LOCUS       NM_133832               2295 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Mus musculus retinol dehydrogenase 10 (all-trans) (Rdh10), mRNA.
ACCESSION   NM_133832
VERSION     NM_133832.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2295)
  AUTHORS   Queen,R., Crosier,M., Eley,L., Kerwin,J., Turner,J.E., Yu,J.,
            Alqahtani,A., Dhanaseelan,T., Overman,L., Soetjoadi,H., Baldock,R.,
            Coxhead,J., Boczonadi,V., Laude,A., Cockell,S.J., Kane,M.A.,
            Lisgo,S. and Henderson,D.J.
  TITLE     Spatial transcriptomics reveals novel genes during the remodelling
            of the embryonic human arterial valves
  JOURNAL   PLoS Genet 19 (11), e1010777 (2023)
   PUBMED   38011284
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2295)
  AUTHORS   Bernheim,S., Borgel,A., Le Garrec,J.F., Perthame,E., Desgrange,A.,
            Michel,C., Guillemot,L., Sart,S., Baroud,C.N., Krezel,W.,
            Raimondi,F., Bonnet,D., Zaffran,S., Houyel,L. and Meilhac,S.M.
  TITLE     Identification of Greb1l as a genetic determinant of crisscross
            heart in mice showing torsion of the heart tube by shortage of
            progenitor cells
  JOURNAL   Dev Cell 58 (21), 2217-2234 (2023)
   PUBMED   37852253
REFERENCE   3  (bases 1 to 2295)
  AUTHORS   Iskusnykh,I.Y., Fattakhov,N., Li,Y., Bihannic,L., Kirchner,M.K.,
            Steshina,E.Y., Northcott,P.A. and Chizhikov,V.V.
  TITLE     Lmx1a is a master regulator of the cortical hem
  JOURNAL   Elife 12, e84095 (2023)
   PUBMED   37725078
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2295)
  AUTHORS   Matern,M.S., Durruthy-Durruthy,R., Birol,O., Darmanis,S.,
            Scheibinger,M., Groves,A.K. and Heller,S.
  TITLE     Transcriptional dynamics of delaminating neuroblasts in the mouse
            otic vesicle
  JOURNAL   Cell Rep 42 (6), 112545 (2023)
   PUBMED   37227818
REFERENCE   5  (bases 1 to 2295)
  AUTHORS   Guertin,T.M., Palaria,A., Mager,J., Sandell,L.L., Trainor,P.A. and
            Tremblay,K.D.
  TITLE     Deciphering the role of retinoic acid in hepatic patterning and
            induction in the mouse
  JOURNAL   Dev Biol 491, 31-42 (2022)
   PUBMED   36028102
REFERENCE   6  (bases 1 to 2295)
  AUTHORS   Shou,S., Scott,V., Reed,C., Hitzemann,R. and Stadler,H.S.
  TITLE     Transcriptome analysis of the murine forelimb and hindlimb autopod
  JOURNAL   Dev Dyn 234 (1), 74-89 (2005)
   PUBMED   16059910
REFERENCE   7  (bases 1 to 2295)
  AUTHORS   Challen,G.A., Martinez,G., Davis,M.J., Taylor,D.F., Crowe,M.,
            Teasdale,R.D., Grimmond,S.M. and Little,M.H.
  TITLE     Identifying the molecular phenotype of renal progenitor cells
  JOURNAL   J Am Soc Nephrol 15 (9), 2344-2357 (2004)
   PUBMED   15339983
REFERENCE   8  (bases 1 to 2295)
  AUTHORS   Zarbalis,K., May,S.R., Shen,Y., Ekker,M., Rubenstein,J.L. and
            Peterson,A.S.
  TITLE     A focused and efficient genetic screening strategy in the mouse:
            identification of mutations that disrupt cortical development
  JOURNAL   PLoS Biol 2 (8), E219 (2004)
   PUBMED   15314648
REFERENCE   9  (bases 1 to 2295)
  AUTHORS   Wu,B.X., Chen,Y., Chen,Y., Fan,J., Rohrer,B., Crouch,R.K. and
            Ma,J.X.
  TITLE     Cloning and characterization of a novel all-trans retinol
            short-chain dehydrogenase/reductase from the RPE
  JOURNAL   Invest Ophthalmol Vis Sci 43 (11), 3365-3372 (2002)
   PUBMED   12407145
REFERENCE   10 (bases 1 to 2295)
  AUTHORS   Ward,A., Bates,P., Fisher,R., Richardson,L. and Graham,C.F.
  TITLE     Disproportionate growth in mice with Igf-2 transgenes
  JOURNAL   Proc Natl Acad Sci U S A 91 (22), 10365-10369 (1994)
   PUBMED   7524092
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AC162442.19.
            
            On Mar 21, 2007 this sequence version replaced NM_133832.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC019796.1, AF456767.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-425               AC162442.19        84329-84753
            426-661             AC162442.19        86242-86477
            662-760             AC162442.19        106612-106710
            761-906             AC162442.19        107643-107788
            907-1038            AC162442.19        109522-109653
            1039-2295           AC162442.19        109741-110997
FEATURES             Location/Qualifiers
     source          1..2295
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 4.94 cM"
     gene            1..2295
                     /gene="Rdh10"
                     /gene_synonym="3110069K09Rik; 4921506A21Rik; D1Ertd762e;
                     m366Asp"
                     /note="retinol dehydrogenase 10 (all-trans)"
                     /db_xref="GeneID:98711"
                     /db_xref="MGI:MGI:1924238"
     exon            1..425
                     /gene="Rdh10"
                     /gene_synonym="3110069K09Rik; 4921506A21Rik; D1Ertd762e;
                     m366Asp"
                     /inference="alignment:Splign:2.1.0"
     CDS             137..1162
                     /gene="Rdh10"
                     /gene_synonym="3110069K09Rik; 4921506A21Rik; D1Ertd762e;
                     m366Asp"
                     /EC_number="1.1.1.300"
                     /codon_start=1
                     /product="retinol dehydrogenase 10"
                     /protein_id="NP_598593.1"
                     /db_xref="CCDS:CCDS14830.1"
                     /db_xref="GeneID:98711"
                     /db_xref="MGI:MGI:1924238"
                     /translation="MNIVVEFFVVTFKVLWAFVLAAARWLVRPKEKSVAGQVCLITGA
                     GSGLGRLFALEFARRRALLVLWDINTQSNEETAGMVRHIYRDLEAADAAALQAGKGEE
                     EILPPCNLQVFTYTCDVGKRENVYLTAERVRKEVGEVSVLVNNAGVVSGHHLLECPDE
                     LIERTMMVNCHAHFWTTKAFLPTMLEINHGHIVTVASSLGLFSTAGVEDYCASKFGVV
                     GFHESLSHELKAAEKDGIKTTLVCPYLVDTGMFRGCRIRKEIEPFLPPLKPDYCVKQA
                     MRAILTDQPMVCTPRLMYIVTFMKSILPFEAVVCMYRFLGADKCMYPFIAQRKQATNN
                     NEAKNGI"
     exon            426..661
                     /gene="Rdh10"
                     /gene_synonym="3110069K09Rik; 4921506A21Rik; D1Ertd762e;
                     m366Asp"
                     /inference="alignment:Splign:2.1.0"
     exon            662..760
                     /gene="Rdh10"
                     /gene_synonym="3110069K09Rik; 4921506A21Rik; D1Ertd762e;
                     m366Asp"
                     /inference="alignment:Splign:2.1.0"
     exon            761..906
                     /gene="Rdh10"
                     /gene_synonym="3110069K09Rik; 4921506A21Rik; D1Ertd762e;
                     m366Asp"
                     /inference="alignment:Splign:2.1.0"
     exon            907..1038
                     /gene="Rdh10"
                     /gene_synonym="3110069K09Rik; 4921506A21Rik; D1Ertd762e;
                     m366Asp"
                     /inference="alignment:Splign:2.1.0"
     exon            1039..2295
                     /gene="Rdh10"
                     /gene_synonym="3110069K09Rik; 4921506A21Rik; D1Ertd762e;
                     m366Asp"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1289..1294
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rdh10"
                     /gene_synonym="3110069K09Rik; 4921506A21Rik; D1Ertd762e;
                     m366Asp"
                     /note="hexamer: AATAAA"
     polyA_site      1309
                     /gene="Rdh10"
                     /gene_synonym="3110069K09Rik; 4921506A21Rik; D1Ertd762e;
                     m366Asp"
                     /note="major polyA site"
     regulatory      2275..2280
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rdh10"
                     /gene_synonym="3110069K09Rik; 4921506A21Rik; D1Ertd762e;
                     m366Asp"
                     /note="hexamer: ATTAAA"
     polyA_site      2295
                     /gene="Rdh10"
                     /gene_synonym="3110069K09Rik; 4921506A21Rik; D1Ertd762e;
                     m366Asp"
                     /note="major polyA site"
ORIGIN      
        1 ctcgggggcg gactccgggc gcagccttcg cgtccggatc gcggtgacaa gcgcctccgg
       61 ggccaggagc tgggctgtct ggcgcaggga gagtgaggac acggtgctgg gctgctgcgg
      121 gacccggggc gtcgcgatga acatcgtagt ggagttcttc gtggtcactt tcaaagtgct
      181 gtgggcgttc gtgctggccg cggcgcgctg gctggtgcgg cccaaggaga agagcgtggc
      241 cggccaggtg tgcctcatca cgggcgcggg cagcggcctg ggccgcctct ttgctctcga
      301 gttcgcccgg cgccgggcgc tgctggttct ctgggacatc aacacgcaga gcaatgagga
      361 gaccgcaggc atggttcgcc acatctaccg ggacctggag gcggccgacg ctgctgctct
      421 gcaagctgga aaaggtgagg aggaaatcct gcccccgtgt aacttacagg tttttaccta
      481 cacttgtgac gtggggaaga gagagaatgt ctacctgaca gctgaaaggg tccgcaagga
      541 ggttggcgag gtctcggtcc tggtcaataa tgctggtgtg gtttctggac atcaccttct
      601 ggaatgtcct gatgagctca ttgaaagaac catgatggtc aactgccacg cacacttctg
      661 gaccactaag gcctttcttc caacgatgct agagattaat catggccaca ttgtgacggt
      721 cgcgagctcc ctgggactgt tcagcactgc tggagttgag gattactgtg ccagtaaatt
      781 tggagttgtg ggttttcacg agtctctgag ccatgagcta aaggctgctg aaaaggatgg
      841 aattaaaaca actctggttt gcccttacct tgtagacacg ggcatgttca gaggctgccg
      901 aatcagaaaa gaaattgagc cctttttgcc ccccttgaag cctgattact gtgtgaagca
      961 ggctatgagg gccatcctca ctgaccagcc catggtctgc accccccgcc tcatgtacat
     1021 cgtgacattc atgaagagca tccttccttt tgaagccgtc gtgtgcatgt atcgatttct
     1081 aggagcggac aagtgtatgt atccctttat tgctcaaaga aaacaagcca caaacaacaa
     1141 tgaagcaaaa aatggaatct aagagtgttt ttgtacggag tgccgtttct atcaggatag
     1201 gtggtccgtg cgcatcaatc agtactgacg gtctggattc taaccccatg ccgactcttt
     1261 tttttttttt ctaatcaact ttttaaaaaa taaagtgtaa attaactgac tagtgtgctt
     1321 gaaaactgtg agcttgggtt tttgccaatg gggtcttttc tagacagggc cctaaaaatg
     1381 agtccaatat ttagacaaac actatgttac atcattattt ttttaatgaa cataaagtct
     1441 agaaatgatg actacagtgt gtttcacgtg ggtccccaca gaattgattc attcattatc
     1501 gtggaagccc agccagcatt caaggaccga cagtgtagtg ctctgttgtg ttctcggttc
     1561 ttctcctgca agcctgggtg gcttgcttat ggtgtctgtg gattttttga tgtcagtttg
     1621 agatcagcgt agtctgagca tcacaatgaa ggccaccagt ctctttctta aacttacagt
     1681 gactaaatat tgggtgattt tcaaattcag tctctgaaat actaaattaa atgtttagag
     1741 acctggttaa tccacgtttg tacattttct acctgtgaat cttgctgcat atagaaagtg
     1801 ccctttcctc acggagctgc aaacttgtgt taggggagga agtgggggat cttgtctaca
     1861 ggacacagca gctccacaga gataatggga atttctgatt aaaaagtccc cgtacttgtg
     1921 ccaactttaa ttagcttggg gagcaaatct tatatggagt gttgtggaag ggtggaaaga
     1981 tttctttgaa aagtttattc acattgtaga acagcaaatg acatttttac agtatttttt
     2041 tgtaaagcaa actattttgt gccttgaatt tggtatatgt gtattagtga aacattgtaa
     2101 aagtgaattt ctacctctgt atctatgtgt accatcctct tgtaaattac tatgaactac
     2161 tatgtgattg cttctgtttg ttcgttctag gatgtctttt ttaaatagtg accaatgttt
     2221 aaggctgtta aaataagcca acttttacaa atcgggatgt tttctaaaga actgattaaa
     2281 tacgtacata actga
//
