LOCUS       NM_016678               4389 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Mus musculus reversion-inducing-cysteine-rich protein with kazal
            motifs (Reck), mRNA.
ACCESSION   NM_016678
VERSION     NM_016678.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4389)
  AUTHORS   Masuda,T., Fukuda,A., Yamakawa,G., Omatsu,M., Namikawa,M., Sono,M.,
            Fukunaga,Y., Nagao,M., Araki,O., Yoshikawa,T., Ogawa,S., Masuo,K.,
            Goto,N., Hiramatsu,Y., Muta,Y., Tsuda,M., Maruno,T., Nakanishi,Y.,
            Masui,T., Hatano,E., Matsuzaki,T., Noda,M. and Seno,H.
  TITLE     Pancreatic RECK inactivation promotes cancer formation,
            epithelial-mesenchymal transition, and metastasis
  JOURNAL   J Clin Invest 133 (18), e161847 (2023)
   PUBMED   37712427
  REMARK    GeneRIF: Pancreatic RECK inactivation promotes cancer formation,
            epithelial-mesenchymal transition, and metastasis.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4389)
  AUTHORS   Wang,Y., Venkatesh,A., Xu,J., Xu,M., Williams,J., Smallwood,P.M.,
            James,A. and Nathans,J.
  TITLE     The WNT7A/WNT7B/GPR124/RECK signaling module plays an essential
            role in mammalian limb development
  JOURNAL   Development 149 (9) (2022)
   PUBMED   35552394
  REMARK    GeneRIF: The WNT7A/WNT7B/GPR124/RECK signaling module plays an
            essential role in mammalian limb development.
REFERENCE   3  (bases 1 to 4389)
  AUTHORS   Gutierrez,J., Gonzalez,D., Escalona-Rivano,R., Takahashi,C. and
            Brandan,E.
  TITLE     Reduced RECK levels accelerate skeletal muscle differentiation,
            improve muscle regeneration, and decrease fibrosis
  JOURNAL   FASEB J 35 (5), e21503 (2021)
   PUBMED   33811686
REFERENCE   4  (bases 1 to 4389)
  AUTHORS   Trombetta-Lima,M., Assis-Ribas,T., Cintra,R.C., Campeiro,J.D.,
            Guerreiro,J.R., Winnischofer,S.M.B., Nascimento,I.C.C., Ulrich,H.,
            Hayashi,M.A.F. and Sogayar,M.C.
  TITLE     Impact of Reck expression and promoter activity in neuronal in
            vitro differentiation
  JOURNAL   Mol Biol Rep 48 (2), 1985-1994 (2021)
   PUBMED   33619662
  REMARK    GeneRIF: Impact of Reck expression and promoter activity in
            neuronal in vitro differentiation.
REFERENCE   5  (bases 1 to 4389)
  AUTHORS   Hiraku,Y., Watanabe,J., Kaneko,A., Ichinose,T. and Murata,M.
  TITLE     MicroRNA expression in lung tissues of asbestos-exposed mice:
            Upregulation of miR-21 and downregulation of tumor suppressor genes
            Pdcd4 and Reck
  JOURNAL   J Occup Health 63 (1), e12282 (2021)
   PUBMED   34679210
  REMARK    GeneRIF: MicroRNA expression in lung tissues of asbestos-exposed
            mice: Upregulation of miR-21 and downregulation of tumor suppressor
            genes Pdcd4 and Reck.
REFERENCE   6  (bases 1 to 4389)
  AUTHORS   Chang,H.C., Liu,L.T. and Hung,W.C.
  TITLE     Involvement of histone deacetylation in ras-induced down-regulation
            of the metastasis suppressor RECK
  JOURNAL   Cell Signal 16 (6), 675-679 (2004)
   PUBMED   15093608
  REMARK    GeneRIF: Oncogenic ras represses RECK expression via a histone
            deacetylation mechanism.
REFERENCE   7  (bases 1 to 4389)
  AUTHORS   Nuttall,R.K., Sampieri,C.L., Pennington,C.J., Gill,S.E.,
            Schultz,G.A. and Edwards,D.R.
  TITLE     Expression analysis of the entire MMP and TIMP gene families during
            mouse tissue development
  JOURNAL   FEBS Lett 563 (1-3), 129-134 (2004)
   PUBMED   15063736
REFERENCE   8  (bases 1 to 4389)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   9  (bases 1 to 4389)
  AUTHORS   Oh,J., Takahashi,R., Kondo,S., Mizoguchi,A., Adachi,E.,
            Sasahara,R.M., Nishimura,S., Imamura,Y., Kitayama,H.,
            Alexander,D.B., Ide,C., Horan,T.P., Arakawa,T., Yoshida,H.,
            Nishikawa,S., Itoh,Y., Seiki,M., Itohara,S., Takahashi,C. and
            Noda,M.
  TITLE     The membrane-anchored MMP inhibitor RECK is a key regulator of
            extracellular matrix integrity and angiogenesis
  JOURNAL   Cell 107 (6), 789-800 (2001)
   PUBMED   11747814
REFERENCE   10 (bases 1 to 4389)
  AUTHORS   Takahashi,C., Sheng,Z., Horan,T.P., Kitayama,H., Maki,M.,
            Hitomi,K., Kitaura,Y., Takai,S., Sasahara,R.M., Horimoto,A.,
            Ikawa,Y., Ratzkin,B.J., Arakawa,T. and Noda,M.
  TITLE     Regulation of matrix metalloproteinase-9 and inhibition of tumor
            invasion by the membrane-anchored glycoprotein RECK
  JOURNAL   Proc Natl Acad Sci U S A 95 (22), 13221-13226 (1998)
   PUBMED   9789069
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL773539.18 and AL772204.13.
            
            On Jan 5, 2023 this sequence version replaced NM_016678.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK143657.1, AB006960.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-132               AL773539.18        132055-132186
            133-191             AL773539.18        147445-147503
            192-266             AL773539.18        151300-151374
            267-303             AL773539.18        152331-152367
            304-389             AL773539.18        154476-154561
            390-437             AL773539.18        156551-156598
            438-471             AL773539.18        166061-166094
            472-669             AL773539.18        168413-168610
            670-937             AL773539.18        170266-170533
            938-1117            AL773539.18        174795-174974
            1118-1330           AL773539.18        179293-179505
            1331-1467           AL773539.18        181542-181678
            1468-1608           AL772204.13        3421-3561
            1609-1797           AL772204.13        4552-4740
            1798-1920           AL772204.13        6468-6590
            1921-2092           AL772204.13        7164-7335
            2093-2285           AL772204.13        13585-13777
            2286-2496           AL772204.13        15164-15374
            2497-2570           AL772204.13        16932-17005
            2571-2726           AL772204.13        18549-18704
            2727-4389           AL772204.13        19419-21081
FEATURES             Location/Qualifiers
     source          1..4389
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 23.05 cM"
     gene            1..4389
                     /gene="Reck"
                     /gene_synonym="mRECK; St15"
                     /note="reversion-inducing-cysteine-rich protein with kazal
                     motifs"
                     /db_xref="GeneID:53614"
                     /db_xref="MGI:MGI:1855698"
     exon            1..132
                     /gene="Reck"
                     /gene_synonym="mRECK; St15"
                     /inference="alignment:Splign:2.1.0"
     CDS             33..2948
                     /gene="Reck"
                     /gene_synonym="mRECK; St15"
                     /note="membrane-anchored glycoprotein RECK; suppression of
                     tumorigenicity 15; Reversion-inducing cysteine-rich
                     protein with Kazal motifs precursor (mRECK)"
                     /codon_start=1
                     /product="reversion-inducing cysteine-rich protein with
                     Kazal motifs precursor"
                     /protein_id="NP_057887.2"
                     /db_xref="CCDS:CCDS18116.1"
                     /db_xref="GeneID:53614"
                     /db_xref="MGI:MGI:1855698"
                     /translation="MASVRASPRSALLLLLAAAGVAEVTGGLAPGSAGAVCCNHSKDN
                     QMCRDVCEQIFSSKSESRLKHLLQRAPDYCPETMVEIWSCMNSSLPGVFKKSDGWVGL
                     GCCELAIGLECRQACKQASSKNDISKVCRKEYENALFSCISRNEMGSVCCSYAGHHTN
                     CREFCQAIFRTDSSPGPSQIKAVENYCASISPQLIHCVNNYTQSYPMRNPTDSLYCCD
                     RAEDHACQNACKRILMSKKTEMEIVDGLIEGCKTQPLPQDPLWQCFLESSQSVHPGVT
                     VHPPPSTGLDGAKLHCCSKANTSTCRELCTKLYSMSWGNTQSWQEFDRICEYNPVEVS
                     MLTCLADVREPCQLGCTNLTYCTNFNNRPTELFRSCTAQSDQGAMSDMKLWEKGSIKM
                     PFISIPVLDIKTCQPEMWKAVACSLQIKPCHSKSRGSIICKSDCVEILKKCGDQNKFP
                     EEHTAESICEFLSPADDLESCIPLDTYLRPSALGNIIEEVTHPCNPNPCPANELCEVN
                     RKGCPSADPCLPYSCVQGCKLGEASDFIVRQGTLIQVPSSAGEVGCYKICSCGQSGLL
                     ENCMEMHCIDLQKSCIVGGKRKSHGTSFTIDCNVCSCFAGNLVCSTRLCLSEHSSDDD
                     RRTFTGLPCNCADQFVPVCAQNGRTYPSACIARCVGLQDHQFEFGPCISKNPCNPNLC
                     PKSQRCVPKPQVCLTTFDKFGCSQYECVPRQLTCDQARDPVCDTDHMEHSNLCTLYQR
                     GKSLSYRGPCQPFCRAKEPVCGHNGETYSSVCAAYSDRVAVDYYGPCQAVGVLSEYSA
                     VAECAAVKCPSLSAIGCKPIIPPGACCPLCAGMLRVLFDKEKLDTIAKVTSKKPITVV
                     EILQKVRMHVSVPQCDVFGYLSIESEIVILIIPVDHYPKALQIEACNKEAEKIESLIN
                     SDSPTLASHVPLSALIISQVQVSSSLPSSAVVGRPLFHSLLLLLSLGLTVHLLWTRP"
     exon            133..191
                     /gene="Reck"
                     /gene_synonym="mRECK; St15"
                     /inference="alignment:Splign:2.1.0"
     exon            192..266
                     /gene="Reck"
                     /gene_synonym="mRECK; St15"
                     /inference="alignment:Splign:2.1.0"
     exon            267..303
                     /gene="Reck"
                     /gene_synonym="mRECK; St15"
                     /inference="alignment:Splign:2.1.0"
     exon            304..389
                     /gene="Reck"
                     /gene_synonym="mRECK; St15"
                     /inference="alignment:Splign:2.1.0"
     exon            390..437
                     /gene="Reck"
                     /gene_synonym="mRECK; St15"
                     /inference="alignment:Splign:2.1.0"
     exon            438..471
                     /gene="Reck"
                     /gene_synonym="mRECK; St15"
                     /inference="alignment:Splign:2.1.0"
     exon            472..669
                     /gene="Reck"
                     /gene_synonym="mRECK; St15"
                     /inference="alignment:Splign:2.1.0"
     exon            670..937
                     /gene="Reck"
                     /gene_synonym="mRECK; St15"
                     /inference="alignment:Splign:2.1.0"
     exon            938..1117
                     /gene="Reck"
                     /gene_synonym="mRECK; St15"
                     /inference="alignment:Splign:2.1.0"
     exon            1118..1330
                     /gene="Reck"
                     /gene_synonym="mRECK; St15"
                     /inference="alignment:Splign:2.1.0"
     exon            1331..1467
                     /gene="Reck"
                     /gene_synonym="mRECK; St15"
                     /inference="alignment:Splign:2.1.0"
     exon            1468..1608
                     /gene="Reck"
                     /gene_synonym="mRECK; St15"
                     /inference="alignment:Splign:2.1.0"
     exon            1609..1797
                     /gene="Reck"
                     /gene_synonym="mRECK; St15"
                     /inference="alignment:Splign:2.1.0"
     exon            1798..1920
                     /gene="Reck"
                     /gene_synonym="mRECK; St15"
                     /inference="alignment:Splign:2.1.0"
     exon            1921..2092
                     /gene="Reck"
                     /gene_synonym="mRECK; St15"
                     /inference="alignment:Splign:2.1.0"
     exon            2093..2285
                     /gene="Reck"
                     /gene_synonym="mRECK; St15"
                     /inference="alignment:Splign:2.1.0"
     exon            2286..2496
                     /gene="Reck"
                     /gene_synonym="mRECK; St15"
                     /inference="alignment:Splign:2.1.0"
     exon            2497..2570
                     /gene="Reck"
                     /gene_synonym="mRECK; St15"
                     /inference="alignment:Splign:2.1.0"
     exon            2571..2726
                     /gene="Reck"
                     /gene_synonym="mRECK; St15"
                     /inference="alignment:Splign:2.1.0"
     exon            2727..4389
                     /gene="Reck"
                     /gene_synonym="mRECK; St15"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4366..4371
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Reck"
                     /gene_synonym="mRECK; St15"
                     /note="hexamer: AATGAA"
     polyA_site      4389
                     /gene="Reck"
                     /gene_synonym="mRECK; St15"
                     /note="major polyA site"
ORIGIN      
        1 atcccgcggc ttcggaccca cccggcccgg acatggcgag cgtccgggcc tccccgcgca
       61 gcgcgctgct acttctgctg gccgcggcgg gggtcgcgga ggtgacgggg ggcctggccc
      121 cgggcagcgc gggtgctgta tgctgtaatc attcaaaaga taaccaaatg tgccgtgatg
      181 tatgtgagca gattttctcc tcaaaaagtg aatcccgact gaaacatctg ttgcagagag
      241 ccccagatta ttgccctgaa acaatggttg aaatttggag ttgcatgaat tcgtctttgc
      301 caggggtatt taagaagtcc gatggttggg ttggcttagg ctgctgtgaa ctggctattg
      361 gcttggagtg ccgacaggca tgcaagcagg catcttcgaa aaatgatatt tccaaagttt
      421 gcaggaaaga atatgagaat gctcttttca gttgcattag cagaaatgaa atgggctcgg
      481 tgtgctgcag ttacgcaggc catcacacca actgccgaga attctgtcaa gccatttttc
      541 gaacagactc ttctcctggg ccatctcaga tcaaagcagt ggaaaattat tgtgcctcta
      601 tcagtccaca gttgatacac tgtgtgaata attacaccca gtcttatcca atgagaaacc
      661 caactgatag tttatattgc tgtgacagag ctgaagacca tgcttgccaa aacgcctgca
      721 agagaattct aatgtctaag aaaacagaaa tggagattgt tgatggtctc attgagggtt
      781 gtaagaccca gcccttgcct caagatcctc tttggcagtg ttttctcgaa agctcacagt
      841 cggttcaccc tggagtcact gtgcaccctc ctccctcaac tggcctcgac ggggccaaat
      901 tgcactgttg ctctaaagca aacacttcaa cctgtaggga actgtgcacc aaactttata
      961 gcatgagctg gggaaataca cagagttggc aagagtttga ccgcatctgt gagtataatc
     1021 cggtggaagt gtccatgctg acgtgtctgg ctgatgtccg ggagccttgc cagttgggct
     1081 gtacaaacct gacttactgt acaaacttta acaacaggcc aacagaactg ttcaggagct
     1141 gcacggctca gtctgaccag ggggccatga gtgacatgaa gctgtgggag aaggggagca
     1201 tcaagatgcc cttcatcagc atccctgtcc tagacatcaa gacctgccag ccagagatgt
     1261 ggaaggccgt ggcctgctcc ctgcagatca agccgtgcca tagcaaatcc cgaggcagta
     1321 ttatctgcaa atcagattgt gtagagattc tcaagaaatg tggagaccag aataaattcc
     1381 ctgaagaaca cacagctgaa agtatctgtg agtttctgtc ccctgcagat gacctggaga
     1441 gctgtatccc tctggacacg tacctcaggc caagtgcttt aggaaacatc atagaagaag
     1501 tgactcaccc ctgtaaccca aacccctgcc cagccaacga gctctgtgaa gtgaaccgga
     1561 aggggtgtcc gtctgcagat ccctgccttc catactcctg tgttcaaggc tgcaaattgg
     1621 gagaagcttc tgacttcatc gtccgccagg ggacactgat ccaggtgccg tcctctgcag
     1681 gggaagttgg ttgctacaag atctgttcct gtggacaaag tggcctcttg gaaaactgta
     1741 tggaaatgca ctgtatcgac ctccagaagt cttgtattgt cggaggaaaa agaaaaagcc
     1801 acggaacatc ctttactatt gactgcaatg tctgttcttg ttttgcgggt aatttagtgt
     1861 gttccacccg cctgtgcctc agtgagcaca gttcagacga cgaccgccgc accttcacag
     1921 gtctgccctg taactgcgca gatcagtttg tcccagtgtg tgcacagaat ggacgcactt
     1981 accccagtgc ctgcatcgct cgctgtgtgg gtctccagga ccatcagttt gagtttggac
     2041 cttgtatctc caagaatccc tgtaatccta acctctgccc caaaagccaa agatgtgtgc
     2101 caaaaccaca agtctgcctg acgacttttg ataaatttgg atgtagccaa tatgagtgtg
     2161 tgcccagaca gctcacctgt gaccaggccc gagatcctgt gtgtgacaca gatcacatgg
     2221 agcacagcaa cctctgcact ctgtaccaaa gagggaaaag cctgtcttac agaggccctt
     2281 gccagccttt ctgcagagcc aaggagcctg tctgtgggca caatggtgag acatacagca
     2341 gtgtgtgtgc tgcctactca gatcgtgtgg ccgtggatta ctacgggccc tgccaggctg
     2401 tcggcgtcct ctcggaatac agtgctgtgg ctgagtgtgc tgctgtcaag tgtccttccc
     2461 tctcagccat aggctgcaaa cccatcatcc caccaggggc ttgctgtcca ctatgtgctg
     2521 ggatgttacg ggtattattt gacaaagaaa aactggacac tattgctaag gtgacaagca
     2581 agaagcccat aaccgttgtg gagattcttc agaaggtccg catgcacgtg tctgtgccgc
     2641 agtgtgacgt gtttggatac ttgagcatcg agtcggaaat tgtgatcctc attattcctg
     2701 tggaccatta cccaaaagct ttgcagattg aggcctgcaa taaggaggca gagaaaatcg
     2761 agtccctcat caactccgac agccccacgc tggcgtccca cgtcccactc tcggccctca
     2821 tcatttccca agtgcaggtc tccagcagtc tcccgtcatc tgctgttgtg ggcaggcctc
     2881 tcttccactc cctgctcctc ctcctcagcc tgggcctcac cgtgcacttg ctctggacta
     2941 gaccctgacc acccacaact gggaggaact gcaaagcctt cctccaccca gccgtccacc
     3001 ttgtgaaaga cattcaggac tgctagctgg tgaccaagca aaggcatgtg gcacctctta
     3061 gcaccacaca gtattttttt cacctgccaa tattaggggg tttgccttgg tttataaaat
     3121 ggtaaattag actctcccaa tataatgaag atgatgcctc ttcctggtgg atccctggcc
     3181 agttcacact cgctcagtag atggcccccc ttccccaaag caaatttagc atccctgatc
     3241 aatggcatgg tcactttata ggaggcagcc ccctttgtcc ttgggtgggt gccctggtct
     3301 cctcagagtt cctgtgagtg ctgaggccgc catgtgcttg tttctgtgtc tggaggctga
     3361 gggctcagtg aaaagccgct acctgccatg acagggcggg ccggaggaga aaaacatcat
     3421 tgaattctca ctagctcata ggctgactcc atagaaatgt aaggcaggac tctactctgc
     3481 ttagcaaaag caagacgacc aagtgacact cgtgcctgtc tcacacttgg gcctctcagc
     3541 agttgtcatt tgtgcctgtg agtgggggcg gccccacaac atccaagcat ctatgtcatg
     3601 cctgccgtgt tgtgttagcc agatacactc gccagtactc accaagtcca caggtttaaa
     3661 ggtcagactt taaaccactt gctgctacta tataactgcc aaaaagtaag attattagga
     3721 gttcatgtaa atagtacatg attttttatt ttattatgaa ggtgaatagc catatttgta
     3781 aaatgacaat catgtgtgtt agccccatac tttcatgaag acacatctgc tttttgtaat
     3841 gtgcacagtg tggataagtg tgtgtccgac tttcctttga tatagaatta taaagaatgt
     3901 ggtttatata tttaaaatat caggctaaat agtaaaatgt ttgcatgttg tctaagaaat
     3961 tggatacttt gaatgtttta cagtttgaaa taagctatta atgtaatact tcctgtttgt
     4021 atgcacctga acttagattt tacatgaagt atttttcagt gttatatgta ccctctgaaa
     4081 tatagcaata tgcttattat accaaaatgt tgttgaaagt gggcacttaa tgctttcaga
     4141 ggatctcagt gccgatgtcg atgtacctct gtcacagttg cctgtttctg tctaaatgtt
     4201 ttcaacatac tagactatat tatatgtata ttctctatat agtataccac aatatactat
     4261 atatattcta tatatagtat acagcactat actagaaagc ctttctattt taataaaagt
     4321 aattttatat gattatttgt acttccaagc aatgtgaaca ttgagaatga aacagttcct
     4381 tacccttaa
//
