LOCUS       NM_001030290            3355 bp    mRNA    linear   ROD 04-MAR-2025
DEFINITION  Mus musculus retinol dehydrogenase 8 (Rdh8), mRNA.
ACCESSION   NM_001030290 XM_134689
VERSION     NM_001030290.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3355)
  AUTHORS   Riedmayr,L.M., Hinrichsmeyer,K.S., Thalhammer,S.B., Mittas,D.M.,
            Karguth,N., Otify,D.Y., Bohm,S., Weber,V.J., Bartoschek,M.D.,
            Splith,V., Brummer,M., Ferreira,R., Boon,N., Wogenstein,G.M.,
            Grimm,C., Wijnholds,J., Mehlfeld,V., Michalakis,S., Fenske,S.,
            Biel,M. and Becirovic,E.
  TITLE     mRNA trans-splicing dual AAV vectors for (epi)genome editing and
            gene therapy
  JOURNAL   Nat Commun 14 (1), 6578 (2023)
   PUBMED   37852949
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3355)
  AUTHORS   Matsuyama,M., Ortega,J.T., Fedorov,Y., Scott-McKean,J.,
            Muller-Greven,J., Buck,M., Adams,D., Jastrzebska,B., Greenlee,W.
            and Matsuyama,S.
  TITLE     Development of novel cytoprotective small compounds inhibiting
            mitochondria-dependent cell death
  JOURNAL   iScience 26 (10), 107916 (2023)
   PUBMED   37841588
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3355)
  AUTHORS   Ortega,J.T., Parmar,T. and Jastrzebska,B.
  TITLE     Galanin receptor 3 - A new pharmacological target in retina
            degeneration
  JOURNAL   Pharmacol Res 188, 106675 (2023)
   PUBMED   36693600
REFERENCE   4  (bases 1 to 3355)
  AUTHORS   Mavlyutov,T.A., Li,J., Liu,X., Shen,H., Yang,H., McCurdy,C.R.,
            Pattnaik,B. and Guo,L.W.
  TITLE     Retinal Photoreceptor Protection in an AMD-Related Mouse Model by
            Selective Sigma-1 or Sigma-2 Receptor Modulation
  JOURNAL   Genes (Basel) 13 (12), 2386 (2022)
   PUBMED   36553653
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3355)
  AUTHORS   Ortega,J.T., McKee,A.G., Roushar,F.J., Penn,W.D., Schlebach,J.P.
            and Jastrzebska,B.
  TITLE     Chromenone derivatives as novel pharmacological chaperones for
            retinitis pigmentosa-linked rod opsin mutants
  JOURNAL   Hum Mol Genet 31 (20), 3439-3457 (2022)
   PUBMED   35642742
REFERENCE   6  (bases 1 to 3355)
  AUTHORS   Maeda,A., Maeda,T., Golczak,M., Chou,S., Desai,A., Hoppel,C.L.,
            Matsuyama,S. and Palczewski,K.
  TITLE     Involvement of all-trans-retinal in acute light-induced retinopathy
            of mice
  JOURNAL   J Biol Chem 284 (22), 15173-15183 (2009)
   PUBMED   19304658
REFERENCE   7  (bases 1 to 3355)
  AUTHORS   Maeda,A., Maeda,T., Golczak,M. and Palczewski,K.
  TITLE     Retinopathy in mice induced by disrupted all-trans-retinal
            clearance
  JOURNAL   J Biol Chem 283 (39), 26684-26693 (2008)
   PUBMED   18658157
  REMARK    GeneRIF: mice lacking both the ATP-binding cassette transporter 4
            (Abca4) and enzyme retinol dehydrogenase 8 (Rdh8), proteins
            critical for all-trans-retinal clearance from photoreceptors,
            developed severe RPE/photoreceptor dystrophy at an early age
REFERENCE   8  (bases 1 to 3355)
  AUTHORS   Maeda,A., Maeda,T., Sun,W., Zhang,H., Baehr,W. and Palczewski,K.
  TITLE     Redundant and unique roles of retinol dehydrogenases in the mouse
            retina
  JOURNAL   Proc Natl Acad Sci U S A 104 (49), 19565-19570 (2007)
   PUBMED   18048336
REFERENCE   9  (bases 1 to 3355)
  AUTHORS   Maeda,A., Maeda,T., Imanishi,Y., Golczak,M., Moise,A.R. and
            Palczewski,K.
  TITLE     Aberrant metabolites in mouse models of congenital blinding
            diseases: formation and storage of retinyl esters
  JOURNAL   Biochemistry 45 (13), 4210-4219 (2006)
   PUBMED   16566595
REFERENCE   10 (bases 1 to 3355)
  AUTHORS   Maeda,A., Maeda,T., Imanishi,Y., Kuksa,V., Alekseev,A.,
            Bronson,J.D., Zhang,H., Zhu,L., Sun,W., Saperstein,D.A., Rieke,F.,
            Baehr,W. and Palczewski,K.
  TITLE     Role of photoreceptor-specific retinol dehydrogenase in the
            retinoid cycle in vivo
  JOURNAL   J Biol Chem 280 (19), 18822-18832 (2005)
   PUBMED   15755727
  REMARK    GeneRIF: prRDH is an enzyme that catalyzes reduction of
            all-trans-retinal in the rod outer segment, most noticeably at
            higher light intensities and prolonged illumination, but is not an
            essential enzyme of the retinoid cycle
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC166365.4.
            
            On Jun 17, 2019 this sequence version replaced NM_001030290.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-113               AC166365.4         146801-146913
            114-275             AC166365.4         150930-151091
            276-455             AC166365.4         151611-151790
            456-549             AC166365.4         152623-152716
            550-733             AC166365.4         153485-153668
            734-3355            AC166365.4         153744-156365
FEATURES             Location/Qualifiers
     source          1..3355
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 7.64 cM"
     gene            1..3355
                     /gene="Rdh8"
                     /gene_synonym="Gm182; prRDH"
                     /note="retinol dehydrogenase 8"
                     /db_xref="GeneID:235033"
                     /db_xref="MGI:MGI:2685028"
     exon            1..113
                     /gene="Rdh8"
                     /gene_synonym="Gm182; prRDH"
                     /inference="alignment:Splign:2.1.0"
     CDS             11..964
                     /gene="Rdh8"
                     /gene_synonym="Gm182; prRDH"
                     /EC_number="1.1.1.300"
                     /codon_start=1
                     /product="retinol dehydrogenase 8"
                     /protein_id="NP_001025461.1"
                     /db_xref="CCDS:CCDS22884.1"
                     /db_xref="GeneID:235033"
                     /db_xref="MGI:MGI:2685028"
                     /translation="MASQQRTVLISGCSSGIGLELALQLAHDPRQRYQVVATMRDLGK
                     KEPLEAAAGEALGKTLSVVQLDVCNDESVTDCLSHIEGGQVDVLVNNAGVGLVGPLEG
                     LSLATMQSVFNTNFFGAVRLVKAVLPGMKRRRQGHIVVVSSVMGLQGVMFNDVYAASK
                     FALEGFFESLAIQLRQFNIFISMVEPGPVTTDFEGKLLAQVSKAEFPDTDPDTLGYFR
                     DLYLPASRELFRSVGQSPRDVAQVIAKVIGTTRPPLRRQTNTRYLPLTALKAMDPSGS
                     LYVKTAHRLLFRWPHLLNLGLRCLACGCLPTRVWPRQTEQN"
     exon            114..275
                     /gene="Rdh8"
                     /gene_synonym="Gm182; prRDH"
                     /inference="alignment:Splign:2.1.0"
     exon            276..455
                     /gene="Rdh8"
                     /gene_synonym="Gm182; prRDH"
                     /inference="alignment:Splign:2.1.0"
     exon            456..549
                     /gene="Rdh8"
                     /gene_synonym="Gm182; prRDH"
                     /inference="alignment:Splign:2.1.0"
     exon            550..733
                     /gene="Rdh8"
                     /gene_synonym="Gm182; prRDH"
                     /inference="alignment:Splign:2.1.0"
     exon            734..3355
                     /gene="Rdh8"
                     /gene_synonym="Gm182; prRDH"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3332..3337
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rdh8"
                     /gene_synonym="Gm182; prRDH"
                     /note="hexamer: AATAAA"
     polyA_site      3355
                     /gene="Rdh8"
                     /gene_synonym="Gm182; prRDH"
                     /note="major polyA site"
ORIGIN      
        1 gaggatcagc atggcctctc agcagcggac ggtgctcatc tctggctgct cttcggggat
       61 cggccttgaa ctagcgcttc agctggctca tgaccccagg cagcgttacc aggtggtggc
      121 caccatgagg gacctgggga agaaggagcc attggaggca gctgctggag aagctcttgg
      181 aaagaccctc agcgtggtcc agctggacgt gtgcaatgat gaatcagtga ctgactgtct
      241 cagccacatc gagggaggac aagtggatgt gctagtgaac aatgcaggag taggccttgt
      301 ggggcccctg gagggactca gcctagccac catgcagagc gtgttcaaca ccaacttttt
      361 tggagctgtc cgtctggtca aagctgtgct tccaggcatg aagaggaggc gtcagggcca
      421 catcgtggtg gtcagcagtg ttatggggct tcagggtgtc atgttcaatg acgtctatgc
      481 agcctccaag tttgccctag aagggttctt tgagagtctc gctatccagc tgcgacaatt
      541 caatatcttc atctcaatgg tggagccagg cccagtcacc actgactttg aaggaaaact
      601 tctggctcag gtttccaagg cggagttccc agacacggac cctgacaccc tgggctactt
      661 ccgggacttg tacctcccag cctccaggga gctcttccgc tctgtgggac agagcccacg
      721 ggatgtggcc caggtcattg ccaaggtcat cggtaccacc agacccccac tccgcagaca
      781 gaccaacact cgctacctcc cactgacagc gcttaaggcc atggacccct ctggaagcct
      841 gtatgtgaaa actgcccaca ggctcctttt tcgctggcct cacctcctca accttggtct
      901 ccgatgcctg gcctgtggct gcctcccaac acgtgtgtgg cctagacaaa cagagcagaa
      961 ctgacctgtc ccacccttcc acctggaaca gcagggctct gcccagagac agtcagtaca
     1021 gactctcttg ttcactcatt caggcccatg ggggaagaat ttgggatgga gtgggaggca
     1081 gagggagttg aggaggttcc agccatggct ttacatcact ctggatttcc cgaggctgag
     1141 accacgatcc cctgaactca ccatacattc ctatgctgct gaaatcacac tgagtcagac
     1201 tcagctgcat cgaagagaga atcctcattg ctaagagtgg taactataca aacaaacaca
     1261 gccaggggaa gctggtgtta gacactggct ggatgttatt gctgacctga cagggaggct
     1321 ggcccaagtt cagccgatgc tggagacagg cccacacttg gttctgcatt gctgcagtcc
     1381 agtcgtcccc agctcaggca ggacaaccca tcctgcagct gctcaggcta aagtacctga
     1441 gtttctctct tgacagtgaa gctatgtctc ccctccctcc ctccctccct ccctccctcc
     1501 ctccctccct ccctcccttc ctttctcctt ctcctttttc ttctctccca cccccagaag
     1561 atgtcagcat gccagtctca tgtcctaaca ctcagcagca ctctaccaat ctttattatt
     1621 tactttgttt tgaggagtta tgttgttggt ttgggggggg gtttattgta ttgtttgttt
     1681 tgagacaggg tttctctttg tagccttggc tgtcctggaa ctcaccctgt agcccaggct
     1741 ggcctcgaac tcagagattt gcctgcctct gactcccaag tgctaggact aaagccttgc
     1801 accaccacca cccgactacc atttactttt taaattttct gtgtttgagt gcatgtatgg
     1861 tcgccaattg catgcagtgc ttgatgaggc cagaacaggg tgtcatatct cctgaaactg
     1921 gagttacaaa tggttgctga gccaagatta agggtgctgg gaacccaacc caggttcctt
     1981 gtaagagttg caagagcttt taactactga gccatcactc cagcctagtg gtaagaattg
     2041 tttgcatcga tgtagaagtc tcatctcacc cagagtaagc aatgttccag gggagcaaac
     2101 aagccagcac gtagacagca gcccttcagg atggagatga gcttgaagat gctcatacag
     2161 caattccaaa ggcacaggct gtggccaagt tatctcatga actctggcac acgtgtgaaa
     2221 tgatgtattc attctagtgt ttatataaca gcaaaaaaca ccctagagac agccaaagga
     2281 tctgtcagta gcagaccagc cccagaaatg attattcctg tacaagacag aatgcattgc
     2341 aggtttgaaa gagaaaggaa gcctgattgg gcctctgcag aaaatgctcc aaggtgcatt
     2401 attcaaaaaa gaactccgta acagagcaac aagatggctg ctctcagcaa aaaggattaa
     2461 aataatgata tgcttgggtt tttcccacta aaacgttctg tcttaattaa atatatatgt
     2521 gtatatacgt ataaatatat atgtatgtat gtatatatat atgtataaat atatatgatg
     2581 aaatatacac aatgtgaaat ttcccatctt aattttctct tctgagttca gggcctcagc
     2641 actctccagt tcctgacccc ccccccccca cacacttgct ataactgcta ggattgcagt
     2701 cctgagccac cacagccagt gttagccatt tttttataat tttaatttta catatgttgg
     2761 tgttttgcct gcatgattgt gtgtgagagt gtgccagatt ccctgaactg aagttacaga
     2821 cagttgtaag atgccatgtg ggtgctggga attgaaccca ggtcctctgg aaaagcagcc
     2881 ggtgttgttt gttgttactg agccatcttt tcatccccca gctttagtca tttttaaaaa
     2941 attaaaaaca agaagctaga gagatggtgc agaggttaag gacactggct gttcttccag
     3001 aggacctggg ttcaattccc agcacccaca tggcagctca caactgtaac tccaggtcca
     3061 gaggatctgg catcctcaca caacatacat gtaggtaaaa caccaaagca cataaaataa
     3121 aaataaatta gttaaaatta aaaacaaaat ctggagagat ggctcaacag ttaagagcac
     3181 tcagttgctc ttgcagcaga cccaggtttc caaacaccca cattaggcaa ctcagagtca
     3241 actgtaattc catcctcggg ggacccgcca ccctcttcta accaccaagg atactgcaca
     3301 acatatgtgc acaaacacac aaagaaaact aaataaatct tttcaaataa ataaa
//
