LOCUS       NM_009041               4580 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus radixin (Rdx), transcript variant 1, mRNA.
ACCESSION   NM_009041
VERSION     NM_009041.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4580)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 4580)
  AUTHORS   Bondarenko,V., Nikolaev,M., Kromm,D., Belousov,R., Wolny,A.,
            Blotenburg,M., Zeller,P., Rezakhani,S., Hugger,J., Uhlmann,V.,
            Hufnagel,L., Kreshuk,A., Ellenberg,J., van Oudenaarden,A.,
            Erzberger,A., Lutolf,M.P. and Hiiragi,T.
  TITLE     Embryo-uterine interaction coordinates mouse embryogenesis during
            implantation
  JOURNAL   EMBO J 42 (17), e113280 (2023)
   PUBMED   37522872
REFERENCE   3  (bases 1 to 4580)
  AUTHORS   Knapp,L., Sun,H., Wang,Y.M., Chen,B.J., Lin,X., Gao,N., Chen,P. and
            Ren,D.
  TITLE     Rab11a Is Essential for the Development and Integrity of the
            Stereocilia and Kinocilia in the Mammalian Organ of Corti
  JOURNAL   eNeuro 10 (6) (2023)
   PUBMED   37225424
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4580)
  AUTHORS   Zhang,Y., Wang,Y., Feng,X., Zhang,S., Xu,X., Li,L., Niu,S., Bo,Y.,
            Wang,C., Li,Z., Xia,G. and Zhang,H.
  TITLE     Oocyte-derived microvilli control female fertility by optimizing
            ovarian follicle selection in mice
  JOURNAL   Nat Commun 12 (1), 2523 (2021)
   PUBMED   33953177
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4580)
  AUTHORS   Lantz,B., White,C., Liu,X., Wan,Y., Gabriel,G., Lo,C.W.Y. and
            Szabo-Rogers,H.L.
  TITLE     Finding the Unicorn, a New Mouse Model of Midfacial Clefting
  JOURNAL   Genes (Basel) 11 (1), 83 (2020)
   PUBMED   31940751
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4580)
  AUTHORS   Liang,H.C., McKinnon,R.A. and Nebert,D.W.
  TITLE     Sensitivity of CYP1A1 mRNA inducibility by dioxin is the same in
            Cyp1a2(+/+) wild-type and Cyp1a2(-/-) null mutant mice
  JOURNAL   Biochem Pharmacol 54 (10), 1127-1131 (1997)
   PUBMED   9464455
REFERENCE   7  (bases 1 to 4580)
  AUTHORS   Fazioli,F., Wong,W.T., Ullrich,S.J., Sakaguchi,K., Appella,E. and
            Di Fiore,P.P.
  TITLE     The ezrin-like family of tyrosine kinase substrates:
            receptor-specific pattern of tyrosine phosphorylation and
            relationship to malignant transformation
  JOURNAL   Oncogene 8 (5), 1335-1345 (1993)
   PUBMED   8479753
REFERENCE   8  (bases 1 to 4580)
  AUTHORS   Wilgenbus,K.K., Milatovich,A., Francke,U. and Furthmayr,H.
  TITLE     Molecular cloning, cDNA sequence, and chromosomal assignment of the
            human radixin gene and two dispersed pseudogenes
  JOURNAL   Genomics 16 (1), 199-206 (1993)
   PUBMED   8486357
REFERENCE   9  (bases 1 to 4580)
  AUTHORS   Sato,N., Funayama,N., Nagafuchi,A., Yonemura,S., Tsukita,S. and
            Tsukita,S.
  TITLE     A gene family consisting of ezrin, radixin and moesin. Its specific
            localization at actin filament/plasma membrane association sites
  JOURNAL   J Cell Sci 103 (Pt 1), 131-143 (1992)
   PUBMED   1429901
REFERENCE   10 (bases 1 to 4580)
  AUTHORS   Funayama,N., Nagafuchi,A., Sato,N., Tsukita,S. and Tsukita,S.
  TITLE     Radixin is a novel member of the band 4.1 family
  JOURNAL   J Cell Biol 115 (4), 1039-1048 (1991)
   PUBMED   1955455
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY739389.1, AK168449.1, AK162204.1 and BE994963.1.
            
            [WARNING] On Oct 7, 2024 this sequence was replaced by NM_009041.4.
            
            On Sep 15, 2007 this sequence version replaced NM_009041.2.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longer protein (isoform a). Variants 1
            and 2 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC034438.1, AK156370.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-330               BY739389.1         1-330
            331-3414            AK168449.1         2-3085
            3415-4558           AK162204.1         2987-4130
            4559-4580           BE994963.1         1-22                c
FEATURES             Location/Qualifiers
     source          1..4580
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 28.62 cM"
     gene            1..4580
                     /gene="Rdx"
                     /note="radixin"
                     /db_xref="GeneID:19684"
                     /db_xref="MGI:MGI:97887"
     exon            1..492
                     /gene="Rdx"
                     /inference="alignment:Splign:2.1.0"
     exon            493..564
                     /gene="Rdx"
                     /inference="alignment:Splign:2.1.0"
     CDS             553..2304
                     /gene="Rdx"
                     /note="isoform a is encoded by transcript variant 1;
                     ESP10"
                     /codon_start=1
                     /product="radixin isoform a"
                     /protein_id="NP_033067.2"
                     /db_xref="CCDS:CCDS40634.1"
                     /db_xref="GeneID:19684"
                     /db_xref="MGI:MGI:97887"
                     /translation="MPKPINVRVTTMDAELEFAIQPNTTGKQLFDQVVKTVGLREVWF
                     FGLQYVDSKGYSTWLKLNKKVTQQDVKKENPLQFKFRAKFFPEDVSEELIQEITQRLF
                     FLQVKEAILNDEIYCPPETAVLLASYAVQAKYGDYNKEIHKPGYLANDRLLPQRVLEQ
                     HKLTKEQWEERIQNWHEEHRGMLREDSMMEYLKIAQDLEMYGVNYFEIKNKKGTELWL
                     GVDALGLNIYEHDDKLTPKIGFPWSEIRNISFNDKKFVIKPIDKKAPDFVFYAPRLRI
                     NKRILALCMGNHELYMRRRKPDTIEVQQMKAQAREEKHQKQLERAQLENEKKKREIAE
                     KEKERIEREKEELMERLRQIEEQTVKAQKELEEQTRKALELEQERQRAKEEAERLDRE
                     RRAAEEAKSAIAKQAADQMKNQEQLAAELAEFTAKIALLEEAKKKKEEEATEWQHKAF
                     AAQEDLEKTKEELKTVMSAPPPPPPPPVIPPTENEHDEQDENSAEASAELSSEGVMNH
                     RSEEERVTETQKNERVKKQLQALSSELAQARDETKKTQNDVLHAENVKAGRDKYKTLR
                     QIRQGNTKQRIDEFEAM"
     exon            565..648
                     /gene="Rdx"
                     /inference="alignment:Splign:2.1.0"
     exon            649..744
                     /gene="Rdx"
                     /inference="alignment:Splign:2.1.0"
     exon            745..1019
                     /gene="Rdx"
                     /inference="alignment:Splign:2.1.0"
     exon            1020..1103
                     /gene="Rdx"
                     /inference="alignment:Splign:2.1.0"
     exon            1104..1250
                     /gene="Rdx"
                     /inference="alignment:Splign:2.1.0"
     exon            1251..1347
                     /gene="Rdx"
                     /inference="alignment:Splign:2.1.0"
     exon            1348..1511
                     /gene="Rdx"
                     /inference="alignment:Splign:2.1.0"
     exon            1512..1642
                     /gene="Rdx"
                     /inference="alignment:Splign:2.1.0"
     exon            1643..1803
                     /gene="Rdx"
                     /inference="alignment:Splign:2.1.0"
     exon            1804..1896
                     /gene="Rdx"
                     /inference="alignment:Splign:2.1.0"
     exon            1897..2139
                     /gene="Rdx"
                     /inference="alignment:Splign:2.1.0"
     exon            2140..4563
                     /gene="Rdx"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4535..4540
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rdx"
                     /note="hexamer: AATAAA"
     polyA_site      4554
                     /gene="Rdx"
                     /note="major polyA site"
ORIGIN      
        1 gagtttcaag tttccactcg cggggcgggg gcaggcggcg ggcgcgcggc gagcttcggg
       61 ccgcgcggct ccgcttcgtt cactgcgggc ttcggactcg ggctggcccg cggcgtcctc
      121 gtcccgcggg gaaagcttcg cgaaggcccc gcagcgcgta ttctcccccc aacccccggc
      181 tgaggcccac tcgattccgc ccggggcggc cgggagacac gctcgcgggg ttggcgctcg
      241 agccccggcc tcgccccgcc actggcggcc cgcgggagga gggggcgcag ggcggccccg
      301 ccttcccccc cgaggaggcg ccgggcggcc atattgccga gctgtctgcg gcggctgcgg
      361 cgcgtcttct ctcaggcggc tcagggctcg caccgccgac tctccgctcg ttcgccgcca
      421 gccacgacgc ccccgccgag ccgcgcctca gccagccggc ggcgggcagg gaaggagcca
      481 ctcattttcg gggctataat tgtttataga agtgaagagt ttctaaagaa ggtaacaaac
      541 aagaaaaaga aaatgccgaa gccaatcaat gtaagagtaa ctacaatgga cgctgagcta
      601 gaatttgcca tccagcccaa tacaactggc aaacaacttt ttgaccaggt tgtaaaaaca
      661 gttggcttac gtgaggtctg gttttttggg ctgcaatatg tagacagcaa aggatattct
      721 acatggctta aattgaataa aaaggtaaca cagcaagatg ttaaaaaaga aaatccttta
      781 cagttcaagt ttagagctaa attctttcct gaagatgttt ctgaggaatt gattcaagaa
      841 ataacacaga gacttttctt cttgcaagtt aaagaagcca tcttaaatga tgagatatat
      901 tgcccaccag aaactgcagt tcttttggct tcgtatgctg tccaagccaa gtatggagat
      961 tataataaag agattcacaa accaggctat ctggctaatg acagactctt accacagcgt
     1021 gttttggaac aacacaaact gaccaaagag cagtgggagg agagaataca gaactggcat
     1081 gaggaacaca gagggatgct aagggaagat tcgatgatgg aatacttgaa gattgcgcaa
     1141 gatctagaga tgtatggtgt caactacttt gaaatcaaga ataagaaggg tactgagctg
     1201 tggctaggtg ttgatgcttt aggcctgaat atttatgaac atgatgacaa gttaacacct
     1261 aaaattggtt ttccctggag tgaaatcaga aatatttcat ttaatgacaa aaaattcgtt
     1321 ataaagccaa ttgacaaaaa ggcacctgat tttgtcttct atgcacctcg tctgagaatc
     1381 aataaacgaa ttttggcctt atgtatggga aaccatgaac tgtacatgcg aaggagaaag
     1441 cctgatacta ttgaagtaca gcagatgaag gctcaggccc gggaggaaaa gcatcagaag
     1501 cagctagaaa gggcacaatt agagaatgaa aagaagaaac gagaaatagc agaaaaggaa
     1561 aaggaaagaa tagaacgtga aaaggaagag ctgatggagc gtctgaggca gatcgaagag
     1621 caaacagtga aagcccagaa agaactagaa gaacagactc ggaaagctct agaactggag
     1681 caggagcgcc agcgagcaaa agaggaggca gagcggctag acagggagcg ccgggctgca
     1741 gaagaagcca agtctgcaat cgccaagcaa gctgctgacc agatgaagaa ccaggagcag
     1801 ctggcagcag aacttgccga attcactgcc aagattgcac ttttagaaga agccaagaag
     1861 aaaaaggaag aggaagctac tgagtggcag cacaaagctt ttgcagctca ggaagacttg
     1921 gaaaagacca aagaagagct aaaaactgtg atgtctgcgc cacctccacc tccccctcct
     1981 ccagtcatcc ctcccacgga gaacgagcat gacgagcagg acgagaacag tgcggaggcc
     2041 agcgccgagc tgtccagcga gggggtgatg aaccaccgaa gcgaggagga gcgggtcacc
     2101 gaaacccaga agaatgaacg cgtgaagaag cagctccagg cattgagttc agaattagcc
     2161 caagctagag atgaaaccaa gaagacacag aacgatgttc ttcacgctga gaatgtcaag
     2221 gccggccgtg ataagtacaa gacccttcgg cagattcgac aaggcaatac gaagcagcgc
     2281 atcgatgagt ttgaagccat gtgagagctg ttcttgtgat ccatgtcctt cataagctga
     2341 accaccacca gagaaaagca ggcctgtgca gtgcagatgc aatggaacgc atcccacctt
     2401 gccaaagcac tcataccagt cgactgtgct cactagcagg acactgaagg gtgtccttca
     2461 tcattaaggc agtgtgatgt catgtttggt catttttctt ttgtccaggg aatggataat
     2521 gacattctgt cacccaccct tttgtacatt tttcactttt tgtttgtttc atctttttca
     2581 gttgaatatt aatactaatg gccacgtctg acaaatgtgt gtatgtgctt tgagcactgt
     2641 gtacatctta ggataatggt ggacatttca gtgcatgttt agctaatgaa cttagttttc
     2701 tttgcccttt ccatgttgta ggctacatac atctccatgt tcattctcat gttttttgtc
     2761 agtgtgacct tctcatgccc tgtcatgata gagctgtaat tctggtgtca cacggatcac
     2821 ttactggagg tgtataatat gagatagtga ggcagacaga cagacagaca gacatgggac
     2881 tacatcataa gatgattaga atgttggaca gcgtagtatg cagccagtgg ttagttatta
     2941 caaagatccc ttagttactg tattgtttgc tttccttaag tgcagtcatc tctgatagct
     3001 tgagtgatgg tgtttcaaat cctgtagtcc tatggtggct ttccttgcct gttactttag
     3061 agatctagcc actaggcagt cgcttctaag aaaattattg atgaagtggc cttgtaagta
     3121 catggtctct gaaaaaaatt caagttttgt tcttaggatg tccaatagaa gataactgtg
     3181 gatgataact aattctaatt gttgaagggg gaaaaaaacc caaaccttgg cctttctgca
     3241 agggcagcat atggaaacat caactctgag aacaaaatac tacctcactc tttacgtacg
     3301 tggtgactgt acgcacagtc tgtgctgcat gtctgtcacc catacgcagt ctcaatcatg
     3361 gccttcactg agtgcttttg agatcccagt gctaatgttt taactgcctt tctgttgaac
     3421 tgtggggctc tgatttgtgt ctagattatt gtatattctc actggtatgc tgttccctgg
     3481 ggggtgttct gtgtccgacg ctgagtgacc ctttgtgaga aagacgttgc ctttgcagta
     3541 catgaaacat cccattcttt gttcttgatg ggataggggt cgttattgta gcatatttgg
     3601 tttctaaatc actgcttatt tttatttgca atctctaaaa acaaatttta tttcaattac
     3661 gtcttactga agaagtcttt ccagctagaa agatgttctg acactgtctg atcgtgaagc
     3721 acctgaattt acagaagatg cagaaagcct cgttttctct gcgtggttca gctactttcc
     3781 atttggtatt atgcactcaa acttaacatt tatctattaa aattgccatt tcattaagca
     3841 attttcacgc acagtagatt caacttgttt tttgtgctgt tttttgattt ttgctgactt
     3901 aaaaaggatt aatttgggca gacattataa aaaggaaagg gttaatatat ttttggactc
     3961 tgtaggacaa aagagaactg gttaaccttg aagtgactgt tgtacagtgg ctgtgcacgt
     4021 gcttcagact catttgcgag ggaatgcttt ctgtatgaga gggagacggt aggccttacc
     4081 actcagacct ggacgtataa gtgctcactt ttccaacaca tcacagcgat agtccttatt
     4141 gctaaaggac ttggcttccc tcggagtttt actgatttat ttttttctct ttgcattgtg
     4201 tacattatca ttgctacatc agttgttaca gtgttgaaag gctaccagtt atatttgctg
     4261 ttaatagtct atttgtagat taggattaaa gtgggtttaa tccattttta tagctgtatg
     4321 aatttttcta aacaggaaca gccatttgca aaatgggttt tcatagtgat tgcatcaatt
     4381 ataacattta tcattagcag ttgagagcac atgttcatat agcaatgtaa aaacctacta
     4441 atgagtattt ggtaatttcc cattagcata attttatgtt gtacaagtaa attacaattc
     4501 catctctaat cttggataat actggttggt taacaataaa gtgacaaaag ctcccgcctt
     4561 ggaaaaaaaa aaaaaaaaaa
//
