LOCUS       NM_130454               4001 bp    mRNA    linear   ROD 10-OCT-2024
DEFINITION  Mus musculus RecQ protein-like 5 (Recql5), mRNA.
ACCESSION   NM_130454
VERSION     NM_130454.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4001)
  AUTHORS   Iwata,S., Nagahara,M., Ido,R. and Iwamoto,T.
  TITLE     A Recql5 mutant facilitates complex CRISPR/Cas9-mediated
            chromosomal engineering in mouse zygotes
  JOURNAL   Genetics 227 (2) (2024)
   PUBMED   38577877
  REMARK    GeneRIF: A Recql5 mutant facilitates complex CRISPR/Cas9-mediated
            chromosomal engineering in mouse zygotes.
REFERENCE   2  (bases 1 to 4001)
  AUTHORS   Liao,W.Q., Qi,Y.L., Wang,L., Dong,X.M., Xu,T., Ding,C.D., Liu,R.,
            Liang,W.C., Lu,L.T., Li,H., Li,W.F., Luo,G.B. and Lu,X.C.
  TITLE     Recql5 protects against lipopolysaccharide/D-galactosamine-induced
            liver injury in mice
  JOURNAL   World J Gastroenterol 21 (36), 10375-10384 (2015)
   PUBMED   26420964
  REMARK    GeneRIF: Recql5 protects the liver against LPS/D-Gal-induced injury
            by suppressing hepatocyte apoptosis and oxidative stress and
            modulation of CYP450 expression.
REFERENCE   3  (bases 1 to 4001)
  AUTHORS   Kim,T.M., Son,M.Y., Dodds,S., Hu,L., Luo,G. and Hasty,P.
  TITLE     RECQL5 and BLM exhibit divergent functions in cells defective for
            the Fanconi anemia pathway
  JOURNAL   Nucleic Acids Res 43 (2), 893-903 (2015)
   PUBMED   25520194
REFERENCE   4  (bases 1 to 4001)
  AUTHORS   Hu,Y., Lu,X. and Luo,G.
  TITLE     Effect of Recql5 deficiency on the intestinal tumor susceptibility
            of Apc(min) mice
  JOURNAL   World J Gastroenterol 16 (12), 1482-1486 (2010)
   PUBMED   20333788
  REMARK    GeneRIF: Recql5 has a tumor suppressor role in the gastrointestinal
            tract of Apc(min) mice.
REFERENCE   5  (bases 1 to 4001)
  AUTHORS   Hu,Y., Lu,X., Zhou,G., Barnes,E.L. and Luo,G.
  TITLE     Recql5 plays an important role in DNA replication and cell survival
            after camptothecin treatment
  JOURNAL   Mol Biol Cell 20 (1), 114-123 (2009)
   PUBMED   18987339
  REMARK    GeneRIF: Data suggest that Recql5 helps maintain active DNA
            replication to prevent collapse of replication forks and
            accumulation of DSBs, preserve genome integrity and prevent cell
            death after replication stress due to topoisomerase I poisoning.
REFERENCE   6  (bases 1 to 4001)
  AUTHORS   Hu,Y., Raynard,S., Sehorn,M.G., Lu,X., Bussen,W., Zheng,L.,
            Stark,J.M., Barnes,E.L., Chi,P., Janscak,P., Jasin,M., Vogel,H.,
            Sung,P. and Luo,G.
  TITLE     RECQL5/Recql5 helicase regulates homologous recombination and
            suppresses tumor formation via disruption of Rad51 presynaptic
            filaments
  JOURNAL   Genes Dev 21 (23), 3073-3084 (2007)
   PUBMED   18003859
  REMARK    GeneRIF: Recql5-deficient cells exhibit elevated frequencies of
            spontaneous DNA double-strand breaks and homologous recombination (
REFERENCE   7  (bases 1 to 4001)
  AUTHORS   Hu,Y., Lu,X., Barnes,E., Yan,M., Lou,H. and Luo,G.
  TITLE     Recql5 and Blm RecQ DNA helicases have nonredundant roles in
            suppressing crossovers
  JOURNAL   Mol Cell Biol 25 (9), 3431-3442 (2005)
   PUBMED   15831450
REFERENCE   8  (bases 1 to 4001)
  AUTHORS   Bachrati,C.Z. and Hickson,I.D.
  TITLE     RecQ helicases: suppressors of tumorigenesis and premature aging
  JOURNAL   Biochem J 374 (Pt 3), 577-606 (2003)
   PUBMED   12803543
  REMARK    Review article
REFERENCE   9  (bases 1 to 4001)
  AUTHORS   Ohhata,T., Araki,R., Fukumura,R., Kuroiwa,A., Matsuda,Y. and Abe,M.
  TITLE     Cloning, genomic structure and chromosomal localization of the gene
            encoding mouse DNA helicase RECQL5beta
  JOURNAL   Gene 280 (1-2), 59-66 (2001)
   PUBMED   11738818
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL645647.8, BC059000.1, AK049269.1 and AW049927.1.
            
            On Mar 18, 2011 this sequence version replaced NM_130454.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC059000.1, AB059999.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-26                AL645647.8         95628-95653         c
            27-2074             BC059000.1         1-2048
            2075-3982           AK049269.1         475-2382
            3983-4001           AW049927.1         1-19                c
FEATURES             Location/Qualifiers
     source          1..4001
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 80.91 cM"
     gene            1..4001
                     /gene="Recql5"
                     /gene_synonym="RecQ5; Recq5b; Recql5b"
                     /note="RecQ protein-like 5"
                     /db_xref="GeneID:170472"
                     /db_xref="MGI:MGI:2156841"
     exon            1..704
                     /gene="Recql5"
                     /gene_synonym="RecQ5; Recq5b; Recql5b"
                     /inference="alignment:Splign:2.1.0"
     CDS             575..3523
                     /gene="Recql5"
                     /gene_synonym="RecQ5; Recq5b; Recql5b"
                     /EC_number="5.6.2.4"
                     /note="RECQL5beta; DNA helicase, RecQ-like type 5; DNA
                     3'-5' helicase RecQ5"
                     /codon_start=1
                     /product="ATP-dependent DNA helicase Q5"
                     /protein_id="NP_569721.1"
                     /db_xref="CCDS:CCDS25650.1"
                     /db_xref="GeneID:170472"
                     /db_xref="MGI:MGI:2156841"
                     /translation="MSARPFSTPFDRERRVRSTLKKVFGFDSFKTPLQESATMAVVKG
                     AEDVFVCMPTGAGKSLCYQLPALLASGITIVVSPLIALIQDQVDHLLALKVQVSSLNS
                     KLSVQERKELLSDLERDKPRTKLLYITPEMAASASFQPTLNSLVSRNLLSYLVVDEAH
                     CVSQWGHDFRPDYLRLGALRSRLAHAPCVALTATATPQVQEDVFAALHLKQPVASFKT
                     PCFRANLFYDVQFKELIPDVYGNLRDFCLKALGQKAENGSSSGCGIVYCRTREACEQL
                     AIELSSRGVNAKAYHAGLKASDRTQVQNEWMEEKVPVIVATISFGMGVDKANVRFVAH
                     WNIAKSMAGYYQESGRAGRDGKPSWCRLYYSRNDRDQVSFLIRKELAKLQEKRGNKPS
                     DKATLLAFDALVTFCEEVGCRHAAIAKYFGDAPPACAKGCDYCQNPAAITKKLDALER
                     SSSWSKTCIGPSQGNGFDPELYEGGRRGYGGFSRYDEGSGGSGDEGRDEAHKREWNLF
                     YQKQMSLRKGKEPKIEEFTPPDEDCPLREASSRKIPKLTVKAREHCLRLLEEALISNH
                     QAAGSTHGADLQAKAVELEHETFRNAKMVNLYKASVLKKVAEIHKASKDGQLYDMESG
                     TKSCGAAAEFSEPSDYDIPPTSHVYSLKPKRVGAGFSKGPCSFQTATELLGKSHSQKQ
                     APEAMLEGGQEPPGWVCDLQDEDRSKPHPGYQEKALGSSVNCGDPSPEKKTKGSSQGS
                     AKARASKKQQLLATAARKDSQNITRFLCQRTESPPLPASVPRSEDASPSCGDVPGKCT
                     QEVGAQGHLVAVFQTEGPRERPSTCSLRDQSFPEGQPSPLKETQAEKRPRPQQGNPER
                     RAQKRLRPSTKSSILAEAKDSTLASDRSTENKVAQEPCQLSASGTSLREAADIVVRHL
                     TPFYKEGRFISKDLFKGFARHLSHLLAQQLSPGRSVKEEAQSLIKQFFHNRARCESEA
                     DWHSLRGPQR"
     exon            705..826
                     /gene="Recql5"
                     /gene_synonym="RecQ5; Recq5b; Recql5b"
                     /inference="alignment:Splign:2.1.0"
     exon            827..1345
                     /gene="Recql5"
                     /gene_synonym="RecQ5; Recq5b; Recql5b"
                     /inference="alignment:Splign:2.1.0"
     exon            1346..1451
                     /gene="Recql5"
                     /gene_synonym="RecQ5; Recq5b; Recql5b"
                     /inference="alignment:Splign:2.1.0"
     exon            1452..1563
                     /gene="Recql5"
                     /gene_synonym="RecQ5; Recq5b; Recql5b"
                     /inference="alignment:Splign:2.1.0"
     exon            1564..1726
                     /gene="Recql5"
                     /gene_synonym="RecQ5; Recq5b; Recql5b"
                     /inference="alignment:Splign:2.1.0"
     exon            1727..1806
                     /gene="Recql5"
                     /gene_synonym="RecQ5; Recq5b; Recql5b"
                     /inference="alignment:Splign:2.1.0"
     exon            1807..2025
                     /gene="Recql5"
                     /gene_synonym="RecQ5; Recq5b; Recql5b"
                     /inference="alignment:Splign:2.1.0"
     exon            2026..2125
                     /gene="Recql5"
                     /gene_synonym="RecQ5; Recq5b; Recql5b"
                     /inference="alignment:Splign:2.1.0"
     exon            2126..2162
                     /gene="Recql5"
                     /gene_synonym="RecQ5; Recq5b; Recql5b"
                     /inference="alignment:Splign:2.1.0"
     exon            2163..2221
                     /gene="Recql5"
                     /gene_synonym="RecQ5; Recq5b; Recql5b"
                     /inference="alignment:Splign:2.1.0"
     exon            2222..2295
                     /gene="Recql5"
                     /gene_synonym="RecQ5; Recq5b; Recql5b"
                     /inference="alignment:Splign:2.1.0"
     exon            2296..2389
                     /gene="Recql5"
                     /gene_synonym="RecQ5; Recq5b; Recql5b"
                     /inference="alignment:Splign:2.1.0"
     exon            2390..2524
                     /gene="Recql5"
                     /gene_synonym="RecQ5; Recq5b; Recql5b"
                     /inference="alignment:Splign:2.1.0"
     exon            2525..3036
                     /gene="Recql5"
                     /gene_synonym="RecQ5; Recq5b; Recql5b"
                     /inference="alignment:Splign:2.1.0"
     exon            3037..3127
                     /gene="Recql5"
                     /gene_synonym="RecQ5; Recq5b; Recql5b"
                     /inference="alignment:Splign:2.1.0"
     exon            3128..3352
                     /gene="Recql5"
                     /gene_synonym="RecQ5; Recq5b; Recql5b"
                     /inference="alignment:Splign:2.1.0"
     exon            3353..3422
                     /gene="Recql5"
                     /gene_synonym="RecQ5; Recq5b; Recql5b"
                     /inference="alignment:Splign:2.1.0"
     exon            3423..3986
                     /gene="Recql5"
                     /gene_synonym="RecQ5; Recq5b; Recql5b"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3949..3954
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Recql5"
                     /gene_synonym="RecQ5; Recq5b; Recql5b"
                     /note="hexamer: AATAAA"
     polyA_site      3986
                     /gene="Recql5"
                     /gene_synonym="RecQ5; Recq5b; Recql5b"
                     /note="major polyA site"
ORIGIN      
        1 gaagtaaggt cttgcggctt ctacttcgct gacttctcgg gcggtttggc ttctgagttc
       61 gagttaggga gtagtgttct ttggaaagct gcagagccaa ccgaaaagag cctggggtct
      121 gacatcttgg agagcatttg tctggcaaag ggcgagagct gttgacttgg gggctcagag
      181 gaggaacggg gggtcggcgt ccttgatgaa tggtatctat ggcttcgctt ctagaacaag
      241 gaccctagaa aaaggattcc aagttctctg gtcgactttg aagacgtttg tgggctttgt
      301 tgtggtccga tttgtagctc tgtccacctg acctggaaag ttcattgttt ttatttttat
      361 taaagggaga agtaatgtta atccctcagg aatgtattgc gtgaagcaat tcagccttca
      421 cttttactgc tggggaatga gatatttaag tgtaacatag cagcttactc ggcaggagaa
      481 acataggcta tattttaacg tggagcagag ggttttttcg ggattgcctt tgcccacctt
      541 tgcgttaacc ttttggctgc tgctttttgc aaagatgagc gcccgtcctt tctccactcc
      601 cttcgaccgg gagcggcgag tccggagcac cctgaagaaa gtctttgggt ttgattcttt
      661 taaaacacct ttacaagaga gtgcgaccat ggctgtagtg aaaggtgccg aggatgtgtt
      721 tgtgtgcatg cccacagggg cagggaagtc tctgtgctat caactccctg ccctgttggc
      781 cagtgggatc accattgtag tctctcctct cattgccttg attcaggacc aggtagacca
      841 tttgctggcc ttgaaggtac aagttagttc cctgaactca aagctctcgg tacaggagag
      901 gaaggagctg ctgtctgacc tggagcgaga caaacctcgg accaaacttt tgtacatcac
      961 cccagagatg gcagcttcag cctccttcca gcccaccctg aattccctgg tgtcccgaaa
     1021 cctgctctcc tacttggtgg tggatgaagc tcattgcgtt tcccagtggg gacatgactt
     1081 ccgtcctgac tatttgcgtc tgggtgccct acgttcccgc ttggcacatg ccccgtgcgt
     1141 ggctctgacg gctacagcca ccccacaggt tcaagaggat gtgtttgctg ccctgcactt
     1201 gaagcagcca gtcgcctctt tcaagactcc ctgtttccgg gccaacctct tctatgatgt
     1261 gcagttcaag gaactgattc ccgacgtcta tggcaatctg agggacttct gccttaaggc
     1321 tcttggacag aaggctgaga acgggtcgtc ctctggctgt ggcattgtct actgcaggac
     1381 tagagaagct tgtgaacaac tggccattga gctcagcagc aggggtgtga acgccaaggc
     1441 ttaccacgca ggcctgaagg catctgatag aacacaggta cagaacgagt ggatggagga
     1501 gaaggtccct gtaattgttg cgaccatcag ttttgggatg ggagtagaca aagctaatgt
     1561 ccggtttgtt gctcattgga atattgccaa gtccatggct ggctactacc aggagtctgg
     1621 ccgtgctggc agggatggca aaccatcttg gtgccgcctg tattactcta ggaatgaccg
     1681 agaccaagtc agcttcctta tcaggaagga actagccaaa ctccaggaaa agagggggaa
     1741 caaaccgtct gataaggcca ccctgctggc ctttgatgcc ctggtgacct tctgtgaaga
     1801 agtggggtgc cgccatgctg ccattgctaa gtactttggg gatgcacccc ccgcctgcgc
     1861 caaaggctgt gactactgcc agaatcctgc agccataacg aagaagctgg atgccctgga
     1921 gcgcagcagc agctggagca agacctgcat cgggccctca caggggaatg gcttcgatcc
     1981 tgagctgtat gagggaggcc gcaggggcta tggtggcttc agcaggtatg atgaaggttc
     2041 tggaggtagc ggtgatgagg gcagagatga ggcccacaag cgggaatgga atcttttcta
     2101 tcagaaacag atgagcctgc gcaagggcaa agagcccaag atagaagaat tcacgccccc
     2161 agatgaagac tgtcccctga gagaggcttc aagcaggaag atcccgaagc tcacagtgaa
     2221 ggcccgtgag cactgcctgc gacttctgga ggaggctctg atcagtaacc atcaggctgc
     2281 aggctccact catggagctg acctgcaggc caaggctgtg gaactggagc atgagacatt
     2341 ccggaatgcc aagatggtca atctgtacaa ggccagtgtc ctgaagaagg tggccgagat
     2401 ccacaaagcc tccaaggatg gtcagctcta tgacatggaa agcggcacca agagctgtgg
     2461 ggccgcagct gagttctcgg agcccagtga ctatgacatc ccgccaacct cacatgtgta
     2521 ctcgctcaaa cccaagagag taggagctgg cttctccaaa ggcccctgct cattccagac
     2581 agccacagaa ctgttgggga agtctcactc ccagaagcaa gccccagagg ctatgctaga
     2641 gggtggacag gagcccccag gctgggtctg tgaccttcaa gatgaagaca ggagcaagcc
     2701 ccaccctggg taccaagaaa aggctctagg aagcagtgtt aattgtgggg acccctcgcc
     2761 tgagaagaag acgaaagggt cttcccaggg cagtgccaaa gctagagcca gcaagaaaca
     2821 acagctccta gccacagcag cccgcaagga ttcccagaat atcactcgat tcctctgtca
     2881 gaggacagaa tctccacctc tccctgcttc agttccaaga tcagaagatg ccagcccctc
     2941 ctgtggggat gtcccaggga agtgcacaca agaggttgga gctcagggac atttggttgc
     3001 tgtatttcag actgagggtc ccagggagag gccaagcacc tgctcactca gagaccagag
     3061 cttccctgaa ggtcagccta gccctctaaa ggaaacccag gcagagaagc ggcccagacc
     3121 acagcagggc aacccagaga gaagggctca aaagaggctt cgcccctcaa ccaagtcctc
     3181 catcttggct gaggccaagg acagtacctt ggccagtgat cgcagcactg aaaacaaagt
     3241 ggctcaagaa ccctgccagc tctcagcatc tggcacctcc ctgagggagg ccgcagacat
     3301 tgtggtcagg cacctgaccc ccttctacaa ggagggcagg tttatatcca aggacctgtt
     3361 taagggcttt gcccgccacc tctcacattt gctggctcag cagctctctc ctggaaggag
     3421 tgtgaaggaa gaggcccaga gcctcatcaa gcagttcttc cacaatcgtg cccgctgtga
     3481 gagtgaagct gactggcaca gcctgcgtgg cccacagcga tgagtgcagc tggctgggca
     3541 gccctccttg ccacaggcac cagctttctc agggtctttc ttcccatgcc caaacctcac
     3601 tttggaggtg ttactagaca cccaaatgaa gtggaaggtc agaggtcaga ccaccctccc
     3661 atttaaaccc cgcttctcct gccttcctat ccaggtccct agatgagaag gtccagataa
     3721 tatggccgct gccaggtggg ggtgggctgg gagaaccaat gggcctcctg tcttgtacct
     3781 aagttctcta tcagggtgat gcccattcca gtcctccact gccctcttcc aggagatgcc
     3841 aggcagtagg ccttgttcta gcagagctct ctgggagaga agcagccgtt ctccaagccc
     3901 tgagctctgc tggtcgggaa ggccaggcac aagtgagcca tttgcgagaa taaagtcctc
     3961 cggtggagac acatgctcac acacaaaaaa aaaaaaaaaa a
//
