LOCUS       NM_178608               3815 bp    mRNA    linear   ROD 29-JUL-2024
DEFINITION  Mus musculus receptor accessory protein 1 (Reep1), mRNA.
ACCESSION   NM_178608
VERSION     NM_178608.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3815)
  AUTHORS   Qin,S., You,P., Yu,H. and Su,B.
  TITLE     REEP1 Preserves Motor Function in SOD1G93A Mice by Improving
            Mitochondrial Function via Interaction with NDUFA4
  JOURNAL   Neurosci Bull 39 (6), 929-946 (2023)
   PUBMED   36520405
  REMARK    GeneRIF: REEP1 Preserves Motor Function in SOD1[G93A] Mice by
            Improving Mitochondrial Function via Interaction with NDUFA4.
REFERENCE   2  (bases 1 to 3815)
  AUTHORS   Zhu,P.P., Hung,H.F., Batchenkova,N., Nixon-Abell,J., Henderson,J.,
            Zheng,P., Renvoise,B., Pang,S., Xu,C.S., Saalfeld,S., Funke,J.,
            Xie,Y., Svara,F., Hess,H.F. and Blackstone,C.
  TITLE     Transverse endoplasmic reticulum expansion in hereditary spastic
            paraplegia corticospinal axons
  JOURNAL   Hum Mol Genet 31 (16), 2779-2795 (2022)
   PUBMED   35348668
  REMARK    GeneRIF: Transverse endoplasmic reticulum expansion in hereditary
            spastic paraplegia corticospinal axons.
REFERENCE   3  (bases 1 to 3815)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3815)
  AUTHORS   Leca,I., Phillips,A.W., Hofer,I., Landler,L., Ushakova,L.,
            Cushion,T.D., Durnberger,G., Stejskal,K., Mechtler,K. and
            Keays,D.A.
  TITLE     A proteomic survey of microtubule-associated proteins in a R402H
            TUBA1A mutant mouse
  JOURNAL   PLoS Genet 16 (11), e1009104 (2020)
   PUBMED   33137126
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3815)
  AUTHORS   Wang,B., Yu,Y., Wei,L. and Zhang,Y.
  TITLE     Inhibition of ER stress improves progressive motor deficits in a
            REEP1-null mouse model of hereditary spastic paraplegia
  JOURNAL   Biol Open 9 (9) (2020)
   PUBMED   32878877
  REMARK    GeneRIF: Inhibition of ER stress improves progressive motor
            deficits in a REEP1-null mouse model of hereditary spastic
            paraplegia.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3815)
  AUTHORS   Hashimoto,Y., Shirane,M., Matsuzaki,F., Saita,S., Ohnishi,T. and
            Nakayama,K.I.
  TITLE     Protrudin regulates endoplasmic reticulum morphology and function
            associated with the pathogenesis of hereditary spastic paraplegia
  JOURNAL   J Biol Chem 289 (19), 12946-12961 (2014)
   PUBMED   24668814
REFERENCE   7  (bases 1 to 3815)
  AUTHORS   Falk,J., Rohde,M., Bekhite,M.M., Neugebauer,S., Hemmerich,P.,
            Kiehntopf,M., Deufel,T., Hubner,C.A. and Beetz,C.
  TITLE     Functional mutation analysis provides evidence for a role of REEP1
            in lipid droplet biology
  JOURNAL   Hum Mutat 35 (4), 497-504 (2014)
   PUBMED   24478229
  REMARK    GeneRIF: Functional mutation analysis reveal that distinct
            pathomechanisms are associated with REEP1 mutations and shed new
            light on its probable functions.
REFERENCE   8  (bases 1 to 3815)
  AUTHORS   Bjork,S., Hurt,C.M., Ho,V.K. and Angelotti,T.
  TITLE     REEPs are membrane shaping adapter proteins that modulate specific
            g protein-coupled receptor trafficking by affecting ER cargo
            capacity
  JOURNAL   PLoS One 8 (10), e76366 (2013)
   PUBMED   24098485
  REMARK    Erratum:[PLoS One. 2013;8(12).
            doi:10.1371/annotation/6f86410c-63c3-4fcd-b1cb-9fd8d2ea95d0]
            Publication Status: Online-Only
REFERENCE   9  (bases 1 to 3815)
  AUTHORS   Beetz,C., Koch,N., Khundadze,M., Zimmer,G., Nietzsche,S.,
            Hertel,N., Huebner,A.K., Mumtaz,R., Schweizer,M., Dirren,E.,
            Karle,K.N., Irintchev,A., Alvarez,V., Redies,C., Westermann,M.,
            Kurth,I., Deufel,T., Kessels,M.M., Qualmann,B. and Hubner,C.A.
  TITLE     A spastic paraplegia mouse model reveals REEP1-dependent ER shaping
  JOURNAL   J Clin Invest 123 (10), 4273-4282 (2013)
   PUBMED   24051375
  REMARK    Erratum:[J Clin Invest. 2014 Jun 2;124(6):2809]
REFERENCE   10 (bases 1 to 3815)
  AUTHORS   Saito,H., Kubota,M., Roberts,R.W., Chi,Q. and Matsunami,H.
  TITLE     RTP family members induce functional expression of mammalian
            odorant receptors
  JOURNAL   Cell 119 (5), 679-691 (2004)
   PUBMED   15550249
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CX239705.1 and BC046826.1.
            
            On Mar 16, 2011 this sequence version replaced NM_178608.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC046826.1, SRR1660819.90492.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            RefSeq Select criteria             :: based on conservation,
                                                  expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-229               CX239705.1         1-229
            230-3815            BC046826.1         1-3586
FEATURES             Location/Qualifiers
     source          1..3815
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 32.2 cM"
     gene            1..3815
                     /gene="Reep1"
                     /gene_synonym="D6Ertd253e"
                     /note="receptor accessory protein 1"
                     /db_xref="GeneID:52250"
                     /db_xref="MGI:MGI:1098827"
     exon            1..321
                     /gene="Reep1"
                     /gene_synonym="D6Ertd253e"
                     /inference="alignment:Splign:2.1.0"
     CDS             290..895
                     /gene="Reep1"
                     /gene_synonym="D6Ertd253e"
                     /codon_start=1
                     /product="receptor expression-enhancing protein 1"
                     /protein_id="NP_848723.1"
                     /db_xref="CCDS:CCDS51807.1"
                     /db_xref="GeneID:52250"
                     /db_xref="MGI:MGI:1098827"
                     /translation="MVSWIISRLVVLIFGTLYPAYYSYKAVKSKDIKEYVKWMMYWII
                     FALFTTAETFTDIFLCWFPFYYELKIAFVAWLLSPYTKGSSLLYRKFVHPTLSSKEKE
                     IDDCLVQAKDRSYDALVHFGKRGLNVAATAAVMAASKGQGALSERLRSFSMQDLTTIR
                     GDGAPAPSGPPPPGTGRSSGKHSQPKMSRSASESAGSSGTA"
     exon            322..394
                     /gene="Reep1"
                     /gene_synonym="D6Ertd253e"
                     /inference="alignment:Splign:2.1.0"
     exon            395..471
                     /gene="Reep1"
                     /gene_synonym="D6Ertd253e"
                     /inference="alignment:Splign:2.1.0"
     exon            472..592
                     /gene="Reep1"
                     /gene_synonym="D6Ertd253e"
                     /inference="alignment:Splign:2.1.0"
     exon            593..706
                     /gene="Reep1"
                     /gene_synonym="D6Ertd253e"
                     /inference="alignment:Splign:2.1.0"
     exon            707..884
                     /gene="Reep1"
                     /gene_synonym="D6Ertd253e"
                     /inference="alignment:Splign:2.1.0"
     exon            885..3804
                     /gene="Reep1"
                     /gene_synonym="D6Ertd253e"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3773..3778
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Reep1"
                     /gene_synonym="D6Ertd253e"
                     /note="hexamer: AATAAA"
     polyA_site      3804
                     /gene="Reep1"
                     /gene_synonym="D6Ertd253e"
                     /note="major polyA site"
ORIGIN      
        1 ggaggacccg ccctggctgc agctctgggg ctgggacgat cggagcaggg gcgggtcgcg
       61 ctggtgccct caccgctagc cgcccaatcg ccgtgggccc gcggagcccc tgggggctgg
      121 ggcagcgggc ggaacgtgcc gcggctgcgc caacgcgcga gcgcggggcc ggaccgggcg
      181 ggtgcgctca gtctggcggc agcggcggtg cacagacaga cagacgtgcc gggagcgcag
      241 caccgcccgc agcccagcaa tccgggccgc gccagcccgc ccgcccgcca tggtgtcgtg
      301 gatcatctcc aggctggtgg tgcttatatt tggcaccctt tatcctgcat attattcata
      361 caaggctgtg aagtccaagg acattaaaga atatgtcaaa tggatgatgt attggattat
      421 atttgccctc ttcaccacgg cagagacgtt cacagacatc ttcctttgct ggtttccatt
      481 ctattatgaa ctaaaaatag cgtttgtagc ctggctgctg tctccctata caaaaggatc
      541 cagcctcctg tacaggaagt ttgttcatcc cacattgtct tcaaaagaaa aggaaatcga
      601 tgactgcctg gtccaagcaa aagatcgaag ctatgacgcc cttgtgcact ttgggaagcg
      661 gggcttgaat gtggcagcca ctgcagctgt gatggctgcc tccaagggac agggtgcctt
      721 gtcagagaga ctccggagct tcagcatgca ggacctcacc accatcaggg gtgatggtgc
      781 tcctgctccc tcgggccctc ctccaccagg gactgggcgg tccagcggca aacacagcca
      841 gcccaagatg tccaggagtg cttctgagag tgccggcagc tcgggcaccg cctagaaccc
      901 tacgatcccg cttcaggaag aaaagtacct catcctcggc cactgaaacc acgtgagatg
      961 agccaacagc cccggatcca cacatgtctg tctcctctgc cttaaagagc tagtcactag
     1021 taccatggaa gtccgcaggc tgggtgtgct tcgagtgtgc agcccacgga catggccttt
     1081 actcgctccc ctcttctgcc tttaagactc ttctgttctt tcctttttgt tcctgctggg
     1141 gagaggctaa agggaaaagg tggtggtgga gggtgacctt tacgtcttct ggggttagtg
     1201 attttcccca attggattgt cattgtggcc gcagtgtttt tagatctata agcactcttt
     1261 ccatgatgct gctgagatgt acatttgtaa tttgtttgtt gcatagtttt tagtcctgta
     1321 aatgcaaacg acgtgatctt ttttaaaaac ccttttgttg ttcttggtac taatacattg
     1381 gactatggtg tacatagtta cagcttttgg cttaatgtaa tgaactcgca agggctgcca
     1441 gaagttctgg tgagagagct gcaaaaacaa aaatgtagac aaatatttta attctaggca
     1501 atgtctccaa cttccttaca aaggcagtgc cagtaaggca tcccttctcc tgcaggaagg
     1561 cggtggtgtg cttctggcgg ctgagtggtt ggtaggtcag agcggaggca ggagtgcagt
     1621 gttccagcaa caggaagaaa gttggtgggc atcagggaag agggaggaag agtacggctt
     1681 cttcagttct gggtccctgg ctgtcctaat aggtttgttg tgctgtacct aatctcaccc
     1741 ttcctgccct ttggggtcaa gaacagaagc ttccgagccc tttggggagc actggccctg
     1801 cttcaggcag gccagctcac ccttacttag cacggccatt tagggaatga agatcagctg
     1861 ctggcagaat tgtgagtatc tcagaagggc ttggcaagag tgtttctcct tcagggacca
     1921 gcgctgtggc cgacttctcc aggagcctac atctgagcac cttgttttag agtacacaag
     1981 gcaaaaagaa aagtctagaa ctagcttttg ttacagatgt gctcaaaaca catgagacac
     2041 tcaaatctca aatggtcgcc agaaggcagg gtctagggag gactgaggct aagccacagg
     2101 cagctgtggc tcttgctcct ttctggcttg tgtggaaggt gaatgggaag gactgacact
     2161 catgctcact ccatgtcttc gtggatgttt tatacaagcc aggactgcag tgagaatttt
     2221 gacaagtctc tgacttagat aacattgcgt tgagggagct gccctctcct ctgatagctg
     2281 agccaaattg tagggctagt ctgtgtgtgc gtagagttgg tgttttcgtt ccatggaatg
     2341 catgcagcag tcacaaccca gttactccta tttggattat atttgttcac agctatgccc
     2401 tgaaggctag agaaatagtg ttgtatacca catagaactg tcaactgact gcaaacaggc
     2461 tcaattacaa accgctctgg taccgagcta tgcaaacatg cactgggaga ctgctccatc
     2521 agctgggcct tggccatttc acaaagggtt tcagttgcga gttcattgct gccagataca
     2581 cctaatggaa ttttccaaag gtgattttgt atttcagaac taacccaaga gctgatgact
     2641 gacggtaaat agtctgcctg ggccccatat ccatctgaac ccattaagca aagcatctgc
     2701 cctcttcaag ctcaccccac agctccagac aagagaagtg acacccttca aacataccaa
     2761 cgtgtcagct gggtgtagcc aggatgaaga ggaacaggtg caggaaagcc tgagagaagc
     2821 agctttgcag ctccccctcc accccccgaa ataataaatg gctttagaga cagagttcaa
     2881 gtcctagtgt attttcatcg ttttacaaca ggaagtcata acacatcgag gctcttgagt
     2941 ttgtactcag ccatgccaaa acccagtttg aagcactcct cagacatgct gtattacttc
     3001 tcgctcaaga tttaaaatat aaaggtatct aaatcgttgt cttattgtaa atgtaactcc
     3061 ttttccttca agtgttgact aagttgtttc ctctcttaaa gacactcact gtacagccaa
     3121 acacagctgt cttacttctt gagaactgtg tttacttttc tgacaagctg tgtatttgta
     3181 tgtagactga catatgatgt gaatgacctt gtatgtagaa gtgcggtgct ctgtctacgc
     3241 aggataaatg aatgtttcta gttcgctgac ttaagacaca ggctgtttac aaatcgctag
     3301 ctcgaaggtc tacttgtcgc ggctttgagt tactctccat ttctgcagag gtgaggtgca
     3361 gtctcctgct catcaactgg agatttagtc ataatgcctc ctgagtttgt gtgaatagct
     3421 tgctcacttt gctggccttt gatatgtatg ttctctgtgg taaactgtcc atgtgtttgt
     3481 attaagtgct tatcaaccac aaccatcacg tagccatccc agttcttcac cttgcacagt
     3541 atttgaagta ttagacgtgg tggaagatgt gcttcatcct ctgacagtgg acgctcgaag
     3601 agctcatgtt ccagattgtg actgtgcgca tttcctctag tttctttctg aaatctctct
     3661 ataaatgagt acaattaata gtatactgga ctgtgtatct acaggatgta aattgcagta
     3721 ttccaaaggc tgaagctctg ctgttttgtt ataatgcctg ataaacatct tgaataaagt
     3781 cttaacattt ttcttttaaa aaaaaaaaaa aaaaa
//
