LOCUS       NM_001410306            3328 bp    mRNA    linear   ROD 11-MAR-2025
DEFINITION  Mus musculus RecQ protein-like (Recql), transcript variant 6, mRNA.
ACCESSION   NM_001410306
VERSION     NM_001410306.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3328)
  AUTHORS   Rousseau,V., Einig,E., Jin,C., Horn,J., Riebold,M., Poth,T.,
            Jarboui,M.A., Flentje,M. and Popov,N.
  TITLE     Trim33 masks a non-transcriptional function of E2f4 in replication
            fork progression
  JOURNAL   Nat Commun 14 (1), 5143 (2023)
   PUBMED   37612308
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3328)
  AUTHORS   Sharma,S., Stumpo,D.J., Balajee,A.S., Bock,C.B., Lansdorp,P.M.,
            Brosh,R.M. Jr. and Blackshear,P.J.
  TITLE     RECQL, a member of the RecQ family of DNA helicases, suppresses
            chromosomal instability
  JOURNAL   Mol Cell Biol 27 (5), 1784-1794 (2007)
   PUBMED   17158923
  REMARK    GeneRIF: Recql suppresses chromosomal instability.
REFERENCE   3  (bases 1 to 3328)
  AUTHORS   Bachrati,C.Z. and Hickson,I.D.
  TITLE     RecQ helicases: suppressors of tumorigenesis and premature aging
  JOURNAL   Biochem J 374 (Pt 3), 577-606 (2003)
   PUBMED   12803543
  REMARK    Review article
REFERENCE   4  (bases 1 to 3328)
  AUTHORS   Wang,W.S., Seki,M., Yamaoka,T., Seki,T., Tada,S., Katada,T.,
            Fujimoto,H. and Enomoto,T.
  TITLE     Cloning of two isoforms of mouse DNA helicase Q1/RecQL cDNA; alpha
            form is expressed ubiquitously and beta form specifically in the
            testis
  JOURNAL   Biochim Biophys Acta 1443 (1-2), 198-202 (1998)
   PUBMED   9838113
REFERENCE   5  (bases 1 to 3328)
  AUTHORS   Matsui,M., Ichihara,H., Kobayashi,S., Tanaka,H., Tsuchida,J.,
            Nozaki,M., Yoshimura,Y., Nojima,H., Rochelle,J.M., Nishimune,Y.,
            Taketo,M.M. and Seldin,M.F.
  TITLE     Mapping of six germ-cell-specific genes to mouse chromosomes
  JOURNAL   Mamm Genome 8 (11), 873-874 (1997)
   PUBMED   9337410
REFERENCE   6  (bases 1 to 3328)
  AUTHORS   Puranam,K.L., Kennington,E., Sait,S.N., Shows,T.B., Rochelle,J.M.,
            Seldin,M.F. and Blackshear,P.J.
  TITLE     Chromosomal localization of the gene encoding the human DNA
            helicase RECQL and its mouse homologue
  JOURNAL   Genomics 26 (3), 595-598 (1995)
   PUBMED   7607686
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC142413.4 and AC102125.13.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR17784649.719701.1,
                                           SRR13422598.853522.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-55                AC142413.4         16500-16554         c
            56-103              AC142413.4         14007-14054         c
            104-301             AC102125.13        2039-2236
            302-481             AC102125.13        3429-3608
            482-588             AC102125.13        5463-5569
            589-787             AC102125.13        7375-7573
            788-954             AC102125.13        10932-11098
            955-1036            AC102125.13        11835-11916
            1037-1185           AC102125.13        12760-12908
            1186-1303           AC102125.13        12998-13115
            1304-1442           AC102125.13        13584-13722
            1443-1534           AC102125.13        14782-14873
            1535-1754           AC102125.13        15734-15953
            1755-1884           AC102125.13        16713-16842
            1885-1948           AC102125.13        17520-17583
            1949-3328           AC102125.13        22063-23442
FEATURES             Location/Qualifiers
     source          1..3328
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 73.91 cM"
     gene            1..3328
                     /gene="Recql"
                     /gene_synonym="RecQ1"
                     /note="RecQ protein-like"
                     /db_xref="GeneID:19691"
                     /db_xref="MGI:MGI:103021"
     exon            1..55
                     /gene="Recql"
                     /gene_synonym="RecQ1"
                     /inference="alignment:Splign:2.1.0"
     exon            56..103
                     /gene="Recql"
                     /gene_synonym="RecQ1"
                     /inference="alignment:Splign:2.1.0"
     CDS             88..2082
                     /gene="Recql"
                     /gene_synonym="RecQ1"
                     /EC_number="5.6.2.4"
                     /note="isoform 4 is encoded by transcript variant 6;
                     ATP-dependent DNA helicase Q1; DNA-dependent ATPase Q1;
                     recQ protein-like 1; DNA 3'-5' helicase Q1"
                     /codon_start=1
                     /product="ATP-dependent DNA helicase Q1 isoform 4"
                     /protein_id="NP_001397235.1"
                     /db_xref="GeneID:19691"
                     /db_xref="MGI:MGI:103021"
                     /translation="MASVSALTEELESVASELHAIDIQIQELTERRQELLQRKSVLTG
                     KIKQYLEDSSAEASSDLDTSPAAWNKEDFPWFGKVKDVLQNVFKLQKFRPLQLETINV
                     TMARKDIFLVMPTGGGKSLCYQLPALCSDGFTLVICPLISLMEDQLMVLKQLGISATM
                     LNASSSKEHVKWVHAEMVNKNSQLKLIYVTPEKIAKSKMFMSRLEKAYEAGRLTGAAV
                     DEVHCCSQWGHDFRPDYKALGILKRQFPNASLMGLTATATNHVLKDVQKILCVGKCLT
                     FTASFNRPNLFYEVRQKPSSAEDFTEDIVKLINGRYKGQSGIIYCFSQKDSEQITISL
                     QKLGIHAGTYHANMEPEDKTKVHTQWSANELQVVVATVAFGMGIDKPDVRFVIHHSMS
                     KSMENYYQESGRAGRDDSRADCILYYGFGDIFRISSMVVMENVGQQKLYEMVSYCQNV
                     SKCRRVLIAQHFDEVWNADACNKMCDNCCKDVSFEKKNVTQHCRDLIKILKQAEGLNE
                     KLTPLKLIDAWMGKGAAKLRVAGVVAPALPREDLERIVAHALLQQYLKEDYSFTAYAT
                     ISYLKVGPRACLLSNEAHAVTMQVKKSAQSSVRGALSEARQVEQVDSKGEEQSSGTAR
                     RQTASEGRPLYFLKVHWPRQLSAMAVLYLAASRARYSKGD"
     exon            104..301
                     /gene="Recql"
                     /gene_synonym="RecQ1"
                     /inference="alignment:Splign:2.1.0"
     exon            302..481
                     /gene="Recql"
                     /gene_synonym="RecQ1"
                     /inference="alignment:Splign:2.1.0"
     exon            482..588
                     /gene="Recql"
                     /gene_synonym="RecQ1"
                     /inference="alignment:Splign:2.1.0"
     exon            589..787
                     /gene="Recql"
                     /gene_synonym="RecQ1"
                     /inference="alignment:Splign:2.1.0"
     exon            788..954
                     /gene="Recql"
                     /gene_synonym="RecQ1"
                     /inference="alignment:Splign:2.1.0"
     exon            955..1036
                     /gene="Recql"
                     /gene_synonym="RecQ1"
                     /inference="alignment:Splign:2.1.0"
     exon            1037..1185
                     /gene="Recql"
                     /gene_synonym="RecQ1"
                     /inference="alignment:Splign:2.1.0"
     exon            1186..1303
                     /gene="Recql"
                     /gene_synonym="RecQ1"
                     /inference="alignment:Splign:2.1.0"
     exon            1304..1442
                     /gene="Recql"
                     /gene_synonym="RecQ1"
                     /inference="alignment:Splign:2.1.0"
     exon            1443..1534
                     /gene="Recql"
                     /gene_synonym="RecQ1"
                     /inference="alignment:Splign:2.1.0"
     exon            1535..1754
                     /gene="Recql"
                     /gene_synonym="RecQ1"
                     /inference="alignment:Splign:2.1.0"
     exon            1755..1884
                     /gene="Recql"
                     /gene_synonym="RecQ1"
                     /inference="alignment:Splign:2.1.0"
     exon            1885..1948
                     /gene="Recql"
                     /gene_synonym="RecQ1"
                     /inference="alignment:Splign:2.1.0"
     exon            1949..3328
                     /gene="Recql"
                     /gene_synonym="RecQ1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3304..3309
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Recql"
                     /gene_synonym="RecQ1"
                     /note="hexamer: AATACA"
     polyA_site      3328
                     /gene="Recql"
                     /gene_synonym="RecQ1"
                     /note="major polyA site"
ORIGIN      
        1 gtgggcgctg catgccgggc ggcgggaagg tttttacgcg cggagcggct gacagaagga
       61 catttggatc tccggttcag ttttagaatg gcatccgtct cagctttgac agaggaactg
      121 gaatccgtag ccagtgagct tcatgccatt gacatccaga ttcaggaact cacagagagg
      181 cggcaagagc tccttcagag aaagtcagtc ctgacaggga aaatcaaaca gtacttggag
      241 gactcttcgg ctgaggcgag cagcgacttg gacacatcac cagctgcttg gaataaagaa
      301 gattttccat ggttcggaaa ggtaaaagat gtgctgcaaa atgtttttaa actgcaaaaa
      361 ttcagacctc tgcagctgga aaccatcaat gtcaccatgg ctagaaagga tatctttctt
      421 gtcatgccca caggaggagg gaagagctta tgctaccagc tacctgcgct gtgctcagac
      481 ggttttacac ttgtgatttg cccactcatc tctcttatgg aagatcagct gatggtttta
      541 aaacagttgg gaatttcagc tactatgttg aatgcttcca gctctaagga acatgtaaaa
      601 tgggtgcacg ctgaaatggt gaataaaaac tcccagttaa agctgattta tgtaactcca
      661 gagaaaattg caaaaagcaa gatgttcatg tcaagactgg agaaagccta tgaagccggg
      721 aggctgacgg gagcggcagt ggatgaagtg cattgctgca gtcagtgggg tcatgacttc
      781 aggcctgatt ataaggctct tggcatcttg aagcgccagt ttcccaacgc ctcactgatg
      841 gggctgactg caacagcaac caaccatgtt ctgaaggatg tacagaaaat cctgtgtgtg
      901 ggaaagtgtt tgacttttac agcgtctttc aaccggccaa atctttttta tgaggttcgg
      961 caaaagccct caagtgctga agactttact gaggacattg tcaagctaat taatggacgg
     1021 tacaaaggac aatcaggaat catatactgt ttctctcaga aagactctga acaaattacc
     1081 atcagtttac agaagttggg aattcatgca ggcacttacc atgccaatat ggaaccagaa
     1141 gataagacca aggttcatac acagtggtca gccaatgagc ttcaggtggt agtggcaaca
     1201 gtcgcatttg gcatgggaat tgataagcca gacgtgaggt ttgtcatcca tcattcaatg
     1261 agcaaatcca tggagaatta ctatcaagag agcgggcgtg ccggtcgcga tgactcgaga
     1321 gcagactgta ttctgtatta cggctttggg gacatattca ggatcagctc gatggtggtc
     1381 atggagaacg tggggcagca gaagctgtat gagatggtgt catactgcca gaatgtcagc
     1441 aagtgtcgcc gtgtgttaat agcacagcat tttgatgaag tgtggaacgc agatgcctgt
     1501 aacaaaatgt gtgacaactg ctgtaaagac gtttcgtttg agaaaaagaa tgtgacacag
     1561 cactgccggg acctgataaa gattctgaag caggctgaag gcctgaatga aaagctgacc
     1621 ccgctgaagc tgattgatgc ttggatggga aagggagcag ccaagttgag agtggctggc
     1681 gttgttgccc cggcccttcc ccgggaagac ctggagagaa tcgtcgccca cgccctcctg
     1741 cagcaatatc tcaaagaaga ctacagcttc acggcttacg ccaccatctc ctatctgaag
     1801 gtgggaccca gagcttgtct tctcagcaac gaagcccatg ctgtcactat gcaagtgaag
     1861 aagtcagcac agagcagcgt taggggtgca ctgtctgaag ctcgtcaggt ggaacaagtg
     1921 gattcgaagg gggaagagca aagctcagga acggcgagaa gacagacggc ttcagaagga
     1981 aggccacttt attttctgaa ggtccattgg ccgagacaac tgagcgcaat ggcagtcttg
     2041 tacctggcag cttcaagagc acggtactct aaaggagact aagcacgatc actttctaaa
     2101 ctacctgtga aacagtttga ttaacacttc atgtcactca gtgcttaatc ctcttttttt
     2161 ctttttcttc ctttatcaat gatttatttt atgatatgag tacactgttg ctgccttcag
     2221 acacaccaga caagagcatc agatcccatt acagatggtt gtgagccacc gtgtggaaga
     2281 gcagtctctc aactgctgag ctacctctcc agcccaccta ctttttcttg ttgatgtttt
     2341 tcctcactgt tcagactccc tgtgaactct accatctcct tttgtacaaa cagctggaag
     2401 acaacaggac atgagctgcc tgacggcaga gttgattatt cacaggacgg cgtgtggagg
     2461 atcccacagc tcacacgtgc tgtacaggaa gtctggggat ctgcacttag tcccaaacac
     2521 acaggctttt taatgaagaa ggcatggtac ttatgaaagc tgttttgttt tgatctgtga
     2581 aatactgact gactgggttg ggttatgatg gtccaaatcc taccaaagat ttgacaagta
     2641 aaatggaaag ttgcataaca tggaattagt gaaatgaggg cctgtagtta ggccaaattt
     2701 tatatgaaat tgagcagttt aaaatatagc aagactaact taagtaataa ctttcctttt
     2761 acctttatca gctgtaactg acttatggtg gtcctttgga aaagccaagg actttttctt
     2821 cataatctta aattcctctt caaggtagat tttctttact tcacatctgg tttcaatgtg
     2881 aacactgtga gaaaactgga agcaaaataa ctactggtca gcaggcttca gacggtgcct
     2941 gtgtagacag ggacaggcag agcttcccgg gaagcctctc aggctgaggg caacaggggg
     3001 agcaggagcc acccacccag cacgggaagg ccaagcgaat ggcgagtgaa ggggcctgga
     3061 agtgatatct gcagagcttc agtgtggtcc ccctggccgt gtgctctatc agaagggagc
     3121 aatgaggaaa cagcaggcag ccgtgtttgc tgaaggactc ttaaaacctt caggagatgt
     3181 taaagtgcaa tcttaggaga cccaagaatc caggagcagt gatttcatgt cattcctatc
     3241 cccagttaga tatcatttag ccagctcccc tcccacccac ttaaacctgg aagtttcaaa
     3301 ataaatacac atatttgtat tcctgcaa
//
