LOCUS       NM_009040               3208 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus retinol dehydrogenase 16 (Rdh16), mRNA.
ACCESSION   NM_009040
VERSION     NM_009040.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3208)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3208)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3208)
  AUTHORS   Hu,P., Zhang,M. and Napoli,J.L.
  TITLE     Ontogeny of rdh9 (Crad3) expression: ablation causes changes in
            retinoid and steroid metabolizing enzymes, but RXR and androgen
            signaling seem normal
  JOURNAL   Biochim Biophys Acta 1770 (4), 694-705 (2007)
   PUBMED   17270348
REFERENCE   4  (bases 1 to 3208)
  AUTHORS   Liden,M., Tryggvason,K. and Eriksson,U.
  TITLE     The C-terminal region of cis-retinol/androgen dehydrogenase 1
            (CRAD1) confers ER localization and in vivo enzymatic function
  JOURNAL   Exp Cell Res 311 (2), 205-217 (2005)
   PUBMED   16223484
REFERENCE   5  (bases 1 to 3208)
  AUTHORS   Matt,N., Schmidt,C.K., Dupe,V., Dennefeld,C., Nau,H., Chambon,P.,
            Mark,M. and Ghyselinck,N.B.
  TITLE     Contribution of cellular retinol-binding protein type 1 to retinol
            metabolism during mouse development
  JOURNAL   Dev Dyn 233 (1), 167-176 (2005)
   PUBMED   15765518
REFERENCE   6  (bases 1 to 3208)
  AUTHORS   Zhang,M., Hu,P. and Napoli,J.L.
  TITLE     Elements in the N-terminal signaling sequence that determine
            cytosolic topology of short-chain dehydrogenases/reductases.
            Studies with retinol dehydrogenase type 1 and cis-retinol/androgen
            dehydrogenase type 1
  JOURNAL   J Biol Chem 279 (49), 51482-51489 (2004)
   PUBMED   15355969
  REMARK    GeneRIF: Rdh1, Crad1, and other short-chain
            dehydrogenases/reductases, which share similar N-terminal signaling
            sequences such as human Rdh5 and mouse Rdh4, orient with their
            catalytic domains facing the cytoplasm
REFERENCE   7  (bases 1 to 3208)
  AUTHORS   Zhuang,R., Lin,M. and Napoli,J.L.
  TITLE     cis-Retinol/androgen dehydrogenase, isozyme 3 (CRAD3): a
            short-chain dehydrogenase active in a reconstituted path of
            9-cis-retinoic acid biosynthesis in intact cells
  JOURNAL   Biochemistry 41 (10), 3477-3483 (2002)
   PUBMED   11876656
REFERENCE   8  (bases 1 to 3208)
  AUTHORS   Ulven,S.M., Gundersen,T.E., Sakhi,A.K., Glover,J.C. and Blomhoff,R.
  TITLE     Quantitative axial profiles of retinoic acid in the embryonic mouse
            spinal cord: 9-cis retinoic acid only detected after
            all-trans-retinoic acid levels are super-elevated experimentally
  JOURNAL   Dev Dyn 222 (3), 341-353 (2001)
   PUBMED   11747070
REFERENCE   9  (bases 1 to 3208)
  AUTHORS   Ulven,S.M., Gundersen,T.E., Weedon,M.S., Landaas,V.O., Sakhi,A.K.,
            Fromm,S.H., Geronimo,B.A., Moskaug,J.O. and Blomhoff,R.
  TITLE     Identification of endogenous retinoids, enzymes, binding proteins,
            and receptors during early postimplantation development in mouse:
            important role of retinal dehydrogenase type 2 in synthesis of
            all-trans-retinoic acid
  JOURNAL   Dev Biol 220 (2), 379-391 (2000)
   PUBMED   10753524
REFERENCE   10 (bases 1 to 3208)
  AUTHORS   Chai,X., Zhai,Y. and Napoli,J.L.
  TITLE     cDNA cloning and characterization of a
            cis-retinol/3alpha-hydroxysterol short-chain dehydrogenase
  JOURNAL   J Biol Chem 272 (52), 33125-33131 (1997)
   PUBMED   9407098
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY144003.1, AF030513.1, AK149404.1 and AC131690.3.
            
            On Nov 15, 2007 this sequence version replaced NM_009040.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF030513.1, BC089612.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849377, SAMN00849378
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1                 BY144003.1         1-1
            2-1086              AF030513.1         1-1085
            1087-2535           AK149404.1         831-2279
            2536-3208           AC131690.3         51586-52258
FEATURES             Location/Qualifiers
     source          1..3208
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 75.7 cM"
     gene            1..3208
                     /gene="Rdh16"
                     /gene_synonym="CRAD; CRAD1; Rdh6"
                     /note="retinol dehydrogenase 16"
                     /db_xref="GeneID:19683"
                     /db_xref="MGI:MGI:1201375"
     exon            1..358
                     /gene="Rdh16"
                     /gene_synonym="CRAD; CRAD1; Rdh6"
                     /inference="alignment:Splign:2.1.0"
     CDS             46..999
                     /gene="Rdh16"
                     /gene_synonym="CRAD; CRAD1; Rdh6"
                     /EC_number="1.1.1.105"
                     /EC_number="1.1.1.315"
                     /EC_number="1.1.1.209"
                     /EC_number="1.1.1.53"
                     /note="retinol dehydrogenase 6; retinol dehydrogenase type
                     6; cis-retinol/androgen dehydrogenase 1"
                     /codon_start=1
                     /product="retinol dehydrogenase 16"
                     /protein_id="NP_033066.1"
                     /db_xref="CCDS:CCDS24252.1"
                     /db_xref="GeneID:19683"
                     /db_xref="MGI:MGI:1201375"
                     /translation="MWLYLVALVGLWTLLRFFRVRQVVSHLQDKYVFITGCDSGFGTL
                     LARQLDRRGMRVLAACLTEKGAEELRNKTSDRLETVILDVTKTESIVTATQWVKEHVG
                     NRGLWGLVNNAGISTPSGPNEWMKKQDFAHVLDVNLLGMIEVTLSMLPLVRKARGRVV
                     NVSSVMGRVSLFGGGYCISKYGVEAFSDSLRRELSYFGVKVAIIEPGFFLTGVTSSAR
                     LCSNTQMLWDQTSSEIREIYGEKYLASYLKRLNKLDKRCNKDLSGVTDCMEHALTACH
                     PRTRYSAGWDAKLFYLPLSYLPTFLVDALLYWTSLKPEKAL"
     exon            359..617
                     /gene="Rdh16"
                     /gene_synonym="CRAD; CRAD1; Rdh6"
                     /inference="alignment:Splign:2.1.0"
     exon            618..781
                     /gene="Rdh16"
                     /gene_synonym="CRAD; CRAD1; Rdh6"
                     /inference="alignment:Splign:2.1.0"
     exon            782..3208
                     /gene="Rdh16"
                     /gene_synonym="CRAD; CRAD1; Rdh6"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2185..2190
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rdh16"
                     /gene_synonym="CRAD; CRAD1; Rdh6"
                     /note="hexamer: AATGAA"
     polyA_site      2211
                     /gene="Rdh16"
                     /gene_synonym="CRAD; CRAD1; Rdh6"
                     /note="major polyA site"
ORIGIN      
        1 attttgacac agagtatctc tctctctgct tgacttctac aagccatgtg gctctacctg
       61 gtggcactgg tgggcctgtg gacgcttctg cgcttcttca gggtgaggca ggtggtgagc
      121 catctccaag acaaatatgt cttcatcacg ggctgtgact ctggctttgg gaccctgctg
      181 gccagacagc tggacaggag aggcatgagg gtgctggctg catgtctgac ggagaaggga
      241 gccgaggagc tgaggaacaa gacatctgac aggctggaga cagtgatcct ggatgtcacc
      301 aagacagaga gtattgtgac agccactcag tgggtgaagg agcatgttgg gaacagagga
      361 ctctggggcc tggtcaacaa cgctggcatc tccaccccct cgggtcccaa cgagtggatg
      421 aaaaagcagg actttgcaca tgtactggat gtgaacctgt tgggcatgat cgaggtgact
      481 ctgagcatgc tgcctttagt gaggaaggcg aggggtcgtg tggtcaacgt ctccagtgtc
      541 atgggtcgag tgtctctctt tggtggtggt tactgcatct ctaagtatgg tgtagaggcc
      601 ttctcagact ccctcaggag ggagctctcc tactttgggg tgaaggtggc tattatagag
      661 cctggcttct tcctgaccgg tgtgaccagt agtgccagat tatgctcaaa tacccagatg
      721 ctgtgggacc agaccagctc agaaatcagg gagatctatg gcgagaagta cctggcatcc
      781 tatctgaaaa ggctaaacaa attggacaag aggtgcaaca aggacctgtc tggggtgact
      841 gactgcatgg agcatgctct gactgcctgt caccctcgta cccgatactc agctggctgg
      901 gatgctaagc tcttctacct ccccttgagc tacctgccca cctttcttgt ggatgccctt
      961 ctctactgga cttccctgaa gcctgaaaaa gccctctgaa gtattcacct atgtgcatac
     1021 ctggggagat gtaggtagag tttgagagag agaatattta ggggaaatta ggagagttgg
     1081 ggggggattt tattactctg gggttctagt caatacactt catcttgtta attctcctat
     1141 gacactactc aagactgatg atgaccaaag aaataggcaa agaattctgc caagggattc
     1201 agttacaaaa gagctggctg atgcccagat tatgagcatc atggctacca tgaaggtcca
     1261 cacagatgag gaggctggga caagtttgtg ccaagcactc tcctgtgtcc tcctctgcag
     1321 gaaatgtaca tgccctggct agtttaaacc cctatgcaag atggaattat ccctgttctg
     1381 aaatcacctc tgtccaaggt actaggtctg agggagttac taataatgcc agcacccatt
     1441 ccctggtgtc aggttgccag gctctgggtg gaaggttcag ttcctggtgg tgaaacctag
     1501 cagagtacgg agacaccaat ttttcatttg tattgaaatt atgggtttct ttctttttct
     1561 tttctttcct ttttttttga cacttcttat ttttaaaggt aatatgaggt gatctctgtt
     1621 gctctgcgtt ttgaagtatg gctttatcct ttagtgaagt ttggaacaca gagctaaggg
     1681 gaatgtcctg agaaggattg gcacaggcca gcaggctttc tttgactgtc tcatcccttc
     1741 cagctaccga ggtgggaaca actgctctcc attcaaaact taataataac acataaggca
     1801 gaagactgtg catgcaagtc catggacaga atttacctgt aggcctcagt ttcacaagtc
     1861 tttttcctgt agaatcacta tgtgaccatg tagagagtat ccttctcaac actagtcttt
     1921 catattggac atttttcaaa agaataaggg tcttgaactt ctcatggcct ctgagagctg
     1981 gctctgcctg ctgctaggtt ggtgaggttt aagagtaggc tgtgcagtga aatcatgtgt
     2041 ggaagagaca gagaatcctg ggctaagtac agacttgccc tgggaagggg ttcccataga
     2101 tgcctgactc ctcttctctc agtagaaatg tgggggaaga ggggacgcag gagaaacttg
     2161 taaatataca ataatttctg gattaatgaa aatagaaatt cctctaccct atcagttgcc
     2221 tggtcattca ttttacctat gttattttga gttttttagg accattgagc atatgtgtgt
     2281 ttacctgtgt gttccatgtg tgggagcacc tcagagatga gaagaaagat gagggttgct
     2341 ggttacaaga aacttttagc tggctgcaga gatggctcag cagttaaggg cactgactgc
     2401 tcttccagag ctcctgagtt caaatcccag caaccacgtg gtggctcaca accacctgca
     2461 atgggttttg atgccctctt ctggtgtctg aagatagcga ctgtgtactc acatatataa
     2521 aataaataaa tttttaaaaa gaaaagaaaa gaaaaatgga aagaagcttt cagccataca
     2581 atatggctgt caggaaatga atttgggtta tactgaacag caggaagcat tcttgatttt
     2641 ggactcattt cttcaaacca tgtactgata ctgcatcttg tttcatttta ttttgagatg
     2701 tctcactgca tggcaggttt accatgacct tgtaagctct agccttactg tcttcatcac
     2761 tacataaatc atgctgtagt acatcaacag catctctgca tgttgtgccc tgtgagaagg
     2821 tcaggaggct ggacctttct cagtatactc tggagcatcg tgatggtttc acaggggaag
     2881 gggcagcacc caggacagat ctacagcccc aagtatgggt agagactcaa gaacatcatg
     2941 atgagacaga accatgtgta attagcagga agtactctgt aaggtgatcc caggatgcct
     3001 gcaacatttc ccctttcctc ctcacccagt tttttgttgt tgttcttaga agccagtgta
     3061 ctcagaggga catagaatga ctcaggctgg cacaagagga tgtttcactc aatcatgcat
     3121 gagaattgca ctgtacccaa ccaagaccca tccctccaac ctgagatctt caactattag
     3181 aatacaataa aattctggtt attagttc
//
