
     2641 cctgcagaaa acagccaagg cctgtaagga agttcttgcc tgtcctcagg tgtgagtaga
     2701 aatgatgtgc ccagtgcctc cttacacgtt cccagactcc cctggctgcc tgaacctgga
     2761 agagtactga actctatgtg gactgttctt tcctgtgtgt gtacatatgt gacaaaggtt
     2821 actggctgaa caaagtgaca attagaagaa ttacaacata tactcaaata aagattatgt
     2881 ttatgtggtc tctcaaaaaa aaaaaaaaaa
//
