LOCUS       NP_569721                982 aa            linear   ROD 27-APR-2025
DEFINITION  ATP-dependent DNA helicase Q5 [Mus musculus].
ACCESSION   NP_569721
VERSION     NP_569721.1
DBSOURCE    REFSEQ: accession NM_130454.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 982)
  AUTHORS   Iwata,S., Nagahara,M., Ido,R. and Iwamoto,T.
  TITLE     A Recql5 mutant facilitates complex CRISPR/Cas9-mediated
            chromosomal engineering in mouse zygotes
  JOURNAL   Genetics 227 (2) (2024)
   PUBMED   38577877
  REMARK    GeneRIF: A Recql5 mutant facilitates complex CRISPR/Cas9-mediated
            chromosomal engineering in mouse zygotes.
REFERENCE   2  (residues 1 to 982)
  AUTHORS   Liao,W.Q., Qi,Y.L., Wang,L., Dong,X.M., Xu,T., Ding,C.D., Liu,R.,
            Liang,W.C., Lu,L.T., Li,H., Li,W.F., Luo,G.B. and Lu,X.C.
  TITLE     Recql5 protects against lipopolysaccharide/D-galactosamine-induced
            liver injury in mice
  JOURNAL   World J Gastroenterol 21 (36), 10375-10384 (2015)
   PUBMED   26420964
  REMARK    GeneRIF: Recql5 protects the liver against LPS/D-Gal-induced injury
            by suppressing hepatocyte apoptosis and oxidative stress and
            modulation of CYP450 expression.
REFERENCE   3  (residues 1 to 982)
  AUTHORS   Kim,T.M., Son,M.Y., Dodds,S., Hu,L., Luo,G. and Hasty,P.
  TITLE     RECQL5 and BLM exhibit divergent functions in cells defective for
            the Fanconi anemia pathway
  JOURNAL   Nucleic Acids Res 43 (2), 893-903 (2015)
   PUBMED   25520194
REFERENCE   4  (residues 1 to 982)
  AUTHORS   Hu,Y., Lu,X. and Luo,G.
  TITLE     Effect of Recql5 deficiency on the intestinal tumor susceptibility
            of Apc(min) mice
  JOURNAL   World J Gastroenterol 16 (12), 1482-1486 (2010)
   PUBMED   20333788
  REMARK    GeneRIF: Recql5 has a tumor suppressor role in the gastrointestinal
            tract of Apc(min) mice.
REFERENCE   5  (residues 1 to 982)
  AUTHORS   Hu,Y., Lu,X., Zhou,G., Barnes,E.L. and Luo,G.
  TITLE     Recql5 plays an important role in DNA replication and cell survival
            after camptothecin treatment
  JOURNAL   Mol Biol Cell 20 (1), 114-123 (2009)
   PUBMED   18987339
  REMARK    GeneRIF: Data suggest that Recql5 helps maintain active DNA
            replication to prevent collapse of replication forks and
            accumulation of DSBs, preserve genome integrity and prevent cell
            death after replication stress due to topoisomerase I poisoning.
REFERENCE   6  (residues 1 to 982)
  AUTHORS   Hu,Y., Raynard,S., Sehorn,M.G., Lu,X., Bussen,W., Zheng,L.,
            Stark,J.M., Barnes,E.L., Chi,P., Janscak,P., Jasin,M., Vogel,H.,
            Sung,P. and Luo,G.
  TITLE     RECQL5/Recql5 helicase regulates homologous recombination and
            suppresses tumor formation via disruption of Rad51 presynaptic
            filaments
  JOURNAL   Genes Dev 21 (23), 3073-3084 (2007)
   PUBMED   18003859
  REMARK    GeneRIF: Recql5-deficient cells exhibit elevated frequencies of
            spontaneous DNA double-strand breaks and homologous recombination (
REFERENCE   7  (residues 1 to 982)
  AUTHORS   Hu,Y., Lu,X., Barnes,E., Yan,M., Lou,H. and Luo,G.
  TITLE     Recql5 and Blm RecQ DNA helicases have nonredundant roles in
            suppressing crossovers
  JOURNAL   Mol Cell Biol 25 (9), 3431-3442 (2005)
   PUBMED   15831450
REFERENCE   8  (residues 1 to 982)
  AUTHORS   Bachrati,C.Z. and Hickson,I.D.
  TITLE     RecQ helicases: suppressors of tumorigenesis and premature aging
  JOURNAL   Biochem J 374 (Pt 3), 577-606 (2003)
   PUBMED   12803543
  REMARK    Review article
REFERENCE   9  (residues 1 to 982)
  AUTHORS   Ohhata,T., Araki,R., Fukumura,R., Kuroiwa,A., Matsuda,Y. and Abe,M.
  TITLE     Cloning, genomic structure and chromosomal localization of the gene
            encoding mouse DNA helicase RECQL5beta
  JOURNAL   Gene 280 (1-2), 59-66 (2001)
   PUBMED   11738818
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL645647.8, BC059000.1, AK049269.1 and AW049927.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC059000.1, AB059999.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..982
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 80.91 cM"
     Protein         1..982
                     /product="ATP-dependent DNA helicase Q5"
                     /EC_number="5.6.2.4"
                     /note="RECQL5beta; DNA helicase, RecQ-like type 5; DNA
                     3'-5' helicase RecQ5"
                     /calculated_mol_wt=108115
     Region          12..449
                     /region_name="RecQ"
                     /note="Superfamily II DNA helicase RecQ [Replication,
                     recombination and repair]; COG0514"
                     /db_xref="CDD:440280"
     Region          157..160
                     /region_name="DEAH box"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8VID5.1)"
     Site            489
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:D4ACP5; propagated from
                     UniProtKB/Swiss-Prot (Q8VID5.1)"
     Region          491..621
                     /region_name="Interaction with POLR2A.
                     /evidence=ECO:0000250"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8VID5.1)"
     Site            492
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:O94762; propagated from
                     UniProtKB/Swiss-Prot (Q8VID5.1)"
     Site            527
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q8VID5.1)"
     Region          626..817
                     /region_name="RecQ5"
                     /note="RecQ helicase protein-like 5 (RecQ5); pfam06959"
                     /db_xref="CDD:399738"
     Region          653..726
                     /region_name="Interaction with RAD51.
                     /evidence=ECO:0000250"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8VID5.1)"
     Region          675..797
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8VID5.1)"
     Site            728
                     /site_type="phosphorylation"
                     /note="Phosphoserine, by CDK1.
                     /evidence=ECO:0000250|UniProtKB:O94762; propagated from
                     UniProtKB/Swiss-Prot (Q8VID5.1)"
     Region          812..893
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8VID5.1)"
     CDS             1..982
                     /gene="Recql5"
                     /gene_synonym="RecQ5; Recq5b; Recql5b"
                     /coded_by="NM_130454.2:575..3523"
                     /db_xref="CCDS:CCDS25650.1"
                     /db_xref="GeneID:170472"
                     /db_xref="MGI:MGI:2156841"
ORIGIN      
        1 msarpfstpf drerrvrstl kkvfgfdsfk tplqesatma vvkgaedvfv cmptgagksl
       61 cyqlpallas gitivvspli aliqdqvdhl lalkvqvssl nsklsvqerk ellsdlerdk
      121 prtkllyitp emaasasfqp tlnslvsrnl lsylvvdeah cvsqwghdfr pdylrlgalr
      181 srlahapcva ltatatpqvq edvfaalhlk qpvasfktpc franlfydvq fkelipdvyg
      241 nlrdfclkal gqkaengsss gcgivycrtr eaceqlaiel ssrgvnakay haglkasdrt
      301 qvqnewmeek vpvivatisf gmgvdkanvr fvahwniaks magyyqesgr agrdgkpswc
      361 rlyysrndrd qvsflirkel aklqekrgnk psdkatllaf dalvtfceev gcrhaaiaky
      421 fgdappacak gcdycqnpaa itkkldaler ssswsktcig psqgngfdpe lyeggrrgyg
      481 gfsrydegsg gsgdegrdea hkrewnlfyq kqmslrkgke pkieeftppd edcplreass
      541 rkipkltvka rehclrllee alisnhqaag sthgadlqak avelehetfr nakmvnlyka
      601 svlkkvaeih kaskdgqlyd mesgtkscga aaefsepsdy dipptshvys lkpkrvgagf
      661 skgpcsfqta tellgkshsq kqapeamleg gqeppgwvcd lqdedrskph pgyqekalgs
      721 svncgdpspe kktkgssqgs akaraskkqq llataarkds qnitrflcqr tespplpasv
      781 prsedaspsc gdvpgkctqe vgaqghlvav fqtegprerp stcslrdqsf pegqpsplke
      841 tqaekrprpq qgnperraqk rlrpstkssi laeakdstla sdrstenkva qepcqlsasg
      901 tslreaadiv vrhltpfyke grfiskdlfk gfarhlshll aqqlspgrsv keeaqslikq
      961 ffhnrarces eadwhslrgp qr
//
