LOCUS       NM_153133               2698 bp    mRNA    linear   ROD 06-AUG-2023
DEFINITION  Mus musculus retinol dehydrogenase 9 (Rdh9), mRNA.
ACCESSION   NM_153133
VERSION     NM_153133.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2698)
  AUTHORS   Rocha AS, Vidal V, Mertz M, Kendall TJ, Charlet A, Okamoto H and
            Schedl A.
  TITLE     The Angiocrine Factor Rspondin3 Is a Key Determinant of Liver
            Zonation
  JOURNAL   Cell Rep 13 (9), 1757-1764 (2015)
   PUBMED   26655896
REFERENCE   2  (bases 1 to 2698)
  AUTHORS   Li X, Dai Y, Chuang PY and He JC.
  TITLE     Induction of retinol dehydrogenase 9 expression in podocytes
            attenuates kidney injury
  JOURNAL   J Am Soc Nephrol 25 (9), 1933-1941 (2014)
   PUBMED   24652806
  REMARK    GeneRIF: podocyte-specific overexpression of Rdh9 in established
            kidney disease due to either HIV-associated nephropathy or
            adriamycin-induced nephropathy decreases proteinuria, attenuates
            kidney injury, and restores podocyte differentiation markers
REFERENCE   3  (bases 1 to 2698)
  AUTHORS   Hesse K, Vaupel K, Kurt S, Buettner R, Kirfel J and Moser M.
  TITLE     AP-2delta is a crucial transcriptional regulator of the posterior
            midbrain
  JOURNAL   PLoS One 6 (8), e23483 (2011)
   PUBMED   21858141
REFERENCE   4  (bases 1 to 2698)
  AUTHORS   Hu P, Zhang M and Napoli JL.
  TITLE     Ontogeny of rdh9 (Crad3) expression: ablation causes changes in
            retinoid and steroid metabolizing enzymes, but RXR and androgen
            signaling seem normal
  JOURNAL   Biochim Biophys Acta 1770 (4), 694-705 (2007)
   PUBMED   17270348
REFERENCE   5  (bases 1 to 2698)
  AUTHORS   Zhuang R, Lin M and Napoli JL.
  TITLE     cis-Retinol/androgen dehydrogenase, isozyme 3 (CRAD3): a
            short-chain dehydrogenase active in a reconstituted path of
            9-cis-retinoic acid biosynthesis in intact cells
  JOURNAL   Biochemistry 41 (10), 3477-3483 (2002)
   PUBMED   11876656
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC129576.11 and AC131690.3.
            
            On Nov 17, 2006 this sequence version replaced NM_153133.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF372838.1, AK132181.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849377, SAMN00849378
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-393               AC129576.11        133615-134007
            394-652             AC131690.3         25027-25285
            653-816             AC131690.3         26608-26771
            817-2698            AC131690.3         27235-29116
FEATURES             Location/Qualifiers
     source          1..2698
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 75.21 cM"
     gene            1..2698
                     /gene="Rdh9"
                     /gene_synonym="Crad3"
                     /note="retinol dehydrogenase 9"
                     /db_xref="GeneID:103142"
                     /db_xref="MGI:MGI:2143528"
     exon            1..393
                     /gene="Rdh9"
                     /gene_synonym="Crad3"
                     /inference="alignment:Splign:2.1.0"
     CDS             81..1034
                     /gene="Rdh9"
                     /gene_synonym="Crad3"
                     /note="cis-retinol/androgen dehydrogenase type 3"
                     /codon_start=1
                     /product="retinol dehydrogenase 9 precursor"
                     /protein_id="NP_694773.1"
                     /db_xref="CCDS:CCDS24251.1"
                     /db_xref="GeneID:103142"
                     /db_xref="MGI:MGI:2143528"
                     /translation="MWLFLVALVGLWTLLCFFRERQVVSYLQDKYVFITGCDSGFGNL
                     LARQLDRRGMRVLAACLTEKGAEELRNKTSDRLETVILDVTKTESIVTATQWVKERVG
                     NRGLWGLVNNAGISIPSGPNEWMKKQDFAHVLDVNLLGLIEVTLSMLPLVRKARGRVI
                     NVASVLGRVSLCGGAYCISKYGVEAFSDSLRRELSYFGVKVAIIEPGFFLTGVTSSAR
                     LCSNTQMLWDQTSSEIREIYGEKYLASYLKRLNELDKRCNKDLSLVTDCMEHALTACH
                     PRTRYSAGWDAKLFYLPLSYLPTFLVDALLYWTSLKPEKAL"
     exon            394..652
                     /gene="Rdh9"
                     /gene_synonym="Crad3"
                     /inference="alignment:Splign:2.1.0"
     exon            653..816
                     /gene="Rdh9"
                     /gene_synonym="Crad3"
                     /inference="alignment:Splign:2.1.0"
     exon            817..2698
                     /gene="Rdh9"
                     /gene_synonym="Crad3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcctacacct tcctgtgtga gcagaggcca ggctcatttt gacaccgagt atctctctct
       61 ctgcttggct tctacaaact atgtggctct ttctagtggc actggtgggc ctttggactc
      121 tcctgtgctt cttcagggag aggcaggtgg tgagctatct ccaagacaag tatgtcttca
      181 tcacgggctg tgactctggc tttgggaacc tgctggccag acagctggac aggagaggca
      241 tgagagtgtt ggctgcatgt ctgacggaga agggagccga ggagctgagg aacaagacat
      301 ctgacaggct ggagacagtg atcctggatg tcaccaagac agagagtatt gtgacagcca
      361 ctcagtgggt gaaggagcgt gttgggaaca gaggactctg gggcctggtc aacaacgctg
      421 gcatctccat cccctcgggt cccaacgagt ggatgaagaa acaggacttt gcacatgtac
      481 tggatgtgaa cctgttgggc ttgatcgagg tgactctgag catgctgccc ttagtgagga
      541 aggcaagggg tcgtgtgatc aacgtcgcca gtgtcttggg ccgagtatct ttgtgtggtg
      601 gtgcttactg catctctaag tatggtgtag aggccttctc agactccctc aggagggagc
      661 tctcctactt tggggtgaag gtggctatta tagagcctgg cttcttcctg accggtgtga
      721 ccagtagtgc cagattatgc tcaaataccc agatgctgtg ggaccagacc agctcagaaa
      781 tcagggagat ctatggcgag aagtacctgg catcctatct gaaaaggcta aacgaattgg
      841 acaagaggtg caacaaggac ctgtctttgg tgactgactg catggagcat gctctgactg
      901 cctgtcaccc tcgtacccga tactcagctg gctgggatgc taagctcttc tacctcccct
      961 tgagctacct gcctaccttt cttgtggatg cccttctcta ttggacttcc ctgaagcctg
     1021 agaaagccct ctgacgtgtt cacctatgtg catacctggg gagatgtagg tagagtttga
     1081 gagagagaat atttagggga aatttggagg gttgagggag ggagtttatt actctggggt
     1141 tctagtcaac acacttcatc tcattaattc tcctatgaca ctactgaaga ctgatgatga
     1201 ccaaagaaat aggcaaagaa ttctgccaag ggattcagtt acaagagatc tggctgttgc
     1261 ccagactatg aacatcatgg ctaccatgaa ggttgacaca gatgaagagg ctgggaccag
     1321 cttgtgccaa gcactcttct gtgtcctcct ctgcaggaaa tgcacatgcc ctggctagtt
     1381 taaagcccta tgcagcatgg aagtgtccct gctctgcagt cacctctgtc catggtataa
     1441 agtctgaggg agtcactaat aatgccagca cccattccct ggagtcagct tgccagcctc
     1501 tgcgtggaag gttcagttcc tggtggtgaa agctagcaaa ggatggagac accaattttt
     1561 catttatatt gaaatcatgg gtttctttct cttcttcttt ttttttttgt cacttcttat
     1621 ttttaaaggt aatatgaggt gatctctgtt gctctgcgtt ttgaagtatg gctttaccct
     1681 ttagtgaaat ttggaacaca gaggtaaagg gaatgtcctg agaaggattg gcacaggcca
     1741 gcagttactt tctttgactg tctcatccct tcctgccagt gagtgggaac aactgctctc
     1801 catttaaaac ttaataataa cacataaggc agaagcctgt gcatgcaagt ccatggacag
     1861 aatttacctg taggcctcag cttcacaagt tccttttctg tagaatcact aagtgaccat
     1921 ccctccctga aaactaacta tgtcaccata tacagagtat ccttctcaac actaattttt
     1981 catattttgg gaatttttca aaagagcaag ggtcttgaac ttcccatggc ctctgagatc
     2041 tggctctgcc tgctgctagg ttggtgagtc ttaagagtag gctgagcagg gaaatcatgt
     2101 gtggaagaga cagagaatcc tgggctcaat acagatgtgc cctggggagg ggttcccata
     2161 gatgcctgac tcctcttctc tcagtagaaa tgtgggggaa gaggggacgc aggagaaact
     2221 tgtaaataaa caatgatttc tgggttaatg aaaatagaaa ttcctctacc ctatcagttg
     2281 catggtcatt cattttacct atgttatttt gagagtttgt tttaggacca ttgagcatat
     2341 ttgtgtgtac ctgtatggta catgtgtggg agagccttca gagatgggaa ggtgtggaga
     2401 gccgtgccgc gagcaatcgc gtgtgtgccg tgagcaatcg ccattataag atggtgctgg
     2461 cttccattgt gcctaactag taaacaagtc ttatgcgcaa gtgcaagagt gaactcacgc
     2521 ctagtcactg cccatctcgt agcatagtaa tggggtgatg ggcgagcaac gaatcaggag
     2581 ctgtcacgcc acatcaggtg ctgaaacgtc atgctgcagg gtatataagc agcaccattt
     2641 tcccggttcg gggtcttccc tcctgataag taagcaataa aagctttgcc acagaaga
//
