LOCUS       NM_001204914            1920 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Mus musculus receptor accessory protein 2 (Reep2), transcript
            variant 2, mRNA.
ACCESSION   NM_001204914
VERSION     NM_001204914.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1920)
  AUTHORS   Zhou,J., Shi,Q., Ge,Y.Y., He,W., Hu,X., Xia,W. and Yan,R.
  TITLE     Reticulons 1 and 3 are essential for axonal growth and synaptic
            maintenance associated with intellectual development
  JOURNAL   Hum Mol Genet 32 (16), 2587-2599 (2023)
   PUBMED   37228035
REFERENCE   2  (bases 1 to 1920)
  AUTHORS   Bjork,S., Hurt,C.M., Ho,V.K. and Angelotti,T.
  TITLE     REEPs are membrane shaping adapter proteins that modulate specific
            g protein-coupled receptor trafficking by affecting ER cargo
            capacity
  JOURNAL   PLoS One 8 (10), e76366 (2013)
   PUBMED   24098485
  REMARK    Erratum:[PLoS One. 2013;8(12).
            doi:10.1371/annotation/6f86410c-63c3-4fcd-b1cb-9fd8d2ea95d0]
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1920)
  AUTHORS   Ilegems,E., Iwatsuki,K., Kokrashvili,Z., Benard,O., Ninomiya,Y. and
            Margolskee,R.F.
  TITLE     REEP2 enhances sweet receptor function by recruitment to lipid
            rafts
  JOURNAL   J Neurosci 30 (41), 13774-13783 (2010)
   PUBMED   20943918
  REMARK    GeneRIF: REEP2 recruits sweet receptors into lipid raft
            microdomains localized near the taste cell's apical region, thereby
            improving G-protein-coupled receptor signaling and promoting
            receptor access to tastants arriving through the apical taste pore.
REFERENCE   4  (bases 1 to 1920)
  AUTHORS   Saito,H., Kubota,M., Roberts,R.W., Chi,Q. and Matsunami,H.
  TITLE     RTP family members induce functional expression of mammalian
            odorant receptors
  JOURNAL   Cell 119 (5), 679-691 (2004)
   PUBMED   15550249
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CX216997.1, EU555417.1, BC020184.1 and BB709634.1.
            
            Transcript Variant: This variant (2) uses an alternate in-frame
            splice site in the coding region, compared to variant 1. The
            encoded isoform (2) is shorter than isoform 1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: EU555417.1, SRR7345562.3134423.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849379
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-167               CX216997.1         1-167
            168-926             EU555417.1         1-759
            927-1912            BC020184.1         864-1849
            1913-1920           BB709634.1         411-418
FEATURES             Location/Qualifiers
     source          1..1920
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="18"
                     /map="18 18.75 cM"
     gene            1..1920
                     /gene="Reep2"
                     /note="receptor accessory protein 2"
                     /db_xref="GeneID:225362"
                     /db_xref="MGI:MGI:2385070"
     exon            1..199
                     /gene="Reep2"
                     /inference="alignment:Splign:2.1.0"
     CDS             168..926
                     /gene="Reep2"
                     /note="isoform 2 is encoded by transcript variant 2;
                     receptor expression-enhancing protein 2"
                     /codon_start=1
                     /product="receptor expression-enhancing protein 2 isoform
                     2"
                     /protein_id="NP_001191843.1"
                     /db_xref="GeneID:225362"
                     /db_xref="MGI:MGI:2385070"
                     /translation="MVSWIISRLVVLIFGTLYPAYSSYKAVKTKNVKEYVKWMMYWIV
                     FAFFTTAETLTDIILSWFPFYFELKIAFVIWLLSPYTKGSSVLYRKFVHPTLSNKEKE
                     IDEYITQARDKSYETMMRVGKRGLNLAANAAVTAAAKGVLSEKLRSFSMQDLTLIRDE
                     DALPLQGPDGRLQPGPVGLLDTIEDLGDEPALSLRSSTSQPDPRTETSEDDLGDKAPK
                     RTKPIKKVPRAEPPASKTLKTRPKKKSSGGGDSA"
     exon            200..272
                     /gene="Reep2"
                     /inference="alignment:Splign:2.1.0"
     exon            273..349
                     /gene="Reep2"
                     /inference="alignment:Splign:2.1.0"
     exon            350..470
                     /gene="Reep2"
                     /inference="alignment:Splign:2.1.0"
     exon            471..584
                     /gene="Reep2"
                     /inference="alignment:Splign:2.1.0"
     exon            585..726
                     /gene="Reep2"
                     /inference="alignment:Splign:2.1.0"
     exon            727..857
                     /gene="Reep2"
                     /inference="alignment:Splign:2.1.0"
     exon            858..1920
                     /gene="Reep2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1894..1899
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Reep2"
                     /note="hexamer: AATAAA"
     polyA_site      1916
                     /gene="Reep2"
                     /note="major polyA site"
ORIGIN      
        1 ccaccgccca cggaccgccg ctgcggcagg gacctcccct ttaacggcgg caactccacg
       61 ctccgctgac cccaaagccg ctgccgctgc taacagcggc tcctgctgcc tcagccgccg
      121 gcctcgggca gctgcatcca taccccgggc tgggtccccg ccccgccatg gtgtcctgga
      181 tcatctctcg cctggtggtg ctcatctttg gcaccctgta cccagcctat tcttcctaca
      241 aggccgtgaa gaccaaaaac gtgaaggaat acgtaaaatg gatgatgtat tggatagtct
      301 tcgccttctt caccacagct gagacactta cagatataat actgtcctgg ttccccttct
      361 actttgagct caagattgcc tttgtgatat ggctgttgtc cccttacacc aagggctcca
      421 gtgtcctcta ccgcaagttc gtgcacccaa cactgtccaa caaggaaaag gagatcgacg
      481 aatacatcac acaagctcga gacaagagct atgagacgat gatgagggtg ggcaagaggg
      541 gcctgaacct ggctgccaat gctgcagtca cagctgctgc caagggggtg ctgtcggaaa
      601 agctgcggag cttcagcatg caggacctga ctctcattcg agatgaggat gcgttaccgc
      661 tgcaggggcc agatggccgc ctccaacccg gccccgtggg tctcctggac actattgagg
      721 acttaggaga tgagcctgcc ctaagtctaa ggtctagcac aagccagcca gatccccgga
      781 cagagacctc agaagatgac ctgggagaca aggcacccaa gaggaccaaa cctatcaaaa
      841 aagtacccag agctgagccg ccggcttcca agacactgaa gacccggccc aagaagaaga
      901 gttctggagg gggcgactca gcatgagagg ctcggctccc cgcacccctc catctctagg
      961 acaagcacgg agaagagctg cagccctggc ccctccaaca gtgagccact agccccaagt
     1021 gtttcagacc cgcaaacccc ccaggtggct gtccccagca cccccttccc atgaacatgc
     1081 ctccggaggg ggcttggcaa agaggaggtt gaggacagag gtgatgacta agcccttgag
     1141 gaggtggagg ctccgtggcc agccagcgct gctctttttg ctgctccagt cccacgctgc
     1201 ccatccagtg ccttgctgac catggccgtc ccctctcaga ggcctaacct gcttccccca
     1261 cccccaggga ggggaccttg agaaagggaa gaaactgggc aggcctggga ggagggtgtt
     1321 cctcaggcgc agctatgcat ggagacaagg gctttgaata agcagcacgg ccaggccagc
     1381 attgcagctg gtagggctgt gtattctacc aaaagagagg tgagatgcta agggtgtgcg
     1441 tgttagggag gttgggtgag aggggtcacc tcctccctac atcagctctg gtctttcttc
     1501 ctctttatcc acccctgctg gtctctgaac ctcagaactc aagcccttga cagaacgagg
     1561 ctcccaggga ctcctcccta cccttccatc cttgatccct tttacacatt catgcccacg
     1621 taagctggac tcctctgctc ctaggctcca tcacagaggg cctgccaaga tggctccttt
     1681 cctctcctgt aaaggggatg catcccacct tgccatgggg tccccttcct gtgccaagca
     1741 aaccctggtc agaactaacc tggaccccac ccctggcgct ggtcctgcca gcctcaatgg
     1801 ggccaagtgg tacctgtgca gggaaggaga tgcaggagct gggaggctcc caactccacg
     1861 gtgcccacac tggaccttgg cactggatga gccaataaac gaaactctga cacctccttt
//
