LOCUS       NM_028598                883 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Mus musculus REC114 meiotic recombination protein (Rec114), mRNA.
ACCESSION   NM_028598 XM_001480342 XM_001480346 XM_134948
VERSION     NM_028598.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 883)
  AUTHORS   Xu,J., Li,T., Kim,S., Boekhout,M. and Keeney,S.
  TITLE     Essential roles of the ANKRD31-REC114 interaction in meiotic
            recombination and mouse spermatogenesis
  JOURNAL   Proc Natl Acad Sci U S A 120 (47), e2310951120 (2023)
   PUBMED   37976262
  REMARK    GeneRIF: Essential roles of the ANKRD31-REC114 interaction in
            meiotic recombination and mouse spermatogenesis.
REFERENCE   2  (bases 1 to 883)
  AUTHORS   Laroussi,H., Juarez-Martinez,A.B., Le Roy,A., Boeri Erba,E.,
            Gabel,F., de Massy,B. and Kadlec,J.
  TITLE     Characterization of the REC114-MEI4-IHO1 complex regulating meiotic
            DNA double-strand break formation
  JOURNAL   EMBO J 42 (16), e113866 (2023)
   PUBMED   37431931
  REMARK    GeneRIF: Characterization of the REC114-MEI4-IHO1 complex
            regulating meiotic DNA double-strand break formation.
REFERENCE   3  (bases 1 to 883)
  AUTHORS   Nore,A., Juarez-Martinez,A.B., Clement,J., Brun,C., Diagouraga,B.,
            Laroussi,H., Grey,C., Bourbon,H.M., Kadlec,J., Robert,T. and de
            Massy,B.
  TITLE     TOPOVIBL-REC114 interaction regulates meiotic DNA double-strand
            breaks
  JOURNAL   Nat Commun 13 (1), 7048 (2022)
   PUBMED   36396648
  REMARK    GeneRIF: TOPOVIBL-REC114 interaction regulates meiotic DNA
            double-strand breaks.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 883)
  AUTHORS   Guan,Y., Lin,H., Leu,N.A., Ruthel,G., Fuchs,S.Y., Busino,L., Luo,M.
            and Wang,P.J.
  TITLE     SCF ubiquitin E3 ligase regulates DNA double-strand breaks in early
            meiotic recombination
  JOURNAL   Nucleic Acids Res 50 (9), 5129-5144 (2022)
   PUBMED   35489071
REFERENCE   5  (bases 1 to 883)
  AUTHORS   Boekhout,M., Karasu,M.E., Wang,J., Acquaviva,L., Pratto,F.,
            Brick,K., Eng,D.Y., Xu,J., Camerini-Otero,R.D., Patel,D.J. and
            Keeney,S.
  TITLE     REC114 Partner ANKRD31 Controls Number, Timing, and Location of
            Meiotic DNA Breaks
  JOURNAL   Mol Cell 74 (5), 1053-1068 (2019)
   PUBMED   31003867
  REMARK    GeneRIF: A crystal structure defines a pleckstrin homology (PH)
            domain in REC114 and its direct intermolecular contacts with
            ANKRD31. In vivo, ANKRD31 stabilizes REC114 association with the
            PAR and elsewhere. Our findings inform a model in which ANKRD31 is
            a scaffold anchoring REC114 and other factors to specific genomic
            locations, thereby regulating DSB formation.
REFERENCE   6  (bases 1 to 883)
  AUTHORS   Nguyen,N.M.P., Ge,Z.J., Reddy,R., Fahiminiya,S., Sauthier,P.,
            Bagga,R., Sahin,F.I., Mahadevan,S., Osmond,M., Breguet,M.,
            Rahimi,K., Lapensee,L., Hovanes,K., Srinivasan,R., Van den
            Veyver,I.B., Sahoo,T., Ao,A., Majewski,J., Taketo,T. and Slim,R.
  TITLE     Causative Mutations and Mechanism of Androgenetic Hydatidiform
            Moles
  JOURNAL   Am J Hum Genet 103 (5), 740-751 (2018)
   PUBMED   30388401
REFERENCE   7  (bases 1 to 883)
  AUTHORS   Sabik,O.L., Medrano,J.F. and Farber,C.R.
  TITLE     Genetic Dissection of a QTL Affecting Bone Geometry
  JOURNAL   G3 (Bethesda) 7 (3), 865-870 (2017)
   PUBMED   28082324
  REMARK    Publication Status: Online-Only
REFERENCE   8  (bases 1 to 883)
  AUTHORS   Stanzione,M., Baumann,M., Papanikos,F., Dereli,I., Lange,J.,
            Ramlal,A., Trankner,D., Shibuya,H., de Massy,B., Watanabe,Y.,
            Jasin,M., Keeney,S. and Toth,A.
  TITLE     Meiotic DNA break formation requires the unsynapsed chromosome
            axis-binding protein IHO1 (CCDC36) in mice
  JOURNAL   Nat Cell Biol 18 (11), 1208-1220 (2016)
   PUBMED   27723721
REFERENCE   9  (bases 1 to 883)
  AUTHORS   Kumar,R., Bourbon,H.M. and de Massy,B.
  TITLE     Functional conservation of Mei4 for meiotic DNA double-strand break
            formation from yeasts to mice
  JOURNAL   Genes Dev 24 (12), 1266-1280 (2010)
   PUBMED   20551173
REFERENCE   10 (bases 1 to 883)
  AUTHORS   Kaji,K., Nichols,J. and Hendrich,B.
  TITLE     Mbd3, a component of the NuRD co-repressor complex, is required for
            development of pluripotent cells
  JOURNAL   Development 134 (6), 1123-1132 (2007)
   PUBMED   17287250
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AV474073.1, AK010725.1 and BY715467.1.
            
            [WARNING] On Aug 8, 2024 this sequence was replaced by NM_028598.2.
            
            On or before Sep 29, 2009 this sequence version replaced
            XM_001480342.1, XM_001480346.1, XM_134948.5.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK010725.1, BC038688.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3                 AV474073.1         1-3
            4-856               AK010725.1         1-853
            857-883             BY715467.1         483-509
FEATURES             Location/Qualifiers
     source          1..883
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 31.79 cM"
     gene            1..883
                     /gene="Rec114"
                     /gene_synonym="2410076I21Rik; 4930527A11Rik"
                     /note="REC114 meiotic recombination protein"
                     /db_xref="GeneID:73673"
                     /db_xref="MGI:MGI:1920923"
     exon            1..173
                     /gene="Rec114"
                     /gene_synonym="2410076I21Rik; 4930527A11Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             18..797
                     /gene="Rec114"
                     /gene_synonym="2410076I21Rik; 4930527A11Rik"
                     /codon_start=1
                     /product="meiotic recombination protein REC114"
                     /protein_id="NP_082874.1"
                     /db_xref="CCDS:CCDS52814.1"
                     /db_xref="GeneID:73673"
                     /db_xref="MGI:MGI:1920923"
                     /translation="MSEAGNVASGLGLPGEVSQWSLKRYGRFMLLDNVGSPGPSSEAA
                     AAGSPTWKVFESSEESGSLVLTIVVSGHFFISQGQTLLEGFSLIGSKNWLKIVRRMDC
                     LLFGTTIKNKSRMFRVQFSGESKEEALERCCGCVQTLAQYVTVQEPDSTTQELQQSQG
                     PREAGESQGKDPLQQGPSLTLEQHVCMAAGAGVLQERTSVTHRAQSILAPEKLTLAYE
                     GSSWGTEELGPFLRLCLMDQNFPAFVEEVEKELKKITGLRN"
     exon            174..263
                     /gene="Rec114"
                     /gene_synonym="2410076I21Rik; 4930527A11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            264..347
                     /gene="Rec114"
                     /gene_synonym="2410076I21Rik; 4930527A11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            348..545
                     /gene="Rec114"
                     /gene_synonym="2410076I21Rik; 4930527A11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            546..632
                     /gene="Rec114"
                     /gene_synonym="2410076I21Rik; 4930527A11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            633..883
                     /gene="Rec114"
                     /gene_synonym="2410076I21Rik; 4930527A11Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      839..844
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rec114"
                     /gene_synonym="2410076I21Rik; 4930527A11Rik"
                     /note="hexamer: AATAAA"
     polyA_site      861
                     /gene="Rec114"
                     /gene_synonym="2410076I21Rik; 4930527A11Rik"
                     /note="major polyA site"
ORIGIN      
        1 caggaccttt gacaggcatg tctgaagcgg gaaatgtggc ctccggcctc ggacttccag
       61 gcgaagtctc ccagtggtct ctgaagcgct atggtcgctt catgctcttg gacaacgtgg
      121 ggtcccctgg gcctagctcg gaagctgctg cagcgggctc gcccacatgg aaggtttttg
      181 aatccagtga agaatccggg agtcttgtcc tcacgatcgt tgtatcaggt cacttcttca
      241 tttcccaagg gcagacactg ctggaagggt tttcactcat tggcagcaag aactggttga
      301 agattgtaag acgcatggac tgtcttctgt ttggaacaac aataaagaac aagagccgaa
      361 tgtttcgtgt ccagtttagt ggggagtcca aggaagaggc gctggagcgc tgctgtggct
      421 gtgtgcagac cctggcccag tacgtcaccg ttcaggagcc tgacagcacc acccaggagc
      481 ttcagcagag ccaaggcccc cgggaggcag gtgaaagcca agggaaggac ccactgcagc
      541 aggggccctc cctgaccctg gagcagcacg tgtgtatggc agctggggca ggtgttctac
      601 aggaaaggac ctcagtgaca catcgagctc agtctatcct ggcgccagag aagctgaccc
      661 tcgcctatga aggctcttca tggggaacag aagaattggg accttttcta cgcttatgtc
      721 tcatggatca aaacttccca gcatttgtgg aagaggtgga aaaggaactt aaaaagatta
      781 cagggttgag aaactaaagc cctgcacatg tatgcaacta aggaactgaa ggtatttgaa
      841 taaagagtat tattccaagc accttttatc aatgttttat tgt
//
