LOCUS       NM_021557               2928 bp    mRNA    linear   ROD 26-JUN-2024
DEFINITION  Mus musculus retinol dehydrogenase 11 (Rdh11), transcript variant
            1, mRNA.
ACCESSION   NM_021557 XM_991992
VERSION     NM_021557.6
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2928)
  AUTHORS   Zhang,D., Deng,W., Jiang,T., Zhao,Y., Bai,D., Tian,Y., Kong,S.,
            Zhang,L., Wang,H., Gao,S. and Lu,Z.
  TITLE     Maternal Ezh1/2 deficiency impairs the function of mitochondria in
            mouse oocytes and early embryos
  JOURNAL   J Cell Physiol 239 (6), e31244 (2024)
   PUBMED   38529784
REFERENCE   2  (bases 1 to 2928)
  AUTHORS   Wu,L., Belyaeva,O.V., Adams,M.K., Klyuyeva,A.V., Lee,S.A.,
            Goggans,K.R., Kesterson,R.A., Popov,K.M. and Kedishvili,N.Y.
  TITLE     Mice lacking the epidermal retinol dehydrogenases SDR16C5 and
            SDR16C6 display accelerated hair growth and enlarged meibomian
            glands
  JOURNAL   J Biol Chem 294 (45), 17060-17074 (2019)
   PUBMED   31562240
REFERENCE   3  (bases 1 to 2928)
  AUTHORS   Belyaeva,O.V., Wu,L., Shmarakov,I., Nelson,P.S. and Kedishvili,N.Y.
  TITLE     Retinol dehydrogenase 11 is essential for the maintenance of
            retinol homeostasis in liver and testis in mice
  JOURNAL   J Biol Chem 293 (18), 6996-7007 (2018)
   PUBMED   29567832
  REMARK    GeneRIF: results indicate that in mouse testis and liver, RDH11
            functions as an all-trans-retinaldehyde reductase essential for the
            maintenance of physiological levels of all-trans-retinol under
            reduced vitamin A availability
REFERENCE   4  (bases 1 to 2928)
  AUTHORS   Adams,M.K., Belyaeva,O.V., Wu,L. and Kedishvili,N.Y.
  TITLE     The retinaldehyde reductase activity of DHRS3 is reciprocally
            activated by retinol dehydrogenase 10 to control retinoid
            homeostasis
  JOURNAL   J Biol Chem 289 (21), 14868-14880 (2014)
   PUBMED   24733397
REFERENCE   5  (bases 1 to 2928)
  AUTHORS   Parker,R.O. and Crouch,R.K.
  TITLE     Retinol dehydrogenases (RDHs) in the visual cycle
  JOURNAL   Exp Eye Res 91 (6), 788-792 (2010)
   PUBMED   20801113
  REMARK    Review article
REFERENCE   6  (bases 1 to 2928)
  AUTHORS   Maeda,A., Maeda,T., Imanishi,Y., Golczak,M., Moise,A.R. and
            Palczewski,K.
  TITLE     Aberrant metabolites in mouse models of congenital blinding
            diseases: formation and storage of retinyl esters
  JOURNAL   Biochemistry 45 (13), 4210-4219 (2006)
   PUBMED   16566595
REFERENCE   7  (bases 1 to 2928)
  AUTHORS   Kasus-Jacobi,A., Ou,J., Birch,D.G., Locke,K.G., Shelton,J.M.,
            Richardson,J.A., Murphy,A.J., Valenzuela,D.M., Yancopoulos,G.D. and
            Edwards,A.O.
  TITLE     Functional characterization of mouse RDH11 as a retinol
            dehydrogenase involved in dark adaptation in vivo
  JOURNAL   J Biol Chem 280 (21), 20413-20420 (2005)
   PUBMED   15790565
  REMARK    GeneRIF: propose that mouse retinol dehydrogenase 11(mRDH11)
            disruption affects retinoid metabolism in photoreceptor inner
            segments and delays the kinetics of dark adaptation through
            modulation of calcium homeostasis
REFERENCE   8  (bases 1 to 2928)
  AUTHORS   Kim,T.S., Maeda,A., Maeda,T., Heinlein,C., Kedishvili,N.,
            Palczewski,K. and Nelson,P.S.
  TITLE     Delayed dark adaptation in 11-cis-retinol dehydrogenase-deficient
            mice: a role of RDH11 in visual processes in vivo
  JOURNAL   J Biol Chem 280 (10), 8694-8704 (2005)
   PUBMED   15634683
  REMARK    GeneRIF: RDH11 has a measurable role in regenerating the visual
            pigment by complementing RDH5 in retinal pigment epithelium.
REFERENCE   9  (bases 1 to 2928)
  AUTHORS   Kasus-Jacobi,A., Ou,J., Bashmakov,Y.K., Shelton,J.M.,
            Richardson,J.A., Goldstein,J.L. and Brown,M.S.
  TITLE     Characterization of mouse short-chain aldehyde reductase (SCALD),
            an enzyme regulated by sterol regulatory element-binding proteins
  JOURNAL   J Biol Chem 278 (34), 32380-32389 (2003)
   PUBMED   12807874
  REMARK    GeneRIF: characterization of catalytic properties and tissue
            distribution
REFERENCE   10 (bases 1 to 2928)
  AUTHORS   Moore,S., Pritchard,C., Lin,B., Ferguson,C. and Nelson,P.S.
  TITLE     Isolation and characterization of the murine prostate short-chain
            dehydrogenase/reductase 1 (Psdr1) gene, a new member of the
            short-chain steroid dehydrogenase/reductase family
  JOURNAL   Gene 293 (1-2), 149-160 (2002)
   PUBMED   12137953
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BU053368.1, AK004413.1 and AK135443.1.
            
            On Apr 11, 2018 this sequence version replaced NM_021557.5.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK135443.1, AF474027.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849384, SAMN01164131
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-36                BU053368.1         2-37
            37-1610             AK004413.1         2-1575
            1611-2928           AK135443.1         1605-2922
FEATURES             Location/Qualifiers
     source          1..2928
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="12"
                     /map="12 35.51 cM"
     gene            1..2928
                     /gene="Rdh11"
                     /gene_synonym="2610319N22Rik; Arsdr1; CGI-82; HCBP12;
                     M42C60; Mdt1; Psdr1; ralR1; SCALD; Ube-1c; UBE-1c1"
                     /note="retinol dehydrogenase 11"
                     /db_xref="GeneID:17252"
                     /db_xref="MGI:MGI:102581"
     exon            1..130
                     /gene="Rdh11"
                     /gene_synonym="2610319N22Rik; Arsdr1; CGI-82; HCBP12;
                     M42C60; Mdt1; Psdr1; ralR1; SCALD; Ube-1c; UBE-1c1"
                     /inference="alignment:Splign:2.1.0"
     CDS             66..1016
                     /gene="Rdh11"
                     /gene_synonym="2610319N22Rik; Arsdr1; CGI-82; HCBP12;
                     M42C60; Mdt1; Psdr1; ralR1; SCALD; Ube-1c; UBE-1c1"
                     /EC_number="1.1.1.300"
                     /note="isoform 1 is encoded by transcript variant 1;
                     androgen-regulated short-chain dehydrogenase/reductase 1;
                     short-chain aldehyde dehydrogenase; retinal reductase 1;
                     cell line MC/9.IL4-derived protein 1; prostate short-chain
                     dehydrogenase/reductase 1; cell line MC/9.IL4 derived
                     transcript 1; all-trans and 9-cis"
                     /codon_start=1
                     /product="retinol dehydrogenase 11 isoform 1"
                     /protein_id="NP_067532.2"
                     /db_xref="CCDS:CCDS36480.1"
                     /db_xref="GeneID:17252"
                     /db_xref="MGI:MGI:102581"
                     /translation="MFGFLLLLSLPFILYLVTPKIRKMLSSGVCTSNVQLPGKVAIVT
                     GANTGIGKETAKDLAQRGARVYLACRDVDKGELAAREIQAVTGNSQVFVRKLDLADTK
                     SIRAFAKDFLAEEKHLHLLINNAGVMMCPYSKTADGFEMHIGVNHLGHFLLTHLLLEK
                     LKESAPSRIVNLSSLGHHLGRIHFHNLQGEKFYSAGLAYCHSKLANILFTKELAKRLK
                     GSGVTTYSVHPGTVHSELTRYSSIMRWLWQLFFVFIKTPQEGAQTSLYCALTEGLESL
                     SGSHFSDCQLAWVSYQGRNEIIARRLWDVSCDLLGLPVDW"
     exon            131..249
                     /gene="Rdh11"
                     /gene_synonym="2610319N22Rik; Arsdr1; CGI-82; HCBP12;
                     M42C60; Mdt1; Psdr1; ralR1; SCALD; Ube-1c; UBE-1c1"
                     /inference="alignment:Splign:2.1.0"
     exon            250..405
                     /gene="Rdh11"
                     /gene_synonym="2610319N22Rik; Arsdr1; CGI-82; HCBP12;
                     M42C60; Mdt1; Psdr1; ralR1; SCALD; Ube-1c; UBE-1c1"
                     /inference="alignment:Splign:2.1.0"
     exon            406..510
                     /gene="Rdh11"
                     /gene_synonym="2610319N22Rik; Arsdr1; CGI-82; HCBP12;
                     M42C60; Mdt1; Psdr1; ralR1; SCALD; Ube-1c; UBE-1c1"
                     /inference="alignment:Splign:2.1.0"
     exon            511..720
                     /gene="Rdh11"
                     /gene_synonym="2610319N22Rik; Arsdr1; CGI-82; HCBP12;
                     M42C60; Mdt1; Psdr1; ralR1; SCALD; Ube-1c; UBE-1c1"
                     /inference="alignment:Splign:2.1.0"
     exon            721..910
                     /gene="Rdh11"
                     /gene_synonym="2610319N22Rik; Arsdr1; CGI-82; HCBP12;
                     M42C60; Mdt1; Psdr1; ralR1; SCALD; Ube-1c; UBE-1c1"
                     /inference="alignment:Splign:2.1.0"
     exon            911..2928
                     /gene="Rdh11"
                     /gene_synonym="2610319N22Rik; Arsdr1; CGI-82; HCBP12;
                     M42C60; Mdt1; Psdr1; ralR1; SCALD; Ube-1c; UBE-1c1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1588..1593
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rdh11"
                     /gene_synonym="2610319N22Rik; Arsdr1; CGI-82; HCBP12;
                     M42C60; Mdt1; Psdr1; ralR1; SCALD; Ube-1c; UBE-1c1"
                     /note="hexamer: AATAAA"
     polyA_site      1610
                     /gene="Rdh11"
                     /gene_synonym="2610319N22Rik; Arsdr1; CGI-82; HCBP12;
                     M42C60; Mdt1; Psdr1; ralR1; SCALD; Ube-1c; UBE-1c1"
     regulatory      2806..2811
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rdh11"
                     /gene_synonym="2610319N22Rik; Arsdr1; CGI-82; HCBP12;
                     M42C60; Mdt1; Psdr1; ralR1; SCALD; Ube-1c; UBE-1c1"
                     /note="hexamer: AATAAA"
     polyA_site      2826
                     /gene="Rdh11"
                     /gene_synonym="2610319N22Rik; Arsdr1; CGI-82; HCBP12;
                     M42C60; Mdt1; Psdr1; ralR1; SCALD; Ube-1c; UBE-1c1"
                     /note="major polyA site"
     regulatory      2874..2879
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rdh11"
                     /gene_synonym="2610319N22Rik; Arsdr1; CGI-82; HCBP12;
                     M42C60; Mdt1; Psdr1; ralR1; SCALD; Ube-1c; UBE-1c1"
                     /note="hexamer: AATAAT"
     polyA_site      2890
                     /gene="Rdh11"
                     /gene_synonym="2610319N22Rik; Arsdr1; CGI-82; HCBP12;
                     M42C60; Mdt1; Psdr1; ralR1; SCALD; Ube-1c; UBE-1c1"
ORIGIN      
        1 agaagccata agtcccgctg tcctctttag agcatcaact tcaactgcgc ttcggtggtg
       61 ctgagatgtt cggattcctg cttctgctct ctcttccctt catcctgtac ttggtcacgc
      121 caaaaatcag gaaaatgctg tccagtgggg tgtgcacatc taatgttcag cttcccggga
      181 aggtagccat agtcactggt gctaacacag gcattgggaa ggagacagct aaagatctgg
      241 cccaaagagg agcccgtgtg tatttagctt gccgggatgt ggacaagggg gaactggcgg
      301 ctcgtgagat ccaagccgtc acagggaaca gtcaggtctt cgtacggaaa ctggacctag
      361 ctgataccaa gtctattcga gcctttgcca aagacttctt agctgaggaa aagcatctgc
      421 accttctcat caacaatgcg ggcgtgatga tgtgccccta ctcgaagact gcagacggct
      481 ttgagatgca cattggcgtc aaccacctgg gtcacttcct cctgacccat ttgctgctag
      541 aaaagctgaa ggagtcggcc ccatcaagga tagtcaactt gtcttctttg ggacaccatc
      601 tgggcaggat ccacttccat aacctgcagg gggagaagtt ctacagtgcg ggtctcgcgt
      661 actgccacag caaactagcc aacattctct tcactaagga gctggccaag aggctgaaag
      721 gttctggagt gacaacatac tctgtacacc ctggcacagt ccattctgaa ttgacgcggt
      781 actcctctat tatgagatgg ctttggcaac ttttctttgt tttcatcaag acccctcaag
      841 agggagctca gacgagcctg tactgtgccc tgacagaagg tctcgagagc ctaagtggca
      901 gtcatttcag tgattgccag ttggcatggg tctcttacca aggtcgcaat gagataatag
      961 ccaggcggct gtgggatgtc agctgtgacc tgctgggcct cccagtggat tggtaagtgg
     1021 tggtttggac tcaaaagaag attggaggag atgatgatta tccttcaaag tggccaaaac
     1081 cttgaacctg aagagcgaag aacttcaagc ctttcctgct tggcatccag ttaaatccta
     1141 gtacactgcc aggttcctcg aaaccccttg agtttgtatt gacttatttt gttcctgctc
     1201 ctgccagcgt ttctagtggt atcactaaga cagaggacct tcatgtgacc tacacagctc
     1261 ctattttcct ttggaaactc cccctaacca ggagcatgaa agccctatga agattggtac
     1321 atgacaatgt ggattagatg gagctcctcc gagccgacca tcctctcctt gaagaactcc
     1381 attgtaacct cagctgaacc tcaggagtcc cggagcctgg ctcaagggca ggcagggctt
     1441 tgtggtccca acatctggat acttaagaaa agtttttact aaatctggca gtctgaagct
     1501 ttggcttctg agacactttt ctatgtccag accactgaag agcttccttc tctaagaaat
     1561 ttgtgggatt tgaagggcag agataaaaat aaagccaaac tgtcattttc tcccgctgtt
     1621 tctcagccta gtaaggaggt aatgaaagga acggtatgag acgataggtc actggggtca
     1681 gttactgacc ccagacccac agaggcctct tttttgtgcc ttagtttctc ttaggaaact
     1741 agaaaaggaa aggccttctc attgtcattg tgtcgatttt gtgtgtcttc ttgtgcattc
     1801 atgcagttga atgtgtttcc acaaaattca caatagccac aaaggaaaag ttcttaatca
     1861 gactgtagtg tagacaaatt accagagatg ggacaaatca ctgtggagtc tttgagtaca
     1921 gttgcaaagc aagggagaca ctatctgtgt tgtaatcggt cactgagaag cacagatgcc
     1981 gcagggaaga agtttaaaag aaaaatccta ggaggggaca catgataatg aaggggtcag
     2041 ctgaggatct aaaaccataa cggaaaggca gtaatagaca gctacagaaa ggcacactgt
     2101 cttaatcacc agtcagtcag agtgatagga aaatgtccaa agcacaagag tgaaatattt
     2161 ctctattcag aaatgttatc ctaaggattg gtaattatag tcagttcata atcttttaga
     2221 gcattttctt acattagctt aacaagatgt ccatttcagg aatgtgtatg gagagatggg
     2281 atggcttagt aatgcctgct gttccagagg accctggttc aattactagg acccacttgg
     2341 caaccacaac catctataac ctcagttata gatgatctag aggatcagac agcctcatct
     2401 acctccacag gccctgcagg aatgtggtgc atagatatat atgcaggcac acatacaaat
     2461 aattttgtaa aaaaaaaaga aatcaatttt gactttgggg gtatgctctc ctgaaatgtt
     2521 gaggcccctg ggtttgatcc cagcactgca aaagaaagta gagatagcct caatttacta
     2581 cgattctgct ttatttggag agcttttatc aaaagcaatg cagaccaagg gtgtcaggaa
     2641 tccctcatgt tcccatcact ggtttggagg atgctattct aagggagttt gccatttcct
     2701 cgggctgaca attatatttt aagcttgaat atgtaagact gacaggacca caatctttaa
     2761 cttctaatat ttgtaaatta ataaatttat gggtttgttc tgaccaataa acgtatttta
     2821 aaattagttt atggggatat tggaaaattt ttgacaatgc agtgattaat taaaataata
     2881 tttcacttaa tttatattca cttgtcaatg aaaacaaagg ttcttttc
//
