LOCUS       NM_020002               2055 bp    mRNA    linear   ROD 12-NOV-2024
DEFINITION  Mus musculus REC8 meiotic recombination protein (Rec8), transcript
            variant 1, mRNA.
ACCESSION   NM_020002
VERSION     NM_020002.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2055)
  AUTHORS   Chotiner,J.Y., Leu,N.A., Yang,F., Cossu,I.G., Guan,Y., Lin,H. and
            Wang,P.J.
  TITLE     TRIP13 localizes to synapsed chromosomes and functions as a
            dosage-sensitive regulator of meiosis
  JOURNAL   Elife 12, 92195 (2024)
   PUBMED   39207914
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2055)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 2055)
  AUTHORS   Souali-Crespo,S., Condrea,D., Vernet,N., Feret,B., Klopfenstein,M.,
            Grandgirard,E., Alunni,V., Cerciat,M., Jung,M., Mayere,C., Nef,S.,
            Mark,M., Chalmel,F. and Ghyselinck,N.B.
  TITLE     Loss of NR5A1 in mouse Sertoli cells after sex determination
            changes cellular identity and induces cell death by anoikis
  JOURNAL   Development 150 (24) (2023)
   PUBMED   38078651
REFERENCE   4  (bases 1 to 2055)
  AUTHORS   Yoon,S., Choi,E.H., Park,S.J. and Kim,K.P.
  TITLE     alpha-Kleisin subunit of cohesin preserves the genome integrity of
            embryonic stem cells
  JOURNAL   BMB Rep 56 (2), 108-113 (2023)
   PUBMED   36571142
  REMARK    GeneRIF: alpha-Kleisin subunit of cohesin preserves the genome
            integrity of embryonic stem cells.
REFERENCE   5  (bases 1 to 2055)
  AUTHORS   Chen,J., Gao,C., Luo,M., Zheng,C., Lin,X., Ning,Y., Ma,L., He,W.,
            Xie,D., Liu,K., Hong,K. and Han,C.
  TITLE     MicroRNA-202 safeguards meiotic progression by preventing premature
            SEPARASE-mediated REC8 cleavage
  JOURNAL   EMBO Rep 23 (8), e54298 (2022)
   PUBMED   35712867
  REMARK    GeneRIF: MicroRNA-202 safeguards meiotic progression by preventing
            premature SEPARASE-mediated REC8 cleavage.
REFERENCE   6  (bases 1 to 2055)
  AUTHORS   Bannister,L.A., Reinholdt,L.G., Munroe,R.J. and Schimenti,J.C.
  TITLE     Positional cloning and characterization of mouse mei8, a disrupted
            allelle of the meiotic cohesin Rec8
  JOURNAL   Genesis 40 (3), 184-194 (2004)
   PUBMED   15515002
REFERENCE   7  (bases 1 to 2055)
  AUTHORS   Lee,J., Iwai,T., Yokota,T. and Yamashita,M.
  TITLE     Temporally and spatially selective loss of Rec8 protein from
            meiotic chromosomes during mammalian meiosis
  JOURNAL   J Cell Sci 116 (Pt 13), 2781-2790 (2003)
   PUBMED   12759374
  REMARK    GeneRIF: Rec8 protein, in association with SMC3 and SMC1beta but
            not SMC1alpha, is involved in meiosis-specific chromosome behavior;
            homologous chromosome separation is triggered by selective loss of
            Rec8 from chromosome arms in meiosis I.
REFERENCE   8  (bases 1 to 2055)
  AUTHORS   Prieto,I., Pezzi,N., Buesa,J.M., Kremer,L., Barthelemy,I.,
            Carreiro,C., Roncal,F., Martinez,A., Gomez,L., Fernandez,R.,
            Martinez-A,C. and Barbero,J.L.
  TITLE     STAG2 and Rad21 mammalian mitotic cohesins are implicated in
            meiosis
  JOURNAL   EMBO Rep 3 (6), 543-550 (2002)
   PUBMED   12034751
REFERENCE   9  (bases 1 to 2055)
  AUTHORS   Lee,J., Yokota,T. and Yamashita,M.
  TITLE     Analyses of mRNA expression patterns of cohesin subunits Rad21 and
            Rec8 in mice: germ cell-specific expression of rec8 mRNA in both
            male and female mice
  JOURNAL   Zoolog Sci 19 (5), 539-544 (2002)
   PUBMED   12130806
  REMARK    GeneRIF: Analyses of mRNA expression patterns of cohesin subunits
            Rad21 and Rec8 in mice: germ cell-specific expression of rec8 mRNA
            in both male and female mice.
REFERENCE   10 (bases 1 to 2055)
  AUTHORS   Parisi,S., McKay,M.J., Molnar,M., Thompson,M.A., van der Spek,P.J.,
            van Drunen-Schoenmaker,E., Kanaar,R., Lehmann,E., Hoeijmakers,J.H.
            and Kohli,J.
  TITLE     Rec8p, a meiotic recombination and sister chromatid cohesion
            phosphoprotein of the Rad21p family conserved from fission yeast to
            humans
  JOURNAL   Mol Cell Biol 19 (5), 3515-3528 (1999)
   PUBMED   10207075
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AU080225.1, BC052155.1 and AC174678.2.
            
            On Mar 17, 2011 this sequence version replaced NM_020002.2.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC052155.1, AK146832.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-4                 AU080225.1         2-5
            5-2050              BC052155.1         1-2046
            2051-2055           AC174678.2         35770-35774         c
FEATURES             Location/Qualifiers
     source          1..2055
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 28.19 cM"
     gene            1..2055
                     /gene="Rec8"
                     /gene_synonym="mrec; Rec8L1"
                     /note="REC8 meiotic recombination protein"
                     /db_xref="GeneID:56739"
                     /db_xref="MGI:MGI:1929645"
     exon            1..188
                     /gene="Rec8"
                     /gene_synonym="mrec; Rec8L1"
                     /inference="alignment:Splign:2.1.0"
     exon            189..301
                     /gene="Rec8"
                     /gene_synonym="mrec; Rec8L1"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    198..200
                     /gene="Rec8"
                     /gene_synonym="mrec; Rec8L1"
                     /note="upstream in-frame stop codon"
     CDS             246..2021
                     /gene="Rec8"
                     /gene_synonym="mrec; Rec8L1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     meiotic recombination protein REC8 homolog; cohesin Rec8p;
                     meiotic cohesion Rec8; REC8-like 1"
                     /codon_start=1
                     /product="meiotic recombination protein REC8 homolog
                     isoform 1"
                     /protein_id="NP_064386.2"
                     /db_xref="CCDS:CCDS27120.1"
                     /db_xref="GeneID:56739"
                     /db_xref="MGI:MGI:1929645"
                     /translation="MFYYPNVLQRHTGCFATIWLAATRGSRLVKREYLNVNVVKTCEE
                     ILNYVLVRVQPPVAGLPRPRFSLYLSAQLQIGVIRVYFQQCQYLVEDIQHILEHLHRA
                     QLRIRIDMEEADLPSLLLPNCLAMMETLEDAPEPFFGKMSVDPRLPSPFDIPQIRHLL
                     EAATPEKTRKETLPEATPDPRKPDRTLATVQSPEVITLQEAEPIRMLQIEGEQDLPEI
                     SRGDLELLIAEKDDAILLEERQRGRLLRQRRASLPLDESREEPRALEGAGLVSALSPP
                     APAQVEGIQEALPGQVFPPEVQKMTGWEPGALLTEVTPPQELRLPAPPSTEKRLPSLQ
                     RPLPRRHRRRQLLFWDKETQISREKFEEQLQTGAHCWEYPVAQPPKRMLTSPAELFRT
                     PTLSGWLPPELLGLWTHCAQVPQRMLRQRPQLETEETVEEERAADEEERRKTEALSEI
                     EVLREAQEPSGPLMLSSELSLEAAEDEKSRTSLIPPEWWAWSEEGQPEPPALPMLPEL
                     PEVPMEMPPRPELSSEAVLRAVALKLQANKELDFSSLVPPLSPRKLASRVFYLLLVLS
                     TQKILLVEQQKPYGPLLIRPGPKFP"
     misc_feature    690..692
                     /gene="Rec8"
                     /gene_synonym="mrec; Rec8L1"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q8C5S7.1); phosphorylation site"
     misc_feature    732..803
                     /gene="Rec8"
                     /gene_synonym="mrec; Rec8L1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8C5S7.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    735..737
                     /gene="Rec8"
                     /gene_synonym="mrec; Rec8L1"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:Q6AYJ4; propagated from
                     UniProtKB/Swiss-Prot (Q8C5S7.1); phosphorylation site"
     misc_feature    819..821
                     /gene="Rec8"
                     /gene_synonym="mrec; Rec8L1"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q6AYJ4; propagated from
                     UniProtKB/Swiss-Prot (Q8C5S7.1); phosphorylation site"
     misc_feature    1191..1253
                     /gene="Rec8"
                     /gene_synonym="mrec; Rec8L1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8C5S7.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    1503..1586
                     /gene="Rec8"
                     /gene_synonym="mrec; Rec8L1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8C5S7.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     exon            302..370
                     /gene="Rec8"
                     /gene_synonym="mrec; Rec8L1"
                     /inference="alignment:Splign:2.1.0"
     exon            371..513
                     /gene="Rec8"
                     /gene_synonym="mrec; Rec8L1"
                     /inference="alignment:Splign:2.1.0"
     exon            514..589
                     /gene="Rec8"
                     /gene_synonym="mrec; Rec8L1"
                     /inference="alignment:Splign:2.1.0"
     exon            590..710
                     /gene="Rec8"
                     /gene_synonym="mrec; Rec8L1"
                     /inference="alignment:Splign:2.1.0"
     exon            711..795
                     /gene="Rec8"
                     /gene_synonym="mrec; Rec8L1"
                     /inference="alignment:Splign:2.1.0"
     exon            796..875
                     /gene="Rec8"
                     /gene_synonym="mrec; Rec8L1"
                     /inference="alignment:Splign:2.1.0"
     exon            876..1011
                     /gene="Rec8"
                     /gene_synonym="mrec; Rec8L1"
                     /inference="alignment:Splign:2.1.0"
     exon            1012..1084
                     /gene="Rec8"
                     /gene_synonym="mrec; Rec8L1"
                     /inference="alignment:Splign:2.1.0"
     exon            1085..1176
                     /gene="Rec8"
                     /gene_synonym="mrec; Rec8L1"
                     /inference="alignment:Splign:2.1.0"
     exon            1177..1226
                     /gene="Rec8"
                     /gene_synonym="mrec; Rec8L1"
                     /inference="alignment:Splign:2.1.0"
     exon            1227..1364
                     /gene="Rec8"
                     /gene_synonym="mrec; Rec8L1"
                     /inference="alignment:Splign:2.1.0"
     exon            1365..1431
                     /gene="Rec8"
                     /gene_synonym="mrec; Rec8L1"
                     /inference="alignment:Splign:2.1.0"
     exon            1432..1598
                     /gene="Rec8"
                     /gene_synonym="mrec; Rec8L1"
                     /inference="alignment:Splign:2.1.0"
     exon            1599..1647
                     /gene="Rec8"
                     /gene_synonym="mrec; Rec8L1"
                     /inference="alignment:Splign:2.1.0"
     exon            1648..1711
                     /gene="Rec8"
                     /gene_synonym=
