LOCUS       NM_080436               3890 bp    mRNA    linear   ROD 29-MAR-2020
DEFINITION  Mus musculus retinol dehydrogenase 1 (all trans) (Rdh1), mRNA.
ACCESSION   NM_080436
VERSION     NM_080436.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3890)
  AUTHORS   Krois CR, Vuckovic MG, Huang P, Zaversnik C, Liu CS, Gibson CE,
            Wheeler MR, Obrochta KM, Min JH, Herber CB, Thompson AC, Shah ID,
            Gordon SP, Hellerstein MK and Napoli JL.
  TITLE     RDH1 suppresses adiposity by promoting brown adipose adaptation to
            fasting and re-feeding
  JOURNAL   Cell. Mol. Life Sci. 76 (12), 2425-2447 (2019)
   PUBMED   30788515
  REMARK    GeneRIF: Rdh1-generated all-trans-retinoic acid in brown adipose
            tissue regulates multiple genes that promote brown adipose tissue
            adaptation to whole-body energy status, such as fasting and
            re-feeding.
REFERENCE   2  (bases 1 to 3890)
  AUTHORS   Zhang M, Hu P, Krois CR, Kane MA and Napoli JL.
  TITLE     Altered vitamin A homeostasis and increased size and adiposity in
            the rdh1-null mouse
  JOURNAL   FASEB J. 21 (11), 2886-2896 (2007)
   PUBMED   17435174
  REMARK    GeneRIF: Altered vitamin A homeostasis and increased size and
            adiposity is associated with rdh1-null mouse
REFERENCE   3  (bases 1 to 3890)
  AUTHORS   Hu P, Zhang M and Napoli JL.
  TITLE     Ontogeny of rdh9 (Crad3) expression: ablation causes changes in
            retinoid and steroid metabolizing enzymes, but RXR and androgen
            signaling seem normal
  JOURNAL   Biochim. Biophys. Acta 1770 (4), 694-705 (2007)
   PUBMED   17270348
REFERENCE   4  (bases 1 to 3890)
  AUTHORS   Matt N, Schmidt CK, Dupe V, Dennefeld C, Nau H, Chambon P, Mark M
            and Ghyselinck NB.
  TITLE     Contribution of cellular retinol-binding protein type 1 to retinol
            metabolism during mouse development
  JOURNAL   Dev. Dyn. 233 (1), 167-176 (2005)
   PUBMED   15765518
REFERENCE   5  (bases 1 to 3890)
  AUTHORS   Zhang M, Hu P and Napoli JL.
  TITLE     Elements in the N-terminal signaling sequence that determine
            cytosolic topology of short-chain dehydrogenases/reductases.
            Studies with retinol dehydrogenase type 1 and cis-retinol/androgen
            dehydrogenase type 1
  JOURNAL   J. Biol. Chem. 279 (49), 51482-51489 (2004)
   PUBMED   15355969
  REMARK    GeneRIF: Rdh1, Crad1, and other short-chain
            dehydrogenases/reductases, which share similar N-terminal signaling
            sequences such as human Rdh5 and mouse Rdh4, orient with their
            catalytic domains facing the cytoplasm
REFERENCE   6  (bases 1 to 3890)
  AUTHORS   Zhang M, Chen W, Smith SM and Napoli JL.
  TITLE     Molecular characterization of a mouse short chain
            dehydrogenase/reductase active with all-trans-retinol in intact
            cells, mRDH1
  JOURNAL   J. Biol. Chem. 276 (47), 44083-44090 (2001)
   PUBMED   11562362
REFERENCE   7  (bases 1 to 3890)
  AUTHORS   Ulven SM, Gundersen TE, Sakhi AK, Glover JC and Blomhoff R.
  TITLE     Quantitative axial profiles of retinoic acid in the embryonic mouse
            spinal cord: 9-cis retinoic acid only detected after
            all-trans-retinoic acid levels are super-elevated experimentally
  JOURNAL   Dev. Dyn. 222 (3), 341-353 (2001)
   PUBMED   11747070
REFERENCE   8  (bases 1 to 3890)
  AUTHORS   Ulven SM, Gundersen TE, Weedon MS, Landaas VO, Sakhi AK, Fromm SH,
            Geronimo BA, Moskaug JO and Blomhoff R.
  TITLE     Identification of endogenous retinoids, enzymes, binding proteins,
            and receptors during early postimplantation development in mouse:
            important role of retinal dehydrogenase type 2 in synthesis of
            all-trans-retinoic acid
  JOURNAL   Dev. Biol. 220 (2), 379-391 (2000)
   PUBMED   10753524
REFERENCE   9  (bases 1 to 3890)
  AUTHORS   Chai X, Zhai Y and Napoli JL.
  TITLE     cDNA cloning and characterization of a
            cis-retinol/3alpha-hydroxysterol short-chain dehydrogenase
  JOURNAL   J. Biol. Chem. 272 (52), 33125-33131 (1997)
   PUBMED   9407098
REFERENCE   10 (bases 1 to 3890)
  AUTHORS   Driessen CA, Winkens HJ, Kuhlmann LD, Janssen BP, van Vugt AH,
            Deutman AF and Janssen JJ.
  TITLE     Cloning and structural analysis of the murine GCN5L1 gene
  JOURNAL   Gene 203 (1), 27-31 (1997)
   PUBMED   9426003
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK136574.1, AY028928.1 and AC129576.11.
            
            On Jan 16, 2008 this sequence version replaced NM_080436.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY028928.1, BC137930.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN00849382
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-534               AK136574.1         44-577
            535-997             AY028928.1         489-951
            998-2512            AK136574.1         1041-2555
            2513-3890           AC129576.11        124132-125509
FEATURES             Location/Qualifiers
     source          1..3890
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 75.21 cM"
     gene            1..3890
                     /gene="Rdh1"
                     /note="retinol dehydrogenase 1 (all trans)"
                     /db_xref="GeneID:107605"
                     /db_xref="MGI:MGI:1195275"
     exon            1..488
                     /gene="Rdh1"
                     /inference="alignment:Splign:2.1.0"
     CDS             176..1129
                     /gene="Rdh1"
                     /note="retinol dehydrogenase 1 (11-cis)"
                     /codon_start=1
                     /product="retinol dehydrogenase 16 precursor"
                     /protein_id="NP_536684.2"
                     /db_xref="CCDS:CCDS24250.1"
                     /db_xref="GeneID:107605"
                     /db_xref="MGI:MGI:1195275"
                     /translation="MWLYLVALVGLWTLLRFFRERQVVSHLQDKYVFITGCDSGFGNL
                     LARQLDRRGMRVLAACLTEKGAEELRNKTSDRLETVILDVTKTESIVAATQWVKERVG
                     NRGLWGLVNNAGISTPSGPNEWMKKQDFARVLDVNLLGMIEVTLSMLPLVRKARGRVV
                     NVSSVMGRMSFFGGGYCISKYGVEAFSDSLRRELSYFGVKVAIIEPGGFKTCVTSSDR
                     LSSNTKMIWDKASSEVKEIYGEKFLLFYLKNLNELDKRCNKDLSVVTDCMEHALTACH
                     PRTRYSAGWDAKFLFLPLSYLPTFLVDALLYWTSMKPEKAL"
     exon            489..747
                     /gene="Rdh1"
                     /inference="alignment:Splign:2.1.0"
     exon            748..911
                     /gene="Rdh1"
                     /inference="alignment:Splign:2.1.0"
     exon            912..3890
                     /gene="Rdh1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggaaagaaaa gcaagttcta gagagagaca atcagagagg agcagatcag agaggagcaa
       61 ctgtcatact tgccagaagt ctgtaggcta tgctgcctgc cacagttttt tgcattccta
      121 ttactctctg aaaacggggc aggctcattt tgtcctgaaa gcagctgtgt aaaccatgtg
      181 gctctacctg gttgcactgg tgggcctgtg gacgctcctg cgcttcttta gggagaggca
      241 ggtggtgagc catctccaag acaagtatgt cttcatcacg ggctgtgact ctggctttgg
      301 gaacctgctg gccagacagc tggacaggag aggcatgagg gtattggctg catgtctgac
      361 ggagaaggga gccgaggagc tgaggaacaa gacatctgac aggctggaga cagtgatcct
      421 ggatgtcacc aagacagaga gtattgtggc agccactcag tgggtgaagg agcgtgttgg
      481 gaacagagga ctctggggcc tggtcaacaa cgctggcatc tccaccccct cgggtcccaa
      541 cgagtggatg aaaaaacagg actttgcaag agtactggat gtgaacctgt tgggcatgat
      601 cgaggtgact ctgagcatgc tgcccttagt gaggaaggcg aggggtcgtg tggtcaacgt
      661 ctccagcgtc atgggccgaa tgtctttctt tggtggtggt tactgcatct ccaagtatgg
      721 tgtagaggcc ttctcagact ccctcaggag ggagctctcc tattttgggg tgaaggtggc
      781 tattatagag cctggaggct tcaagacttg tgtgacaagt agtgacaggc tatcatcaaa
      841 caccaagatg atctgggaca aggccagctc ggaagtcaaa gagatctatg gcgagaagtt
      901 tttattattc tatctgaaaa acctaaacga attggacaag aggtgcaaca aggacctgtc
      961 tgtggtgact gactgcatgg agcacgctct gactgcctgc caccctcgca ctcgatactc
     1021 agcaggctgg gatgccaagt tcctcttcct ccccttgagc tacctgccca cctttcttgt
     1081 ggatgccctt ctctactgga cttccatgaa gcctgagaaa gccctctgaa gtgttcacct
     1141 atgtgcatac ctggggagat gtaggtagag tgtgagagag agaatattta ggggaaatta
     1201 ggagggttga gggagggagt ttattagtct ggggttctta gtcaacacac ttcatctcat
     1261 taattctcct atgacactac acaagactga tgatgaccaa ataaataggc aaagaattct
     1321 gccaagggat tcagatacaa aagtgctggc tgatgtccag actatgagca tcatggctac
     1381 catgaaggtc gacacagatg aggaggctgg gaccagcttg tgccaagcat tcttctgtgt
     1441 cctcctctgc aggaaatgca catgccctgg ctagtttaaa cccctatgca gcatggaagt
     1501 gtccctgctc tgaagtcacc tgagaccatg gtgtagggtc tgagagagtc actaataaag
     1561 ccagcaccca tgccctggag tcaagttggc aggccctggg tgggaggttc agttcccggt
     1621 gatgaaacct agcagaggat ggagacacca ttttttttta aaaatcatgg cttcttttgg
     1681 actctttatt tttagaacaa agtatgaggt catctcctgt accctgtgat ttaaattatg
     1741 gcttttctgg ttagtgaggt ttggatcaca ggggtcaggg ttggcacagg ccagcaggct
     1801 ttctgagttg cagactcact aagtgaccat gctttcctgc agacccacta ggggaccatc
     1861 ccttgctgca gactcactaa ttgaccgtat cttacctgca tattcactaa ttgaccgtat
     1921 cttacctgca gaatcaggaa gttgccatcc cttcctgcag actcaataca tgataatcaa
     1981 ttccctgcag actcactaag tgaccatccc tttcctgcag acccattaag tgatcattcc
     2041 ttccctgcag acccattaag tcaccattcc ttcatataag tatcactaac tgaccattat
     2101 aataaaaccc ttctgatttt ctgtctgaac ttgtcccagg ccacttctca tgtcccctcc
     2161 ctctgtccca ctgccacact cctccagcag catgcagaga ttgcctttct tatctcttgt
     2221 ctttcatttt atggacaata tttacaaaag atcaagggtc tttaactccc atagcctctg
     2281 aggcctggct ctgcctggtg ctaggttggt gaatctcaag aataggctga gcagggacag
     2341 catgtgtggg agagacagaa tcctgggctc agtgcagact tgcccttggg agggaattcc
     2401 atagatgcct gactcctctt ctctcagtag aaatgtgggg gctgaggtgc cataagagga
     2461 acttgtaaat aaacgataat ttctgaatta atgaaaatag aaattccaac cctatcatgt
     2521 gcctggccat ccatttaatt tatgttattt tgaaagcttt gttttaggac ctttgagcat
     2581 atgtttgtat atctgtatgt ttcatgtgtg ggagtgccct aagatgtgag aaggaagatg
     2641 agggccactg gtttcaagaa gttttcagcc atataatgtg ggtgtcagga attgaatttg
     2701 ggtttgccat aagagcagga agcacttttt ttctgatttt ttattaaata ttttctttat
     2761 ttacattaca aatgttatcc cctttcctag tttcccctcc gaaaaacccc atcccccccc
     2821 cccactcccc tgctcaccaa cccacacact cctgcttcct ggctctggca ttcctttaca
     2881 ctggggcata cagccttcat aggactaagg gcctctcctc ccattgatga ccaacaaggc
     2941 catcctctgc tacatgtgcg gctggagcca tgggtccctc catgtgtact ctttggttgg
     3001 tggtttagtc cgtgggaact ctgggggtgc tagttggttc atattgttgt tcctcctatg
     3061 gggctgcaaa ccccttcagc tccttgggtc ccttctctag ttccttcatt ggggacatgg
     3121 tgctcagtcc actggatgcc tgagagcacc catctctgta tttgtcaggt actggtagaa
     3181 cccttcagga gacagcttta tcaagttcct gtcagctctt gttggcatct acagtagtgt
     3241 ctgggtttga tgactgtata tgggatggat acccaggtgg ggcagtctct ggatggcctt
     3301 tccttcagtc tctgctccat acttcgtaac tcctttcatg ggtattttgt tctcccttct
     3361 aagaaggacc caagtatcta cactttggtc ttccttttcc tttctttcct ttttttgttt
     3421 tgcttctggt ttggtttggt tttttgagac agagtttctc tgtgtagccc gggctgtcct
     3481 ggaactcact ctgtagacca ggctggcctt gaactcagaa atccacctgc ctgtgcctcc
     3541 agagtgctgg gattaaaggc gtgcgccatc acgcccatct ggtcttcctt tttcttgagc
     3601 ttcaggtggt ctgtgaattg tatcttgggt attcgaagct tctgggttaa tacccacttt
     3661 tcactgagtg cataccatgt gtgtgtgttc ttttatgatt gggttacctc actcaggatg
     3721 atattttcta gttccatcca attgcctaag aatttcataa attcattgtt tttaacagct
     3781 gagtagtact ccattgtgta aatgtaccac attttctgta tccattcctc tgttgtggga
     3841 catctgggtt ctttccagct tctggctatt aaaaataagg ctgctatgaa
//
