LOCUS       NM_001358527            1281 bp    mRNA    linear   ROD 09-FEB-2024
DEFINITION  Mus musculus retinol dehydrogenase 5 (Rdh5), transcript variant 2,
            mRNA.
ACCESSION   NM_001358527 XM_006513387
VERSION     NM_001358527.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1281)
  AUTHORS   Xie,Y., Gonome,T., Yamauchi,K., Maeda-Monai,N., Tanabu,R.,
            Ishiguro,S.I. and Nakazawa,M.
  TITLE     A spectral-domain optical coherence tomographic analysis of Rdh5-/-
            mice retina
  JOURNAL   PLoS One 15 (4), e0231220 (2020)
   PUBMED   32271812
  REMARK    GeneRIF: the longitudinal findings of spectral-domain optical
            coherence tomography (SD-OCT) in relation to the morphologic
            features in Rdh5 knockout (Rdh5-/-) mice, was investigated.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1281)
  AUTHORS   Michael,H.T., Graff-Cherry,C., Chin,S., Rauck,C.,
            Habtemichael,A.D., Bunda,P., Smith,T., Campos,M.M., Bharti,K.,
            Arnheiter,H., Merlino,G. and Day,C.P.
  TITLE     Partial Rescue of Ocular Pigment Cells and Structure by Inducible
            Ectopic Expression of Mitf-M in MITF-Deficient Mice
  JOURNAL   Invest Ophthalmol Vis Sci 59 (15), 6067-6073 (2018)
   PUBMED   30590377
REFERENCE   3  (bases 1 to 1281)
  AUTHORS   Wen,B., Li,S., Li,H., Chen,Y., Ma,X., Wang,J., Lu,F., Qu,J. and
            Hou,L.
  TITLE     Microphthalmia-associated transcription factor regulates the visual
            cycle genes Rlbp1 and Rdh5 in the retinal pigment epithelium
  JOURNAL   Sci Rep 6, 21208 (2016)
   PUBMED   26876013
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1281)
  AUTHORS   Sahu,B., Sun,W., Perusek,L., Parmar,V., Le,Y.Z., Griswold,M.D.,
            Palczewski,K. and Maeda,A.
  TITLE     Conditional Ablation of Retinol Dehydrogenase 10 in the Retinal
            Pigmented Epithelium Causes Delayed Dark Adaption in Mice
  JOURNAL   J Biol Chem 290 (45), 27239-27247 (2015)
   PUBMED   26391396
REFERENCE   5  (bases 1 to 1281)
  AUTHORS   Parker,R.O. and Crouch,R.K.
  TITLE     Retinol dehydrogenases (RDHs) in the visual cycle
  JOURNAL   Exp Eye Res 91 (6), 788-792 (2010)
   PUBMED   20801113
  REMARK    Review article
REFERENCE   6  (bases 1 to 1281)
  AUTHORS   Gamble,M.V., Shang,E., Zott,R.P., Mertz,J.R., Wolgemuth,D.J. and
            Blaner,W.S.
  TITLE     Biochemical properties, tissue expression, and gene structure of a
            short chain dehydrogenase/ reductase able to catalyze cis-retinol
            oxidation
  JOURNAL   J Lipid Res 40 (12), 2279-2292 (1999)
   PUBMED   10588954
REFERENCE   7  (bases 1 to 1281)
  AUTHORS   Driessen,C.A., Winkens,H.J., Kuhlmann,E.D., Janssen,A.P., van
            Vugt,A.H., Deutman,A.F. and Janssen,J.J.
  TITLE     The visual cycle retinol dehydrogenase: possible involvement in the
            9-cis retinoic acid biosynthetic pathway
  JOURNAL   FEBS Lett 428 (3), 135-140 (1998)
   PUBMED   9654122
REFERENCE   8  (bases 1 to 1281)
  AUTHORS   Romert,A., Tuvendal,P., Simon,A., Dencker,L. and Eriksson,U.
  TITLE     The identification of a 9-cis retinol dehydrogenase in the mouse
            embryo reveals a pathway for synthesis of 9-cis retinoic acid
  JOURNAL   Proc Natl Acad Sci U S A 95 (8), 4404-4409 (1998)
   PUBMED   9539749
REFERENCE   9  (bases 1 to 1281)
  AUTHORS   Driessen,C.A., Winkens,H.J., Kuhlmann,L.D., Janssen,B.P., van
            Vugt,A.H., Deutman,A.F. and Janssen,J.J.
  TITLE     Cloning and structural analysis of the murine GCN5L1 gene
  JOURNAL   Gene 203 (1), 27-31 (1997)
   PUBMED   9426003
REFERENCE   10 (bases 1 to 1281)
  AUTHORS   Mertz,J.R., Shang,E., Piantedosi,R., Wei,S., Wolgemuth,D.J. and
            Blaner,W.S.
  TITLE     Identification and characterization of a stereospecific human
            enzyme that catalyzes 9-cis-retinol oxidation. A possible role in
            9-cis-retinoic acid formation
  JOURNAL   J Biol Chem 272 (18), 11744-11749 (1997)
   PUBMED   9115228
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK135139.1, CK625406.1 and BQ176151.1.
            
            [WARNING] On Mar 25, 2024 this sequence was replaced by
            NM_001358527.2.
            
            On Dec 1, 2017 this sequence version replaced XM_006513387.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC021372.1, SRR7652917.617671.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380, SAMN00849386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-7                 AK135139.1         2-8
            8-614               CK625406.1         4-610
            615-1263            AK135139.1         611-1259
            1264-1281           BQ176151.1         1-18                c
FEATURES             Location/Qualifiers
     source          1..1281
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 77.19 cM"
     gene            1..1281
                     /gene="Rdh5"
                     /gene_synonym="9-cis; cRDH; RDH4"
                     /note="retinol dehydrogenase 5"
                     /db_xref="GeneID:19682"
                     /db_xref="MGI:MGI:1201412"
     exon            1..151
                     /gene="Rdh5"
                     /gene_synonym="9-cis; cRDH; RDH4"
                     /inference="alignment:Splign:2.1.0"
     exon            152..496
                     /gene="Rdh5"
                     /gene_synonym="9-cis; cRDH; RDH4"
                     /inference="alignment:Splign:2.1.0"
     CDS             187..1143
                     /gene="Rdh5"
                     /gene_synonym="9-cis; cRDH; RDH4"
                     /EC_number="1.1.1.315"
                     /EC_number="1.1.1.209"
                     /EC_number="1.1.1.53"
                     /note="9-cis-retinol dehydrogenase; 11-cis retinol
                     dehydrogenase; retinol dehydrogenase type 5; 11-cis RDH;
                     11-cis RoDH"
                     /codon_start=1
                     /product="retinol dehydrogenase 5"
                     /protein_id="NP_001345456.1"
                     /db_xref="CCDS:CCDS24298.1"
                     /db_xref="GeneID:19682"
                     /db_xref="MGI:MGI:1201412"
                     /translation="MWLPLLLGALLWAVLWLLRDRQSLPASDAFIFITGCDSGFGRLL
                     ALQLDQKGFQVLAGCLTPSGAEDLQQMASSRLHTTLLDITDPQNVQQVAKWVKTRVGE
                     TGLFGLVNNAGVAGIIGPTPWLTQDDFQRVLSVNTLGPIGVTLALLPLLQQARGRVVN
                     ITSVLGRIAANGGGYCVSKFGLEAFSDSLRRDMAPFGVQVSIVEPGFFRTPVTNLESL
                     ESTLKACWARLPPAIQAHYGEAFLDTYLRVQRRIMNLICDPELTKVTSCLEHALTARH
                     PRTRYSPGWDAKLLWLPASYLPARVVDAVLTWILPRPAQSVS"
     exon            497..755
                     /gene="Rdh5"
                     /gene_synonym="9-cis; cRDH; RDH4"
                     /inference="alignment:Splign:2.1.0"
     exon            756..919
                     /gene="Rdh5"
                     /gene_synonym="9-cis; cRDH; RDH4"
                     /inference="alignment:Splign:2.1.0"
     exon            920..1268
                     /gene="Rdh5"
                     /gene_synonym="9-cis; cRDH; RDH4"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 actcctggtc cacagcgaga gtccacccac tccagacttt ggccttagct gtagctagtg
       61 tgggagcctg ggaagtctag gagcaaagtc tctcaagcag acagaaagct acagcttcac
      121 acattgtgtt gcctgccagc tttccccaga gcctaggctg ccctcagcag ggcatctcat
      181 cccatcatgt ggctgcctct gcttctgggt gccttgctgt gggcagtgct gtggttgctc
      241 agagaccggc agagcctgcc ggccagtgat gctttcatct tcatcactgg ctgtgactct
      301 ggctttgggc gccttctggc actgcaactt gaccagaagg gcttccaagt cctggccggc
      361 tgcctgaccc cctctggagc agaagacctg cagcagatgg cctcctcccg cctccacaca
      421 acactactgg atatcactga tccccagaat gtccagcaag ttgccaagtg ggtgaagaca
      481 cgtgttggag aaactggact ttttggtctg gtgaataacg ctggcgtagc tggtatcatc
      541 gggcccacac catggctaac acaggatgat ttccagagag tactgagtgt gaacacactg
      601 gggcccatcg gtgtcaccct tgccctgctg cccctgctac agcaggccag gggtcgggtg
      661 gtcaacatca ccagtgtctt gggccgcata gcagccaatg gcgggggcta ctgtgtctcc
      721 aagtttggcc tggaggcctt ctctgacagc ctgaggcggg acatggctcc gttcggagta
      781 caagtctcca ttgtggagcc tggcttcttt cgaacccctg tgaccaacct ggagagtctg
      841 gagagcaccc tgaaggcttg ttgggcccgg ctacctccag ctatacaggc ccactacggg
      901 gaagccttcc tcgatactta tcttcgagta cagcgccgca tcatgaacct gatctgtgac
      961 ccagaactaa cgaaggtgac cagctgcctg gagcatgccc tgactgctcg ccacccccga
     1021 acacgctaca gcccaggctg ggatgccaag ctgctctggc tgcctgcctc ctaccttcca
     1081 gccagggtgg tggatgctgt gctcacctgg atccttcccc ggcccgccca gtcagtctcc
     1141 tgattccagc tttacagcaa gaggctgatt ttgaaaagca aggcatctat ttctgtgtct
     1201 acccagtgct gcctggtttc tgataccaat taggctctca ataaatatgt attgctttaa
     1261 atcaaaaaaa aaaaaaaaaa a
//
