LOCUS       NM_030017               1694 bp    mRNA    linear   ROD 07-MAY-2024
DEFINITION  Mus musculus retinol dehydrogenase 12 (Rdh12), transcript variant
            1, mRNA.
ACCESSION   NM_030017 XM_126957
VERSION     NM_030017.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1694)
  AUTHORS   Bian,J., Chen,H., Sun,J., Han,S., Qi,M. and Pan,Q.
  TITLE     Retinol dehydrogenase 12 (RDH12) knock out may cause hyperuricemia
            phenotype in mice
  JOURNAL   Biochem Biophys Res Commun 709, 149809 (2024)
   PUBMED   38552555
  REMARK    GeneRIF: Retinol dehydrogenase 12 (RDH12) knock out may cause
            hyperuricemia phenotype in mice.
REFERENCE   2  (bases 1 to 1694)
  AUTHORS   Maddala,R., Gao,J., Mathias,R.T., Lewis,T.R., Arshavsky,V.Y.,
            Levine,A., Backer,J.M., Bresnick,A.R. and Rao,P.V.
  TITLE     Absence of S100A4 in the mouse lens induces an aberrant
            retina-specific differentiation program and cataract
  JOURNAL   Sci Rep 11 (1), 2203 (2021)
   PUBMED   33500475
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1694)
  AUTHORS   Shalom-Barak,T., Zhang,X., Chu,T., Timothy Schaiff,W., Reddy,J.K.,
            Xu,J., Sadovsky,Y. and Barak,Y.
  TITLE     Placental PPARgamma regulates spatiotemporally diverse genes and a
            unique metabolic network
  JOURNAL   Dev Biol 372 (1), 143-155 (2012)
   PUBMED   22967998
REFERENCE   4  (bases 1 to 1694)
  AUTHORS   Osuala,K., Baker,C.N., Nguyen,H.L., Martinez,C., Weinshenker,D. and
            Ebert,S.N.
  TITLE     Physiological and genomic consequences of adrenergic deficiency
            during embryonic/fetal development in mice: impact on retinoic acid
            metabolism
  JOURNAL   Physiol Genomics 44 (19), 934-947 (2012)
   PUBMED   22911456
REFERENCE   5  (bases 1 to 1694)
  AUTHORS   Chen,C., Thompson,D.A. and Koutalos,Y.
  TITLE     Reduction of all-trans-retinal in vertebrate rod photoreceptors
            requires the combined action of RDH8 and RDH12
  JOURNAL   J Biol Chem 287 (29), 24662-24670 (2012)
   PUBMED   22621924
  REMARK    GeneRIF: RDH12 in inner segments can protect vital cell organelles
            against aldehyde toxicity caused by an intracellular leak of
            all-trans-retinal, as well as other aldehydes originating both
            inside and outside the cell.
REFERENCE   6  (bases 1 to 1694)
  AUTHORS   Kurth,I., Thompson,D.A., Ruther,K., Feathers,K.L., Chrispell,J.D.,
            Schroth,J., McHenry,C.L., Schweizer,M., Skosyrski,S., Gal,A. and
            Hubner,C.A.
  TITLE     Targeted disruption of the murine retinal dehydrogenase gene Rdh12
            does not limit visual cycle function
  JOURNAL   Mol Cell Biol 27 (4), 1370-1379 (2007)
   PUBMED   17130236
  REMARK    GeneRIF: The present findings, together with those of earlier
            studies showing only minor functional deficits in mice deficient
            for Rdh5, Rdh8, or Rdh11, suggest that the activity of any one
            isoform is not rate limiting in the visual response.
REFERENCE   7  (bases 1 to 1694)
  AUTHORS   Maeda,A., Maeda,T., Imanishi,Y., Sun,W., Jastrzebska,B.,
            Hatala,D.A., Winkens,H.J., Hofmann,K.P., Janssen,J.J., Baehr,W.,
            Driessen,C.A. and Palczewski,K.
  TITLE     Retinol dehydrogenase (RDH12) protects photoreceptors from
            light-induced degeneration in mice
  JOURNAL   J Biol Chem 281 (49), 37697-37704 (2006)
   PUBMED   17032653
  REMARK    GeneRIF: RDH12 plays a unique, nonredundant role in the
            photoreceptor inner segments to regulate the flow of retinoids in
            the eye.
REFERENCE   8  (bases 1 to 1694)
  AUTHORS   Keller,B., Volkmann,A., Wilckens,T., Moeller,G. and Adamski,J.
  TITLE     Bioinformatic identification and characterization of new members of
            short-chain dehydrogenase/reductase superfamily
  JOURNAL   Mol Cell Endocrinol 248 (1-2), 56-60 (2006)
   PUBMED   16406282
REFERENCE   9  (bases 1 to 1694)
  AUTHORS   Blackshaw,S., Harpavat,S., Trimarchi,J., Cai,L., Huang,H.,
            Kuo,W.P., Weber,G., Lee,K., Fraioli,R.E., Cho,S.H., Yung,R.,
            Asch,E., Ohno-Machado,L., Wong,W.H. and Cepko,C.L.
  TITLE     Genomic analysis of mouse retinal development
  JOURNAL   PLoS Biol 2 (9), E247 (2004)
   PUBMED   15226823
REFERENCE   10 (bases 1 to 1694)
  AUTHORS   Haeseleer,F., Jang,G.F., Imanishi,Y., Driessen,C.A.G.G.,
            Matsumura,M., Nelson,P.S. and Palczewski,K.
  TITLE     Dual-substrate specificity short chain retinol dehydrogenases from
            the vertebrate retina
  JOURNAL   J Biol Chem 277 (47), 45537-45546 (2002)
   PUBMED   12226107
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC154585.2, AK039233.1 and
            AW491970.1.
            
            On Sep 17, 2015 this sequence version replaced NM_030017.3.
            
            Summary: The protein encoded by this gene is an NADPH-dependent
            retinal reductase whose highest activity is toward 9-cis and
            all-trans-retinol. The encoded enzyme also plays a role in the
            metabolism of short-chain aldehydes but does not exhibit steroid
            dehydrogenase activity. Defects in the human gene are associated
            with Leber congenital amaurosis type 13, and Retinitis Pigmentosa
            53. [provided by RefSeq, Sep 2015].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK039233.1, AK020927.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1                 AC154585.2         164877-164877
            2-955               AK039233.1         2-955
            956-956             AC154585.2         174809-174809
            957-1675            AK039233.1         957-1675
            1676-1694           AW491970.1         1-19                c
FEATURES             Location/Qualifiers
     source          1..1694
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="12"
                     /map="12 35.51 cM"
     gene            1..1694
                     /gene="Rdh12"
                     /note="retinol dehydrogenase 12"
                     /db_xref="GeneID:77974"
                     /db_xref="MGI:MGI:1925224"
     exon            1..196
                     /gene="Rdh12"
                     /inference="alignment:Splign:2.1.0"
     exon            197..315
                     /gene="Rdh12"
                     /inference="alignment:Splign:2.1.0"
     exon            316..471
                     /gene="Rdh12"
                     /inference="alignment:Splign:2.1.0"
     exon            472..576
                     /gene="Rdh12"
                     /inference="alignment:Splign:2.1.0"
     exon            577..786
                     /gene="Rdh12"
                     /inference="alignment:Splign:2.1.0"
     exon            787..976
                     /gene="Rdh12"
                     /inference="alignment:Splign:2.1.0"
     exon            977..1678
                     /gene="Rdh12"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1656..1661
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rdh12"
                     /note="hexamer: AATAAA"
     polyA_site      1678
                     /gene="Rdh12"
                     /note="major polyA site"
ORIGIN      
        1 cagccagttg ctgagtgtcc cagagtgaga ggaaccaaga accaacagaa gctgccagga
       61 attggagcca gagaaggatc ctcgggctag gttgagggtg ggaagcagca actaagaaag
      121 ttgacaagat gctgtttatc ttggtactgc ttacgtcctt cctctccatc ttgtatctga
      181 cagctccatc catcaggaag ttctttgctg gtggagtttg tacaacaaat gtccagatcc
      241 cagggaaggt agtggtcatc acaggtgcca acacaggcat tggcaaggag acagccagag
      301 agcttgctcg aagaggagca cgagtataca ttgcttgccg agatgtgctg aagggagagt
      361 ctgctgctag tgaaatccga gcagatacca agaactccca ggtgctagtg cggaaattgg
      421 acctgtctga caccaaatcc atccgagcct ttgctgaacg cttcctagca gaggaaaaga
      481 agcttcatat tttgatcaac aatgcaggag tgatgatgtg cccatattct aagacaacag
      541 atggctttga gacccacttt ggagtcaacc acctgggaca ctttcttctt acatacctgc
      601 tgttggagag gctgaaggag tctgctcccg cacgggtggt caacctttcc tcaatagctc
      661 acctgattgg caagatccgt ttccatgacc tccaaggcca gaaacgatac tgcagtgctt
      721 ttgcctatgg ccacagcaag ctggccaatc tgctcttcac tcgagaactg gctaagcggc
      781 tccaagggac tggagtcacc gcctatgcgg ttcacccggg cgttgtattg tcagagatca
      841 ccaggaactc ctacctgctg tgtttgctat ggcggctctt ctcacccttc ttcaagtcca
      901 cttctcaggg ggctcagacc agcctgcact gtgctctggc ggaggaccta gagcccctga
      961 gtggaaagta cttcagtgac tgcaagagga tgtgggtatc ctcaagggcc cggaacaaga
     1021 aaacagctga gcgattgtgg aacgtcagct gcgagcttct aggaatccag tgggaatagt
     1081 tggcccgaag accagagcct tttcaggccc aatccatgcc agaaaaaaaa aggaccaaag
     1141 agaaggttga tctgaaagga ttatcctggc ttgttgctgc tgtgactcct gcctactaag
     1201 aatcttcggg aaccctgtat acacacaaca tttttgtgag gcagggtcag agtacaggat
     1261 gatagtcaca tttccagctc attctcaaag gcttagagaa tccacagctc tccggggcaa
     1321 gagagctgaa catgggggtg gtagaggatc ctgggaagtt ggattagttt cctccccagt
     1381 accactgaca tgagcttaca cgctcacagg gacaccggca tcacacattt ctattccctc
     1441 cagctctaga ttggcctctt tttctttgaa atgaaatgtt agtcacagcc ctggagtctg
     1501 gaccaactca ggaagacgta gctcactttg gccaagcttc attttttttc ctttgagcat
     1561 cctggagcca ttgtatgaag ctgggccttc ccgttttttt accatgtaga tttcccccct
     1621 ccccaaacca ttctctttac ctcaattttt agagaaataa agatttatat tcttctcaaa
     1681 aaaaaaaaaa aaaa
//
