LOCUS       NM_144865               1926 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Mus musculus receptor accessory protein 2 (Reep2), transcript
            variant 1, mRNA.
ACCESSION   NM_144865
VERSION     NM_144865.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1926)
  AUTHORS   Zhou,J., Shi,Q., Ge,Y.Y., He,W., Hu,X., Xia,W. and Yan,R.
  TITLE     Reticulons 1 and 3 are essential for axonal growth and synaptic
            maintenance associated with intellectual development
  JOURNAL   Hum Mol Genet 32 (16), 2587-2599 (2023)
   PUBMED   37228035
REFERENCE   2  (bases 1 to 1926)
  AUTHORS   Bjork,S., Hurt,C.M., Ho,V.K. and Angelotti,T.
  TITLE     REEPs are membrane shaping adapter proteins that modulate specific
            g protein-coupled receptor trafficking by affecting ER cargo
            capacity
  JOURNAL   PLoS One 8 (10), e76366 (2013)
   PUBMED   24098485
  REMARK    Erratum:[PLoS One. 2013;8(12).
            doi:10.1371/annotation/6f86410c-63c3-4fcd-b1cb-9fd8d2ea95d0]
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1926)
  AUTHORS   Ilegems,E., Iwatsuki,K., Kokrashvili,Z., Benard,O., Ninomiya,Y. and
            Margolskee,R.F.
  TITLE     REEP2 enhances sweet receptor function by recruitment to lipid
            rafts
  JOURNAL   J Neurosci 30 (41), 13774-13783 (2010)
   PUBMED   20943918
  REMARK    GeneRIF: REEP2 recruits sweet receptors into lipid raft
            microdomains localized near the taste cell's apical region, thereby
            improving G-protein-coupled receptor signaling and promoting
            receptor access to tastants arriving through the apical taste pore.
REFERENCE   4  (bases 1 to 1926)
  AUTHORS   Saito,H., Kubota,M., Roberts,R.W., Chi,Q. and Matsunami,H.
  TITLE     RTP family members induce functional expression of mammalian
            odorant receptors
  JOURNAL   Cell 119 (5), 679-691 (2004)
   PUBMED   15550249
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CX216997.1, BC020184.1 and BB709634.1.
            
            On Mar 16, 2011 this sequence version replaced NM_144865.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660815.153654.1, BC020184.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849377
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-69                CX216997.1         1-69
            70-1918             BC020184.1         1-1849
            1919-1926           BB709634.1         411-418
FEATURES             Location/Qualifiers
     source          1..1926
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="18"
                     /map="18 18.75 cM"
     gene            1..1926
                     /gene="Reep2"
                     /note="receptor accessory protein 2"
                     /db_xref="GeneID:225362"
                     /db_xref="MGI:MGI:2385070"
     exon            1..199
                     /gene="Reep2"
                     /inference="alignment:Splign:2.1.0"
     CDS             168..932
                     /gene="Reep2"
                     /note="isoform 1 is encoded by transcript variant 1;
                     receptor expression-enhancing protein 2"
                     /codon_start=1
                     /product="receptor expression-enhancing protein 2 isoform
                     1"
                     /protein_id="NP_659114.2"
                     /db_xref="CCDS:CCDS29135.1"
                     /db_xref="GeneID:225362"
                     /db_xref="MGI:MGI:2385070"
                     /translation="MVSWIISRLVVLIFGTLYPAYSSYKAVKTKNVKEYVKWMMYWIV
                     FAFFTTAETLTDIILSWFPFYFELKIAFVIWLLSPYTKGSSVLYRKFVHPTLSNKEKE
                     IDEYITQARDKSYETMMRVGKRGLNLAANAAVTAAAKGQGVLSEKLRSFSMQDLTLIR
                     DEDALPLQGPDGRLQPGPVGLLDTIEDLGDEPALSLRSSTSQPDPRTETSEDDLGDKA
                     PKRTKPIKKVPRAEPPASKTLKTRPKKKSSGGGDSA"
     exon            200..272
                     /gene="Reep2"
                     /inference="alignment:Splign:2.1.0"
     exon            273..349
                     /gene="Reep2"
                     /inference="alignment:Splign:2.1.0"
     exon            350..470
                     /gene="Reep2"
                     /inference="alignment:Splign:2.1.0"
     exon            471..584
                     /gene="Reep2"
                     /inference="alignment:Splign:2.1.0"
     exon            585..732
                     /gene="Reep2"
                     /inference="alignment:Splign:2.1.0"
     exon            733..863
                     /gene="Reep2"
                     /inference="alignment:Splign:2.1.0"
     exon            864..1926
                     /gene="Reep2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1900..1905
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Reep2"
                     /note="hexamer: AATAAA"
     polyA_site      1922
                     /gene="Reep2"
                     /note="major polyA site"
ORIGIN      
        1 ccaccgccca cggaccgccg ctgcggcagg gacctcccct ttaacggcgg caactccacg
       61 ctccgctgac cccaaagccg ctgccgctgc taacagcggc tcctgctgcc tcagccgccg
      121 gcctcgggca gctgcatcca taccccgggc tgggtccccg ccccgccatg gtgtcctgga
      181 tcatctctcg cctggtggtg ctcatctttg gcaccctgta cccagcctat tcttcctaca
      241 aggccgtgaa gaccaaaaac gtgaaggaat acgtaaaatg gatgatgtat tggatagtct
      301 tcgccttctt caccacagct gagacactta cagatataat actgtcctgg ttccccttct
      361 actttgagct caagattgcc tttgtgatat ggctgttgtc cccttacacc aagggctcca
      421 gtgtcctcta ccgcaagttc gtgcacccaa cactgtccaa caaggaaaag gagatcgacg
      481 aatacatcac acaagctcga gacaagagct atgagacgat gatgagggtg ggcaagaggg
      541 gcctgaacct ggctgccaat gctgcagtca cagctgctgc caagggccag ggggtgctgt
      601 cggaaaagct gcggagcttc agcatgcagg acctgactct cattcgagat gaggatgcgt
      661 taccgctgca ggggccagat ggccgcctcc aacccggccc cgtgggtctc ctggacacta
      721 ttgaggactt aggagatgag cctgccctaa gtctaaggtc tagcacaagc cagccagatc
      781 cccggacaga gacctcagaa gatgacctgg gagacaaggc acccaagagg accaaaccta
      841 tcaaaaaagt acccagagct gagccgccgg cttccaagac actgaagacc cggcccaaga
      901 agaagagttc tggagggggc gactcagcat gagaggctcg gctccccgca cccctccatc
      961 tctaggacaa gcacggagaa gagctgcagc cctggcccct ccaacagtga gccactagcc
     1021 ccaagtgttt cagacccgca aaccccccag gtggctgtcc ccagcacccc cttcccatga
     1081 acatgcctcc ggagggggct tggcaaagag gaggttgagg acagaggtga tgactaagcc
     1141 cttgaggagg tggaggctcc gtggccagcc agcgctgctc tttttgctgc tccagtccca
     1201 cgctgcccat ccagtgcctt gctgaccatg gccgtcccct ctcagaggcc taacctgctt
     1261 cccccacccc cagggagggg accttgagaa agggaagaaa ctgggcaggc ctgggaggag
     1321 ggtgttcctc aggcgcagct atgcatggag acaagggctt tgaataagca gcacggccag
     1381 gccagcattg cagctggtag ggctgtgtat tctaccaaaa gagaggtgag atgctaaggg
     1441 tgtgcgtgtt agggaggttg ggtgagaggg gtcacctcct ccctacatca gctctggtct
     1501 ttcttcctct ttatccaccc ctgctggtct ctgaacctca gaactcaagc ccttgacaga
     1561 acgaggctcc cagggactcc tccctaccct tccatccttg atccctttta cacattcatg
     1621 cccacgtaag ctggactcct ctgctcctag gctccatcac agagggcctg ccaagatggc
     1681 tcctttcctc tcctgtaaag gggatgcatc ccaccttgcc atggggtccc cttcctgtgc
     1741 caagcaaacc ctggtcagaa ctaacctgga ccccacccct ggcgctggtc ctgccagcct
     1801 caatggggcc aagtggtacc tgtgcaggga aggagatgca ggagctggga ggctcccaac
     1861 tccacggtgc ccacactgga ccttggcact ggatgagcca ataaacgaaa ctctgacacc
     1921 tccttt
//
