LOCUS       NM_001150749            1614 bp    mRNA    linear   ROD 24-DEC-2024
DEFINITION  Mus musculus retinol dehydrogenase 7 (Rdh7), transcript variant 1,
            mRNA.
ACCESSION   NM_001150749
VERSION     NM_001150749.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1614)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1614)
  AUTHORS   Grizotte-Lake,M., Zhong,G., Duncan,K., Kirkwood,J., Iyer,N.,
            Smolenski,I., Isoherranen,N. and Vaishnava,S.
  TITLE     Commensals Suppress Intestinal Epithelial Cell Retinoic Acid
            Synthesis to Regulate Interleukin-22 Activity and Prevent Microbial
            Dysbiosis
  JOURNAL   Immunity 49 (6), 1103-1115 (2018)
   PUBMED   30566883
REFERENCE   3  (bases 1 to 1614)
  AUTHORS   Chen,S., Li,H., Gaudenz,K., Paulson,A., Guo,F., Trimble,R.,
            Peak,A., Seidel,C., Deng,C., Furuta,Y. and Xie,T.
  TITLE     Defective FGF signaling causes coloboma formation and disrupts
            retinal neurogenesis
  JOURNAL   Cell Res 23 (2), 254-273 (2013)
   PUBMED   23147794
REFERENCE   4  (bases 1 to 1614)
  AUTHORS   Brown,A.C., Olver,W.I., Donnelly,C.J., May,M.E., Naggert,J.K.,
            Shaffer,D.J. and Roopenian,D.C.
  TITLE     Searching QTL by gene expression: analysis of diabesity
  JOURNAL   BMC Genet 6, 12 (2005)
   PUBMED   15760467
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1614)
  AUTHORS   Ulven,S.M., Gundersen,T.E., Sakhi,A.K., Glover,J.C. and Blomhoff,R.
  TITLE     Quantitative axial profiles of retinoic acid in the embryonic mouse
            spinal cord: 9-cis retinoic acid only detected after
            all-trans-retinoic acid levels are super-elevated experimentally
  JOURNAL   Dev Dyn 222 (3), 341-353 (2001)
   PUBMED   11747070
REFERENCE   6  (bases 1 to 1614)
  AUTHORS   Tomita,K., Sato,M., Kajiwara,K., Tanaka,M., Tamiya,G., Makino,S.,
            Tomizawa,M., Mizutani,A., Kuwano,Y., Shiina,T., Ishii,H. and
            Kimura,M.
  TITLE     Gene structure and promoter for Crad2 encoding mouse
            cis-retinol/3alpha-hydroxysterol short-chain dehydrogenase isozyme
  JOURNAL   Gene 251 (2), 175-186 (2000)
   PUBMED   10876094
REFERENCE   7  (bases 1 to 1614)
  AUTHORS   Ulven,S.M., Gundersen,T.E., Weedon,M.S., Landaas,V.O., Sakhi,A.K.,
            Fromm,S.H., Geronimo,B.A., Moskaug,J.O. and Blomhoff,R.
  TITLE     Identification of endogenous retinoids, enzymes, binding proteins,
            and receptors during early postimplantation development in mouse:
            important role of retinal dehydrogenase type 2 in synthesis of
            all-trans-retinoic acid
  JOURNAL   Dev Biol 220 (2), 379-391 (2000)
   PUBMED   10753524
REFERENCE   8  (bases 1 to 1614)
  AUTHORS   Su,J., Chai,X., Kahn,B. and Napoli,J.L.
  TITLE     cDNA cloning, tissue distribution, and substrate characteristics of
            a cis-Retinol/3alpha-hydroxysterol short-chain dehydrogenase
            isozyme
  JOURNAL   J Biol Chem 273 (28), 17910-17916 (1998)
   PUBMED   9651397
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ097101.1, AB015165.1, CB951082.1 and AI255893.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript. Variants 1 and 2 encode the same protein.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC024603.1, AB015165.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849386, SAMN01164135
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-12                CJ097101.1         2-13
            13-1107             AB015165.1         101-1195
            1108-1543           CB951082.1         207-642
            1544-1614           AI255893.1         5-75                c
FEATURES             Location/Qualifiers
     source          1..1614
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 76.39 cM"
     gene            1..1614
                     /gene="Rdh7"
                     /gene_synonym="CRAD2"
                     /note="retinol dehydrogenase 7"
                     /db_xref="GeneID:54150"
                     /db_xref="MGI:MGI:1860517"
     exon            1..433
                     /gene="Rdh7"
                     /gene_synonym="CRAD2"
                     /inference="alignment:Splign:2.1.0"
     CDS             121..1071
                     /gene="Rdh7"
                     /gene_synonym="CRAD2"
                     /EC_number="1.1.1.105"
                     /note="CRAD-2; cis-retinol/androgen dehydrogenase type 2;
                     cis-retinol/3alpha-hydroxysterol short-chain dehydrogenase
                     isozyme 2"
                     /codon_start=1
                     /product="retinol dehydrogenase 7"
                     /protein_id="NP_001144221.1"
                     /db_xref="CCDS:CCDS24255.1"
                     /db_xref="GeneID:54150"
                     /db_xref="MGI:MGI:1860517"
                     /translation="MWLYLVALVGLWTLLRFFRERQVVSHLQDKYVFITGCDSGFGNL
                     LARQLDRRGMRVLAACLTEKGAEQLRNKTSDRLETVILDVTKTESIVAATQWVKERVG
                     NRGLWGLVNNAGICVFAINEWLKKEDFANILDVNLLGMIEVTLSMLPLVRKARGRVVN
                     ISSSMGRVSLCGGGYCISKYGVEAFSDSLRREISYFGVKVAIIEPGGFRTNVSNYERL
                     SHSIEKLWDQTSSEVKEVYDKNFLDSYIKAIQSLTDTCSDDLSVVTDCMEHALTACHP
                     RTRYSAGWDAKLFYLPLSYMPTFLVDAMLYWSSVKPAQAL"
     exon            434..689
                     /gene="Rdh7"
                     /gene_synonym="CRAD2"
                     /inference="alignment:Splign:2.1.0"
     exon            690..853
                     /gene="Rdh7"
                     /gene_synonym="CRAD2"
                     /inference="alignment:Splign:2.1.0"
     exon            854..1595
                     /gene="Rdh7"
                     /gene_synonym="CRAD2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1576..1581
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rdh7"
                     /gene_synonym="CRAD2"
                     /note="hexamer: AATAAA"
     polyA_site      1595
                     /gene="Rdh7"
                     /gene_synonym="CRAD2"
                     /note="major polyA site"
ORIGIN      
        1 atactggtca gaggaacatg atagaaacct gacattctca gtgcctatac cttcctgtgt
       61 aagcagaggc caggctcatt ttgacacaga atatctctct ctgcttgact tctacaaacc
      121 atgtggctct acctggttgc actggtgggc ctgtggacgc tcctgcgctt cttcagggag
      181 aggcaggtgg tgagccatct ccaagacaag tatgtcttca tcacgggctg tgactctggc
      241 tttgggaacc ttctggccag acagctggac aggagaggca tgagggtgct agctgcatgt
      301 ctgacggaga agggagctga gcagctgagg aacaagacat ctgacaggct ggagacagtg
      361 atcctggatg tcaccaagac agagagtatt gtggcagcca ctcagtgggt gaaggagcgt
      421 gttgggaaca gaggactctg gggcctggtc aacaatgctg gcatctgtgt ctttgctatc
      481 aatgagtggc tgaaaaaaga ggactttgca aatatactgg atgtgaacct gttgggcatg
      541 atcgaggtga ctctgagcat gctgccctta gtgaggaagg cgaggggccg tgtggtcaac
      601 atctccagct ccatgggtcg agtgtctttg tgtggtggtg gttactgcat ctccaagtat
      661 ggtgtagagg ccttctcaga ctccctcagg agggagatct cctattttgg ggtgaaggtg
      721 gctatcatag agcctggcgg gttcaggact aatgtctcca actacgagag gctatcacac
      781 agcatagaga agctgtggga ccagacatcc tcggaggtca aggaggtcta tgacaagaat
      841 tttctggact cctatatcaa agcaatacag tcattgacag acacatgctc agatgacctg
      901 tctgtggtaa ctgactgcat ggagcacgct ctgactgcct gtcaccctcg cacaagatac
      961 tcagctggct gggatgccaa gctcttctac ctacccttga gctacatgcc caccttcctg
     1021 gtagatgcca tgttgtactg gagctctgta aagcctgccc aagccctgtg aatctgcacg
     1081 tgtgtgcaga cttgtggcgg gtggagggag ataatggcac agggcatgtg gttcttgaga
     1141 ctcattaaaa caattcagct tccatactac tcagaaccag taaagttcag gggaaagagg
     1201 cagtaaagtt ctgccaaggg ggagtgatac aaaggggctg gcaatatcct gtgaacttag
     1261 cttcttgggg cttcatcttg gcctattgtg agaatccaca ggactgcaga gattgtaaac
     1321 acctaggatg agctttgcct ctggcccttc ctcatgatgt ccatgggcct ggccatcatg
     1381 gaagatcgaa agaatccact tcacaatcac ctttttccat ggtgtcagga gggagggccc
     1441 ccacccgcac tccacatcct aatgccgttt aggaggtggt tttgctggtg ggatagaatc
     1501 ttgctaagat aaacaacaac aacaattttt atttgtctca aaaccatggt tttctttgga
     1561 ttcctttcat ttcagaataa aagttgaaaa gattaaaaaa aaaaaaaaaa aaaa
//
